JPS61187867A - Medical pressure-sensitive sheet or tape - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

Detailed Description of the Invention (Industrial Application Field) The present invention relates to a medical adhesive sheet or tape, particularly a medical adhesive sheet having an aqueous and antibacterial acrylic adhesive layer provided on a base material. Or about the tape.

(Prior Art) Adhesives for medical adhesive sheets or tapes, such as patches and adhesive plasters containing drugs, have good adhesion to the skin and excellent aging resistance.

Traditionally, acrylic adhesives have been most frequently used because they have excellent properties such as not altering the quality of the drugs they contain and not irritating the skin.

Acrylic pressure-sensitive adhesives usually have as a main component a (co)polymer of acrylic ester or a (co)polymer of acrylic ester and methacrylic ester. If necessary, various other monomers may be copolymerized to obtain an acrylic pressure-sensitive adhesive having desired properties. Such monomers include (meth)acrylic acid, (meth)acrylamide,
(meth)acrylic acid hydroxyalkyl ester,
Examples include (meth)acrylic acid polyalkylene glycol ester, (meth)acrylic acid glycidyl ester, (meth)acrylic acid alkoxyalkyl ester, and vinyl acetate. For example, a copolymer containing acrylic acid as a copolymerization component has good adhesiveness at room temperature. Special Public Service 1977
Publication No. 31405 discloses a patch in which the adhesive contains a steroid anti-inflammatory agent, and the adhesive is a copolymer of acrylic acid alkyl ester and acrylic acid. JP-A-52-18813 also discloses a patch in which the adhesive contains a steroidal anti-inflammatory agent, and the adhesive contains an acrylic acid alkyl ester, (
It is a copolymer consisting of meth)acrylic acid, methyl methacrylate or vinyl acetate, and a polyfunctional monomer. Furthermore, JP-A-57-77167 discloses a patch containing nitroglycerin as a drug, and its adhesive is a copolymer consisting of methacrylic acid dodecyl ester, (meth)acrylic acid, and vinyl acetate. be. Furthermore, Japanese Patent Application Laid-Open No. 56-45412 discloses a drug-containing patch using an adhesive with high drug solubility. The adhesive has an ether bond in one molecule (
Meth)acrylic acid ester, a copolymer of (meth)acrylic acid and (meth)acrylic acid alkyl ester.

As described above, medical sheets or tapes using acrylic adhesives have various excellent features such as good adhesion to the skin surface. However, this is because the conventional acrylic adhesives are essentially insoluble in water or have poor hydrophilicity.

Sheets or tapes using adhesives have the following drawbacks.

■It is difficult to apply the sheet or tape to a wet (or damp) surface. for example.

Poor adhesion to sweating skin surfaces. If you continue to sweat a lot after applying it, remove it.

■Adhesive that protrudes from the periphery of the patch or tape, or adhesive that remains on the skin surface after the sheet or tape is peeled off, cannot be washed away with water.

■ For example, water-soluble drugs in the form of sodium salts, potassium salts, ammonium salts, hydrochlorides, etc.1 are usually dissolved only in water or alcohol.

Therefore, it is difficult to dissolve such a drug in an adhesive, and therefore it is difficult to prepare an adhesive sheet or tape containing it.

■Since the adhesive has poor moisture absorption ability and poor breathability, stuffiness occurs when the sheet or tape is applied to the skin for a long time. As a result, the skin becomes easily sensitized to even the slightest irritation caused by drugs or the like, causing a rash.

■ Bacteria, fungi, and other germs can grow abnormally in the stuffy application area, which can easily cause a rash due to secondary sensitization.

(Meta) to impart hydrophilicity to acrylic adhesives.
Copolymerization of hydrophilic monomers such as acrylic acid, acrylamide, and (meth)acrylic acid hydroxyalkyl esters has also been carried out. However, unless 60 mol% or more of such hydrophilic monomers are copolymerized, the resulting adhesive will not exhibit hydrophilicity. When 60 mol % or more of the hydrophilic monomer is copolymerized, the balance between the tackiness and internal cohesive force of the adhesive is lost, resulting in adhesive residue. Furthermore, the inherent excellent properties of acrylic pressure-sensitive adhesives, such as aging resistance and non-irritation to the skin, are impaired.

(Problems to be Solved by the Invention) The present invention solves the above-mentioned conventional drawbacks, and its purpose is to provide a hydrophilic acrylic pressure-sensitive adhesive layer on a base material as described below. An object of the present invention is to provide a medical adhesive sheet or tape having excellent properties.

■Can be attached to wet (moist) skin surfaces.

A sheet or tape that does not peel off easily even if you sweat during application.

■A sheet or tape that can be easily removed by washing with water even if the adhesive protrudes around the sheet or tape when it is applied or remains on the skin surface after peeling off.

■Water-soluble drugs that could not be dissolved and contained in acrylic adhesives 2 For example, drugs in the form of salts such as sodium salts, potassium salts, ammonium salts, and hydrochlorides can be dissolved and contained in high concentrations. Sheet or tape with adhesive.

(2) A sheet or tape that does not cause stuffiness during application because the adhesive has water absorption ability and/or water permeability, and therefore does not cause rashes caused by this stuffiness.

Still another object of the present invention is to provide a medical adhesive sheet or tape in which the adhesive itself has a bactericidal or antibacterial effect and does not cause secondary sensitization rash caused by the proliferation of microorganisms. .

Still another object of the present invention is, in addition to the above-mentioned valuable properties, to
It is an object of the present invention to provide a medical adhesive sheet or tape provided with an adhesive layer on its surface that has the inherent advantages of an acrylic adhesive.

(Means for solving problems) The medical adhesive sheet or tape of the present invention is:

A medical adhesive sheet or tape having a layer of an adhesive mainly composed of a copolymer containing a (meth)acrylamide derivative as a copolymerization component, the adhesive layer being provided on at least one side of a base material, wherein the (meth)acrylamide derivative is , is a monomer in which a saturated hydrocarbon group having a quaternary ammonium salt is substituted with one of the amide hydrogen atoms of (meth)acrylamide, thereby achieving the above object.

The copolymer that is the main component of the adhesive used in the medical adhesive sheet or tape of the present invention contains a (meth)acrylamide derivative as a copolymer component. This (meth)acrylamide derivative.

A saturated hydrocarbon group with a quaternary ammonium salt (meta)
It is a radically reactive monomer substituted with one of the amide hydrogen atoms of acrylamide and has the following 9-dimensional structural formula: R1 (where +RI is H or CH3; R2 has 1 to 1 carbon atoms)
6 saturated hydrocarbon groups; R3+R4 and R2 have 1 carbon number
~3 alkyl groups; and X is a halogen atom).

Among the compounds represented by the above structural formula, suitable examples include 3 (acrylamido)propyltrimethylammonium chloride, 3 (methacrylamido)propyltrimethylammonium chloride, 3 (acrylamido)isopentyltrimethylammonium chloride, 3 (methacrylamide) Examples include propyldimethylethylammonium chloride. Such (meth)acrylamide derivatives can be obtained, for example, by adding an alkyl halide to aminoalkyl (meth)acrylamide. Examples of the halogen of the alkyl halide include CI, Br, and I.

The copolymer that is the main component of the above-mentioned adhesive includes, in addition to the first copolymer component consisting of the above-mentioned (meth)acrylamide derivative,
Contains a second copolymer component. The main components of the second copolymer component are acrylic acid alkyl esters in which the alkyl group has 12 or less carbon atoms and/or vinyl alcohol fatty acid esters in which the fatty acid alkyl group has 12 or less carbon atoms. It accounts for 50 mol% or more of the polymerization component. The remainder of the second copolymer component is methacrylic acid alkyl ester.

Vinylpyrrolidone, diacetone acrylamide.

At least one monomer selected from the group consisting of N-alkyl (meth)acrylamide and N-alkoxyalkyl (meth)acrylamide.

The copolymer contains the first copolymer component and the second copolymer component in a molar ratio of 2:98 to 60:40. If the amount of the first copolymer component is too small, the resulting copolymer will have insufficient hydrophilicity. If it is in excess, the water absorption of the copolymer will be too high, and the adhesive will absorb moisture during storage or when prepared into a sheet or tape, causing a change in the properties of the adhesive.

In this way, the content of the first copolymer component controls the degree of hydrophilicity of the copolymer, and as the proportion of the first copolymer component increases, the properties of the copolymer change from hydrophilic to water-soluble. However, the degree of hydrophilicity of the copolymer also differs depending on the type of the alkyl group of the acrylic acid alkyl ester and the alkyl group of the fatty acid of the vinyl alcohol fatty acid ester as the second copolymer component. For example, when the second copolymerization component is an acrylic acid alkyl ester, the smaller the number of carbon atoms in the alkyl group, the higher the degree of hydrophilicity tends to be.

Furthermore, when a methacrylic acid alkyl ester is added to the second copolymerization component, the degree of hydrophilicity tends to decrease compared to the case where only an acrylic acid alkyl ester is used. Further, when a water-soluble monomer such as vinylpyrrolidone or diacetone acrylamide is added to the second copolymerization component.

The hydrophilicity of the copolymer increases. As described above, the degree of hydrophilicity of the copolymer can be adjusted by the type of monomer used as the second copolymer component.

Furthermore, the copolymer containing the first copolymer component and the second copolymer component has hydrophilicity and antibacterial (anti)bacterial properties. The bactericidal (anti)bicidal property increases uniquely as the molar ratio of the first copolymer component increases.

When copolymerization is carried out by adding a trace amount of a polyfunctional monomer in addition to the first copolymerization component and the second copolymerization component.

The internal cohesive force of the resulting copolymer can be improved. The polyfunctional monomer refers to a monomer in which (meth)acrylic acid ester groups are substituted at two or more positions at the ends of the nine molecules. For example, 1,6-hexane glycol dimethacrylate is preferably used. This is because when a polyfunctional monomer is contained, crosslinking (slight crosslinking) occurs, albeit very slightly, during copolymerization.

The internal cohesive force of the copolymer increases. Therefore, even if a large amount of the plasticizer described below is added, the copolymer does not become fluidized, so a pressure-sensitive adhesive with high adhesive strength can be obtained.

The polyfunctional monomer is added at a rate of 0.8% by weight or less based on the total polymerizable monomers during polymerization. If it is in excess, the resulting copolymer will have poor solubility in solvents such as alcohol and water.

The above-mentioned first copolymerization component and second copolymerization component, and if necessary, a polyfunctional monomer are subjected to a polymerization reaction by a normal polymerization method 2, for example, a solution polymerization method, an emulsion polymerization method, or a suspension polymerization method. , a copolymer is obtained.

Among them, solution polymerization method is preferably used. When performing solution polymerization, a solvent is selected that can dissolve the first polymerization component and the second polymerization component at least under polymerization temperature conditions.

As such a solvent, alcoholic solvents such as methyl alcohol, ethyl alcohol, and isopropyl alcohol are preferably used. Depending on the composition of the monomers to be copolymerized, a small amount of ethyl acetate, methyl ethyl ketone, toluene, etc. may be added.

To obtain a copolymer, the above-mentioned monomer, catalyst, and solvent are charged into a reactor equipped with a reflux condenser, and the reaction is carried out under an inert gas atmosphere while heating and stirring.

It is necessary to make the monomer concentration of the reaction solution at the initial stage of polymerization as high as possible in order to obtain a highly viscous polymer, and the monomer concentration is preferably adjusted to 60 to 90% by weight. As the process progresses, the viscosity of the reaction solution gradually increases as in the case of normal solution polymerization. When the viscosity of the reaction solution increases rapidly and stirring becomes difficult, a gradual concentration reduction method is used in which a solvent is added as appropriate to maintain the reaction solution at an appropriate viscosity. As the catalyst, a typical radical polymerization catalyst is used. In consideration of the solvent system, an azobis-based catalyst is particularly preferably used. The amount of catalyst is usually 1.

A range of 0.1 to 0.5 mol % of the total number of monomer moles is adopted. The catalyst is preferably added to the reaction system in appropriate portions depending on the progress of the monopolymerization reaction.

The reaction temperature varies depending on the type of monomer, but is usually 50 to 8.
0°C Preferably 60 to 70°C 0 For example, 1 A preferred method is to conduct the reaction under relatively mild conditions of around 60°C in the first half of the polymerization reaction, and under temperature conditions of around 70°C in the second half. used. It is preferable to carry out the polymerization reaction for 40 hours or more from the start of polymerization in order to increase the polymerization rate.

If the copolymer solution obtained in this way is applied as is, the coating film may become tough and may not function as an adhesive, depending on the composition of the copolymer. However, when a suitable plasticizer is added to it, the copolymer becomes soft and sticky. The internal cohesive force is also moderate and it has viscoelastic properties. As the plasticizer, a water-soluble or hydrophilic liquid with a high boiling point and/or a water-soluble substance with high water retention is used. Such plasticizers include 1, for example glycerin; diglycerin; propylene glycol; trimethylene glycol; α-butylene glycol; 2,3-butylene glycol; β-butylene glycol; α-amylene gellicol;
Amylene gelicol: 2,4-amylene gelicol; 1
- 4-amylene gellicol; 1,5-bentanediol; trimethylolethane; polyethylene glycol; polypropylene glycol; sugars such as starch sugar and sucrose; sorbitol; urea; cationic surfactants such as long-chain alkyltrimethylammonium chloride; Polyoxyethylene alkyl ether.

Examples include nonionic surfactants such as polyoxyethylene alkyl ester, fatty acid jetanolamide, and sorbitan alkyl ester; amphoteric surfactants such as dimethylalkyl betaine; and liquid amino acids. Among these plasticizers, glycerin and diglycerin are particularly preferably used. Two or more plasticizers may be used in combination.

The amount of plasticizer depends on the molar ratio of the first copolymer component and the second copolymer component, the type and composition of the second copolymer component.

Although it varies depending on the type of plasticizer, the thickness of the adhesive layer, the desired degree of tackiness, etc., it is usually in the range of 0 to 150% by weight, preferably 40 to 80111t% of the copolymer. In other words, the copolymer in the adhesive is 40 to 100% by weight.
and a plasticizer in a proportion of 60-0% by weight. The amount of plasticizer is within the above range and is mainly determined by the molar ratio of the first copolymer component and the second copolymer component in the copolymer. For example, butyl acrylate is used as the second copolymerization component.

When the degree of tackiness of the obtained sheet or tape is to be the same as that of commercially available cellophane tape, the amount of plasticizer varies as follows depending on the molar ratio of the first copolymer component and the second copolymer component. When the molar ratio of the first copolymer component and the second copolymer component is 10:90.30:70 and 60:40, the plasticizer is contained in the adhesive at O~20.30~40, respectively.
．． It is contained in a proportion of 40 to 60% by weight. This value is a guideline for the amount of plasticizer.

In reality, the degree of tackiness of an adhesive is determined by a combination of many factors, so the amount of plasticizer is determined by testing each individual case. If too much plasticizer is added, the water absorbency of the adhesive will become too large, so care must be taken.

Adhesives are usually made of the above-mentioned copolymer and, if necessary, a plasticizer added thereto, but may also contain other polymeric additives within a range that does not impair the properties of the copolymer. Good too.

(The following is a blank space) The adhesive thus obtained has appropriate hydrophilicity, water absorption, and moisture permeability, and also has bactericidal (antibacterial) properties and electrical conductivity. Although there are still many unknowns about its mechanism of action, it is presumed that the (meth)acrylamide derivative, which is the first copolymerization component, is one of the main causes of this effect. In the copolymer, the unique properties of the above-mentioned (meth)acrylamide derivatives such as hydrophilicity are utilized, and each monomer is combined so that the second copolymerization component, such as acrylic acid alkyl ester, exhibits viscoelasticity. It is thought that the components are copolymerized to form nine molecular chains. In such a copolymer, the polarity of the (meth)acrylamide derivative is thought to be significantly enhanced. Therefore, even if the second copolymer component mainly composed of alkyl nitsyl acrylate, which has poor hydrophilicity, is contained in the copolymer at a ratio of 50 mol% or more, the copolymer has strong hydrophilicity. show. Such copolymers are water-soluble or capable of absorbing a large amount of water, and exhibit properties similar to those of polymers consisting only of (meth)acrylamide derivatives, such as being completely soluble in alcoholic solvents. It is also possible to mix equal weight or more of a water-soluble substance such as glycerin into the copolymer, and such a water-soluble substance acts as a plasticizer to fully exert the adhesive properties of the adhesive. do.

A layer of the above adhesive is formed on at least one side of the base material to obtain a desired medical adhesive sheet or tape. When obtaining a sheet or tape intended for drug treatment, the drug is blended into the adhesive. As a drug, it is an anti-inflammatory agent and an anti-inflammatory analgesic.

Antihistamines, antiallergic agents, bactericidal and antibacterial agents.

antifungal agents, antihypertensive agents, coronary vasodilators, sedatives, stimulants,
Anti-motion sickness drugs, anesthetics, etc.

The base material includes, for example, polyurethane, polyurethane-polyamino acid cocondensate, polyethylene, ethylene-vinyl acetate copolymer, ethylene-acrylic acid ester copolymer,
Polyvinyl chloride, unplasticized flexible polyvinyl chloride (internal copolymer or blend type), polypropylene, nylon,
polyester.

Soluble polyvinyl alcohol, insolubilized polyvinyl alcohol, insolubilized polyvinyl acetal, regenerated cellulose,
Cellulose esters, cellulose ether, silicone rubber, foamed polyethylene.

Foamed polyurethane, foamed ethylene-vinyl acetate copolymer, etc. are used in the form of a film or sheet. In addition, paper, non-woven fabric, two-knit woven fabric, etc. made of natural fibers or synthetic fibers may also be used, and a breathable base material or a non-breathable base material is selected as appropriate depending on the purpose. . Also.

It is also possible to use the above-mentioned films, woven fabrics, and the like in combination as a laminated body. For example, a laminate of a stretchable nonwoven fabric made of polyurethane fibers and a polyurethane film, or a laminate of the nonwoven fabric and a silicone rubber film are preferably used. The laminate body having such a structure has excellent gas permeability, so water vapor and oxygen can easily pass therethrough (on the other hand, it has the property of not allowing liquids to pass through it).

Furthermore, it has excellent mechanical wilting resistance (adhesive workability).

It blends well into the skin.

Thin polyurethane films and the like are usually formed by casting onto a mount (processing paper) using a casting method.

Since the formed film is highly elastic, in order to maintain its original shape as a base material through subsequent processing, it is preferable to process the film with the processing paper still attached. This makes it easier, for example, to apply the adhesive to the film and to cut the resulting final product into desired lengths. Since it is easier to apply the prepared sheet or tape to the skin with the process paper still attached, it is recommended to peel off the process paper after application.

A layer of an adhesive or an adhesive containing a drug can be formed on a substrate by two known methods.

For example, applying a solution containing an adhesive directly to the substrate surface.
Direct coating method that dries; once the adhesive solution is applied.

A direct transfer method is used in which the adhesive is applied onto a flat endless belt having a releasable surface, dried, and then a base material is pressed onto this surface and then peeled off to transfer the adhesive onto the surface of the base material. In addition, an indirect transfer method may also be suitably used, in which the adhesive solution No. 7 is once coated on a release paper, dried, and then a base material is pressed onto the coated surface.

In the case of the indirect transfer method, the patch is provided with a release paper attached. For sheets or tapes prepared by methods other than indirect transfer, the surface of the adhesive layer is covered and protected with a silicone release paper or the like, if necessary. Because the adhesive is hydrophilic, the base material can be polyethylene, polypropylene,
When the base material is made of a hydrophobic material such as polyethylene terephthalate (PET), it is preferable to subject the surface of the base material to a corona discharge treatment or the like in advance. The sheet or tape thus obtained is suitably cut into a desired shape.

The sheet or tape of the present invention can be used for medical purposes, etc.

For example, it is suitably used for the following purposes: ① It can be applied directly to a traumatized area of the human body to simply protect the traumatized area.

■Put gauze, pads, etc. for treating traumatized areas on the skin surface and fix it, or use it as a large adhesive bandage (dressing tape) with gauze.

■Place it on the surgical site in advance and perform the surgery over it. When used as a drape in this way, excessive disinfection before surgery can be omitted and infection due to infiltration of various bacteria into the wound during surgery can be prevented.

■Fix the intravenous needles, tubes, etc. to the skin surface when inserting tubes such as intravenous drips, blood washing, or catheters into the body, which require a long time.

■Immobilize or protect areas that require rest, such as fractures, for the necessary period of time to prevent them from moving.

■Keep parts such as the colostomy tightly in place.

■By incorporating the drug into the adhesive.

Used as a therapeutic sheet or tape for transdermal absorption therapy.

■Used for beauty purposes such as smoothing out deep wrinkles on the face, fixing hair, and shaping hair.

(Function) The adhesive used in the present invention has the characteristics of conventional acrylic adhesives and has excellent hydrophilicity. Therefore, the sheet or tape may become wet (moist).
It can also adhere to the skin surface and does not peel off easily even if you sweat during application. This is a feature not available with conventional acrylic adhesives or rubber adhesives. In addition, even if the adhesive spills out around the skin when applying the sheet or tape, for example due to body movement, or if the adhesive remains on the skin after peeling off, it can be easily washed and removed with water. be. Furthermore, the adhesive contains water-soluble drugs 1, such as drugs in the form of salts such as alkali metal salts, ammonium salts, and hydrochlorides.

can be dissolved at high concentrations. Therefore.

Medical adhesive sheets or tapes containing water-soluble drugs, which have been difficult to prepare in the past, can be easily obtained.

The adhesive used for sheets or tapes has excellent water absorption and moisture permeability, and its ability is more than five times that of conventional acrylic adhesives. Therefore, even if a sheet or tape in which a pressure-sensitive adhesive layer is provided on a base material that does not permeate water vapor is applied to the skin for a long time, almost no rash due to moisture is observed.

If the base material itself is permeable to water vapor, no steaming will occur. Furthermore, the adhesive has bactericidal (antibacterial) properties depending on the proportion of the acrylamide derivative in the copolymer that is the main component of the adhesive. Therefore, even if stuffiness occurs during application of the sheet or tape, bacteria and the like will not grow abnormally in that area, and therefore rashes due to secondary sensitization will not occur.

Furthermore, since the adhesive has conductivity, it has a large antistatic effect. For example, when a conventional roll-shaped adhesive tape made of a highly electrically insulating base material such as polyethylene or polypropylene is unwound, the tape may be charged with static electricity of several thousand to several thousand volts.

Therefore, the adhesive may adhere to other objects or cause spark discharge before it is attached to the object. When spark discharge occurs 2
For example, in operating rooms where anesthetic ether is used, there is also a risk of ignition. On the other hand, if the sheet or tape of the present invention is used.

There is no such danger because the adhesive has no electrostatic properties.

When a polyfunctional monomer is added during copolymer preparation, a pressure-sensitive adhesive with even better internal cohesive strength can be obtained due to slight crosslinking. Sheets or tapes using such adhesives do not suffer from the phenomenon of so-called adhesive cracking or adhesive residue, regardless of the adhesive film thickness.

(Example) The invention will now be explained with reference to examples.

Preparation of copolymer (A): (meth)acrylamide derivative (first copolymer component) 3 (methacrylamide)
Propyltrimethylammonium chloride 66.5g
(0.3 mol), butyl acrylate 89.6 g (0.7 mol) as the second copolymerization component, 0.127 g (0°) l,6-hexane glycol dimethacrylate as the polyfunctional monomer 05 mol %) and 70 g of ethyl alcohol as a solvent were charged into the reaction vessel (11), and the polymerization reaction was started at 60° C. with stirring under a Nz gas flow. Azobisisobutyronitrile 0 as a polymerization catalyst
．． 33 g was used. The catalyst was dissolved in 100 ml of ethyl acetate, and 10 Ill of it was added to the reaction vessel to initiate polymerization. After the start of the polymerization reaction, a small amount of the catalyst solution was added every 4 hours to continue the reaction for 24 hours.

Thereafter, the temperature of the second reaction was set to 70°C, and the catalyst solution was added in small portions every 3 hours.

If the viscosity of the reaction solution increases significantly during the polymerization reaction, especially at the beginning of the polymerization, stirring may become difficult and gelation or runaway reactions may occur.
Added 0 to 30 ml each. In this way, one reaction solution has an apparent viscosity of 20.0OOcps (centivoids).
It was kept below. The temperature remains the same (70℃) after the catalyst solution has been added.
), and the reaction was terminated 44 hours after the start of 9 polymerization. The resulting reaction solution was a colorless and transparent viscous liquid.
Concentration of copolymer contained is 31.2%, viscosity is 21℃
It was 24,000 cps.

(B) Preparation of adhesive solution: The coating film obtained by applying and drying the copolymer solution obtained in section (A) is as follows.

It was a transparent film that was somewhat hard and non-adhesive. To the resulting copolymer solution, 47 g of diglycerin was added as a plasticizer per 100 g of the polymer component. Further diluted with ethyl alcohol to obtain a polymer concentration of 26%.

An adhesive solution with a viscosity of about 10.0OOcps was obtained.

(C) Preparation of adhesive sheet: A 33 μm thick polyether polyurethane film was used as the base material. This film was formed on one side of processing paper by a casting method, and subsequent processing was performed with the processing paper still attached. This process paper is a laminate of high-density bleached kraft paper (80 g/m) and a 30 micron thick stretched polypropylene film.

The polyether-based polyurethane film that is the base material is formed on the polypropylene surface side of the processing paper. The base material is in proper contact with the processing paper, and excessive stretching of the base material during 8 processing is suppressed.

The adhesive solution obtained in section (A) was applied onto a silicone release paper for adhesive transfer coating while controlling the coating gap so that the thickness after drying was 25 μm.

This was dried with hot air at 80° C. for 4 minutes. The dried adhesive surface and the polyurethane surface of the base material were overlapped and passed between two pressure rolls to be pressure-bonded. As described above, an adhesive sheet composite consisting of process paper, substrate, adhesive, and release paper was obtained by an indirect transfer coating method in which an adhesive layer was formed on a release paper and the adhesive layer was transferred to a base material. This pressure-sensitive adhesive sheet composite is cut into a desired size and handled in the composite form until use. When in use, the adhesive sheet is attached to the target surface by peeling off the release paper and attaching it to the target surface, or by peeling off the process paper on the back after pasting. It is also possible to peel off only the release paper of the composite, apply a wound protection material such as gauze to a part of the adhesive surface, and then apply another release paper to make a gauze-attached bandage.

The adhesive sheet obtained in this example can be applied directly to a wound and covered to protect the wound and prevent infection from the wound, and can also be used to heal the wound. In addition, an intravenous needle.

It is also used to fix and hold medical equipment such as catheters and colostomies in a predetermined location in the human body for a predetermined period of time. Furthermore, it can be applied to a relatively wide area including one surgical site before two surgeries, and used as a drape for performing surgery over it.

(D) Performance evaluation of the adhesive sheet = <1) Adhesion to wet surfaces, (2) water vapor permeability, and (3) sterilization of the adhesive of the adhesive sheet obtained in section (C) using the following methods. The test was conducted. The results are shown in the table below. The respective test methods are as follows.

(1) Adhesion to wet surfaces: The adhesive sheet composite obtained in section (C) was cut into a tape shape with a width of 15 fins and a length of about 200 ws to obtain an adhesive tape composite. The adherend used in the test was a laminate of cellophane and polyethylene film (thickness: 50μ+1). The cellophane surface side of this laminate was used as the surface to be adhered, and the surface to be adhered was lightly rubbed several times with gauze soaked in water to make it wet. Next.

The release paper of the adhesive tape composite was peeled off to expose the adhesive surface. The adhesive side of this tape was adhered to the surface to be adhered within 1 minute after wetting the surface so that about 80 degrees or more of the adhesive surface was in contact with the tip of the tape. However, the other end of the tape is not bonded and is left open. Then, a 2 kg rubber-covered roller was moved back and forth once over the bonded portion to apply pressure and bond. Ten minutes after pressing the adhesive tape onto the surface to be adhered, the object to be adhered was hung vertically with the adhesive end of the adhesive tape facing down and the open end facing up. Then, the other end (open end) of the adhesive tape was folded back 1800 degrees, and the adhesive tape was peeled downward about 200 degrees from the 7 folded points, and then a load of 100 g was applied to the open end of the adhesive tape. With this load,
The time required for the tape adhered to the surface to be adhered to be separated by 50111ff, II was measured. This test was conducted at 21°C.

(2) Water vapor permeability 20 to 30 liters of distilled water was placed in a glass bottle with a diameter of 48 mm. The pressure-sensitive adhesive sheet composite obtained in section (C) was cut into pieces larger than the opening of a glass bottle. Peel off the release paper from this adhesive sheet composite,
It was applied around the opening so that the adhesive surface evenly covered the opening. Next, while gradually peeling off the process paper, the edges of the adhesive sheet were slightly stretched and pasted around the opening, and the opening was sealed with the adhesive sheet. Vinyl tape was wrapped several times around the opening of the sealed glass bottle to ensure that the adhesive sheet was completely adhered around the opening. The glass bottle with its opening sealed with an adhesive sheet was weighed to the nearest 0.01 g, and then heated to 40°C.

It was left in an atmosphere with a relative humidity of 30% for 24 hours. This was weighed again and the amount of water loss was calculated. From this value, the amount of water vapor permeation (g) per 1rrl of adhesive sheet was calculated.

The water vapor permeation rate of the base material of the adhesive sheet used here was 2
It was 530 g/rd/24Hv/40°C.

(3) Sterilizing properties of adhesive: Cut the adhesive sheet composite obtained in section (C) into 5 cm square pieces, peel off the release paper, and apply a bacterial stock solution containing Staphylococcus aureus to the adhesive surface. It was applied so that the amount of bacterial cells was approximately 10'. This is 3
The sample was left at 5° C. for 2 hours in an atmosphere with enough humidity to prevent the surface of the adhesive from drying out. Next, the processing paper was removed, and the obtained adhesive sheet was transferred to 100 mJ of a known bacterial cell culture medium prepared separately and shaken for about 1 minute to transfer bacteria from the adhesive surface into the medium.

The number of bacterial cells that have migrated into the medium is counted using the usual method.

The number of bacterial cells was compared with that at the time of application. A similar test was conducted using Pseudomonas aeruginosa and Escherichia coli instead of Staphylococcus aureus.

(A) Preparation of adhesive solution 2-ethylhexyl diacrylate 173.0 g (0.94 mol), acrylic acid 4.3
g (0.06 mol) and 80 g of ethyl acetate were charged into a reaction vessel, and a copolymer was synthesized according to Section (A) of Example 1. However, if the amount of azobisisobutyronitrile is 0.
The weight was 41 g. The resulting copolymer solution is transparent;
The polymer concentration is 33.1% and the additive viscosity is 26 at 21°C.
．． It was 900 cps. When this copolymer solution was applied and dried to form an adhesive layer, the so-called stringy phenomenon and adhesive residue phenomenon occurred due to insufficient internal cohesive force. Therefore, 8 g of a diisocyanate compound (an adduct of hexamethylene isocyanate and alkylene glycol) with a molecular weight of about 500 is added to the copolymer solution per 100 g of the polymer component.
was added as a crosslinking agent. Further dilute with ethyl acetate,
An adhesive solution with a polymer concentration of 26% was obtained.

(B) Preparation of two comparative examples of adhesive sheets Using the adhesive solution obtained in section (A) (6 hours after preparation), Example 1 (C)
A pressure-sensitive adhesive sheet composite was prepared according to the method described in Section 1. however,
After applying and drying the adhesive solution, curing was performed at 90° C. for 10 minutes.

(C) Performance evaluation of adhesive sheet: Example 1 Performed in the same manner as in section (D). The results are shown in the table below.

Le comparison Masmata For comparison with the copolymer obtained in Example 1.

A copolymer was obtained using vinylpyrrolidone, a typical water-soluble monomer, instead of a (meth)acrylamide derivative.

(A> Preparation of adhesive solution 2N-vinyl-2-pyrrolidone 33.3g (0.3 mol), butyl acrylate 89.
6 g (0.7 mol), 0.127 g of 1,6-hexane glycol dimethacrylate, and 55 g of ethyl acetate were placed in a reaction vessel, and a copolymer was synthesized according to Section (A) of Example 1. The resulting reaction solution was a slightly milky white solution with a solid content concentration of 28.6%.
The viscosity at 21°C was 21,600 cps. Although the adhesive layer obtained by applying and drying this solution had a considerable viscosity, it was thought that the adhesive strength was still insufficient, so a plasticizer was added.

Polypropylene glycol is used as a plasticizer.

It was added at a ratio of 15 g to 100 g of the polymer component of the copolymer solution. Further dilute with ethyl acetate.

An adhesive solution with a polymer concentration of 25% was obtained.

(B) Preparation of pressure-sensitive adhesive sheet: Using the pressure-sensitive adhesive solution obtained in Section (A) of this comparative example, a pressure-sensitive adhesive sheet composite was prepared by the method described in Section (C) of Example 1.

(C) Performance evaluation of adhesive sheet: Example 1 Performed in the same manner as in section (D). The results are shown in the table below.

(Hereinafter, blank space) Major hematopoiesis 1 (A) Preparation of copolymer: Example 1 Same as section (A).

(B) Preparation of adhesive solution: Same as Example 1 (B).

(C) Preparation of adhesive sheet - 120 μι thick Japanese paper made of rayon/manila hemp fiber (70:30) as the base material (
50g/rrr) was used. The adhesive solution obtained in Example (B) was applied and dried on a release paper for adhesive transfer coating so that the thickness after drying was 40 μm. Two pieces of release paper having such an adhesive layer were prepared, and a sandwich-like double-sided adhesive sheet was obtained by pressing the two sheets of release paper with the adhesive layer on the inside and sandwiching the base material between them.

This kind of double-sided adhesive sheet is in the form of a sheet.

Alternatively, it can be cut into a tape shape and used. for example,
It is suitably used for holding and fixing physiological pads, fixing the overlapping portions of diapers, fixing the end portions of bandages, etc.

Large Group 1 (A) Preparation of copolymer: (meth)acrylamide derivative 3 (acrylamido)propyltrimethylammonium chloride 51.8 g (0.25 mol),
2-ethylhexyl acrylate 5 as the second copolymerization component
5.2 g (0.3 mol) and vinyl acetate 38.7
g (0.45 mol), 0.05 g of trimethylolpropane trimethacrylic acid ester as polyfunctional monomer
(0,015 mol %) and 70 g of ethyl alcohol as a solvent were charged into a reaction vessel, and a polymerization reaction was carried out in the same manner as in Example 1 (A). The resulting reaction solution was transparent and had a polymer concentration of 30.6%.

The viscosity at 21°C was 20.900 cps.

(B) Preparation of adhesive solution: For 100 g of the polymer component in the copolymer solution obtained in section (A), 20 g of glycerin and 33 g of polypropylene glycol as plasticizers were added.
Added 0g. It was further diluted with isopropyl alcohol to obtain an adhesive solution with a polymer concentration of 26%.

(C) Preparation of pressure-sensitive adhesive sheet: As a base material, a 75 μm thick polyvinyl chloride (softness: 100% polyvinyl chloride dioctyl phthalate (DOP) equivalent to 43 ρhr) is used.
A film was used which was calendered to a thickness of . The thickness of the adhesive solution obtained in this example (A) after drying was 2.
It was coated on release paper to a thickness of 5 μm. A pressure-sensitive adhesive layer was formed on the base material using an indirect transfer coating method in accordance with Example 1 (C) to obtain a pressure-sensitive adhesive sheet in which the surface of the pressure-sensitive adhesive layer was protected with a release paper.

Such an adhesive sheet is suitably used as an emergency bandage with gauze or a rolled bandage. To make a rolled bandage 1
For example, while peeling off the release paper, a release agent is applied to the back surface of the base material, the base material is wound onto a roll core, and then cut into slices having a width of 10 to 20W. For example, polyoctadecylethylene urea is used as a release agent.9 Usually, in? Approximately 0 per
．． It is applied to the surface of the substrate at a rate of 2 g. The adhesive sheet of this example is as follows.

It is also suitably used for adhesive drapes as a sheet with a size of 25 to 1000 cd.

Preparation of Oshi Earth (A)'' copolymer = (meth)acrylamide derivative 3 (acrylamide)propyltrimethylammonium chloride 103.6g (0.5 mol)
, 2-ethylhexyl acrylate 73.6 g (0.4 mol) and diacetone acrylamide 16.9 g (0.1 mol) as second copolymerization components, polyethylene glycol dimethacrylic acid as a polyfunctional monomer, ester 0 .25g (0.08% savings) and 110g of ethyl alcohol as a solvent were charged into the reaction vessel.

A polymerization reaction was carried out in the same manner as in Example 1 (A).

However, the amount of catalyst is 0.41g, and this is mixed with 50g of ethyl acetate.
m6 and 50 ml of ethyl alcohol. The obtained copolymer solution was a transparent solution with a slightly pale yellow tinge, and its polymer concentration was 33.8%.
The viscosity at 1°C was 23.200 cps.

(B) Preparation of drug-containing adhesive solution: What is obtained by coating and drying the copolymer solution obtained in section (A) is a slightly hard resin-like coating film with no tackiness.

Therefore, 40 g of glycerin and polyethylene glycol (molecular weight approximately 50
0) 20g was added to 100g of polymer component.

Benzalkonium chloride 1.0 g as a drug.

3.0 g of dibasic sodium phosphate and 0.0 g of acrinol.
5 g were prepared and dissolved in a small amount of water and added to the copolymer solution. It was further diluted with ethyl alcohol to obtain a drug-containing adhesive solution with a polymer concentration of 28%.

(C) Preparation of adhesive sheet: A 45 μm thick film made of ethylene-vinyl acetate (70:30) copolymer by T-die extrusion was used as a base material. This film has been previously subjected to a corona discharge treatment on one side. The drug-containing adhesive solution obtained in Section (B) of this example was coated on release paper so that the thickness after drying was 30 μm. By indirect transfer coating method.

Example 1 A pressure-sensitive adhesive layer was formed on the above base material according to Section (C) to obtain a pressure-sensitive adhesive sheet in which the surface of the pressure-sensitive adhesive layer was protected with a release paper.

The pressure-sensitive adhesive sheet of this example has bactericidal and antifungal properties and is therefore suitable for use in treating athlete's foot and fungal skin diseases, for example. When using the adhesive sheet, it is suitably cut into a desired size.

(A) Preparation of copolymer: Same as Example 4 (A).

(B) Preparation of drug-containing adhesive solution: For 100 g of the polymer component in the copolymer solution obtained in section (A) of this example,
As plasticizers, 30 g of Jigurya 9F, 30 g of octadecyltrimethylammonium chloride, and 10 g of polypropylene glycol were added.

Further, 4.0 g of diphenhydramine hydrochloride, an antihistamine agent, was added as a drug and diluted with ethyl alcohol to obtain a drug-containing adhesive solution with a polymer concentration of 28%.

(C) Preparation of adhesive sheet 2. A nonwoven fabric made of polyether polyurethane fibers (average fiber length 18 m) was used as the base material.
A dry bond laminate of a nonwoven fabric (weight 30 g per rrl) and a polyether polyurethane film (thickness 20 μm) was used.

The drug-containing adhesive solution obtained in Section (B) of this example was coated on release paper so that the thickness after drying was 40 μm.

Using this, indirect transfer coating method is used.

Example 1 A pressure-sensitive adhesive layer was formed on the nonwoven fabric side of the base material according to Section (C).

(A) Preparation of copolymer: 46.5 g (0.2 mol) of 3 (acrylamido)isopentyltrimethylammonium chloride as (meth)acrylamide derivative, 76.8 g of butyl acrylate as second copolymerization component
(0,6 mol) and N-vinyl-2-pyrrolidone 2
2.2 g (0.2 mol), 1.2 g (0.2 mol) as polyfunctional monomer
6-hexane glycol diacrylic acid ester 0.18
1 g (0.08 mol %) and 85 g of ethyl alcohol as a solvent were charged into a reaction vessel, and a polymerization reaction was carried out according to the method in Example 1 (A). However, the amount of catalyst is 0.
The weight was 41 g. The obtained copolymer solution was a colorless and transparent viscous liquid, the polymer concentration was 29.3%, and the viscosity at 21°C was 28.300 cps.

(B) Preparation of drug-containing adhesive solution: To the copolymer solution obtained in section (A) of this example, 35 g of glycerin was added as a plasticizer per 100 g of the polymer component.

Furthermore, an anti-inflammatory and analgesic drug consisting of 5.0 g of Salocol, 2.0 g of methyl salicylate, 5.0 g of l-menthol, 1.0 g of di-camphor, 0.1 g of thymol, and 0.5 g of glycyrrhetinic acid was added.

Further diluted with ethyl alcohol to obtain a polymer concentration of 28%.
A drug-containing adhesive solution was obtained.

(C) Preparation of pressure-sensitive adhesive sheet: As the base material, cotton yarn was used for the warp and spandex core yarn was used for the weft. A woven fabric with lateral stretchability was used. One side of this base material was subjected to a sintering process, followed by a first sealing and undercoating process. Eye stopper/
The undercoating process uses a graft polymer (product name ■ MG-30;
A toluene solution with a grafting rate of 30% was applied using a kiss roll coater so that the graft polymer was applied in an amount of 30 g per coat. Next, the drug-containing adhesive solution obtained in Example (B) was coated on a release paper so that the thickness after drying was 80 μm. Using this, an adhesive layer was formed on the processed surface of the base material according to Example 1 (C) by an indirect transfer coating method.

In this way, an anti-inflammatory and analgesic pressure-sensitive adhesive sheet with the surface of the pressure-sensitive adhesive layer protected with a release paper was obtained.

University 1 Medical Engineering (A) Preparation of adhesive solution = (meth)acrylamide derivative 3 (acrylamido)isopentyltrimethylammonium chloride 81.4g (0.35 mol), butyl acrylate 70.4 as second copolymer component
g (0.55 mol) and 19.8 g (0.1 mol) of 2-ethylhexyl methacrylate, and 0.113 g (0.05 mol%) of 1,6-hexane glycol diacrylate as a polyfunctional monomer. ) Then, 75 g of isopropyl alcohol as a solvent was charged into a reaction vessel, and a polymerization reaction was carried out according to the method in Section (A) of Example 1. However, the amount of catalyst is 0.41g, and this is mixed with 50ml of ethyl acetate.
1 and dissolved in 50 ml of isopropyl alcohol. The obtained copolymer solution is.

Polymer concentration 30.3%, viscosity at 21°C 25,2
It was a clear solution of 00 cps.

(B) Preparation of drug-containing adhesive solution 2 The copolymer solution obtained in Example (A) was added with 30 g of glycerin as a plasticizer per 100 g of polymer component and dimethylalkyl betaine (trade name ■ Anon AB; NOF Corporation) made) 30
g was added. As the drug, 10.0 g of diclofenac sodium, an anti-inflammatory agent, was dissolved in a small amount of water and added to the copolymer solution. Further dilute with isopropyl alcohol.

A drug-containing adhesive solution with a polymer concentration of 28% was obtained.

(C) Preparation of adhesive sheet Two base materials are ether polyurethane and γ-alkyl! - A 50μ thick film consisting of a co-condensation polymer with glutamate (80:20) was used. This film was cast onto one side of processing paper, and processing was performed with this processing paper attached. The process paper was of the same quality as that used in Example 1 (C). The drug-containing adhesive solution obtained in Section (B) of this example was coated on release paper so that the thickness after drying was 40 μl.

Example 1 A pressure-sensitive adhesive layer was formed on a substrate by an indirect transfer coating method according to Section (C). Adhesive sheet composite thus obtained (adhesive sheet having process paper and release paper)
When using the adhesive, it is preferable to peel off the release paper, temporarily apply it to the affected skin area, peel off the process paper, and then re-press the adhesive.

Preparation of copolymer (A) = 33.1 g (0.15 mol) of 3 (methacrylamido)propyltrimethylammonium chloride as the (meth)acrylamide derivative, 2-ethylhexyl acrylate as the second copolymerization component 36.8g (0.2 mol), butyl acrylate 51
．． 2g (0.4 mol), diacetone acrylamide 2
5.4 g (0.15 mol) and 11.1 g (0.10 mol) of N-vinyl-2-pyrrolidone, 0.28 g (0.03 mol%) of polyethylene glycol dimethacrylate as polyfunctional monomer ) Then, 80 g of ethyl alcohol and Log of ethyl acetate were charged into a reaction vessel as a solvent, and a polymerization reaction was carried out according to the method in Section (A) of Example 1. However, the amount of catalyst was 0.41 g.

The resulting copolymer solution had a polymer concentration of 31.9%.

It was a colorless and transparent solution with a viscosity of 22.100 cps at 21°C.

(B) Preparation of adhesive solution: Add 20 g of glycerin and 25 g of polypropylene glycol as plasticizers per 100 g of polymer component to the copolymer solution obtained in section (A) of this example.
and 10 g of octadecyltrimethylammonium chloride (cation AB; manufactured by NOF Corporation) were added. Further dilute with isopropyl alcohol until the polymer concentration is 2.
A 6.0% adhesive solution was obtained.

(C) Preparation of Adhesive Sheet 2. A 60 μm thick soft polyethylene film was used as the base material. This film has been previously subjected to a corona discharge treatment on one side. The adhesive solution obtained in Section (B) of this example was coated on a release paper so that the thickness after drying was 40 μm. A pressure-sensitive adhesive layer was formed on the above substrate by an indirect transfer coating method according to Example 1 (C) to obtain a pressure-sensitive adhesive sheet in which the surface of the pressure-sensitive adhesive layer was protected with a release paper.

Such an adhesive sheet is used not only as a so-called vinyl bandage, but also for protecting and treating an inflamed area in the oral cavity, and for holding and fixing it in a predetermined place such as an artificial anus for a long time.

Preparation of Sumikame (A) copolymer: 22.1 g (0.1 mol) of 3 (methacrylamide) propyltrimethylammonium chloride as the (meth)acrylamide derivative, 64.0 butyl acrylate as the second copolymer component
(0,5 mol) and 2-ethylhexyl acrylate 7
3.6 g (0.4 mol), polyfunctional P, 0.100 g (0.04 mol %) of 1,6-hexaneglycol dimethacrylate as a monomer, and 80 g of isopropyl alcohol as a solvent were charged into a reaction vessel. , Example 1 A polymerization reaction was carried out according to the method in section (A). However, the amount of catalyst was 0.38 g, and a mixed solvent of isopropyl alcohol and ethyl acetate (60:40) was used as the diluting solvent. The resulting copolymer solution had a polymer concentration of 28.7% and a viscosity of 21°C and 400 cp at 21°C.
It was a colorless and transparent solution of s.

(B) Preparation of adhesive solution: To the copolymer solution obtained in section (A) of this example, 20 g of glycerin and 10 g of glycerin monostearate were added as 8 plasticizers per 100 g of the polymer component.

Furthermore, a mixture of isopropyl alcohol and ethyl acetate (
(1:1) to obtain an adhesive solution with a polymer concentration of 25.0%.

(C) Preparation of adhesive tape 2 The average fiber length is 20 as the base material.
M-rayon nonwoven fabric (thickness 150 μn+; approximately 40 g per rrf) was used. This rayon nonwoven fabric has been previously subjected to a release treatment on one side. This peeling process is
This was done by applying a solution of methyl ethyl ketone as a release agent using a gravure coating machine and drying it. As a release agent, an A-B type block polymer containing a fluorinated alkyl group as one component (
Modiper F (manufactured by NOF Corporation) was used. This release agent was made into a 30% methyl ethyl ketone solution and applied onto a rayon nonwoven fabric at a concentration of 1.3 g/m.

The adhesive solution obtained in Example (B) was coated on a release paper so that the thickness after drying was 40 μm. The release paper is peeled off while transferring the adhesive layer coated on the release paper to the non-release treated side of the base material.

The obtained pressure-sensitive adhesive sheet was wound up to a length of about 10 m (standard length) on a paper roll core. 10m of this roll-shaped adhesive sheet,
Adhesive tapes were obtained by appropriately cutting into slices having desired widths such as 15 mm and 25 H.

The roll-shaped adhesive tape obtained in this example is as follows.

It can be used as a bandage for various purposes. for example.

It is suitably used for holding and fixing gauze for treating traumatized areas, pulling and fixing for healing small wounds, fixing and preventing bandages from slipping by winding the bandage treatment area from the outside, etc. In addition to such medical uses.

It is also suitably used for cosmetic purposes such as smoothing out fine wrinkles on the face and tying hair.

(Effects of the Invention) According to the present invention, it has the excellent characteristics of acrylic adhesives such as excellent adhesiveness, high internal cohesive force, and resistance to deterioration, and has excellent hydrophilicity. A medical adhesive sheet or tape with an acrylic adhesive is obtained.This adhesive has hydrophilic properties, so it is possible to adhere the sheet or tape to a wet (moist) skin surface, and there is no sweating during application. It does not peel off easily even if the sheet or tape is applied.
Even if the adhesive remains on the skin layer after peeling off, it can be easily washed and removed with water. Water-soluble drugs can be dissolved in the adhesive at high concentrations. Therefore, it is possible to easily obtain a therapeutic adhesive sheet or tape containing a high unit amount of a water-soluble drug, which has been difficult to prepare in the past.

This adhesive has excellent water absorption and moisture permeability, so even if the sheet or tape is applied to the skin for a long time, it will hardly cause any rash due to stuffiness.

Furthermore, since the adhesive itself has bactericidal (antibacterial) properties, it does not cause rashes due to secondary sensitization to bacteria.

Furthermore, since the adhesive itself is conductive, it has a strong antistatic effect, so for example, when a roll of adhesive tape is rewound, static electricity may cause it to stick to unintended objects, or there is a risk of ignition due to spark discharge. do not have.

Such medical adhesive sheets or tapes.

It is used as a sheet-like or tape-like bandage to protect injured areas and fix fractures, etc.9
For example, when administering an intravenous drip, the intravenous needle is fixed to the skin surface, and medical equipment such as a colostomy is fixed in place.
It is also suitably used for adhesion. It can also be used for drapes during surgery. It can also be used as a patch containing various drugs, and in particular, a patch containing a high content of water-soluble drugs can be easily obtained. It is also used for beauty purposes such as smoothing out deep wrinkles on R faces and fixing and shaping hair.

that's all

Claims (1)

[Scope of Claims] 1. A medical adhesive sheet or tape in which a layer of an adhesive mainly composed of a copolymer containing a (meth)acrylamide derivative as a copolymer component is provided on at least one side of a base material. , the (meth)acrylamide derivative is a medical adhesive sheet or tape, which is a monomer in which a saturated hydrocarbon group having a quaternary ammonium salt is substituted with one of the amidic hydrogen atoms of (meth)acrylamide. 2. In addition to the copolymerization component of the (meth)acrylamide derivative, the copolymer also contains an acrylic acid alkyl ester and/or a fatty acid alkyl ester whose alkyl group has 12 or less carbon atoms as a second copolymerization component. The sheet or tape according to claim 1, which contains a monomer whose main component is a vinyl alcohol fatty acid ester having a group having 12 or less carbon atoms. 3. 2 mol% of the first copolymer component in the copolymer
The sheet or tape according to claim 1, wherein the sheet or tape is contained in a proportion of ~60 mol%. 4. The second copolymer component in the copolymer is 98 to 4
The sheet or tape according to claim 1, 2 or 3, which is contained in a proportion of 0 mol%. 5. The sheet or tape according to claim 2, wherein the second copolymerization component contains the acrylic acid alkyl ester and/or the vinyl alcohol fatty acid ester in a proportion of 50 mol% or more. 6. The sheet or tape according to claim 1, wherein the adhesive contains a plasticizer having an affinity for water. 7. The adhesive contains 40 to 100% by weight of the copolymer.
and a plasticizer in a proportion of 60 to 0% by weight. 8. Claim 1 in which the adhesive contains a drug
Sheets or tapes as described in section.