JP4224546B2 - Hydrocolloid material and patch material using the same - Google Patents

Description

  The present invention relates to local protection of wounds, artificially or naturally made pores, catheter introductions and the like, and absorption of liquids therefrom, or skin protection and pressure relief for pressure ulcer prevention, pharmaceutical substances The present invention relates to a medical hydrocolloid material used as a base material for delivery to the skin, and a patch using the same.

Conventional hydrocolloid materials have the following problems.
(A) Since the followability to the unevenness of the skin is poor, peeling or lifting from the skin occurs.
(B) Due to excessive adhesive strength, a lot of keratin is removed when peeling from the skin.
(C) Since the tensile stress is high, it cannot respond to skin extension, causing peeling from the skin or skin irritation due to partial pressure on the skin.
In particular, the problem (b) is closely related to the problem (b). In other words, conventional hydrocolloids have low flexibility, so when applied to uneven skin, the contact area between the hydrocolloid and the skin is low, and it is necessary to increase the adhesive strength in order to obtain the required fixability with a small contact area. was there. Therefore, there has been a tendency that the amount of exfoliation during exfoliation increases. As for the problem (c), if the adhesive force is increased in order to prevent peeling at the time of skin extension, the problem (b) is promoted. Note that the unevenness of the skin referred to here is a body shape and wrinkles when viewed broadly, and is a skin cleft / cutaneous skin from a minute viewpoint.

  As a technique for solving these problems, proposals have been made to increase the flexibility by blending a liquid component having a plasticizing action. For example, as an adhesive sealing substance used for fistula bags, elastic bodies such as styrene-isoprene-styrene block copolymers that form a continuous phase, hydrocolloids dispersed in these, and hydrocarbon resin adhesive compositions Some gel compositions containing an oil spreader have low resistance to deformation, and quickly revert to their original shape after deformation (see, for example, Patent Document 1). This uses an oil extender such as liquid paraffin to reduce the elastic modulus of the composition and exhibit low resistance to deformation. However, oil extenders are extremely low in molecular weight compared to elastic bodies, so if blended in a large amount in the composition, they tend to bleed, thereby lowering the tackiness and greatly increasing the cohesion after water absorption. There is a tendency to decrease. For this reason, there is a limit to this type of method in order to increase flexibility while maintaining the integrity after water absorption.

  Similarly, the adhesive material used in the fistula bag includes an elastomer compound composed of a high molecular weight polyisobutylene and a styrene block copolymer, a hydrocarbon plasticizer, a water-absorbing hydrocolloid, a tackifier, and an antioxidant. A pressure-bonding composition is shown (for example, see Patent Document 2). This is thought to be due to the use of high molecular weight polyisobutylene and one or more styrene block copolymers without using low molecular weight polyisobutylene, thereby modifying the decrease in cohesiveness caused by the addition of a conventional plasticizer.

  However, even if a certain amount of plasticizer can be added, on the other hand, there is a problem that the tackiness is reduced by the plasticizer, so that it is necessary to add a tackifying resin. By doing so, a number of different raw materials such as tackifying resins and their antioxidants are present in the composition, increasing the likelihood of substances that irritate or sensitize the skin. Further, as a characteristic of the tackifying resin, there is a characteristic that the elastic modulus at a low frequency is reduced, but the elastic modulus at a high frequency is increased. Therefore, the adhesiveness (wetting) at the time of application is improved, but on the other hand, there is a drawback that the irritation to the skin at the time of peeling increases, and considering the irritation to the skin at the time of peeling, the use of tackifier is not It is desirable to refrain.

  In addition, a pressure sensitive adhesive material comprising a mixture of a physically crosslinked solid rubber, a compatible liquid rubber, a continuous phase formed from a resin material, and a discontinuous phase containing a hydrophilic substance is shown as a wound dressing. (For example, refer to Patent Document 3). Here, it is described that an integrated network formed by a combination of solid rubber and liquid rubber maintains high absorbency and shape stability after absorption. However, with such knowledge alone, specific countermeasures have been disclosed for conventional problems in skin, i.e., conformability to skin irregularities, responsiveness to skin extension, and exfoliation during skin exfoliation. Absent.

Japanese Patent Laid-Open No. 54-13893 (pages 3 to 8) JP-A-8-722 (pages 3-5) Japanese translation of PCT publication No. 2001-515091 (pages 9-15)

  The object of the present invention is to have good adhesiveness and responsiveness to skin extension to the affected area to be applied, and sufficient absorbability and shape retention after absorption to sweat and exudate generated from the affected area. It is an object of the present invention to provide a hydrocolloid material that can be maintained and can be peeled off without damaging the skin or wound surface without leaving the composition on the affected area during peeling, and a patch using the hydrocolloid material.

Therefore, in order to solve the above problems, the present inventors have found, after intensive studies on components constituting the hydrocolloid material, select a specific thermoplastic elastomer, and, to this, a specific liquid rubber by combining, they found that the above problems can be solved, and have completed the present invention.

Thus, according to the present invention, a thermoplastic elastomer, a liquid rubber compatible with the thermoplastic elastomer, pectin, carboxymethylcellulose sodium (CMC-Na), guar gum, gelatin, karaya gum, alginic acid, chitin, chitosan, polyvinyl alcohol A water-soluble and / or water-insoluble hydrophilic substance selected from the group consisting of polyacrylates and starch / acrylic acid graft polymers , and an adhesive hydrocolloid material for application to the skin surface. And
The thermoplastic elastomer is hydrogenated styrene-butadiene rubber ;
The hydrocolloid material characterized in that the liquid rubber compatible with the thermoplastic elastomer is any one selected from liquid ethylene / propylene rubber, liquid styrene-ethylene / propylene rubber, liquid polyisobutylene and liquid polybutene, or a mixture thereof. Is provided.
Further, according to the present invention, a thermoplastic elastomer, a liquid rubber compatible with the thermoplastic elastomer, pectin, carboxymethylcellulose sodium (CMC-Na), guar gum, gelatin, karaya gum, alginic acid, chitin, chitosan, polyvinyl alcohol A water-soluble and / or water-insoluble hydrophilic substance selected from the group consisting of polyacrylates and starch / acrylic acid graft polymers , and an adhesive hydrocolloid material for application to the skin surface. And
The thermoplastic elastomer is a styrene-ethylene / propylene-styrene block copolymer;
A hydrocolloid material is provided in which the liquid rubber compatible with the thermoplastic elastomer is liquid ethylene / propylene rubber and / or liquid styrene-ethylene / propylene rubber.

In the present invention, the compatibility, when mixing the thermoplastic elastomer and a liquid rubber, refers to a property that they form a homogenous mixture.

  The adhesive performance of hydrocolloids is highly related to viscoelastic behavior. Viscoelasticity is a property that has both viscosity and elasticity. That is, when an external force is applied, both deformation behavior that causes deformation (strain) and recovers to return to its original shape when the external force is removed, and viscous behavior that remains deformed and does not return to its original shape. It is a property related to a substance with This viscoelasticity is expressed quantitatively by the complex elastic modulus, also called the dynamic viscoelastic coefficient, which is a vector composition component of the viscous component and the elastic component, and is an indicator of the hardness and softness of the substance. . The ratio between the viscous component and the elastic component can be expressed by a phase difference. In the case of a pure viscous body, the phase difference is 90 degrees. On the other hand, in the case of a pure elastic body, the phase difference is 0 degree. Thus, in the function of adhesion, it is important to adjust the hardness and softness (complex elastic modulus) of the adhesive and the viscosity / elasticity balance (phase difference) of the adhesive.

  Viscosity and elasticity can be measured by static measurement methods such as a creep test (so-called holding force test), or by changing the speed of deformation (frequency-dependent) when applying deformation to a measurement substance called oscillation. There is a typical measurement method. Considering the fact that it is actually applied to the skin, the dynamic test method in which the speed of deformation changes can observe a phenomenon closer to actual use. Therefore, this measurement method is employed in the present invention.

  In the present invention, the complex elastic modulus and the phase difference are measured in a frequency band (deformation speed) that seems to be suitable for sticking of a human body, that is, in a low frequency range, a high frequency range, and an intermediate frequency range thereof. Viscoelasticity data is obtained, and 0.1 Hz is used as the low frequency range, 1 Hz is used as the intermediate frequency range, and 10 Hz is used as the high frequency range. The relationship between frequency and adhesion behavior is considered as follows. The complex elastic modulus and phase difference in the measurement in the low frequency range are related to the process of minute deformation at a low speed such as adhesion (wetting) of the adherent to the adherend and creep behavior (plastic deformation). If it is hard in the low frequency range (complex elastic modulus is too high) or there are many elastic components (the phase difference is too low), good deformation at low speed cannot be achieved and wettability is not good. However, if it is too soft (complex elastic modulus is too low) or there are too many viscous components (phase difference is too high), the cohesiveness will decrease, and after cold flow (deformation or sag during storage) or water absorption This causes problems such as a decrease in shape retention. The complex elastic modulus and phase difference in the measurement in the high frequency range are related to high-speed deformation processes such as tack and peeling behavior. If it is hard in the high frequency range (complex elastic modulus is too high) or has a lot of elastic components (the phase difference is too low), good deformation at high speed cannot be achieved, sufficient tack cannot be obtained, or during peeling Excessive stress may be applied to the adherend. Conversely, if it is too soft (complex elastic modulus is too low) or there are too many viscous components (phase difference is too high), problems such as adhesive residue on the skin at the time of peeling occur. Furthermore, the complex elastic modulus and phase difference measured as an intermediate region between the low frequency and the high frequency are considered to affect the followability to the skin being applied. That is, unless it is designed so as to have an appropriate complex elastic modulus and phase difference, it cannot respond to the elasticity of the skin itself, that is, the movement of the skin due to the extension of the skin or the like, and uncomfortable feeling occurs during the application.

In hydrocolloid material of the present invention, the value of the complex modulus and the phase difference measured at 37 ° C., the complex elastic modulus at a frequency 0.1Hz 10, 000-80, the phase difference is 10 ° to 40 ° at 000Pa it is preferred, the complex elastic modulus of 15, 000 to 40, more preferably a phase difference 20 ° to 35 ° at 000Pa. And complex elastic modulus of 10, a retardation smaller than 000Pa is greater than 40 °, (deformation during storage, sag) cold flow reduces the cohesiveness and shape retention after water absorption tends to decrease, whereas, the complex elastic modulus but 80, greater retardation than 000Pa is a less than 10 °, wettability is lowered. Further, the complex elastic modulus is 20 when the frequency 1.0 Hz, 000-130, it is preferable that the phase difference is 20 ° to 55 ° at 000Pa, the complex elastic modulus of 25, 000-100, the phase difference 000Pa 25 More preferably , the angle is from 50 ° to 50 °. A phase difference smaller than the complex elastic modulus is 20, 000Pa is greater than 55 °, it tends to occur displacement or deformation of the attaching position when the absorbed exudates, whereas, the complex elastic modulus is greater retardation than 130, 000Pa 20 If it is smaller than °, it will not be able to respond to skin movement due to stretching or the like, and a strange feeling will occur during application. Further, the complex elastic modulus is 60 when the frequency 10.0 Hz, 000-500, it is preferable that the phase difference is 25 ° to 50 ° at 000Pa, the complex elastic modulus is 100, 000 to 400, the phase difference 000Pa 30 It is more preferable that the angle is from 45 ° to 45 °. A phase difference smaller than the complex elastic modulus is 60, 000Pa is greater than 50 °, reduces the integral retention hydrocolloid after water absorption, easily caused collapse of the adhesive residue and hydrocolloids at the time of peeling, while complex elastic modulus 500, When it is larger than 000 Pa and the phase difference is smaller than 25 °, it is difficult to obtain a good tack at the time of application, and excessive stress is easily applied to the application site at the time of peeling.

In the hydrocolloid material of the present invention, other materials such as an antioxidant, a cohesive strength reinforcing material, a plasticizer, a tackifier, a wound healing agent, an antibacterial agent, a disinfectant, and a deodorant can be added. However, in the present invention, even if these other materials are added, it is preferable that they are blended so as not to depart from the ranges of the complex elastic modulus and phase difference defined by the present invention.

The thermoplastic elastomer used in the hydrocolloid material of the present invention, the viscosity-average molecular weight of that is 100, 000 to 500, also the range of 000 to a suitable imparts elastic properties to hydrocolloid.

The liquid rubber compatible with the thermoplastic elastomer lowers the elasticity of the thermoplastic elastomer and imparts flexibility, and also increases the tackiness. From the point of compatibility, if the thermoplastic elastomer is SEPS (styrene-ethylene / propylene-styrene block copolymer), LEPR (liquid ethylene / propylene rubber) and / or LSEPR (liquid styrene-ethylene / propylene rubber) If the thermoplastic elastomer is HSBR (hydrogenated styrene-butadiene rubber ), any one selected from LEPR, LSEPR, liquid polyisobutylene and liquid polybutene or a mixture thereof is used.

By using such a compatible combination, even when the blending ratio of the liquid rubber is increased, that is, when flexibility is to be increased, bleeding of the liquid rubber and adhesive residue at the time of peeling can be prevented. Furthermore, among the combinations of these, HSBR and LEPR, LSEPR, the combination of the combination as well as SEPS and LEPR and / or LSEPR with any one or a mixture thereof selected from the liquid polyisobutylene and liquid polybutene are especially preferred . This is because these materials do not contain a double bond, and thus have higher stability to heat and light than SIS, and have an appropriate viscosity, and thus can exhibit good adhesion even after water absorption. Further, the liquid rubber may be a cross-linked one, and it is effective to mix it appropriately for the purpose of improving the cohesiveness. The weight ratio of the thermoplastic elastomer, a good liquid rubber having a thermoplastic elastomer compatible (thermoplastic elastomer: liquid rubber) is 1: 2 to 1: 6 by weight, further thermoplastic elastomer and a thermoplastic elastomer the viscosity-average molecular weight of the mixture of good liquid rubber compatible with the 30, 000 to 200, is preferably formulated to be in a range of 000, 30, 000-100, is to blend to be in the range of 000 Further preferred.

In the present invention, the presence of a hydrophilic substance allows the hydrocolloid to absorb sweat and leachate. Is a hydrophilic substance, pectin, carboxymethylcellulose sodium (CMC-Na), guar gum, gelatin, karaya gum, alginic acid, chitin, chitosan, polyvinyl alcohol, from the group consisting of polyacrylates and starch-acrylic acid graft polymers Use what you choose . The hydrophilic substance is preferably contained in an amount of 10 to 60% by weight based on the total weight of the hydrocolloid.

Further, for the purpose of Ru alter the properties for a specific use, Rukoto be added various substances are also effective. For example, in order to soften the thermoplastic elastomer, liquid paraffin, or added mineral oil such as petrolatum, to enhance the adhesion, molecular weight 300, 000 to 500, it can be added or butyl rubber in the range of 000. In addition, a medicinal component for the purpose of skin treatment or prevention of damage, beauty and the like can be added to skin that has already been damaged or is expected to be damaged. For example, for skin that has been damaged due to repeated exfoliation, by adding a substance with a moisturizing effect such as ceramide, it is effective in cooperation with the characteristics of the hydrocoid material with less peeling irritation of the present invention. Can be close to healthy skin. In addition, when applying the hydrocolloid material of the present invention to the site where the occurrence of pressure ulcers is concerned, by adding γ oryzanol or the like with a high blood flow promoting effect, alleviation of the occlusion of blood vessels caused by body pressure, Anti-decubitus can be expected.

  The patch using the hydrocolloid material of the present invention can be formed into a shape suitable for the application site of the skin. However, in order to improve the handleability, the hydrocolloid material is formed into a sheet and supported on one side. It is preferable to provide a layer. As the support layer, a processed polymer compound can be used. Examples of the polymer compound include polyolefin (polyethylene, polypropylene, and modified products thereof), olefin copolymer (ethylene-vinyl acetate copolymer, ethylene-ethyl (meth) acrylate copolymer, ethylene-methyl (meta ) Acrylate copolymer and ethylene- (meth) acrylic acid copolymer), polyurethane, polyester, polyacrylic acid, polyamide, polyvinyl chloride, polyvinylidene chloride, polystyrene, fluororesin, silicone resin, cellulose, natural fiber ( Cotton, wool, hemp and silk, etc.) and chemical fibers (viscose rayon, cupra rayon, polynosic, acetate, triacetate, polyethylene, polypropylene, polyamide, polyester, polyacrylonitrile, vinylon, polyvinyl chloride, vinyl Isopropylidene and polyurethane, etc.) and the like. Of these, preferred are polyolefin, polyurethane, polyester and polyacrylic acid, and particularly preferred is polyurethane. Examples of the shape of the support include a film, foam (sponge), nonwoven fabric, woven fabric, and knitted fabric. Of these, films and foams are preferable, and films are more preferable. In particular, a polyurethane film is preferred from the viewpoints of flexibility, stretchability, moderate water vapor permeability, and fungus barrier properties.

According to the present invention, as a hydrocolloid material , a combination of a specific thermoplastic elastomer and a specific liquid rubber is used, and more preferably by giving a specific complex elastic modulus and phase difference to the affected area to be applied. Has good adhesion and responsiveness to skin extension, maintains sufficient absorbency for sweat and exudate generated from the affected area, and maintains shape retention after absorption, and at the time of peeling, the composition is applied to the affected area. There is no residue and it can be peeled off without damaging the skin or wound surface. Further, the hydrocolloid material of the present invention does not particularly require the presence of a material that easily bleeds or a material that easily irritates the skin, and can be composed of a small number of materials, so that it is easy to manufacture and is economically advantageous.

  Examples of the present invention and evaluation results thereof will be described below.

Example 1: 30.0 parts by weight of SEPS (styrene-ethylene / propylene-styrene block copolymer, manufactured by Kuraray Co., Ltd., molecular weight: about 100,000 ) as a thermoplastic elastomer, and a liquid rubber having good compatibility with the thermoplastic elastomer 70.0 parts by weight of LEPR (liquid ethylene / propylene rubber) (manufactured by Kuraray Co., Ltd., molecular weight of about 25,000) is charged into a pressure kneader and mixed until sufficiently uniform. Next, 45.0 parts by weight of CMC-Na (manufactured by Daicel) was added as a hydrophilic substance and mixed under pressure until uniform, thereby preparing an adhesive compound.

Examples 2 to 5 are examples of the present invention blended with different components using the same method as in Example 1. Examples 4 and 5 are ceramide and γ oryzanol, respectively, in the hydrocolloid material of Example 3. Table 1 shows a list of the blends of the examples added.
In Comparative Example 3, SIS (manufactured by Enychem, molecular weight of about 170,000) is used as the thermoplastic elastomer, liquid isoprene rubber (manufactured by Kuraray, molecular weight of about 29,000) and liquid styrene-isoprene rubber (Kuraray) are used as the liquid rubber. (Made by Co., Ltd., molecular weight of about 31,000).

  The hydrocolloid composition obtained by the above blending was rolled to a thickness of 600 μm, and a specimen of a hydrocolloid patch using a 15 μm polyurethane film as a support layer was prepared. Using this specimen as a target, viscoelasticity, water absorption, adhesive properties (initial adhesive strength, sealability), skin adhesion test, and exfoliation property were verified. Each test method will be described below.

  Viscoelasticity: Three test pieces having a diameter of 20 mm are prepared from a specimen (however, only the specimen used for this measurement is the one before the polyurethane film of the support layer is attached). Measurement at a measurement temperature of 37 degrees, a shear stress of 100 Pa, and a frequency range of 0.03 to 46 Hz using a rotary rheometer (trade name “Rheostress RS150” manufactured by HAAKE, Inc.) in an environment of a relative humidity of 20% and a temperature of 20 ° C. Oscillation was measured under the conditions, and the complex elastic modulus and phase difference were measured at frequencies of 0.1 Hz, 1.0 Hz, and 10.0 Hz.

Water absorption: Three test pieces having a diameter of 30 mm are prepared from the specimen. Immerse in physiological saline (0.9% NaCl solution) at 37 ° C. The weight of the test piece is measured at 3 hours, 6 hours, 24 hours, and 48 hours after the immersion to determine the water absorption amount and the water absorption rate. Both the water absorption amount and the water absorption rate should have a higher value.

Adhesive properties:
a) Initial adhesive strength (based on JIS T9233 Mitsuhashi method): Three test pieces having a width of 15 to 25 mm and a length of 100 mm are prepared from a specimen. The surface of the bonded disk (diameter 50 mm, thickness 14 mm, made of aluminum) is cleaned with an organic solvent and dried. The adhesive disk is brought into contact with the fixed test piece adhesive surface at 4.90 N (500 gf) for 2 seconds and pulled up at a speed of 30 mm / min. Measure the adhesive strength when the bonded disk and test piece are separated. A higher value is better.
b) Sealing property (initial adhesive force upon water absorption): Three test pieces having a diameter of 30 mm are prepared from the specimen. Immerse in physiological saline (0.9% NaCl solution) at 37 ° C. After 100-200% water absorption, the sealing property is measured by the initial adhesive strength test method. A higher value is better.

Skin application test (repeated application test): A test piece having a width of 25 mm and a length of 50 mm is prepared from a specimen. A test piece is affixed to the inner side of the upper arm of two subjects. Replace the specimen every 24 hours and repeat three times. At the time of exchanging the test piece, the area of the peeled (turned) portion of the test piece is measured, and the peel rate is calculated from the area of the entire test piece. The lower this number, the better. Also, the peel force is measured using a push-pull gauge when the test piece is peeled off. A higher value is better.

Exfoliation: Use the specimen after peeling used in the skin patch test. A 15 mm width and a 20 mm length are cut out from the center of the test piece, and after fixing with formalin, the keratin is stained with an eosin solution. Thereafter, it is washed with an ethanol solution and observed with a microscope at a magnification of 100 to evaluate the amount of exfoliation of the keratin. Also, the stratum corneum peeling area is calculated by image analysis software. The lower this number, the better.

Each test result obtained by the measurement method are shown in Tables 2 to 6. In addition, as a comparison of the characteristics of the present invention, the conventional hydrocolloid patch material is referred to as Comparative Example 1 (“Duoactive ET” manufactured by Convatec) and Comparative Example 2 (“Tegassorbite” manufactured by 3M), which are also verified. did.

Table 2 shows the measurement results of viscoelasticity (complex elastic modulus / phase difference). In Table 2, Example 4, the effect of ceramide, complex elastic modulus at a frequency of 0.1 [Hz] is, is considered to have become high as compared to other embodiments, in any of the embodiments, the complex located modulus and phase difference in the good preferable range, as described later, as the hydrocolloid material may comprise a suitable physical properties.

Next, Table 3 showing the results of the water absorption test will be described. As can be seen from Table 3, the selection and the blending amount of the hydrophilic material, you can manipulate the water absorption performance, none of the examples, we use superabsorbent hydrophilic material, wound or artificial Applicable to sites with a relatively large amount of exudate, such as around the anus.

Next, Table 4 of the adhesive property test results will be described. As can be seen from Table 4, Oite in the examples, SIS (Comparative Example 3) viscous than SEPS, due to the use of HSBR, it can be seen that a good sealing properties (water absorption time of adhesion).

Next, according to Table 5 the test results of the skin patch test (repeating application test), both in the embodiment had no adhesive residue on the skin. Further, the peeling force tends to increase in the peeling after the second time, particularly in Comparative Examples 1 and 2 , but the Examples showed almost constant values. Since the stratum corneum has a stronger binding force toward the inside of the skin, such an increase in peeling force is considered to mean that the stratum corneum is peeled off every time the test piece is peeled off.

Table 6 shows the results of measuring the keratin exfoliation area by image analysis software in the keratin exfoliation test. According to the test results, the stratum corneum peeled off by the test piece is dyed dark red. In the first peeling, the test pieces of all Examples and Comparative Examples were stained red, but the degree of staining was lower in the Examples. However, the exfoliated keratin is keratin (so-called dirt) that is not so much involved in the barrier function of the skin, and it is considered that there is almost no damage to the skin. In exfoliation after the second time, all of the test pieces of the comparative example are stained red and many keratins are peeled off, whereas the test pieces of the examples are hardly dyed and only a few keratins are peeled off. It was confirmed.

FIG. 1 is a side view of an embodiment of the patch of the present invention. Reference numeral 1 denotes a hydrocolloid layer formed in a film shape, 2 a support layer provided on one surface thereof, and 3 a release material disposed on the other surface. The support layer 2 retains the shape of the hydrocolloid layer 1 and has a function of facilitating handling, and protects the surface of the hydrocolloid layer 1. In use, when the release material 3 is removed and then the exposed surface of the hydrocolloid layer 1 is pasted on the skin or ulcer to be applied, the hydrocolloid layer 1 is adhered to the application site with its adhesiveness. The

The side view of the Example of the adhesive material of this invention.

Explanation of symbols

1 Hydrocolloid layer 2 Support layer 3 Release material

Claims (10)

Thermoplastic elastomer, liquid rubber compatible with thermoplastic elastomer, pectin, carboxymethylcellulose sodium (CMC-Na), guar gum, gelatin, karaya gum, alginic acid, chitin, chitosan, polyvinyl alcohol, polyacrylate and starch A water-soluble and / or water-insoluble hydrophilic substance selected from the group consisting of acrylic acid graft polymers , and an adhesive hydrocolloid material for application to the skin surface,
The thermoplastic elastomer is hydrogenated styrene-butadiene rubber ;
The hydrocolloid material characterized in that the liquid rubber compatible with the thermoplastic elastomer is any one selected from liquid ethylene / propylene rubber, liquid styrene-ethylene / propylene rubber, liquid polyisobutylene and liquid polybutene, or a mixture thereof. . Thermoplastic elastomer, liquid rubber compatible with thermoplastic elastomer, pectin, carboxymethylcellulose sodium (CMC-Na), guar gum, gelatin, karaya gum, alginic acid, chitin, chitosan, polyvinyl alcohol, polyacrylate and starch A water-soluble and / or water-insoluble hydrophilic substance selected from the group consisting of acrylic acid graft polymers , and an adhesive hydrocolloid material for application to the skin surface,
The thermoplastic elastomer is a styrene-ethylene / propylene-styrene block copolymer;
A hydrocolloid material characterized in that the liquid rubber compatible with the thermoplastic elastomer is liquid ethylene / propylene rubber and / or liquid styrene-ethylene / propylene rubber. Hydrocolloid material according to claim 1 or claim 2 hydrophile water-soluble and / or water-insoluble, characterized in that it contains 10 to 60 wt%. A thermoplastic elastomer, the weight ratio of liquid rubber in the thermoplastic elastomer compatible (thermoplastic elastomer: liquid rubber) is 1: 2 to 1: any of claims 1 to 3, characterized in that the 6 The hydrocolloid material according to claim 1 . It contains mineral oil, The hydrocolloid material of any one of Claims 1-4 characterized by the above-mentioned. The hydrocolloid material according to any one of claims 1 to 5, wherein the hydrocolloid material contains a medicinal component . Hydrocolloid material according to claim 6, wherein the drug active ingredient is moisturizing. The hydrocolloid material according to claim 7, wherein the moisturizing component is ceramide. 3 7 value of complex modulus and the phase difference measured at ℃ is, the complex elastic modulus is 10 when the frequency 0.1 Hz, 000 to 80, the phase difference is 10 ° to 40 ° at 000Pa, frequency 1.0Hz sometimes complex elastic modulus of 20, 000 to 130, a phase difference of 20 ° to 55 ° at 000Pa, complex elastic modulus at a frequency 10.0Hz 60, 000-500, the phase difference is 25 ° to 50 ° at 000Pa The hydrocolloid material according to any one of claims 1 to 8, wherein the hydrocolloid material is. A patch comprising the hydrocolloid material according to any one of claims 1 to 9 .

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