JP2019171067A - Hydrocolloid type adhesive composition for skin sticking, and sticking material containing the same - Google Patents

Abstract

To provide a hydrocolloid type adhesive composition for skin sticking which suppresses exudation from a side face when being applied to a sticking material, has adequate balance with sticking properties, and can be comfortably stuck, and a hydrocolloid type adhesive composition for skin sticking which can make its color tone be a color tone fitting to a color of skin without using a coloring agent.SOLUTION: A hydrocolloid type adhesive composition for skin sticking contains (A) an elastomer, (B) a tackifier resin, (C) a plasticizer and (D) colloidal particles, in which (B) the tackifier resin contains at least one selected from the group consisting of a C5-based resin and a C5/C9-based resin, and ▵b*(D65) of the hydrocolloid type adhesive composition for skin sticking is 8 or more and 17 or less.SELECTED DRAWING: None

Description

  The present invention relates to a hydrocolloid pressure-sensitive adhesive composition for skin application, and more particularly, to a hydrocolloid-type pressure-sensitive adhesive composition for skin application suitable as a wound treatment agent, and a patch containing the same.

  Hydrocolloid pressure-sensitive adhesives have increased in importance in recent years as exhibiting good wound healing effects by adhering to themselves, absorbing wound secretions that exude during healing, and maintaining a moist condition. ing.

  In general, hydrocolloid pressure-sensitive adhesives have a structure in which water-absorbing colloidal particles (water-absorbing agent) are dispersed in a continuous phase (base material) made of plastic rubber, and many of them are self-weight in a certain time. It is prepared to absorb about 3 to 5 times as much water or exudate from a wound site. Various proposals have been made on rubber components so that the base material does not lose its integrity even when water or the like is absorbed, and the desired adhesiveness can be exhibited (for example, Patent Document 1). In addition, the adhesive composition used for the patch should be one that absorbs distilled water per unit volume equivalent to that of physiological saline or has more physiological saline than distilled water. Thus, there has been proposed a patch that has the desired adhesiveness while maintaining the ability to absorb the leachate and can suppress the deterioration of the adhesive performance even after being wetted with water (for example, a patent) Reference 2). In addition, in recent years, even when plasticizers such as DOP and DOA, which are suspected of environmental hormone action and carcinogenicity, have been changed, the use of a new plasticizer that can adjust the amount of water absorption and absorption speed has been examined. Proposals have also been made (for example, Patent Document 3). Furthermore, proposals have also been made in which application of hydrocolloid pressure-sensitive adhesives to patch materials, particularly emergency adhesive bandages, is examined (for example, Patent Document 4). In the past, a relatively thick layer of hydrocolloid adhesive has been used when a hydrocolloid adhesive is applied to an attachment to cover the wound site and make it easy to obtain a wound healing effect.

Japanese translation of PCT publication No. 2002-512295 JP 2017-39706 A JP 2011-45494 A International Publication No. 2013/77134

These hydrocolloid pressure-sensitive adhesives have been used as a pressure-sensitive adhesive layer of adhesive tape with a pad portion of a bandage or a film as a support.
The hydrocolloid pressure-sensitive adhesive needs to be well applied to the skin for a certain period of time in order to maintain a moist environment on the wound surface. Therefore, the pressure-sensitive adhesive layer must have a certain degree of flexibility. On the other hand, it is necessary to prevent the adhesive from oozing out from the end of the support (hereinafter also referred to as “edge”) due to excessive flow over time even in an environment at room temperature or higher. . The tendency of the adhesive to ooze out from the edge of the support is a common problem particularly in the case of having a thick adhesive layer of 200 μm or more or an adhesive tape having an uncrosslinked adhesive layer. Was a problem that occurred remarkably in terms of its composition. When the patch is roll-shaped, if the end of the adhesive layer in the width direction exceeds the end of the support and seepage occurs, the exuded part wraps around the substrate or adhesive layer around itself. There is a problem that handling property is deteriorated, for example, the unraveling force becomes heavy when adhering and unraveling, or stringing of the adhesive is caused. Further, when foreign matter such as dust adheres to the exuded portion, not only the appearance is deteriorated, but also hygiene is problematic.

Adhesive materials such as adhesive bandages and adhesive tapes are used by being applied to the skin, but in order to enable comfortable application in daily life, it is also required to suppress the exudation from the edges of the adhesive material. Yes.
Conventional hydrocolloid compositions have not been intensively studied for the above-described suppression of bleeding.

  The object of the present invention is to provide a hydrocolloid pressure-sensitive adhesive composition for skin patch that solves the above-mentioned problems, that is, when applied to a patch, it suppresses bleeding from the side surface and has a balance with appropriate patchability. Another object of the present invention is to provide a hydrocolloid pressure-sensitive adhesive composition for skin application that enables comfortable application. It is another object of the present invention to provide a hydrocolloid-type pressure-sensitive adhesive composition for skin application, which can be adjusted to the color of the skin without using a colorant.

  As a result of intensive studies on the above problems, the present inventors have found that a pressure-sensitive adhesive composition used for a patch has at least one selected from the group consisting of a C5 resin and a C5 / C9 resin. It has been found that by adopting a resin, it is possible to provide a hydrocolloid pressure-sensitive adhesive composition for skin application that suppresses exudation from the side surface and enables comfortable application with a balance with appropriate adhesive properties. It was. Further, by setting Δb * (D65) of the hydrocolloid-type pressure-sensitive adhesive composition for skin application to 8 or more and 17 or less, it is possible to obtain a hue that adjusts to the color of the skin without using a colorant. The present inventors have found that a patch can be provided and completed the present invention.

  The present invention has the following configuration, which solves the above-described problems of the present invention.

[1]
(A) Elastomer, (B) Tackifying resin, (C) Plasticizer, and (D) Hydrocolloid pressure-sensitive adhesive composition for skin patch, wherein (B) Tackifying resin is C5 Hydrocolloid for skin application, containing at least one selected from the group consisting of / C9 resin and C5 resin, wherein Δb * (D65) of the hydrocolloid adhesive composition for skin application is 8 or more and 17 or less Type pressure-sensitive adhesive composition.
[2]
The hydrocolloid adhesive composition for skin application according to [1], wherein ΔE * ab (D65) of the hydrocolloid adhesive composition for skin application is 10 or more and 20 or less.
[3]
The hydrocolloid pressure-sensitive adhesive composition for skin application according to [1] or [2], wherein the (A) elastomer includes a styrenic block copolymer and polyisobutylene.
[4]
Content of the said polyisobutylene is a hydrocolloid type adhesive composition for skin sticking as described in [3] which is 40 mass%-60 mass% with respect to the total mass of the said (A) elastomer.
[5]
The content of the polyisobutylene is 1% by mass to 30% by mass with respect to the total mass of the hydrocolloid-type pressure-sensitive adhesive composition for skin application, and the hydrocolloid-type adhesive for skin application according to [3] or [4]. Agent composition.
[6]
Content of said (C) plasticizer is 5 mass%-15 mass% with respect to the total mass of the said hydrocolloid type adhesive composition for skin sticking, Any one of [1]-[5] The hydrocolloid pressure-sensitive adhesive composition for skin application as described.
[7]
The content of the (B) tackifying resin is any one of [1] to [6], which is 15% by mass to 30% by mass with respect to the total mass of the hydrocolloid adhesive composition for skin application. A hydrocolloid pressure-sensitive adhesive composition for skin application as described in 1.
[8]
A patch comprising the hydrocolloid pressure-sensitive adhesive composition for skin patch according to any one of [1] to [7].

The present invention provides a hydrocolloid-type pressure-sensitive adhesive composition for skin patching that suppresses bleeding from the side surface when applied to a patch and has a balance with appropriate patchability and enables comfortable patching. be able to. Furthermore, it is possible to provide a hydrocolloid-type pressure-sensitive adhesive composition for skin application, which can have a hue that can be adapted to the skin color without using a colorant.
Therefore, the patch using the hydrocolloid pressure-sensitive adhesive composition for skin patch of the present invention (hereinafter sometimes simply referred to as “pressure-sensitive adhesive composition”) has an appropriate patchability, but also has a proper adhesiveness. Since exudation is suppressed, even when the adhesive sheet is made into a roll, even if the roll-like patch is enclosed in a box with some slits, the drawability from the box is good, and the skin is used as the patch. When it is affixed to the surface, it can be expected that dirt such as clothes will not easily reach the edge of the adhesive material.
And the adhesive material using this adhesive composition can be expected to be developed in the medical and hygiene fields such as emergency bandages and dressings.

<Hydrocolloid adhesive composition for skin application>
The hydrocolloid pressure-sensitive adhesive composition for skin application of the present invention comprises (A) an elastomer, (B) a tackifying resin, (C) a plasticizer, and (D) colloidal particles, and the (B) tackifying resin comprises And at least one selected from the group consisting of C5-based resins and C5 / C9-based resins. The hydrocolloid pressure-sensitive adhesive composition for skin application of the present invention may contain other components as desired.
Hereafter, each said component is explained in full detail.

[(A) Elastomer]
The elastomer used in the present invention is not particularly limited as long as it is a conventionally used elastomer, but preferably includes a styrenic block copolymer and polyisobutylene (hereinafter also referred to as PIB).
Examples of the styrenic block copolymer include styrene / butadiene block copolymer (SBS) and its hydrogenated rubber (SEBS), styrene / isoprene block copolymer (SIS) and its hydrogenated rubber (SEPS), styrene · An isobutylene block copolymer (SIBS) etc. are mentioned, These can be used 1 type or in combination. Among these, SIS and SEBS are more preferable, and SIS is particularly preferably used.

The polyisobutylene can improve the adhesiveness of the pressure-sensitive adhesive composition to the skin, and is preferably used alone or in combination of two or more.
However, since the pressure-sensitive adhesive composition containing polyisobutylene tends to cause a cold flow phenomenon and the tendency for the pressure-sensitive adhesive to bleed out is observed, the content of polyisobutylene is based on the total mass of the pressure-sensitive adhesive composition. The content is preferably 1% by mass to 30% by mass, and more preferably 10% by mass to 30% by mass.

In the present invention, commercially available polyisobutylene can be used. For example, Opanol B30, B50, B80, N80, N100, B15, B15SFN, B12 (above, BASF Japan Ltd.), Vistanex LM-MS, LM-MH, LM-H (exxon), Hymor 4H, 5H, 5.5H, 6H, Tetrax 3T, 4T, 5T, 6T (above, JX Nippon Oil & Energy Corporation). The preferred range of viscosity average molecular weight: Mv of polyisobutylene is 10,000 to 11,110,000. In addition, the viscosity average molecular weight used here is based on the Flory method.
The content of the polyisobutylene is preferably 20% by mass to 65% by mass and more preferably 40% by mass to 60% by mass with respect to the total mass of the (A) elastomer.

In addition, the elastomer used in the present invention may include liquid rubber. Examples of the liquid rubber include liquid elastomer components such as liquid polyisoprene (LIR), liquid polybutadiene (LPB), and polybutene (PB).
The liquid rubber is a component different from the styrene block copolymer and polyisobutylene.
For example, the content of the liquid rubber is preferably 0% by mass to 20% by mass with respect to the total mass of the pressure-sensitive adhesive composition.

  In the present invention, the content of the (A) elastomer is preferably 20% by mass to 60% by mass and more preferably 30% by mass to 45% by mass with respect to the total mass of the pressure-sensitive adhesive composition. .

[(B) Tackifying resin]
The tackifying resin used in the present invention is generally a hydrophobic resin that is compatible with a hydrophobic rubber base component and develops tackiness. Specifically, rosin resin, rosin ester resin, terpene resin, terpene phenol Examples thereof include resins, C5 resins, C5 / C9 resins, DCPD petroleum resins, coumarone-indene resins, and hydrogenated products thereof.

  In the present invention, the (B) tackifier resin contains at least one selected from the group consisting of a C5 resin and a C5 / C9 resin.

Examples of the C5-based resin include C5-based petroleum resins, and examples thereof include C5-based aliphatic hydrocarbon resins. Specifically, a resin obtained by polymerizing (for example, cationic polymerization) an unsaturated monomer such as isoprene or cyclopentadiene, which is a petroleum fraction (C5 fraction) corresponding to 4 to 5 carbon atoms, -Resin made from concentrated pentadiene.
The softening point of the C5 resin is preferably 80 ° C to 100 ° C, more preferably 90 ° C to 100 ° C.
In the present specification, the softening point is a value measured based on JIS-2207.

  As the C5 resin, for example, Quinton A100 (manufactured by Nippon Zeon Co., Ltd.), Quinton M100 (manufactured by Nippon Zeon Co., Ltd.) or the like can be used.

Examples of the C5 / C9 series resin include C5 / C9 series petroleum resins, and examples thereof include C5 / C9 series aliphatic / aromatic hydrocarbon resins. Specifically, it is a resin obtained by copolymerizing the C5 fraction and a petroleum fraction (C9 fraction) having 8 to 10 carbon atoms by polymerization (for example, cationic polymerization).
The softening point of the C5 / C9 resin is preferably 80 ° C to 115 ° C, more preferably 85 ° C to 115 ° C, and still more preferably 90 ° C to 115 ° C.

  Further, in order to affect the hue when the pressure-sensitive adhesive composition is prepared, the solution hue of the C5 / C9 resin based on the JIS-K5600 Gardner method (toluene 50%) is preferably 4 or more, particularly 7 or more. It is more preferable that For example, Quinton N180 (manufactured by ZEON CORPORATION) can be cited as an example having a solution hue of 4 or more. Quinton G100B (manufactured by ZEON Corporation), quinton G115 (manufactured by ZEON Corporation) can be cited as an example having a solution hue of 7 or more. Etc.) can be used.

In the present invention, the (B) tackifying resin contains at least one selected from the group consisting of a C5 resin and a C5 / C9 resin, but other tackifying resins are used in the hue of the pressure-sensitive adhesive composition. It can also be contained in a range that does not affect.
Specific examples of the tackifying resin other than at least one selected from the group consisting of the C5 resin and the C5 / C9 resin of the component (B) tackifying resin include the C5 resin in the specific example of the tackifying resin. And resins other than C5 / C9-based resins, for example, Alcon (registered trademark) P-125 (Arakawa Chemical Industries), which is an alicyclic saturated hydrocarbon resin.

The (B) tackifying resin is preferably present in an amount of 20 to 200 parts by mass, preferably 50 to 180 parts by mass with respect to 100 parts by mass of all elastomer components.
10 mass%-40 mass% are preferable with respect to the total mass of an adhesive composition, and, as for content of the said (B) tackifying resin, it is still more preferable that it is 15 mass%-30 mass%.

[(C) Plasticizer]
The plasticizer (softener) used in the present invention may be a paraffinic or naphthenic petroleum process oil, a castor oil, a vegetable oil such as soybean oil, or a softener such as a fatty acid ester derived from a vegetable oil. Good. In addition, aromatic dicarboxylic acids such as phthalic acid, isophthalic acid and terephthalic acid, and aliphatic dicarboxylic acids such as succinic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid and sebacic acid, and the number of carbon atoms, for example A dibasic acid ester plasticizer with a monoalcohol having about 8 to 10 alkyl groups; the aromatic dicarboxylic acid or aliphatic dicarboxylic acid and a glycol such as ethylene glycol, propylene glycol, butylene glycol, neopentyl glycol or diethylene glycol; Polyester plasticizers obtained by polycondensation of polyethylene; other plasticizers such as polyethylene glycol and citrate can also be used. Two or more of these can be used in combination.
In the present invention, the plasticizer of component (C) is preferably 1% by mass to 15% by mass, and more preferably 5% by mass to 15% by mass with respect to the total mass of the pressure-sensitive adhesive composition. .

[(D) Colloidal particles]
The colloidal particles used in the present invention are not particularly limited. For example, corn starch, guar gum, locust bean gum, starch, pectin, alginic acid and salts thereof, carrageenan, collagen, agar, gelatin, chitin, chitosan, karaya gum, arabic Gum, xanthan gum, dextrin, dextran, carboxymethylcellulose, carboxymethylcellulose sodium (CMC), carboxymethylcellulose calcium, hydroxyalkylmethylcellulose, hydroxypropylcellulose, methylcellulose, starch acetate, starch phosphate, hydroxyethylated starch, hydroxypropyl starch, oxidized Starch, dextrinized starch, starch-acrylic acid graft polymer, Riakuriru acid and salts thereof, polyethylene oxide, polyvinyl alcohol, poly -N- vinylpyrrolidone hydrocolloid particles (hydrophilic polymer) can be mentioned.
Among these colloidal particles, it is preferable to use carboxymethyl cellulose / sodium having good heat resistance. The particle size of carboxymethylcellulose sodium is 5 μm to 500 μm, preferably 15 μm to 250 μm.
Commercially available products of the above carboxymethylcellulose sodium include Cellogen (registered trademark) F-3H (Daiichi Kogyo Seiyaku Co., Ltd.), MAC200HC, Sunrose (registered trademark) F350HC, Sunrose (registered trademark) F10LC (Nippon Paper Industries Co., Ltd.) Chemical Co., Ltd.).

  The colloidal particles used in the present invention may be used alone or in combination of two or more.

  In order to obtain an appropriate water absorption rate and water absorption amount, the amount of these colloidal particles is, for example, carboxymethylcellulose sodium or carboxymethylcellulose, preferably 10% by mass to 50% with respect to the total mass of the pressure-sensitive adhesive composition. It is possible to use at a ratio of 20% by mass, more preferably 20% by mass to 40% by mass, liquid absorption, especially water absorption, adhesion to a wound site, and appropriate shape retention (protrusion of the plaster from the side) From the viewpoint of prevention).

[Other ingredients]
Furthermore, the pressure-sensitive adhesive composition of the present invention includes an antioxidant such as tocopherol acetate and / or a derivative thereof, ascorbic acid and / or a derivative thereof, sodium sulfite, and dibutylhydroxytoluene, which are used in a general rubber-based pressure-sensitive adhesive. Bisphenol-based, hindered amine-based, benzimidazole-based anti-aging agents, ultraviolet absorbers, light stabilizers, and the like may be appropriately added in one or more combinations.
In addition, the pressure-sensitive adhesive composition of the present invention may contain other various additives commonly used for pressure-sensitive adhesive tapes and sheets for skin application, such as fillers, deodorants, and fragrances, or In order to increase the internal cohesive force, a crosslinking agent may be appropriately added.
The compounding quantity of these arbitrary components is 5 mass% or less normally with respect to the total mass of an adhesive composition.

In addition, a medicinal component for the purpose of skin treatment or prevention of damage, beauty and the like may be added to skin that has already been damaged or skin that is expected to be damaged. For example, pharmacologically effective medicinal ingredients include antibiotics, bactericides and antibacterial agents (acrinol, benzalkonium chloride, silver compounds, etc.), disinfectants, anti-inflammatory agents and skin protection agents. Moreover, by adding a substance having a moisturizing effect such as ceramide, regeneration of healthy skin damaged by exfoliation can be promoted, or γ-oryzanol having a high blood flow promoting effect can be promoted. By adding, it can relieve the occlusion of blood vessels caused by body pressure at the site where pressure ulcers are concerned, and it can be expected to prevent pressure ulcers.
These medicinal components can be used in a content of usually 3% by mass or less, preferably 2% by mass or less, based on the total mass of the pressure-sensitive adhesive composition.

The pressure-sensitive adhesive composition of the present invention can contain a colorant to make the wound inconspicuous when applied to a patch, but irritation to the skin may be a problem.
The pressure-sensitive adhesive composition of the present invention preferably contains no colorant.
Regarding the hue of the pressure-sensitive adhesive composition of the present invention, Δb * (D65) of the pressure-sensitive adhesive composition of the present invention is 8 or more and 17 or less. The Δb * (D65) of the pressure-sensitive adhesive composition of the present invention is 8 or more and 17 or less, so that the wound can be made inconspicuous when applied to a wound site without using a coloring agent. It is possible to achieve a hue that matches the color of the color. In addition, (DELTA) b * (D65) has shown the yellow grade of the adhesive composition.
Δb * (D65) is preferably 8 or more and 17 or less, more preferably 10 or more and 17 or less, and more preferably 11 or more and 17 or less.

Furthermore, regarding the hue of the pressure-sensitive adhesive composition of the present invention, ΔE * ab (D65) is preferably 10 to 20, more preferably 10 to 19, and still more preferably 13 to 19.
ΔE * ab (D65) indicates the difference in hue of the pressure-sensitive adhesive composition with respect to white.
By setting the value of ΔE * ab (D65) within the above range, it is possible to obtain a hue that more closely matches the skin color, which is preferable.

  Δb * (D65) and ΔE * ab (D65) are each measured by the SCE method using a spectrocolorimeter (Konica Minolta, CM-2600D).

  The hue can be adjusted by appropriately changing the composition and content of the pressure-sensitive adhesive composition of the present invention. For example, the hue can be adjusted by adjusting the type and content of the tackifying resin in the pressure-sensitive adhesive composition of the present invention.

<Patch material>
The present invention also relates to a patch comprising the hydrocolloid pressure-sensitive adhesive composition for skin patch of the present invention.
The adhesive patch in the first aspect of the present invention has a base material and an adhesive layer on at least one surface of the base material, and the adhesive layer is a hydrocolloid adhesive composition for skin application of the present invention. It is a patch material formed using.

The patch of the present invention can be suitably produced by a calendar method, a hot melt method, or the like, which is a coating method that does not require an organic solvent.
The hot-melt method uses the characteristics of a block copolymer that softens and melts rapidly at high temperatures without using any dilution medium such as organic solvents, and does not require a drying process. There are advantages such as no danger of.
As an example, a manufacturing example of a patch by a hot melt method will be described below. Heat-controllable high-speed rotating mixer to dissolve the elastomer component, tackifier resin, plasticizer and colloidal particles, and other components as needed by heating and stirring at a temperature of 150-200 ° C for 30-120 minutes in a nitrogen atmosphere. As a product, a pressure-sensitive adhesive composition in which each component is uniform can be obtained.
The pressure-sensitive adhesive composition obtained by the above method is extruded from a die head part temperature-controlled at 150 to 200 ° C. with a hot melt coating machine and spread on a release sheet to a thickness of, for example, 100 to 1,000 μm. After that, a patch can be prepared by laminating (preferably laminating) a base material thereon.
As the calendering method, using a pressure kneader, adding an elastomer component, tackifying resin, plasticizer and colloidal particles, and other components as appropriate, kneading temperature 80 to 140 ° C., kneading time 20 to 60 minutes. Prepare a pressure-sensitive adhesive by kneading uniformly. In the calendar method, the adhesive is heated and rolled between several cast steel hot rolls, and the adhesive is spread on the release sheet to a thickness of, for example, 100 to 1,000 μm by friction due to the peripheral speed of the roll. Thereafter, a patch can be produced by laminating (preferably laminating) a base material thereon.

  The substrate used here is not particularly limited as long as it has appropriate stretchability, flexibility, and strength, and those having appropriate air permeability, moisture permeability, and fungus barrier properties are particularly preferable. Examples thereof include films such as polyolefin, polyurethane, polyester and polyacrylic acid, foams, nonwoven fabrics, woven fabrics and knitted fabrics. Among these, a polyurethane film is preferable from the above viewpoint.

Moreover, the release sheet used can use a thing conventionally used in the field | area of a patch. For example, a paper base material such as high-quality paper or glassine paper subjected to silicone release treatment, a polyester film, or the like can be used.
In the present invention, the length of the release sheet is 0.2 mm or more, particularly from the adhesive coating area, from the viewpoint of prevention of adhesive flow-out, productivity, handling, economy, and ease of production. It is preferable to increase it by 1 to 5 mm.

  What is necessary is just to select the shape of the patch of this invention suitably according to the intended purpose. Specific examples of the shape include a circle, an ellipse, a polygon such as a triangle, a rectangle, and a rhombus. Moreover, the shape which combined these shapes suitably may be sufficient, and you may form in a roll shape.

  The patch material can also be obtained by laminating the hydrocolloid pressure-sensitive adhesive composition for skin patching on the entire surface or by pattern coating to form a pressure-sensitive adhesive layer.

The patch in the second aspect of the present invention has a base, an adhesive layer, and a pad layer in this order, and the pad layer contains the hydrocolloid adhesive composition for skin patch of the present invention. At this time, it is preferable that the base material has high moisture permeability, and the adhesive layer is preferably set to have higher adhesive force than the pad layer.
In addition, it can be diverted to the patch in the second aspect by applying a pad layer to the patch in the first aspect.

  The thickness of the pressure-sensitive adhesive layer (hydrocolloid composition layer) of the patch of the present invention is not particularly limited. However, when securing the fixation to the skin and keeping a constant thickness from the balance with the substrate thickness, 100 to 1,200 μm or less is preferable. Especially preferably, it is 150-400 micrometers. Also, for example, the amount of adhesive used at the border of the patch is less than the amount of adhesive used at the center of the patch, and the thickness is reduced to prevent rubbing between the border and clothing, etc. The effect that it becomes difficult to peel off when applied to is obtained. In this case, the amount of the adhesive used is preferably 300 to 1,200 μm, more preferably 600 to 800 μm at the center, and the amount of the adhesive used in the border is preferably 50 to 300 μm, more preferably. 100 to 300 μm.

[Adhesive strength of adhesive layer]
The pressure-sensitive adhesive layer formed using the hydrocolloid pressure-sensitive adhesive composition for skin application is applied to the surface of the applied skin including the wound site and can be peeled without damaging the wound site and healthy skin. It is desirable to have a predetermined adhesive force because it must be maintained and the anchoring property to the support disposed on the back surface must be kept good. For example, the adhesive strength of the adhesive layer to the skin surface is preferably in the range of 0.1 to 2.0 N / 15 mm, more preferably 0.2 to 1.5 N / 15 mm.

  As the physical and chemical properties of the patch of the present invention, those defined in the pamphlet of International Publication No. 2013/077134 can be suitably applied.

  EXAMPLES Hereinafter, the present invention will be described in more detail with reference to examples. However, the present invention is not limited to these examples.

<Preparation of hydrocolloid adhesive composition for skin application>
Using the calender method, the mixture was kneaded with a composition shown in Table 1 using a pressure kneader and kneaded at a temperature of 80 to 140 ° C. for 30 to 50 minutes to prepare a uniform pressure-sensitive adhesive composition.

<Production of patch material>
The prepared pressure-sensitive adhesive composition was spread to a thickness of 300 μm on glassine paper (thickness: 120 μm) treated with silicone using a hot stretching roll to form a pressure-sensitive adhesive layer. A 10 μm polyether-based polyurethane film was laminated as a base material on this pressure-sensitive adhesive layer to produce a 15 × 100 cm sheet to obtain a patch of Example 1.
In Examples 2 to 9 and Comparative Examples 1 to 4, patch materials were produced in the same manner as Example 1.

<Exudation evaluation>
Using each patch cut into a 30 mm × 40 mm sheet, the edges were aligned and 10 sheets were stacked to prepare a sample. This was sandwiched between two glass plates having a length of 50 mm, a width of 70 mm, and a thickness of 2 mm.
A weight of 1000 g was placed on the glass plate, and a load was applied to the glass plate, which was then placed in a constant temperature bath at 60 ° C. After leaving still for one week, it took out from the thermostat and evaluated the degree of oozing of the side surface of the pressure-sensitive adhesive layer. Visual evaluation was performed according to the following criteria.
◯: Good without stickiness △: Sticky, but there is no obvious exudation of the pressure-sensitive adhesive layer.
X: The pressure-sensitive adhesive layer is exuded.
Evaluation (circle) and (triangle | delta) are the levels which are satisfactory practically.

<Evaluation of holding power>
Each patch is measured according to the procedure defined in JIS Z 0237 (holding force). Under conditions of 23 ° C. and 50% RH, a test piece A having a width of 25 mm was attached to a glass plate so as to have an area of width 25 mm × length 20 mm, and was reciprocally crimped at a speed of 300 mm / min with a 2 kg rubber roll. After leaving for 30 minutes in an environment of 60 ° C., hang the test piece A so that it hangs vertically, apply a load of 100 g of weight, and move the adhesive material by 30 minutes and 60 minutes after attachment ( mm) is measured, and the average value (number of tests n = 3) is defined as the holding force.

<Hue>
The hue was evaluated on the pressure-sensitive adhesive layer after peeling the release sheet from the patch, pasting it on white fine paper, and over the support (differing the color of the support layer). Hue was measured using a spectrocolorimeter (Konica Minolta, CM-2600D), and Δb * (D65) and ΔE * ab (D65) were measured by the SCE method, respectively. In this case, Δb * (D65) was measured three times, and the average value was taken as the measurement result (Δb * (D65)). Further, ΔE * ab (D65) was measured three times, and the average value was taken as the measurement result (ΔE * ab (D65)).

<Adhesion to skin>
Each patch was cut into 30 mm × 50 mm (the edge was rounded off) and applied to the skin on the inner side of the forearm, and the adhesiveness of the patch to the skin after 24 hours was evaluated.
○: Peeling less than 10% Δ: Peeling of 10% or more and less than 30% ×: Peeling evaluation of 30% or more ○ and Δ are levels that are practically satisfactory.

<Inconspicuous>
Each patch was cut to 30 mm × 50 mm (the edge was rounded off) and applied to the skin on the inner side of the forearm. The difficulty of conspicuousness of the patch after 5 minutes was visually evaluated according to the following criteria.
A: Inconspicuous B: Slightly conspicuous but no problem C: Conspicuous problem There are obtained results in Table 1.

The components used in Examples and Comparative Examples are as follows.
Opanol B15SFN: manufactured by BASF Japan Ltd. Quinton G100B: manufactured by Nippon Zeon Co., Ltd. Quinton N180: manufactured by Nippon Zeon Co., Ltd. Pine Crystal KE311: manufactured by Arakawa Chemical Industries, Ltd. Quinton A100: manufactured by Nippon Zeon Co., Ltd. FTR-6100: Mitsui Chemicals, Inc. Super ester A100: Arakawa Chemical Industries, Ltd. YS Polystar T100: Yashara Chemical Co., Ltd. Anti-aging agent: BHT: Seiko Chemical Co., Ltd.

Claims (8)

  (A) Elastomer, (B) Tackifying resin, (C) Plasticizer, and (D) Hydrocolloid pressure-sensitive adhesive composition for skin patch, wherein (B) Tackifying resin is C5 Hydrocolloid for skin application, containing at least one selected from the group consisting of / C9 resin and C5 resin, wherein Δb * (D65) of the hydrocolloid adhesive composition for skin application is 8 or more and 17 or less Type pressure-sensitive adhesive composition.   The hydrocolloid adhesive composition for skin application according to claim 1, wherein ΔE * ab (D65) of the hydrocolloid adhesive composition for skin application is 10 or more and 20 or less.   The hydrocolloid pressure-sensitive adhesive composition for skin application according to claim 1 or 2, wherein the (A) elastomer comprises a styrenic block copolymer and polyisobutylene.   The hydrocolloid pressure-sensitive adhesive composition for skin application according to claim 3, wherein the content of the polyisobutylene is 40% by mass to 60% by mass with respect to the total mass of the (A) elastomer.   The hydrocolloid pressure-sensitive adhesive composition for skin patch according to claim 3 or 4, wherein the content of the polyisobutylene is 1% by mass to 30% by mass with respect to the total mass of the hydrocolloid-type pressure-sensitive adhesive composition for skin patch. object.   The content of the (C) plasticizer is 5% by mass to 15% by mass with respect to the total mass of the hydrocolloid pressure-sensitive adhesive composition for skin application, according to any one of claims 1 to 5. Hydrocolloid pressure-sensitive adhesive composition for skin application.   The content of the (B) tackifying resin is 15% by mass to 30% by mass with respect to the total mass of the hydrocolloid-type pressure-sensitive adhesive composition for skin application, according to any one of claims 1 to 6. Hydrocolloid pressure-sensitive adhesive composition for skin application.   A patch comprising the hydrocolloid adhesive composition for skin patch according to any one of claims 1 to 7.