JP2017176203A - Medical pressure-sensitive adhesive sheet and production method of the same, as well as wound covering material - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a thin medical pressure-sensitive adhesive sheet which is thin and which has a sufficient function to absorb exudate; and to provide a production method of the same.MEANS FOR SOLVING THE PROBLEM: A medical pressure-sensitive adhesive sheet has thickness of 20 to 200 μm, contains hydrocolloid particles including a hydrophilic polymer as a main component and a hydrophobic elastomer, in which the content of the hydrophilic polymer is 20 to 50 mass%, the average particle diameter of the hydrocolloid particles is 5 to 25 μm, the hydrocolloid particles have a content of particles with a diameter less than 2 μm of 10 vol.% or less with respect to the entire volume of the hydrocolloid particles, and have a content of particles with diameters more than 50 μm of less than 5 vol.%.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a medical pressure-sensitive adhesive sheet, a method for producing the same, and a wound dressing provided with the medical pressure-sensitive adhesive sheet.

  Hydrocolloid adhesives are known as wound dressings that can absorb exudate from wound sites. In general, the hydrocolloid pressure-sensitive adhesive has a structure in which a hydrophilic material is dispersed in the form of particles in an adhesive polymer material. For example, Patent Document 1 discloses a hydrocolloid pressure-sensitive adhesive using a hydrocolloid composed of sodium polyacrylate.

  Patent Document 1 discloses a pressure-sensitive adhesive sheet obtained by forming a hydrocolloid pressure-sensitive adhesive into a sheet. Furthermore, in patent document 1, the wound dressing provided with the adhesive sheet and the support sheet laminated | stacked on this adhesive sheet is disclosed. Such pressure-sensitive adhesive sheets and wound dressings are used for covering wound sites and fixing stoma, etc., and are widely used because they absorb exudate and sweat from the wound site and prevent wound site drying and healing. ing.

Japanese Patent No. 4339593

  However, a conventional pressure-sensitive adhesive sheet formed from a hydrocolloid pressure-sensitive adhesive is generally a sheet obtained by extruding or press-molding a kneaded product obtained by kneading an adhesive polymer material and a hydrophilic material. It was obtained by converting. Since the heating temperature at this time is limited to around 140 ° C. because of the heat resistance temperature of the hydrophilic material, the kneaded product at the time of forming a sheet is highly viscous and it is difficult to form a thin sheet of less than 250 μm. It was. Also. Hydrocolloids in the kneaded product have a distribution of particle diameters, some of which reach a size of several hundred μm or larger. Furthermore, when forming into a sheet, aggregates are formed in the kneaded product due to particle blocking, so extrusion molding Or the sheet | seat cut | disconnected linearly at the time of press molding, and it was difficult to make uniform sheet | seat of 200 micrometers or less.

  For the above reason, the thickness (limit) of the thickness of the pressure-sensitive adhesive sheet formed from the conventional hydrocolloid pressure-sensitive adhesive is 250 μm. On the other hand, if hydrocolloid particles having a small particle diameter are used, a thin pressure-sensitive adhesive sheet can be produced, but the pressure-sensitive adhesive sheet has a low liquid absorption capacity.

  A wound dressing provided with a pressure-sensitive adhesive sheet in which a hydrocolloid pressure-sensitive adhesive is formed can be used as a fixing tape by thinning the pressure-sensitive adhesive sheet. In addition, this wound dressing reduces skin irritation caused by allergic reaction compared to a wound dressing comprising an adhesive sheet made of an acrylic adhesive, a natural rubber adhesive, or an isoprene rubber adhesive. Can be expected. There is a need for a thin wound dressing that has sufficient function to absorb exudate.

  Moreover, as the pressure-sensitive adhesive sheet in which the hydrocolloid pressure-sensitive adhesive is made into a sheet, a sheet having an ability to absorb sweat as well as exudate from a wound site is required.

  Accordingly, an object of the present invention is to provide a thin medical pressure-sensitive adhesive sheet having a sufficient function of absorbing exudate and a method for producing the same.

  In order to solve the above problems, the medical pressure-sensitive adhesive sheet according to the present invention has a thickness of 20 μm or more and 200 μm or less, and contains hydrocolloid particles mainly composed of a hydrophilic polymer, and a hydrophobic elastomer. The content of the hydrophilic polymer is 20% by mass or more and 50% by mass or less, the average particle size of the hydrocolloid particles is 5 μm or more and 25 μm or less, and the hydrocolloid particles are composed of the hydrocolloid particles. The content of particles having a diameter of less than 2 μm is 10% by volume or less and the content of particles having a diameter of more than 50 μm is less than 5% by volume with respect to the total volume.

  In addition, the medical adhesive sheet may have a peeling force of 3 N / 20 mm or more and 20 N / 20 mm or less with respect to a SUS plate (for JIS Z 0237: 2009).

This medical adhesive sheet, the moisture permeability can be a 1,000g ^/ (m 2 · day) or more and 5,000g ^/ (m 2 · day) or less.

  The medical pressure-sensitive adhesive sheet may further contain a polyhydric alcohol.

  The medical pressure-sensitive adhesive sheet may further contain a tackifier.

  In this medical pressure-sensitive adhesive sheet, the tackifier includes a tackifier (H1) having a hydroxy group and / or a carboxyl group in the molecule, and the content of the tackifier (H1) is 1% by mass or more. And it may be 45 mass% or less.

  In this medical pressure-sensitive adhesive sheet, the tackifier includes a tackifier (H1) having a hydroxy group and / or a carboxyl group in the molecule, and a tackifier having a hydroxy group and / or a carboxyl group in the molecule. In the tackifier (H3), the content of the tackifier (H3) is 1% by mass or more and 45% by mass or less. The mass ratio (H1: H2) of the tackifier (H1) and the hydrogenated product (H2) of the tackifier may be 5: 100 to 100: 5.

  In this medical adhesive sheet, the tackifier comprises a tackifier (H1) having a hydroxy group and / or a carboxyl group in the molecule, and an alicyclic saturated hydrocarbon resin (H4). (H5), the content of the tackifier (H5) is 1% by mass or more and 45% by mass or less, and the tackifier (H1) and the alicyclic saturation in the tackifier (H5). The mass ratio (H1: H4) of the hydrocarbon resin (H4) may be 5: 100 to 100: 5.

  In the medical pressure-sensitive adhesive sheet, the tackifier (H1) may be a rosin ester or a terpene compound.

  In the medical adhesive sheet, the hydrophobic elastomer may include at least one block polymer selected from the group consisting of SIS, SBS, SIBS, SEBS, and SEPS.

  In the medical adhesive sheet, the hydrophilic polymer is selected from the group consisting of sodium carboxymethylcellulose (CMC-Na), polyvinyl alcohol (including partially saponified product), and vinyl acetate / vinylpyrrolidone copolymer. There may be one or more compounds.

  In the present medical pressure-sensitive adhesive sheet, the hydrophilic polymer may contain at least a derivative of a polymer polysaccharide and / or a protein.

  In the medical pressure-sensitive adhesive sheet, the hydrophilic polymer may be CMC-Na.

  The method for producing a wound dressing according to the present invention includes the medical pressure-sensitive adhesive sheet and a support sheet laminated on the medical pressure-sensitive adhesive sheet.

  In the method for producing a medical pressure-sensitive adhesive sheet according to the present invention, a hydrophobic elastomer is mixed with a hydrophobic solvent, and a mixed solution A is present in a state where the hydrophobic elastomer is dissolved in the hydrophobic solvent. A step of preparing, a step of preparing a mixed solution B by mixing a hydrophilic polymer and water and / or a water-soluble solvent, and preparing a mixed solution C by mixing the mixed solution A and the mixed solution B And a step of applying the mixed liquid C onto the release surface and drying.

  In the method for producing the medical pressure-sensitive adhesive sheet, a tackifier can be further mixed in the step of preparing the mixed solution A.

  In the method for producing the medical pressure-sensitive adhesive sheet, a stabilizer can be further mixed in the step of preparing the mixed solution B.

  According to the present invention, a thin medical pressure-sensitive adhesive sheet having a sufficient function of absorbing exudate and a method for producing the same are provided.

The schematic diagram which shows the cross section of the medical adhesive sheet when it affixes on skin. About CMC-Na used for manufacture of Examples 1 to 4, 7 and Comparative Example 1, it was obtained by measuring by a laser diffraction method using a particle size analyzer (product name: Mastersizer 2000, manufactured by Malvern). The graph which shows volume frequency particle size distribution. The particles having a diameter larger than the upper limit of the measurement range (arrow ↑ in the figure) were handled together with the particles at the upper limit. About CMC-Na used for manufacture of the comparative example 3, the volume frequency particle size distribution obtained by measuring on conditions similar to CMC-Na used for manufacture of Examples 1 to 4, 7 and the comparative example 1 is shown. Graph. The particles having a diameter larger than the upper limit of the measurement range (arrow ↑ in the figure) were handled together with the particles at the upper limit.

[Medical adhesive sheet]
The medical pressure-sensitive adhesive sheet is used for the purpose of sticking to a wound site to cover the wound site and preventing the wound site from being dried by absorbing exudate and sweat from the wound site. The medical pressure-sensitive adhesive sheet is used for the purpose of affixing these instruments on the skin by attaching them to a medical instrument attached to the body such as a stoma or an infusion tube. Generally, a medical pressure-sensitive adhesive sheet is laminated on a support sheet and used as a wound dressing.

  The medical adhesive sheet according to the present invention has a thickness of 20 μm or more and 200 μm or less. A medical pressure-sensitive adhesive sheet having a thickness of less than 20 μm has poor adhesive strength and water-absorbing power, is difficult to stick to the surface, and may be torn when it is repeatedly expanded and contracted. In the medical adhesive sheet having a thickness of more than 200 μm, there arises a problem that it cannot be smoothly applied along the curved surface of the skin and a problem that it is easily peeled off.

  The medical pressure-sensitive adhesive sheet contains hydrocolloid particles mainly composed of a hydrophilic polymer and a hydrophobic elastomer. In addition, in this specification, a main component means the component which occupies 50 mass% or more and 100 mass% or less of a structural component when it dries. That is, when the medical pressure-sensitive adhesive sheet is dried, the hydrophilic polymer accounts for 50% by mass or more and 100% by mass or less of the constituent components of the hydrocolloid particles. In addition, the hydrophilic polymer preferably accounts for 80% by mass or more and 100% by mass or less of the constituents of the hydrocolloid particles when the medical pressure-sensitive adhesive sheet is dried from the viewpoint of increasing the water absorption of the hydrocolloid particles. ing.

In this specification, the hydrophilic polymer is a polymer compound having a water absorption of 50% by mass or more when immersed in water at 25 ° C. for 1 hour, or a polymer that dissolves 10 g or more in 100 ml of water at 25 ° C. Refers to a compound. The water absorption rate of the hydrophilic polymer is W / W ₀ × 100, where W ₀ is the dry mass of the hydrophilic polymer and W is the mass of water absorbed by the hydrophilic polymer. (%) Value.

  Examples of the hydrophilic polymer described above include derivatives of high molecular polysaccharides and proteins. Examples of the derivative of the high molecular polysaccharide include carboxymethylcellulose (CMC), sodium carboxymethylcellulose (CMC-Na), and pectin. Examples of the protein include gelatin.

  Examples of the hydrophilic polymer described above include a highly water-absorbing polymer having a water absorption rate exceeding 300% by mass when immersed in water at 25 ° C. for 1 hour. A typical example of this superabsorbent polymer is sodium polyacrylate. However, when a highly water-absorbing polymer is used as the hydrophilic polymer, the medical pressure-sensitive adhesive sheet absorbs exudate too much when applied to a wound and swells to a volume more than twice the original volume. May cause pressure on the wound. However, when used for fixing a medical instrument such as a stoma or a catheter rather than being attached to a wound, it has an advantage that it absorbs sweat well and is difficult to peel off from the skin even when used with a lot of perspiration. Therefore, this medical pressure-sensitive adhesive sheet containing a highly water-absorbing polymer as a hydrophilic polymer can be used in applications where there is no risk of damaging the wound during use, for example, in applications where medical devices are fixed on the skin. is there.

  From the viewpoint of moderate water absorption and avoiding pressure on the wound, the hydrophilic polymer is preferably CMC, CMC-Na, pectin, gelatin, polyvinyl acetate (including partially saponified product), vinyl acetate / vinyl acetate. One or more compounds selected from the group consisting of pyrrolidone copolymers and polyethylene glycol.

An elastomer refers to a polymer material that exhibits rubber elasticity at room temperature (5 ° C. or more and 35 ° C. or less). In the present specification, the hydrophobic elastomer refers to an elastomer having a moisture content of 10% by mass or less when left in air at 25 ° C. and 65% RH for 24 hours. The water content of the hydrophobic elastomer is preferably 5% by mass or less from the viewpoint of stably obtaining hydrocolloid particles. The moisture content is a value of W _w / W _d × 100 (%), where W _d is the absolute dry mass of the elastomer and W _w is the mass of absorbed water.

  The hydrophobic elastomer is, for example, one or more selected from the group consisting of a styrene elastomer, an olefin elastomer, a silicone elastomer, an acrylic elastomer, a urethane elastomer, and natural rubber, and 25 ° C., An elastomer having a water content of 10% by mass or less when left in air at 65% RH for 24 hours can be mentioned.

  The styrene elastomer is a copolymer having elasticity and composed of a styrene polymer and an olefin polymer. For example, styrene / isoprene / styrene block copolymer (SIS), styrene / butadiene / Styrene block copolymer (SBS), styrene / isoprene / butadiene / styrene block copolymer (SIBS), styrene / ethylene / butylene / styrene block copolymer (SEBS), styrene / ethylene / propylene / styrene block copolymer (SEPS). The olefin-based elastomer has elasticity, and is, for example, an alkene polymer or a diene polymer, and examples thereof include polyisobutylene and polyisoprene. Further, the polyisobutylene used as the hydrophobic elastomer has a weight average molecular weight of, for example, 20,000 or more. The silicone elastomer is a polymer having elasticity, having a siloxane bond in a molecule, and being cured in a rubber shape by adding a curing catalyst, for example. An acrylic elastomer is a polymer having elasticity, for example, an acrylic ester as a main component. A urethane-based elastomer is a polymer that has elasticity and is obtained, for example, by a polymerization addition reaction of diisocyanate and glycol, and has a urethane bond in the molecule.

  In addition, the hydrophobic elastomer is preferably a silicone elastomer, an acrylic elastomer, or a urethane elastomer from the viewpoint that the adhesive sheet for medical use can exhibit adhesiveness suitable for use without using a tackifier described later. And an elastomer having a water content of 10% by mass or less when left in air at 25 ° C. and 65% RH for 24 hours. It should be noted that the acrylic elastomer is preferably used as a hydrophobic elastomer when there is no problem in the use of the medical pressure-sensitive adhesive sheet, such as affixing it to something other than a patient who is allergic to the acrylic resin.

  The hydrophobic elastomer is preferably selected from the group consisting of a styrene elastomer, an olefin elastomer, and a urethane elastomer from the viewpoint that a medical adhesive sheet can be affixed to patients who are allergic to an acrylic resin. It is an elastomer that is one or more and has a moisture content of 10% by mass or less when left in air at 25 ° C. and 65% RH for 24 hours. These hydrophobic elastomers are less likely to cause allergies than acrylic elastomers.

  The medical adhesive sheet has a hydrophilic polymer content of 20% by mass or more and 50% by mass or less. In addition, "content" in this specification is total content, when the component used as the object which shows content is contained 2 or more types. That is, when this medical adhesive sheet contains 2 or more types of hydrophilic polymers, the total content is 20 mass% or more and 50 mass% or less. On the other hand, when the content of the hydrophilic polymer is less than 20% by mass, the medical adhesive sheet loses the ability to absorb exudate and sweat from the wound site. When the content of the hydrophilic polymer is more than 50% by mass, the medical pressure-sensitive adhesive sheet is impaired in shape stability and adhesive strength.

  The hydrocolloid particles contained in the medical pressure-sensitive adhesive sheet have an average particle size of 5 μm or more and 25 μm or less. The average particle diameter of the hydrocolloid particles is a particle diameter (median diameter) corresponding to a cumulative 50 volume% in the volume frequency particle size distribution obtained by the laser diffraction method.

  In addition, the hydrocolloid particles contained in the medical pressure-sensitive adhesive sheet contain 10% by volume or less of particles having a diameter of less than 2 μm and have a diameter of more than 50 μm with respect to the total volume of the hydrocolloid particles. The content of particles is less than 5% by volume. That is, in this medical pressure-sensitive adhesive sheet, the number of small particles having a diameter of less than 2 μm and the number of large particles having a diameter of more than 50 μm are reduced.

  As shown in FIG. 1, the hydrocolloid particles 3 in the medical pressure-sensitive adhesive sheet 1 are dispersed between the hydrophobic portions 5 mainly composed of a hydrophobic elastomer. In addition, if the number of small hydrocolloid particles having a diameter of less than 2 μm is suppressed during production, medium-sized particles having a diameter of 2 μm or more and 50 μm or less are gathered in the medical pressure-sensitive adhesive sheet 1. Many portions 11 are easily formed. In this location 11, some of the hydrocolloid particles 3 are often in contact with one surface 7 or the other surface 9 of the medical pressure-sensitive adhesive sheet 1, or the hydrocolloid particles 3 are often in contact with each other.

  Moreover, this medical adhesive sheet 1 is excellent in water absorption. For example, when the medical adhesive sheet 1 is attached to the skin 21, moisture (for example, exudate, sweat, etc.) generated from the skin 21 is generated on one surface (skin contact surface) 7 of the sheet 1. Then, it moves toward the other surface (the surface facing the one surface 7 in the sheet 1) 9 through the sheet 1. The mechanism by which the present medical pressure-sensitive adhesive sheet is excellent in water absorption is unknown, but a large number of locations 11 where medium-sized particles are gathered in the sheet 1 are formed, and each of the hydrocolloid particles 3 absorbs water. It is presumed to be due to swelling and the average particle size of the hydrocolloid particles 3 being 5 μm or more.

  That is, in this medical adhesive sheet 1, since the moisture passes through the portion 11 where the middle-sized particles are gathered as shown by the thick arrow in FIG. It is considered difficult. Further, there may be a thin hydrophobic portion 5a between one hydrocolloid particle 3a and another hydrocolloid particle 3b at this location 11, but these particles (3a, 3b) swell due to water absorption and contact each other. Therefore, it is assumed that the movement of moisture is difficult to be prevented by the hydrophobic component 5a. Furthermore, the hydrocolloid particles 3 have a greater degree of swelling due to water absorption as the particle size increases. For this reason, when the hydrocolloid particles 3 have an average particle size of 5 μm or more, the particles 3 swell and easily come into contact with each other as compared with a case where the average particle size is too smaller than 5 μm. Further, the plurality of particles swell and come into contact with each other at this location 11, thereby forming a water flow path communicating between the plurality of particles, and promoting the diffusion of water into the medical pressure-sensitive adhesive sheet 1. It is estimated that

  If the average particle size of the hydrocolloid particles is too smaller than 5 μm, or if the content of particles having a diameter of less than 2 μm exceeds 10% by volume with respect to the total volume of the hydrocolloid particles, the medical adhesive There arises a problem that the sheet cannot sufficiently absorb exudate and sweat from the wound site. This problem is caused by the fact that the size of the hydrocolloid particles is too small, so that the location where the medium-sized particles are gathered in the sheet is not easily formed, and the movement of moisture is blocked by the thick hydrophobic portion. It is estimated to be. Even if small particles are concentrated in the sheet, the particle size is too small to allow the particles to come into contact with each other. This is probably because the path is difficult to form, and the small particles surrounded by the hydrophobic portion inside the sheet often cannot absorb moisture.

  Further, in the medical pressure-sensitive adhesive sheet 1 shown in FIG. 1, the average particle size of the hydrocolloid particles 3 is 25 μm or less, and the number of large particles having a diameter larger than 50 μm is suppressed to be small. The number of particles 13 protruding from the other surface 9 of the sheet 1 can be reduced. For this reason, when manufacturing the wound dressing mentioned below, a medical adhesive sheet is easy to stick to a support sheet. As a result, in the wound dressing, the medical pressure-sensitive adhesive sheet is difficult to peel off from the support sheet.

  Since this medical adhesive sheet has a thin thickness of 20 μm or more and 200 μm or less, it is flexible and has an elongation stress. For this reason, for example, when applied to prevent pressure ulcers when wearing a respirator mask or to prevent dermatitis due to contamination around the colostomy, it follows along the curved surface or complex shape of medical instruments and skin. Deform. Infection is unlikely to occur because the applied skin and its surroundings are less likely to be loaded. Note that the pressure-sensitive adhesive sheet obtained by forming a conventional hydrocolloid pressure-sensitive adhesive sheet has a thickness of 250 μm or more, so that it does not easily expand and contract following the deformation of the skin, and inflammation tends to occur on the applied skin and its surroundings. In addition, the conventional polyurethane / acrylic adhesive tape is flexible, but there are cases where it cannot be used because it does not absorb exudate and sweat, and there are many patients who are allergic to acrylic resin.

  Since the medical adhesive sheet including the above-described configuration is thin and flexible as described above, it can be easily attached along the curved surface of the wound part. As a result, wound healing proceeds faster and pain is alleviated. Moreover, it is difficult to feel a sense of incongruity on the affixed skin.

  In the medical pressure-sensitive adhesive sheet having the above-described configuration, the hydrophilic polymer as the main component of the hydrocolloid particles accounts for 20% by mass or more and 50% by mass or less with respect to the total mass of the sheet. As this hydrophilic polymer, an inexpensive material such as CMC-Na which is unlikely to cause allergies can be used. For this reason, this medical adhesive sheet can be manufactured at a lower cost than a medical adhesive sheet mainly composed of a silicone gel adhesive. Moreover, it can be used as a medical tape that is less likely to cause allergies to patients who are rashed by applying a medical adhesive sheet mainly composed of an acrylic adhesive.

  Since the medical pressure-sensitive adhesive sheet including the above-described structure is thin and flexible as described above, it can be easily processed into a roll-shaped product and can be used while being cut into a desired size. It can be used as a tape-like hydrocolloid pressure-sensitive adhesive sheet.

  Since this medical pressure-sensitive adhesive sheet including the above configuration is thin, a difference in level generated between the applied sheet and the skin is small. For this reason, even if affixed to a wound portion such as a face, it is difficult to stand out. In addition, since the level difference is small, there is little risk that the adhesive sheet for medical use that has been stuck will be caught by clothes or the like.

  The ease with which the present medical adhesive sheet can be peeled off from the skin, medical instruments, etc. can be evaluated by the peel strength when it is attached to a SUS board. The medical pressure-sensitive adhesive sheet preferably has a peeling force of 3 N / 20 mm or more and 20 N / 20 mm or less. This peeling force was applied to a surface finish BA (after cold rolling, bright heat treatment) SUS304 steel plate (for JIS Z 0237: 2009) by reciprocating once with a 2 kg rubber roller, peeling angle 180 degrees, peeling speed It is the value which measured the peeling force when peeling at 300 mm / min. In addition, this medical adhesive sheet containing the structure demonstrated above in this specification shows the peeling force in the range of 3N / 20mm or more and 20N / 20mm or less.

  When said peeling force is too weak than 3N / 20mm, the adhesive force to the affected part at the time of use tends to be insufficient. When said peeling force is too stronger than 20N / 20mm, it will become easy to feel pain when peeling a medical adhesive sheet from an affected part. Moreover, when this peeling force is too stronger than 20 N / 20 mm, a trouble that a part of the medical pressure-sensitive adhesive sheet remains in the affected part when peeling from the affected part is likely to occur.

  When the peeling force described above is 3 N / 20 mm or more and 20 N / 20 mm or less, the present medical pressure-sensitive adhesive sheet can be peeled off cleanly when peeled off from the skin, medical instrument or the like. A conventional hydrocolloid type medical adhesive sheet, that is, a kneaded product obtained by kneading an adhesive polymer material and a hydrophilic material is heated and softened to form a sheet by extrusion molding or press molding. When the sheet obtained is peeled off from the skin, medical equipment, etc., there is a problem that the sheet is not peeled off cleanly and fragments of the sheet tend to remain on the skin or medical equipment. That is, the conventional hydrocolloid medical pressure-sensitive adhesive sheet has a problem that cohesive failure is likely to occur when the intermediate portion in the thickness direction is broken when peeled off. On the other hand, in this medical adhesive sheet, cohesive failure hardly occurs.

This medical pressure-sensitive adhesive sheet has a moisture permeability of preferably 1,000 g / (m ² · day) or more when the thickness is 100 μm from the viewpoint of avoiding inflammation on the affixed skin and suppressing the feeling of stuffiness. More preferably 1,400 g / (m ² · day) or more. Note that water vapor of about 300 g / (m ² · day) is emitted from the skin surface on a daily basis. For this reason, if a sheet having a moisture permeability of less than 400 g / (m ² · day) is applied to the skin, the skin may be stuffy and the skin resident bacteria may proliferate, causing inflammation. On the other hand, since this medical pressure-sensitive adhesive sheet is thin, it has excellent water vapor permeability and is less prone to stuffiness and inflammation on the applied skin. Moreover, as a factor which this medical adhesive sheet is excellent in water-vapor-permeability, water vapor | steam passes through the location 11 where the medium-sized particle has gathered from one surface 7 like the thick arrow shown in FIG. It is presumed that the movement to the other surface 9 is also involved.

Moreover, it is preferable that the thickness of this medical pressure-sensitive adhesive sheet is appropriately adjusted at the time of production so as to exhibit suitable moisture permeability and water vapor permeability. Here, the medical adhesive sheet preferably has a water vapor transmission rate of 1,000 g / (m ² · day) or more, more preferably 1,400 g / in, from the viewpoint of suppressing stuffiness on the applied skin and avoiding inflammation. (M ² · day) or more. In addition, the medical pressure-sensitive adhesive sheet preferably has a moisture permeability of 5,000 g / (m ² · day) or less, more preferably 3,000 g from the viewpoint of performing wet therapy while maintaining the applied skin in a moist state. / (M ² · day) or less. In addition, when the moisture permeability of the adhesive sheet is too high, the wound surface cannot be maintained in a wet state, so that the wet therapy cannot be performed.

  The moisture permeability of the medical pressure-sensitive adhesive sheet is measured by a cup method based on JIS Z 0208. In the measurement, calcium chloride is used as a hygroscopic agent, and paraffin having a melting point of 52 ° C. or higher and 54 ° C. or lower is used as a sealant. Moreover, the cup containing the hygroscopic agent is placed in a constant temperature and humidity chamber at 40 ° C. and 90% RH, and the mass of the entire cup is measured three times every 1.5 hours from the start of measurement. The moisture permeability is calculated from the average value of the second measurement value and the third measurement value.

  The medical pressure-sensitive adhesive sheet preferably further contains a stabilizer from the viewpoint of excellent affinity for wounds and skin. Further, as will be described later, the medical pressure-sensitive adhesive sheet in this case is preferable from the viewpoint of easy manufacture because the dispersibility and cohesiveness of the hydrophilic polymer can be adjusted at the time of manufacture. Examples of the stabilizer include one or more compounds selected from the group consisting of N-methylpyrrolidone and polyhydric alcohols. Examples of the polyhydric alcohol include glycerin, polyethylene glycol, polyphenol and the like. An example of the polyphenol is catechin.

  The stabilizer is more preferably a polyhydric alcohol. The present medical pressure-sensitive adhesive sheet containing a polyhydric alcohol has an increased affinity for wounds and skin as compared to a pressure-sensitive adhesive sheet not containing a polyhydric alcohol.

  In the present medical pressure-sensitive adhesive sheet containing a stabilizer, the content of the stabilizer is preferably 0.1% by mass or more, from the viewpoint of easily adjusting the dispersibility and cohesiveness of the hydrophilic polymer during production. More preferably, it is 0.5 mass% or more, More preferably, it is 1.0 mass% or more. Further, in the present medical pressure-sensitive adhesive sheet containing a stabilizer, the content of the stabilizer is preferably 15% by mass or less, more preferably 10% from the viewpoint of leaving a room for containing a large amount of hydrophilic polymer. % Or less, and more preferably 5% by mass or less.

  The medical pressure-sensitive adhesive sheet preferably further contains an antioxidant from the viewpoint of suppressing deterioration of the hydrophobic elastomer. The antioxidant is a pharmaceutically acceptable compound, and examples thereof include one or more compounds selected from the group consisting of dibutylhydroxytoluene (BHT), vitamin C and its derivatives, and vitamin E.

  When one or more elastomers selected from the group consisting of olefin elastomers (for example, polyisobutylene, polyisoprene) and styrene elastomers (for example, SIS, SBS, SIBS, SEBS, SEPS) are contained as the hydrophobic elastomer The present medical pressure-sensitive adhesive sheet preferably further contains a tackifier from the viewpoint of obtaining tackiness suitable for use. This tackifier is, for example, one or more compounds selected from the group consisting of rosin compounds, terpene compounds, alicyclic hydrocarbon resins, and hydrogenated products thereof.

  With respect to the tackifier described above, examples of the rosin compound include rosin ester (ester gum), gum rosin, tall rosin, wood rosin, polymerized rosin, disproportionated rosin and the like. The terpene compound is a compound having a polymer of isoprene as a basic skeleton, and examples thereof include a terpene resin, an aromatic modified terpene resin, and a terpene phenol resin. Examples of the alicyclic hydrocarbon resin include various cyclopentadiene resins marketed as QUINTONE (registered trademark of Nippon Zeon Co., Ltd.) 1000 series. Examples of the hydrogenated product of the alicyclic hydrocarbon resin include various alicyclic saturated hydrocarbon resins marketed as Alcon (registered trademark of Arakawa Chemical Industries, Ltd.) series. Moreover, as a tackifier, for example, the water absorption speed of the medical pressure-sensitive adhesive sheet can be adjusted by using a resin having a saturated hydrocarbon group such as a hydrogenated rosin acid ester in combination with a rosin compound.

  The tackifier preferably further includes a tackifier (H1) having a hydroxy group and / or a carboxyl group in the molecule from the viewpoint of easily adjusting the adhesive force of the medical pressure-sensitive adhesive sheet to be suitable for use. In this case, the medical pressure-sensitive adhesive sheet preferably contains 1% by mass to 45% by mass of the tackifier (H1). The hydroxy group is also called a hydroxyl group.

  Examples of the tackifier (H1) include one or more selected from the group consisting of a rosin compound, a terpene compound, and an alicyclic hydrocarbon resin, and a hydroxyl group and / or carboxyl in the molecule. And compounds having a group. Further, the tackifier (H1) described above is preferably a rosin ester (ester gum) or a terpene compound from the viewpoint of excellent adhesive strength.

  From the viewpoint of easily adjusting the water absorption rate of the medical pressure-sensitive adhesive sheet to be suitable for use, the tackifier is more preferably the above-described tackifier (H1), and a hydroxyl group and / or carboxyl group in the molecule. A tackifier (H3) comprising a hydrogenated product (H2) of a tackifier having In this case, the medical pressure-sensitive adhesive sheet preferably contains 1% by mass to 45% by mass of the tackifier (H3). Moreover, as a hydrogenated product (H2) of a tackifier, the hydrogenated product of the tackifier (H1) mentioned above is mentioned, for example. As a tackifier (H3), the composition which combined the tackifier (H1) mentioned above and its hydrogenated product (H2) is mentioned, for example. In this tackifier (H3), the mass ratio (H1: H2) between the tackifier (H1) and the hydrogenated product (H2) of the tackifier is preferably 5: 100 to 100: 5.

  Alternatively, the tackifier is more preferably the above-described tackifier (H1) and the alicyclic saturated hydrocarbon resin (H4) from the viewpoint of easily adjusting the water absorption rate of the medical pressure-sensitive adhesive sheet to be suitable for use. A tackifier (H5). In this case, the medical pressure-sensitive adhesive sheet preferably contains 1% by mass to 45% by mass of the tackifier (H5). Here, the alicyclic saturated hydrocarbon resin (H4) is a kind of the alicyclic hydrocarbon resin described above, for example, hydrogenated alicyclic hydrocarbon resin (hydrogenation of alicyclic hydrocarbon resin). Thing). Specific examples of the alicyclic saturated hydrocarbon resin (H4) include various alicyclic saturated hydrocarbon resins commercially available as Alcon (registered trademark of Arakawa Chemical Industries, Ltd.) series. As a tackifier (H5), the composition which combined the tackifier (H1) mentioned above and the illustrated alicyclic saturated hydrocarbon resin (H4) is mentioned, for example. In this tackifier (H5), the mass ratio (H1: H4) of the above-described tackifier (H1) to the alicyclic saturated hydrocarbon resin (H4) is 5: 100 to 100: 5. preferable.

  In the case where the medical pressure-sensitive adhesive sheet contains a tackifier, the hydrophobic elastomer can be further adjusted from the viewpoint that the tackiness can be finely adjusted by the tackifier, and from the viewpoint that it can be applied to a patient who is allergic to the acrylic elastomer, Preferably, at least one block polymer selected from the group consisting of SIS, SBS, SIBS, SEBS, and SEPS is included. From the same viewpoint, in the present adhesive sheet, a polyisobutylene and a polyisoprene include a tackifier and at least one block polymer selected from the group consisting of SIS, SBS, SIBS, SEBS, and SEPS. It is desirable to use in combination with one or more polymers selected from the group consisting of: Preferable examples of this combination include a combination of a tackifier, SIS, and polyisobutylene.

  The content of the hydrophobic elastomer in the medical adhesive sheet is preferably 20% by mass or more, and more preferably 25% by mass or more, from the viewpoint of stably maintaining the sheet shape. In addition, the content of the hydrophobic elastomer in the medical pressure-sensitive adhesive sheet is preferably 45% by mass or less from the viewpoint of preventing water absorption and water vapor permeability due to the hydrophilic polymer as much as possible. Preferably it is 40 mass% or less.

  In this medical pressure-sensitive adhesive sheet, the mass ratio of hydrophilic polymer to hydrophobic elastomer (hydrophilic polymer / hydrophobic elastomer) is excellent in water absorption and water vapor transmission while maintaining a stable sheet shape. From the viewpoint of exhibiting the properties, it is preferably 0.5 or more and 1.5 or less, more preferably 0.6 or more and 1.2 or less.

  The hydrophilic polymer is more preferably one or more compounds selected from the group consisting of CMC-Na, polyvinyl acetate (including partially saponified product), and vinyl acetate / vinyl pyrrolidone copolymer. When the medical adhesive sheet using these hydrophilic polymers is applied to a wound, the medical adhesive sheet absorbs the exudate appropriately and has little pain due to the stimulation of the wound. In addition, in this medical adhesive sheet, you may use in combination of 2 or more types of hydrophilic polymer, and the combination of CMC-Na and a vinyl acetate vinylpyrrolidone copolymer is mentioned as a suitable example.

  Alternatively, the hydrophilic polymer more preferably includes at least a derivative of a high molecular polysaccharide and / or a protein. For example, the hydrophilic polymer is at least CMC-Na and / or gelatin as compared with the case where the hydrophilic polymer is composed of polyvinyl acetate (including a partially saponified product) and / or vinyl acetate / vinylpyrrolidone copolymer alone. In the case of containing the wound, it is easier to heal the wound when the medical adhesive sheet is applied to the wound. It is thought that derivatives and proteins of high molecular polysaccharides have a high affinity with cells and are difficult to prevent the action of cytokines on the wound surface and its periphery.

  Further, the hydrophilic polymer is more preferably CMC-Na from the viewpoint of appropriately absorbing exudate as described above, less pain due to stimulation of the wound, and easy healing of the wound.

  The medical pressure-sensitive adhesive sheet preferably further contains a softener as necessary. Examples of the softening agent include mineral oil, polybutene, polyisoprene, polyisobutylene and the like. The polyisobutylene used as the softening agent has a weight average molecular weight of, for example, about 3,000 to 9,000.

  The medical pressure-sensitive adhesive sheet preferably further contains an additive other than a stabilizer, a softener, and an antioxidant as necessary. Examples of the additive include one or more selected from the group consisting of fillers, colorants, humectants, drugs, and vitamins. Examples of the drug include bactericides, anti-inflammatory analgesics, antiallergic drugs, antiasthma drugs, angina drugs, and neuropsychiatric drugs. The drug may be a compound containing at least one component selected from the group consisting of a component exhibiting an anti-aging action, polyphenols, α-hydroxy acid, and salicylic acid. Note that α-hydroxy acid and salicylic acid have an effect of promoting skin metabolism. Vitamins are vitamins other than vitamin C and vitamin E, for example, vitamin D.

  Depending on the particle size and particle size distribution of the hydrocolloid particles, the medical adhesive sheet preferably has a thickness of 50 μm or more. In this case, the thickness of the medical pressure-sensitive adhesive sheet is larger than the particle size of most of the hydrocolloid particles contained therein. For this reason, the number of particles 11 protruding from the other surface 9 of the medical pressure-sensitive adhesive sheet 1 shown in FIG. 1 can be further reduced. In addition, the extent to which the particles 13 protrude from the other surface 9 is easily reduced. In this case, in the wound dressing described later, the medical pressure-sensitive adhesive sheet is more difficult to peel off from the support sheet. The medical adhesive sheet preferably has a thickness of 150 μm or less, and more preferably a thickness of 100 μm or less, from the viewpoint of avoiding stuffiness and inflammation of the skin by exhibiting high moisture permeability.

[Wound dressing]
The wound dressing according to the present invention comprises the medical adhesive sheet and a support sheet laminated on the medical adhesive sheet. The support sheet has one surface and another surface formed on the opposite side of the support sheet with respect to the one surface. Moreover, in this wound dressing, this medical adhesive sheet adheres to one surface of the support sheet. Moreover, the other surface of a support sheet will be visible as an external appearance when this wound dressing is stuck.

  Examples of the support sheet include a resin film or cloth. Examples of the resin film include a urethane resin film, a vinyl acetate resin film, an acrylic resin film, and a silicone resin film.

The moisture permeability of the wound dressing, preferably 400g ^/ (m 2 · day) or more and is at 5,000g ^/ (m 2 · day) or less, more preferably 1,000g ^/ (m 2 · day) or more and It is 3,000 g / (m ² · day) or less. To this end, the moisture permeability of the support sheet is preferably 900g ^/ (m 2 · day) or more and 5,000g ^/ (m 2 · day) or less. With such moisture permeability, moist therapy can be performed on the applied wound while suppressing stuffiness and avoiding inflammation with the applied skin. In addition, the moisture permeability of this wound dressing is measured by the same method as the moisture permeability of this medical adhesive sheet.

The thickness of the support sheet is preferably 6 μm or more and 100 μm or less, more preferably 10 μm or more and 60 μm or less. The wound dressing material when the thickness of the support sheet is too thin is less than 6 μm, so it is difficult to handle because it is bent just before being applied and easily adheres between the adhesive sheets, and also follows the movement of the skin while being applied. If it expands and contracts repeatedly, the support sheet may tear. If the thickness of the support sheet is too thick, the moisture permeability of the medical pressure-sensitive adhesive sheet will be less than 400 g / (m ² · day).

  The support sheet preferably has a ten-point average roughness Rz of 6 μm ≦ Rz ≦ 40 μm and Rz ≦ L when the thickness is L. The Rz of the other surface is determined by measuring the surface shape of the other surface using a surface roughness measuring machine under the conditions of a reference length of 500 μm and a cutoff value of 200 μm in accordance with JIS B 0601: 2001. This is the value obtained.

  When Rz of the other surface of the support sheet is 6 μm or more, after applying this wound dressing to the skin, and applying cosmetics such as concealer or foundation on the other surface of the support sheet, Cosmetic powder is held by the unevenness formed on the other surface. For this reason, it is possible to make the present wound dressing material affixed to the face or the like inconspicuous to the extent that it is difficult to determine if it is affixed at a glance. At the same time, the wound covered by applying the wound dressing can be concealed. Moreover, since the unevenness | corrugation is not too deep as Rz of the other surface of a support sheet is 40 micrometers or less, the user can wipe off cosmetics from the other surface of a support sheet easily. For this reason, the hue of the other surface of the support sheet can be adjusted by makeup so as to adjust to the color of the skin. When Rz = L, some through-holes from the other side of the support sheet to one side are formed, and the cosmetic powder is retained on the medical adhesive sheet at the bottom of the hole or in the hole. Is done.

The support sheet preferably has appropriate flexibility and stretchability. In this case, the wound dressing is easily deformed and applied to a shape along the curved surface of the skin or medical device. Moreover, since it expands and contracts following the movement of the skin, it is difficult to peel off from the skin. The support sheet is an acrylic resin film having a thickness L of 6 μm or more and 30 μm or less, where R is 6 μm ≦ Rz ≦ 30 μm and Rz ≦ L. In this case, the support sheet not only exhibits moderate flexibility and stretchability, but also has a moisture permeability of 900 g / (m ² · day) or more and 1,300 g / (m ² · day) or less, which is more preferable. .

Further, the support sheet is more preferably a resin film made of polyether polyurethane or polyester polyurethane having L of 6 μm or more and 60 μm or less when the thickness is L, and the other side of the support sheet Rz is 6 μm ≦ Rz ≦ 30 μm and Rz ≦ L. Support sheet in this case, indicates the appropriate flexibility and stretchability, moisture permeability becomes 900g ^/ (m 2 · day) or more and 5,000g ^/ (m 2 · day) or less, allergic reactions to acrylic resin Can be avoided.

[Method for producing medical adhesive sheet]
In the method for producing the medical pressure-sensitive adhesive sheet, a mixed liquid A in which a hydrophobic elastomer is dissolved in a hydrophobic solvent, a hydrophilic polymer, and water and / or a water-soluble solvent are mixed. The mixed liquid C and the mixed liquid C are applied onto the release surface and dried.

  The mixed solution A is obtained by a step of preparing the mixed solution A, in which a hydrophobic elastomer is mixed with a hydrophobic solvent. The hydrophobic solvent is a solvent composed of a liquid insoluble or hardly soluble in water. The liquid hardly soluble in water means a liquid in which the water at 25 ° C. required to dissolve 1 g of liquid is 1,000 ml or more. Examples of the hydrophobic solvent include toluene, hexane, petroleum hydrocarbons, and the like.

  The mixed solution B is obtained by a step of preparing the mixed solution B in which a hydrophilic polymer and water and / or a water-soluble solvent are mixed. The water-soluble solvent refers to a liquid that dissolves at least 10 ml in 100 ml of water at 25 ° C. Examples of the water-soluble solvent include monovalent lower alcohols and ketones, and ethanol is preferred.

  The liquid mixture C is obtained by the process of preparing the liquid mixture C which mixes the liquid mixture A and the liquid mixture B. In the mixed solution C, components (hydrophilic polymer and the like) derived from the mixed solution B are dispersed between components (such as a hydrophobic elastomer) derived from the mixed solution A.

  The medical pressure-sensitive adhesive sheet can be produced by applying the mixed liquid C onto a release surface such as release paper and drying it. In this production method, when the mixed liquid C is applied onto the release surface of the release sheet, the amount of the mixed liquid C applied can be finely adjusted. For this reason, in this production method, as a pressure-sensitive adhesive sheet in which a hydrocolloid pressure-sensitive adhesive is made into a sheet, a medical pressure-sensitive adhesive having a very thin thickness of 20 μm or more and 200 μm or less that could not be obtained by a conventional molding method or press method. A sheet can be obtained.

  The hydrophilic polymer in this production method is a compound (for example, a copolymer of partially saponified polyvinyl alcohol, vinyl acetate / vinyl pyrrolidone) that hardly swells even when added with water and dissolves freely upon heating. In this case, an aqueous solution of a hydrophilic polymer (mixed solution B) is prepared, and this mixed solution B is mixed with the mixed solution A prepared in advance, for example, a component derived from the mixed solution A ( A coating solution (mixed solution C) in which components (hydrophilic polymer, etc.) derived from the mixed solution B are dispersed between the hydrophobic elastomer and the like is completed, and the mixed solution C is made to have a predetermined thickness. By applying (casting) and drying, a thin medical pressure-sensitive adhesive sheet having a thickness of 200 μm or less can be produced.

  This production method is a step of preparing the mixed solution A, and it is preferable to further mix a tackifier as necessary. For example, when the hydrophobic elastomer contains at least one elastomer selected from the group consisting of an olefin elastomer and a styrene elastomer, in the step of preparing the mixed solution A, the hydrophobic elastomer and It is preferable to prepare a mixed solution A in which a tackifier is mixed to exist in a state where a hydrophobic elastomer is dissolved in a hydrophobic solvent.

  This production method is a step of preparing the mixture A, and if necessary, one or more compounds selected from the group consisting of a softener, an antioxidant, a colorant and the like may be further mixed.

  In the production method, it is preferable that a stabilizer is further mixed in the step of preparing the mixed solution B. That is, in the step of obtaining the mixed solution B, it is preferable to prepare the mixed solution B by mixing a hydrophilic polymer, a stabilizer, and water and / or a water-soluble solvent. At this time, the stabilizer is more preferably a polyhydric alcohol (for example, glycerin, polyol). By using the liquid mixture B containing a stabilizer, the components (hydrophilic polymers, etc.) derived from the liquid mixture B are easily dispersed in the components (mixed liquid A, etc.) derived from the liquid mixture A in the liquid mixture C. Therefore, the stability of the mixed liquid C is improved, and further, the stabilizer remains in the medical pressure-sensitive adhesive sheet to improve the affinity to the wound or skin surface.

  In the case where the hydrophilic polymer is a compound (for example, CMC-Na, polyacrylic acid, etc.) that can obtain only a low concentration (for example, around 5%) aqueous solution even when dissolved in water, this hydrophilic When the hydrophobic polymer solution (mixed solution B) is mixed with the hydrophobic elastomer solution (mixed solution A) so as to be blended at a high ratio of about 20% by mass to about 40% by mass or less, the resulting mixed solution is obtained. It was difficult to maintain the state where the hydrophobic elastomer and the hydrophilic polymer were mixed in (mixed liquid C) for several days. The present inventor has intensively studied to disperse such hydrophilic polymer in ethanol (water-soluble solvent), and further solves the problem that the cohesiveness of the hydrophilic polymer is too low in ethanol. Therefore, a stabilizer (for example, polyhydric alcohol) was mixed to prepare a dispersion (mixed solution B). When the mixture B containing this stabilizer is mixed with the mixture A so as to be blended at a high ratio, the component (hydrophilicity) derived from the mixture B among the components derived from the mixture A (hydrophobic elastomer etc.) The liquid mixture C in which the polymer and the like were stably dispersed could be prepared. Thus, the present inventor could easily obtain a new thin hydrocolloid medical adhesive sheet by improving the stability of the mixed solution C.

  In this production method, for example, when the mixed solution A and the mixed solution B are mixed in the step of preparing the mixed solution B or the step of preparing the mixed solution C, it is preferable to further mix an emulsifier. The emulsifier is preferably a compound having excellent affinity with a hydrophilic polymer, for example, a polyhydric alcohol fatty acid ester. Examples of the polyhydric alcohol fatty acid ester include polyglycerin alkyl ether and polyglycerin fatty acid ester. Specifically, NIKKOL (registered trademark of Nikko Chemicals Co., Ltd.) DECAGLYN 1-OV (manufactured by the same company) and the like can be mentioned.

  In the production method, from the viewpoint of forming a metal salt bridge in CMC or CMC-Na, it is preferable to further mix aluminum gel such as alum in the step of preparing the mixed solution A. In this case, the medical pressure-sensitive adhesive sheet is difficult to dissolve CMC or CMC-Na, and has increased water absorption. In addition, aluminum gel such as alum has an aggregating action, and if it is mixed in a trace amount in a medical pressure-sensitive adhesive sheet, it is effective in healing wounds. The reason for this is presumed to contribute to healing of wounds by forming a film by cross-linking (chelating) proteins and the like dissolved from the wound to form a gel.

  As a conventional method for producing a hydrocolloid type pressure-sensitive adhesive, there is a method in which a mixture of a UV curable elastomer precursor, an ethanol solution and hydrocolloid particles is coated on a support film and dried and then UV cured (Patent Document 1). See). However, in such a method, the hydrocolloid particles are embedded in the elastomer precursor before UV curing and are formed into a sheet in that state, so that the sheet surface becomes flat. Further, in such a method, when porous CMC-Na particles are used, the precursor enters the particles and a polymerization reaction occurs, so that the characteristics of the colloidal particles cannot be fully utilized.

  On the other hand, in the method for producing a medical pressure-sensitive adhesive sheet, a mixed liquid A in which a hydrophobic elastomer is mixed with a hydrophobic solvent and a hydrophilic polymer are mixed with water and / or a water-soluble solvent. A mixed liquid C obtained by mixing the mixed liquid B is applied onto a release sheet and dried. For this reason, in the mixed solution C, the hydrocolloid particles made of a hydrophilic polymer do not adapt to the hydrophobic solvent, and the drying proceeds while a part of the hydrocolloid particles protrudes from the upper surface of the coated material. As a result, the medical pressure-sensitive adhesive sheet obtained has a plurality of protrusions formed by the protrusion of hydrocolloid particles on the surface of the sheet material. Some of the protrusions are exposed on the surface of the hydrocolloid particles, and some of the protrusions are partially or entirely covered with a hydrophobic elastomer.

  Furthermore, since the hydrocolloid particles absorb moisture, the use of the medical pressure-sensitive adhesive sheet with the surface on which a plurality of the protrusions are formed in contact with the skin facilitates the transfer of moisture from the skin to the medical pressure-sensitive adhesive sheet. Is done. For this reason, this medical adhesive sheet is excellent in water absorption. Further, when the medical pressure-sensitive adhesive sheet contains a tackifier (H1) having a hydroxy group and / or a carboxyl group in the molecule as a tackifier, hydrocolloid particles are removed from the skin by the tackifier (H1). In this case, the medical pressure-sensitive adhesive sheet is further excellent in water absorption, and a moist environment can be easily formed at the applied portion, so that a wet therapy can be performed.

[Wound dressing manufacturing method]
The medical pressure-sensitive adhesive sheet produced by this production method is further laminated on the support sheet and used as a wound dressing by a process of laminating a support sheet such as a polyurethane film.

  In addition, the above-mentioned liquid mixture C applied to the release surface of the release paper and dried is the surface opposite to the surface in contact with the release surface (surface to be bonded to one surface of the support sheet). In addition, a large number of protrusions are formed by the hydrocolloid particles. In the step of laminating, in the case where the support sheet is bonded to a mixture obtained by applying the mixed liquid C using an adhesive and drying, it is preferable because the adhesive is well glued by the protrusions.

[Medical adhesive sheet according to Examples 1 to 4]
As a hydrophilic polymer, Sunrose (registered trademark of Nippon Paper Industries Co., Ltd.) series CMC-Na (product name: MAC500LC) was prepared. As shown in FIG. 2, this CMC-Na forms hydrocolloid particles having an average particle size of more than 10 μm and less than 20 μm, and particles having a diameter of less than 2 μm with respect to the total volume of the hydrocolloid particles. The content was less than 10% by volume, and the content of particles having a diameter greater than 50 μm was less than 5% by volume.

表１中の数値の単位は、質量部である。ただし、親水性の高分子／疎水性のエラストマーの数値は、単位なし。
＊１ ＪＳＲ株式会社製、製品名：ＪＳＲ ＳＩＳ５２２９
＊２ 重量平均分子量４０，０００〜７０，０００
＊３ 荒川化学工業株式会社製、脂環族飽和炭化水素樹脂、製品名：アルコンＰ−１００
＊４ カネダ株式会社製、製品名：ハイコールｍ５２５
＊５ ４０質量％水溶液
＊６ 日光ケミカルズ株式会社製、製品名：ＮＩＫＫＯＬ ＤＥＣＡＧＬＹＮ １−ＯＶ Based on the formulation shown in Table 1, medical adhesive sheets according to Examples 1 to 4 were prepared. The SIS and polyisobutylene shown in Table 1 are elastomers having a moisture content of 10% by mass or less when left in air at 25 ° C. and 65% RH for 24 hours.

The unit of numerical values in Table 1 is parts by mass. However, there are no units for hydrophilic polymer / hydrophobic elastomer.
* 1 Product name: JSR SIS5229, manufactured by JSR Corporation
* 2 Weight average molecular weight 40,000-70,000
* 3 Arakawa Chemical Industries, Ltd., alicyclic saturated hydrocarbon resin, product name: Alcon P-100
* 4 Product name: High Call m525, manufactured by Kaneda Corporation
* 5 40% by weight aqueous solution * 6 Nikko Chemicals, product name: NIKKOL DECAGLLY 1-OV

  In Examples 1 to 3, based on the formulation shown in Table 1, a hydrophobic elastomer, a tackifier, an antioxidant, and a softening agent were dissolved in toluene to obtain a mixed solution A. In addition, the prepared CMC-Na was mixed in a mixed liquid obtained by mixing a stabilizer and an emulsifier with ethanol, and dispersed in the liquid. Furthermore, the liquid mixture B was mixed with the liquid mixture A and stirred, and the resulting white dispersion liquid mixture was used as the liquid mixture C. The mixed liquid C was applied to release paper and then dried to produce medical adhesive sheets according to Examples 1 to 3, respectively. In addition, when apply | coating the liquid mixture C to release paper, the application quantity of the liquid mixture C was adjusted so that the medical adhesive sheet obtained after drying might become predetermined | prescribed thickness.

  In Example 4, a medical pressure-sensitive adhesive sheet according to Example 4 was produced in the same manner as in Example 1 based on the formulation shown in Table 1. However, compared with Example 1, Example 4 differs in that, when preparing the mixed solution A, alum is further mixed.

[Medical adhesive sheet according to Example 5]
As a hydrophilic polymer, a Kuraray Poval (registered trademark of Kuraray Co., Ltd.) series polyvinyl acetate partially saponified product (product name: PVA403) was prepared. The degree of saponification of this polyvinyl acetate partially saponified product was 78.5 mol% or more and 81.5 mol% or less.

  Based on the formulation shown in Table 1, a hydrophobic elastomer, a tackifier, an antioxidant, and a softening agent were dissolved in toluene to obtain a mixed solution A. Moreover, the polyvinyl acetate partially saponified product prepared in water was mixed and dispersed in water to obtain a mixed solution B. Furthermore, the liquid mixture B was mixed with the liquid mixture A and stirred, and the resulting white dispersion liquid mixture was used as the liquid mixture C. This mixed solution C contained hydrocolloid particles. The volume frequency particle size distribution of the hydrocolloid particles was measured by a laser diffraction method using a particle size analyzer (product name: Mastersizer 2000, manufactured by Malvern). As a result of the measurement, the average particle size of the hydrocolloid particles is greater than 10 μm and less than 20 μm, and the content of particles having a diameter of less than 2 μm is less than 10% by volume with respect to the total volume of the hydrocolloid particles. The content of particles larger than 50 μm was less than 5% by volume. The mixed liquid C was applied to release paper in the same manner as in Example 1 and dried to produce a medical pressure-sensitive adhesive sheet according to Example 5.

[Medical adhesive sheet according to Example 6]
A vinyl acetate / vinyl pyrrolidone copolymer (manufactured by DSP Gokyo Food & Chemical Co., Ltd., product name: PVP / VA S-630) was prepared as a hydrophilic polymer.

  Based on the formulation shown in Table 1, a hydrophobic elastomer, a tackifier, an antioxidant, and a softening agent were dissolved in toluene to obtain a mixed solution A. The prepared vinyl acetate / vinyl pyrrolidone copolymer was mixed and dispersed in a mixed solution of water and N-methylpyrrolidone to obtain a mixed solution B. Furthermore, the liquid mixture B was mixed with the liquid mixture A and stirred, and the resulting white dispersion liquid mixture was used as the liquid mixture C. About the hydrocolloid particle which this liquid mixture C contains, volume frequency particle size distribution was measured similarly to Example 5 mentioned above. As a result of the measurement, the average particle size of the hydrocolloid particles is greater than 10 μm and less than 20 μm, and the content of particles having a diameter of less than 2 μm is less than 10% by volume with respect to the total volume of the hydrocolloid particles. The content of particles larger than 50 μm was less than 5% by volume. The mixed liquid C was applied to release paper in the same manner as in Example 1 and dried to produce a medical adhesive sheet according to Example 6.

[Medical adhesive sheet according to Example 7]
As hydrophilic polymers, CMC-Na similar to that used in Example 1 and vinyl acetate / vinylpyrrolidone copolymer similar to those used in Example 6 were prepared. Based on the formulation shown in Table 1, a hydrophobic elastomer, a softening agent, a tackifier, and an antioxidant were dissolved in toluene to obtain a mixed solution A. Further, CMC-Na prepared in ethanol and vinyl acetate / vinyl pyrrolidone copolymer were mixed and dispersed, and the resulting dispersion was designated as mixture B. Furthermore, the liquid mixture B was mixed with the liquid mixture A and stirred, and the resulting white dispersion liquid mixture was used as the liquid mixture C. The mixed liquid C was applied to release paper in the same manner as in Example 1 and dried to produce a medical pressure-sensitive adhesive sheet according to Example 7.

[Medical adhesive sheet according to Comparative Examples 1 and 2]
Based on the formulation shown in Table 1, after kneading SIS and polyisobutylene at 140 ° C. first using a kneader, the mixture is mixed well by adding a tackifier and mineral oil to around 100 ° C., and then highly hydrophilic. After adding the molecules and kneading well, the mixture was taken out from the kneader to obtain a mixture. This mixture was subjected to an extruder and extruded from a die to produce medical adhesive sheets according to Comparative Examples 1 and 2. In Comparative Example 1, the same CMC-Na as used in Example 1 was added little by little as a hydrophilic polymer and kneaded little by little. In Comparative Example 2, the hydrophilic polymer used in Example 5 as a hydrophilic polymer. The same polyvinyl acetate partially saponified product was added.

[Tests and test results for medical adhesive sheets according to Examples 1 to 7 and Comparative Examples 1 and 2]
As described above, in Comparative Examples 1 and 2, a dispersion was not formed, and a mixture obtained by heating and kneading was formed into a sheet by extrusion. If the thickness was 250 μm or more, it was possible to form a sheet, but if the thickness was 200 μm, the die was clogged with particle lumps and could not be formed into a uniform sheet. For this reason, it was found that the production method of kneading the raw materials as in Comparative Examples 1 and 2 cannot form a hydrocolloid film (a system containing a large amount of hydrophilic polymer) having a thickness of less than 250 μm. .

  On the other hand, as described above, in Examples 1 to 7, the mixed solution C was prepared, and the mixed solution C was applied and dried to form a sheet. Here, the liquid mixture C used in Examples 1 to 4 was kept in a substantially stable state for 7 days after the preparation by mixing the liquid mixture A and the liquid mixture B. Even if the components of the mixed liquid C might be separated a little, if the mixture was stirred, the system became almost uniform, and the system was kept stable for more than one day. For this reason, it was confirmed that the mixed liquid C used in Examples 1 to 4 had no problem in the period during which coating was easy.

  The mixed solution C prepared in Examples 5 to 7 can be applied uniformly if applied immediately to the release surface of the release paper after the preparation, but the separation occurred within a few hours and the stability was poor. For this reason, it is difficult to store the mixed solution C prepared in Examples 5 to 7 for a long time. In Examples 5 to 7, since the polyhydric alcohol (glycerin) was not mixed with the mixed solution B as a stabilizer, it is considered that the stability of the mixed solution C was impaired.

  The mixed liquid C used in Examples 1 to 7 can be stably applied (cast) to the release surface of the release paper so that the thickness of the medical pressure-sensitive adhesive sheet is within a range of 20 μm or more and 200 μm or less. there were. Further, by drying the mixed liquid C after coating, a medical pressure-sensitive adhesive sheet in which hydrocolloid particles were dispersed almost uniformly in the sheet material could be produced.

  On the upper surface of the medical pressure-sensitive adhesive sheet obtained in Examples 1 to 7 (the surface formed on the opposite side of the medical pressure-sensitive adhesive sheet with respect to the surface that was in contact with the release surface at the time of manufacture), protrusions of hydrocolloid particles It was formed over the entire surface. The width and height of each of these protrusions were on the order of μm, reflecting the diameter of the hydrocolloid particles.

  The medical adhesive sheets according to Examples 1 to 6 and Comparative Examples 1 and 2 were attached to a surface-finished BA SUS304 steel plate (for JIS Z 0237: 2009) by reciprocating once with a 2 kg rubber roller, and the peeling angle was 180 degrees. The peeling force when peeling was performed at a peeling speed of 300 mm / min was measured. The measurement results are shown in Table 2.

＊ 凝集破壊（医療用粘着シートの厚さ方向の中間部分が破壊）されて両方に付着するため、医療用粘着シートとＳＵＳ３０４鋼板の板面との界面での剥離力を測定することができなかった。

* Since the cohesive failure (the middle part of the medical adhesive sheet in the thickness direction is destroyed) and adheres to both, the peel force at the interface between the medical adhesive sheet and the SUS304 steel plate cannot be measured. It was.

[Wound dressing according to Examples 1 to 7]
A polyurethane film having a thickness of 25 μm was prepared as a support sheet. This support sheet was laminated on the upper surface of each of the medical pressure-sensitive adhesive sheets according to Examples 1 to 7 to obtain wound dressings according to Examples 1 to 7. In any of Examples 1 to 7, the medical pressure-sensitive adhesive sheet provided in the wound dressing material showed sufficient adhesive strength, and did not peel off from the support sheet during normal handling, so that it can be commercialized as a wound dressing material. It was judged.

  Each of the wound dressings according to Examples 1 to 7 was used for wound healing with a monitor. As a result, in the treatment with the wound dressing according to Examples 1 to 7, it was confirmed that the medical adhesive sheet absorbs exudate and also absorbs sweat. The healing of the wound progressed smoothly and the pain was confirmed. It turned out to be white when applied to the wound and absorbed exudate. In addition, compared with the case where it was treated with the wound dressing according to Example 5 or 6, the case where it was treated with the wound dressing according to any of Examples 1 to 3, healing of the wound progressed faster, and the pain was reduced. It felt small.

[Medical adhesive sheet and wound dressing according to Comparative Example 3]
As a hydrophilic polymer, Sunrose (registered by Nippon Paper Industries Co., Ltd.), which is a CMC-Na product different from the CMC-Na products used in Examples 1 to 4, 7 and Comparative Example 1 described above. (Trademark) series MAC general products (manufactured by the same company) were prepared. This CMC-Na contains hydrocolloid particles. As shown in FIG. 3, the average particle size of the hydrocolloid particles is about 40 μm, and the particle size is less than 2 μm with respect to the total volume of the hydrocolloid particles. The content was less than 10% by volume, but the content of particles with a diameter greater than 50 μm was greater than 5% by volume. A mixture C was prepared in the same manner as in Example 1 except that this CMC-Na was used, and the mixture was applied onto the release surface of the release paper and dried to prepare a medical pressure-sensitive adhesive sheet having a thickness of 150 μm. Further, similarly to Example 1, a support sheet (a polyurethane film having a thickness of 25 μm) was laminated on the upper surface of the medical pressure-sensitive adhesive sheet according to Comparative Example 3 to obtain a wound dressing according to Comparative Example 3.

  The medical pressure-sensitive adhesive sheet according to Comparative Example 3 was easy to peel off from the support sheet because of its low adhesive force with the support sheet. For this reason, it was judged that the wound dressing according to Comparative Example 3 could not be commercialized. This result is considered to be due to the fact that the medical pressure-sensitive adhesive sheet according to Comparative Example 3 contains more hydrocolloid particles having a larger diameter than the medical pressure-sensitive adhesive sheets according to Examples 1 to 7. .

[Medical adhesive sheet according to Example 8]
A 40% by mass aqueous solution of sodium polyacrylate (manufactured by Toa Gosei Co., Ltd., product name: A-6710) was prepared as a hydrophilic polymer. Based on the formulation shown in Table 1, a mixed solution C was prepared in the same manner as in Example 1, except that sodium polyacrylate was used instead of CMC-Na used in Example 1 described above. In Example 8, since 54.0 parts by mass of a 40% by mass aqueous solution of sodium polyacrylate was blended, about 21.5 parts by mass of sodium polyacrylate was blended. Further, the liquid mixture C in Example 8 contained hydrocolloid particles. Similar to Example 5 described above, the volume frequency particle size distribution of the hydrocolloid particles was measured. As a result, the average particle diameter was larger than 10 μm and smaller than 20 μm, and the diameter of the particles having a diameter smaller than 2 μm with respect to the total volume of the hydrocolloid particles. The content was less than 8% by volume, and the content of particles having a diameter greater than 50 μm was less than 3% by volume. This mixed liquid C could be uniformly applied on the release surface of the release paper. The mixed liquid C after coating was dried to prepare a medical pressure-sensitive adhesive sheet according to Example 8 in which hydrocolloid particles made of sodium polyacrylate having a thickness of 100 μm were dispersed almost uniformly in the sheet.

[Water Absorption Test and Test Results for Medical Adhesive Sheets According to Examples 1 and 8]
For each of the medical pressure-sensitive adhesive sheets according to Examples 1 and 8, the mass was measured and then immersed in water at 25 ° C. After 6 hours, the sheet surface was removed from the water and the sheet surface was well wiped with water-absorbing paper. The mass was measured. Then, the water absorption P of the medical pressure-sensitive adhesive sheet was calculated by the following formula.
P = (W _a −W _b ) / W _b × 100 (%)
In the above-mentioned formula, W _b represents the mass of the medical adhesive sheet before immersion in water, W _a represents the mass of the medical adhesive sheet after immersion in water.

  The water absorption P of the medical pressure-sensitive adhesive sheet according to Example 1 was 36%, while the water absorption P of the medical pressure-sensitive adhesive sheet according to Example 8 was about 500%. In addition, the medical pressure-sensitive adhesive sheet according to Example 8 expanded in water to a volume several times the original, whereas the medical pressure-sensitive adhesive sheet according to Example 1 only expanded slightly in water. there were. In addition, about the water after immersing and taking out the medical adhesive sheet, in Example 8, although the change was not recognized in particular, Example 1 showed a little viscosity.

  About the test result about the above-mentioned water absorption P, in Example 8, since the hydrocolloid particle | grains which consist of sodium polyacrylate absorbed too much water and swelled too much, the medical adhesive sheet expanded to the volume several times the original. It is thought that it has stopped. On the other hand, in Example 1, since the hydrocolloid particle | grains which consist of CMC-Na absorbed water moderately and swollen, it is thought that the grade which a medical adhesive sheet expand | swells was moderately suppressed. Moreover, in Example 1, since CMC-Na some melt | dissolved in water, it is thought that the water after immersing and taking out the adhesive sheet showed the viscosity slightly.

[Wound dressing provided with medical adhesive sheet according to Example 8]
A polyurethane film having a thickness of 25 μm was prepared as a support sheet. This support sheet was laminated on the upper surface of the medical pressure-sensitive adhesive sheet according to Example 8 to produce a wound dressing according to Example 8. The medical pressure-sensitive adhesive sheet according to Example 8 exhibited sufficient adhesive strength and did not peel off from the support sheet during normal handling. For this reason, it was judged that the wound dressing according to Example 8 could be commercialized.

[Tests and test results for wound dressings according to Examples 1 and 8]
A plurality of wound dressings according to Example 1 and a wound dressing according to Example 8 were prepared. Each wound dressing was applied to the wound, and the applied wound dressing was replaced with an unused wound dressing of the same type once a day. During this exchange, the state of the wound was observed.

  When the wound dressing according to Example 8 was affixed to the wound, a few minutes after the affixing, a soreness pain began in addition to the pain of the wound. The tingling pain subsided after a few hours. Also, after a few hours after being applied, the wound dressing absorbed the exudate and became a whitish appearance and swollen. When the adhesive sheet for medical use provided in the wound dressing according to Example 8 was pasted for 1 day, the volume thereof expanded from 5 times to 7 times the original and pressed the wound. When changing the wound dressing, it was observed that when it was peeled off, the wound surface was covered with reddish-brown liquid that caused hemolysis. After that, whenever I changed the wound dressing, I felt tingling pain. Wound healing did not progress easily, and the test was stopped because the wound had not healed 10 days after application.

  On the other hand, when the wound dressing according to Example 1 was applied to the wound, the pain of the wound subsided after a while. When 4 to 5 hours passed after applying, the wound dressing sucked exudate and became a whitish appearance. When the wound dressing was replaced after two days, it was observed that the wound was healing. When the wound dressing was replaced after 3 days, the healing had progressed until about 80% of the original wound area was covered with the epidermis. After 4 days, the wound was closed and the epidermis was regenerated. One week after application, a slight redness due to capillaries was observed in the regenerated skin, but it was observed that the skin was healed cleanly so that the skin surface was not noticeable.

  Separately from the above-described test for wound treatment, a test for fixing the catheter on the skin was performed in summer using each of the wound dressing according to Example 1 and the wound dressing according to Example 8. In both wound dressings, it was observed that sweat was absorbed, but no peeling was observed after 1 day from the application.

[Discussion about wound dressings according to Examples 1 and 8]
The medical pressure-sensitive adhesive sheet provided in the wound dressing according to Example 8 contains sodium polyacrylate as a hydrophilic polymer. Further, sodium polyacrylate has a divergence of 1, and releases a large amount of sodium ions. In the test in Example 8, it is considered that the isotonicity was impaired by locally increasing the sodium ion concentration in the vicinity of the wound where the wound dressing was applied. For this reason, it is presumed that in the vicinity of the wound, the intracellular fluid was forcibly sucked into the sheet, the nerve endings were stimulated, and the tingling pain was felt, causing hemolysis and cell injury. That is, a polyacrylic acid-based superabsorbent resin such as sodium polyacrylate is excellent in water absorbency and can form a moist environment on the wound surface, but delays wound healing. Therefore, the medical pressure-sensitive adhesive sheet and the wound dressing material according to Example 8 can be used for fixing a medical device on the skin when applied to normal skin that sweats, but have scratches. When it is applied to the skin, there is a problem in that it does not promote healing.

  On the other hand, the medical pressure-sensitive adhesive sheet provided in the wound dressing according to Example 1 contains CMC-Na as a hydrophilic polymer. Moreover, when the wound dressing according to Example 1 was applied, the wound was healed well. One cause of this healing effect is considered that CMC-Na is a derivative of a high molecular polysaccharide and has a high affinity with cells. Further, when the wound dressing according to Example 1 is affixed, a certain amount of CMC-Na is dissolved from the medical pressure-sensitive adhesive sheet to cover the wound surface, so that the functions of cytokines and the like are inhibited on the wound surface and its periphery. Probably not. For this reason, the medical pressure-sensitive adhesive sheet and the wound dressing according to Example 1 can be used not only for fixing medical devices on the skin but also for applying and covering wounded skin. .

[Wound dressing according to Example 9]
Compared to the medical pressure-sensitive adhesive sheet according to Example 6, the medical pressure-sensitive adhesive sheet according to Example 9 was manufactured in the same composition but only in that the thickness was 100 μm. Further, the volume frequency particle size distribution of the hydrocolloid particles contained in the liquid mixture C at the time of production was measured in the same manner as in Example 6. As a result, the average particle size of the hydrocolloid particles was greater than 10 μm and less than 20 μm. The content of particles having a diameter of less than 2 μm with respect to the total volume was less than 10% by volume, and the content of particles having a diameter of more than 50 μm was less than 5% by volume. Further, a support sheet (a polyurethane film having a thickness of 25 μm) was laminated on the medical pressure-sensitive adhesive sheet according to Example 9 to produce a wound dressing according to Example 9.

[Wound dressing according to Comparative Example 4]
Compared to the medical pressure-sensitive adhesive sheet according to Example 6, the difference is that it does not contain any vinyl acetate / vinyl pyrrolidone copolymer and the thickness is 100 μm. Such a medical pressure-sensitive adhesive sheet was produced. This medical pressure-sensitive adhesive sheet does not contain hydrocolloid particles because it does not contain a hydrophilic polymer at the time of production. A support sheet (a polyurethane film having a thickness of 25 μm) was laminated on this medical pressure-sensitive adhesive sheet to produce a wound dressing according to Comparative Example 4.

[Comparative test of moisture permeability between the wound dressing according to Example 9 and the wound dressing according to Comparative Example 4]
The moisture permeability of each of the wound dressing according to Example 9 and the wound dressing according to Comparative Example 4 was measured by the cup method based on JIS Z 0208 described above. The water vapor permeability of the wound dressing according to Comparative Example 4 was 29 g / (m ² · day), whereas the water vapor permeability of the wound dressing according to Example 9 was 1,502 g / (m ² · day). Met. For this reason, the medical pressure-sensitive adhesive sheet contains hydrocolloid particles having an average particle size of more than 10 μm and less than 20 μm, and the content of particles having a diameter of less than 2 μm with respect to the total volume of the hydrocolloid particles is 10 It was revealed that when the content of particles having a particle size of less than 50% by volume and less than 50 μm was less than 5% by volume, excellent water vapor permeability was exhibited.

1 Medical adhesive sheet 3 Hydrocolloid particles

Claims (17)

The thickness is 20 μm or more and 200 μm or less,
Containing hydrocolloid particles mainly composed of hydrophilic polymer and hydrophobic elastomer,
The content of the hydrophilic polymer is 20% by mass or more and 50% by mass or less,
The hydrocolloid particles have an average particle size of 5 μm or more and 25 μm or less,
In the hydrocolloid particles, the content of particles having a diameter of less than 2 μm is 10% by volume or less and the content of particles having a diameter of more than 50 μm is less than 5% by volume with respect to the total volume of the hydrocolloid particles.
Medical adhesive sheet.   The medical pressure-sensitive adhesive sheet according to claim 1, wherein the peel force against the SUS plate (for JIS Z 0237: 2009) is 3 N / 20 mm or more and 20 N / 20 mm or less. Moisture permeability 1,000g ^/ (m 2 · day) or more and 5,000g ^/ (m 2 · day) medical adhesive sheet according to claim 1 or 2 less.   Furthermore, the medical adhesive sheet as described in any one of Claims 1-3 containing a polyhydric alcohol.   Furthermore, the medical adhesive sheet as described in any one of Claims 1-4 containing a tackifier. The tackifier includes a tackifier (H1) having a hydroxy group and / or a carboxyl group in the molecule,
The medical adhesive sheet according to claim 5, wherein the content of the tackifier (H1) is 1% by mass or more and 45% by mass or less. The tackifier is a tackifier (H1) having a hydroxy group and / or a carboxyl group in the molecule, and a hydrogenated product (H2) of a tackifier having a hydroxy group and / or a carboxyl group in the molecule. A tackifier (H3) consisting of
The content of the tackifier (H3) is 1% by mass or more and 45% by mass or less,
The mass ratio (H1: H2) of the tackifier (H1) and the hydrogenated product (H2) of the tackifier in the tackifier (H3) is 5: 100 to 100: 5. Medical adhesive sheet. The tackifier includes a tackifier (H1) having a hydroxy group and / or a carboxyl group in the molecule, and a tackifier (H5) composed of an alicyclic saturated hydrocarbon resin (H4),
The content of the tackifier (H5) is 1% by mass or more and 45% by mass or less,
The mass ratio (H1: H4) of the tackifier (H1) and the alicyclic saturated hydrocarbon resin (H4) in the tackifier (H5) is 5: 100 to 100: 5. Medical adhesive sheet.   The medical pressure-sensitive adhesive sheet according to any one of claims 6 to 8, wherein the tackifier (H1) is a rosin ester or a terpene compound.   The medical according to any one of claims 5 to 9, wherein the hydrophobic elastomer includes at least one block polymer selected from the group consisting of SIS, SBS, SIBS, SEBS, and SEPS. Adhesive sheet.   The hydrophilic polymer is one or more compounds selected from the group consisting of sodium carboxymethylcellulose (CMC-Na), polyvinyl acetate (including partially saponified product), and vinyl acetate / vinyl pyrrolidone copolymer. The medical adhesive sheet according to any one of claims 1 to 10.   The medical pressure-sensitive adhesive sheet according to any one of claims 1 to 11, wherein the hydrophilic polymer contains at least a derivative of a polymer polysaccharide and / or a protein.   The medical adhesive sheet according to claim 11 or 12, wherein the hydrophilic polymer is CMC-Na. The medical pressure-sensitive adhesive sheet according to any one of claims 1 to 13,
A support sheet laminated on the medical adhesive sheet;
Wound dressing comprising. A method for producing a medical pressure-sensitive adhesive sheet according to any one of claims 1 to 13,
Mixing a hydrophobic elastomer with a hydrophobic solvent to prepare a mixed solution A in which the hydrophobic elastomer is dissolved in the hydrophobic solvent; and
A step of preparing a mixed solution B by mixing a hydrophilic polymer and water and / or a water-soluble solvent;
Mixing the liquid mixture A and the liquid mixture B to prepare a liquid mixture C;
Applying the mixed liquid C onto the release surface and drying the mixture C;
A method for producing a medical pressure-sensitive adhesive sheet comprising:   The method for producing a medical pressure-sensitive adhesive sheet according to claim 15, further comprising mixing a tackifier in the step of preparing the mixed solution A.   The method for producing a medical pressure-sensitive adhesive sheet according to claim 15 or 16, wherein a stabilizer is further mixed in the step of preparing the mixed solution B.

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