JP4961528B2 - Adhesive composition for skin application - Google Patents

Description

  The present invention relates to a pressure-sensitive adhesive composition used for applying to the skin of a human body, more specifically, a pressure-sensitive adhesive composition useful in cases where the subject is a person with weak skin or a child, and is applied repeatedly for a long time. About. Moreover, this invention relates also to the face plate for excrement accommodation appliances which apply | coats this adhesive composition for skin sticking to a backing material.

  BACKGROUND ART Adhesive compositions for skin application are often used in the medical field for fixing, holding, protecting wounds, etc. for pads, drugs, catheters, excrement storage containers and the like.

In general, the adhesive composition for skin patch is used to increase the adhesive strength so that it can be applied for a long time, but it gradually absorbs exudate from the skin, etc. It has a tendency to decline. For this reason, peeling after a long time can be performed with relatively little irritation. However, there is a case where it is necessary to peel in a short time of about 1 to 2 hours after sticking. In this case, it often has a large peeling adhesive force, and a very large skin irritation is caused at the time of peeling. Since it will give, it is not preferable.
Accordingly, it is desirable that the adhesive strength is reduced to a certain level that does not cause skin irritation even after about 1 to 2 hours after applying the adhesive composition for skin application.
In order not to give skin irritation when peeling in about 1 to 2 hours after sticking, it may be possible to lower the initial peeling adhesive strength, but in that case, there will be a problem of peeling during use .
Until now, there is no skin irritation even if it peels in a short time after sticking, and the adhesive for skin sticking that can satisfy the conflicting requirement that it does not peel off during use even if it is stuck for a long time. No agent composition has been reported.
In particular, the above properties are required for adhesives for skin application used for face plates for excrement accommodation devices.

Patent Document 1 discloses a face plate for excrement accommodation equipment in which a surfactant is further added to a skin protective agent composed of a hydrophilic component and a hydrophobic component, and this is used as an adhesive layer.
However, the pressure-sensitive adhesive composition disclosed here is preferable from the viewpoint of skin irritation when the peel-off adhesive strength does not increase greatly immediately after application and is peeled in a short time. The absolute value of the force is low, and it has not been sufficient from the viewpoint of long-term use of the excrement container.

JP 2002-17765 A

  The object of the present invention is for application to the skin without causing unintentional peeling during the application period, and can be easily peeled without irritation to the skin without being influenced by the application period when peeling. It is in providing an adhesive composition.

Thus, according to the present invention, there is provided a pressure-sensitive adhesive composition for skin patch comprising a pressure-sensitive adhesive, a water-absorbing agent, ceramide and an emulsifier.
In this skin protective composition, the water-absorbing agent is preferably 10 to 160 parts by weight with respect to 100 parts by weight of the adhesive.
Moreover, it is preferable that a ceramide and an emulsifier are respectively ceramide 0.01-3 weight part and emulsifier 0.03-10 weight part with respect to 100 weight part of adhesives.
In the adhesive composition for skin patch of the present invention, the amounts of the water-absorbing agent, ceramide and emulsifier are 10 to 160 parts by weight, 0.01 to 3 parts by weight and 0.1. It is preferable that it is 03-10 weight part.
In the adhesive composition for skin patch of the present invention, the ceramide is preferably a type 2, type 5 or type 7 ceramide.

In the adhesive composition for skin patch of the present invention, the emulsifier is preferably a nonionic emulsifier having an HLB value of 3 to 7.
The nonionic emulsifier is preferably a sorbitan fatty acid ester having an HLB of 3 to 7.
In the adhesive composition for skin application of the present invention, the total content of ceramide and emulsifier is preferably 0.1 to 10 parts by weight with respect to 100 parts by weight of the adhesive.
The adhesive composition for skin application of the present invention preferably has a peel adhesive strength of 2 to 4 N / 25 mm in 2 to 72 hours after application.
Moreover, in the adhesive composition for skin sticking of this invention, it is preferable that the peeling adhesive force 72 hours after sticking is 40% or more of the peeling adhesive force 2 hours after sticking.

  The adhesive composition for skin application of the present invention has a stable peel adhesive strength with little change in peel adhesive strength during the application period. Therefore, it can be used within the range of appropriate and constant peel strength, even after a short time or a long time after application, without causing unintentional peeling and on the skin at the time of peeling. There is little irritation.

  The adhesive composition for skin patch of the present invention comprises an adhesive, a water absorbing agent, a ceramide and an emulsifier.

The pressure-sensitive adhesive is not particularly limited as long as it has a function of retaining the shape due to the adhesiveness and cohesiveness to the skin, and the following materials generally referred to as elastomers can be used.
The elastomer is not particularly limited as long as it is conventionally used for this purpose. Specific examples thereof include natural rubber, styrene-isoprene-styrene block copolymer, styrene-butadiene copolymer, polyisobutylene, isobutylene-isoprene copolymer, polybutene, polyisoprene, ethylene-vinyl acetate copolymer, acrylic. Examples thereof include acid ester copolymers, vinyl acetate-acrylic acid ester copolymers, silicone polymers, and polyvinyl alkyl ethers.
Of these, block copolymers such as styrene-isoprene-styrene block copolymers, and synthetic rubber adhesives such as styrene-butadiene rubber, polyisobutylene, and butyl rubber (isobutylene-isoprene copolymer) are preferable.
These elastomers may be used alone or in combination of two or more.

The pressure-sensitive adhesive may contain a tackifier or a softener. As the tackifier, natural rosin derivatives, coumarone-indene resins, terpene oligomers, aliphatic petroleum resins, alkyl-modified phenol resins, and the like can be used.
What is necessary is just to select suitably the compounding quantity of a tackifier according to the kind of adhesive agent of addition object.

The water-absorbing agent absorbs excretion such as sweat that comes out from the skin surface, and depending on the component contained, there are those that perform functions such as maintaining the pH of the patch surface and buffering the pH.
The water-absorbing agent may be water-soluble or water-insoluble as long as it is a compound that exhibits water absorption.
Specific examples of water-soluble substances include seed gums such as corn starch, guar gum and locust bean gum; tubers and rhizome gums such as potato starch and kuzu starch; seaweed extracts such as alginate, carrageenan and agar and processed products thereof; Plant extracts such as gum karaya and gum arabic; fermented gums such as xanthan gum and dextran; carboxymethylcellulose, hydroxyalkylmethylcellulose, methylcellulose, starch acetate, starch phosphate, hydroxyethylated starch, hydroxypropyl starch, oxidized starch Semi-synthetic water-soluble polymers such as dextrinized starch; synthetic water-soluble polymers such as polyacrylic acid, polyethylene oxide, polyvinyl alcohol, poly N-vinylpyrrolidone; Door can be. One of these water-soluble water-absorbing materials may be used alone, or two or more thereof may be mixed and used.
Examples of the water-insoluble substance include mineral compounds such as kaolin, sulfur-containing aluminum silicate, quaternium-18 hectorite, silica, talc, and magnesium aluminate metasilicate. These mineral water-absorbing materials may be used alone or in combination of two or more.

  The usage-amount of a water absorbing agent is 10-160 weight part normally with respect to 100 weight part of adhesives, Preferably it is 30-140 weight part. If the amount of the water-absorbing agent is less than 10 parts by weight, the adhesive strength does not decrease even after a long time has elapsed after sticking, and the skin irritation tends to be too great during peeling. On the other hand, if it exceeds 160 parts by weight, the peel strength tends to be too low.

It is essential that the adhesive composition for skin patch of the present invention contains ceramide.
As the ceramide, any ceramide of 1 to 7 types may be used, but preferably 2 type, 5 type or 7 type. When these types are used, it is considered that the effect of supplementing the keratinocyte lipid lost at the time of peeling is great.
Ceramides may be used alone or in combination of two or more.

It is essential that the adhesive composition for skin patch of the present invention contains an emulsifier.
As the emulsifier, any of a nonionic emulsifier, an anionic emulsifier, a cationic emulsifier, and an amphoteric emulsifier can be used.

  Specific examples of nonionic emulsifiers include fatty acid-based non-glycerin fatty acid esters, sucrose fatty acid esters, sorbitan fatty acid esters, propylene glycol fatty acid esters, polyoxyethylene fatty acid esters, polyoxyethylene sorbitan fatty acid esters, aliphatic alkanolamides, and the like. Ionic emulsifiers; higher alcohol nonionic emulsifiers such as polyoxyalkylene alkyl ethers and alkylglycosides; alkylphenol nonionic emulsifiers such as polyoxyethylene alkylphenyl ethers; and the like.

  Specific examples of the anionic emulsifier include fatty acid anionic emulsifiers such as higher fatty acid salts and α-sulfo fatty acid methyl ester salts; linear alkylbenzene anionic emulsifiers such as linear alkylbenzene sulfonates; Higher alcohol type anionic emulsifiers such as ether sulfate ester salts and alkyl phosphate ester salts, α-olefin type anionic emulsifiers such as α-olefin sulfonates, normal paraffin type anionic emulsifiers such as alkane sulfonates, etc. Can be mentioned.

  Specific examples of the cationic emulsifier include quaternary ammonium cationic emulsifiers such as alkyltrimethylammonium salts, dialkyldimethylammonium salts and alkyldimethylbenzylammonium salts; amine salt systems such as N-methylbishydroxyethylamine fatty acid ester hydrochlorides. And cationic emulsifiers.

  Specific examples of the zwitterionic emulsifier include amino acid-based zwitterionic emulsifiers such as alkylamino fatty acid salts; betaine-based zwitterionic emulsifiers such as alkylbetaine; amine-oxide-based zwitterionic emulsifiers such as alkylamine oxide; be able to.

These emulsifiers may be used individually by 1 type, and 2 or more types may be mixed and used for them.
The emulsifier is preferably a nonionic emulsifier having an HLB of 3-7. When such an emulsifier is used, it is easy to control the degree of peeling strength reduction.
From the viewpoint of irritation to the skin, it is particularly preferable to use sorbitan fatty acid esters.
Of these, considering the irritation to the skin, it is desirable that the ingredients are described in cosmetic raw material standards, makeup regulations, etc., but this is not limited as long as safety is confirmed.

In the present invention, it is essential to use ceramide and an emulsifier in combination. Even if only one of them is used, the effect of the present invention cannot be obtained.
The total amount of ceramide and emulsifier is preferably 0.1 to 10 parts by weight, more preferably 0.1 to 5 parts by weight, and 0.2 to 3 parts by weight with respect to 100 parts by weight of the pressure-sensitive adhesive. More preferably, it is part. When the total amount is within this range, the object of the present invention is effectively achieved.
Although the compounding quantity of a ceramide changes with purposes of use, 0.01-3 weight part is preferable with respect to 100 weight part of adhesives. More preferably, it is 0.07-2 weight part, More preferably, it is 0.1-1.5 weight part.
When the blending amount is less than 0.01 parts by weight, the initial peeling adhesive strength tends to be high, and even after a certain period of time, there is a tendency to show high peeling adhesive strength. On the other hand, when the amount is more than 3 parts, the peel-off adhesive force tends to be low, and the force for applying the excrement containing appliance to the skin tends to be weak.

Although the usage-amount of an emulsifier changes with use purposes, 0.03-10 weight part is preferable with respect to 100 weight part of adhesives. More preferably, it is 0.05-5 weight part, More preferably, it is 0.1-3 weight part.
When this amount is less than 0.03 part by weight, the adhesive strength tends to be lowered with time. When the amount is more than 10 parts by weight, the peel adhesive strength is too low, and the force for attaching the excrement containing appliance to the skin tends to be weakened.

In the adhesive composition for skin patch of the present invention, the effects of ceramide and emulsifier when combined alone and in combination can be estimated as follows.
That is, when ceramide is used in the pressure-sensitive adhesive composition, since the ceramide has properties as a lipid, the initial peeling strength against the skin is reduced to some extent. Sweat and moisture from the skin are taken into the pressure-sensitive adhesive composition, and the amount of water gradually increases from the skin side, making it easier for ceramide to move through the pressure-sensitive adhesive composition. Thereafter, the ceramide moves to the skin side surface side of the pressure-sensitive adhesive composition over time and becomes unevenly distributed. However, since a sebum film is present on the stratum corneum surface, ceramide is less likely to migrate into the stratum corneum, and ceramide is unevenly distributed near the skin side surface of the pressure-sensitive adhesive composition. And the amount of ceramide unevenly distributed on the skin side surface of the pressure-sensitive adhesive composition increases with time. As a result, when ceramide is blended, the peel adhesive strength is reduced compared to when ceramide is not blended, which may cause peeling during use.
In addition, when only the emulsifier is used, sweat and moisture from the skin are taken into the pressure-sensitive adhesive composition, and the emulsifier easily moves in the pressure-sensitive adhesive composition at the molecular level. Thereafter, the emulsifier becomes unevenly distributed on the skin side surface side of the pressure-sensitive adhesive composition, and the peel strength is reduced due to the presence of the alkyl group in the emulsifier. Sebum is emulsified by the emulsifier and removed from the stratum corneum, but it does not penetrate into the stratum corneum. Moreover, although the adhesive strength generally decreases, the emulsifier does not significantly affect the rate of decrease in adhesive strength.

When ceramide and an emulsifier are used in combination, immediately after the adhesive composition containing both is applied to the skin, the ceramide and the emulsifier are uniformly dispersed in the adhesive composition. Contributes mainly. For this reason, the initial peel-off adhesive strength is reduced by the blending of ceramide and emulsifier, but the degree is not large. Ceramide and emulsifiers are contained in the pressure-sensitive adhesive composition at the molecular level due to the temperature rise of the pressure-sensitive adhesive composition due to sweat, moisture and exudate from the skin surface, body temperature, etc. It becomes easy to move to the skin surface side. As a result, the peel strength decreases with time.
Furthermore, when time passes, the emulsifier emulsifies the sebum covering the stratum corneum surface, and a part thereof is absorbed into the pressure-sensitive adhesive composition. Thereby, a gap is formed in the sebum film. The ceramide penetrates into the stratum corneum from this gap, and the amount of ceramide present on the skin side surface of the pressure-sensitive adhesive composition is reduced, and the decrease in the peeling adhesive strength is suppressed. That is, of the ceramide and the emulsifier, which are components that reduce the peel adhesive strength, only ceramide is absorbed into the stratum corneum and decreases. This makes it possible to suppress the maximum adhesive strength for several hours after sticking and prevent the adhesive strength from being excessively reduced.

The adhesive composition for skin patch of the present invention can contain a sebum absorbent and / or a sebum degrading agent.
By using a sebum absorbent and / or a sebum decomposing agent in combination, it is possible to improve the effect of maintaining the peeling adhesive strength within a suitable range for a long time. This is because the sebum absorbent and / or sebum degrading agent removes sebum from the skin surface, facilitates the transfer of ceramide from the adhesive composition to the skin, and thereby suppresses the decrease in adhesiveness. Presumed to be.
Examples of the sebum absorbent include cellulose, corn starch aluminum octenyl succinate, cyclodextrin, kaolin, sulfur-containing aluminum silicate, quaternium-18 hectorite, silica, talc, magnesium aluminate metasilicate, and the like. Examples of sebum degrading agents include SB bacteria and yeast extract.
Some of these sebum absorbents simultaneously function as sebum absorbents when used as water-absorbing agents in the present invention.

  The adhesive composition for skin application of the present invention preferably has a peel adhesive strength after 72 hours of application of 40% or more of the peel adhesive force after 2 hours of application.

  The adhesive composition for skin application of the present invention can adjust the adhesive strength by peeling it to a range of 2 to 4 N / 25 mm over a long period of 2 to 72 hours after application to the skin. If the peeling adhesive strength is within this range, the adhesive layer will not be unintentionally peeled off, and damage to the stratum corneum can be reduced during peeling.

The pressure-sensitive adhesive composition for skin patch of the present invention can be suitably used for a face plate for excrement accommodation equipment.
The excrement containment device is used when surgical operation is performed for diseases of the digestive system and urinary organs, and when the intestinal tract and ureter are guided to the body surface and excretion holes such as stoma are constructed on the body surface. In order to temporarily store excrement such as stool, urine, and body fluid excreted from the hole, it is attached to the excretion hole.

This excrement accommodation equipment is generally composed of a container part (bag part) and a face plate for excrement accommodation equipment (hereinafter sometimes simply referred to as a “face board”) for attaching it to the skin. It is fixed to the excretion hole on the body surface by the pressure-sensitive adhesive composition layer provided on the body. It is necessary that the excrement container is securely fixed to the body surface during the period of use.
On the other hand, when these excrement storage devices are used, if excrement accumulates in the container part to some extent, the excrement is discarded, washed and used again, or replaced with a new one. At the time of replacement, the one-piece type that integrates the face plate and the container part is the entire device, and the two-piece type that is detachable by adhesion or fitting between the face plate and the container part is the whole device or the container part. Dispose of only the whole or replace only the container part with a new one. The frequency of replacement is usually about 1 day for the one-piece type and 2 to 4 days for the two-piece type.
At the time of this replacement, it is necessary that there is no irritation to the skin and that there is no risk of skin damage due to removal of horny layer cells of the outer skin layer.
Therefore, the adhesive used for the faceplate for attaching the excrement containing device to the skin is required to maintain the necessary peeling adhesive force during the application period and not to irritate the skin when peeling for replacement. It is done.

FIG. 3 shows an example used for the excrement accommodation apparatus of the present invention (hereinafter, simply referred to as “accommodation apparatus”).
The accommodation appliance has a face plate 1 for excrement accommodation appliances.
The face plate 1 includes an adhesive composition layer 2 for fixing it on the human skin with an adhesive function, and a backing material 3 that supports the adhesive composition layer 2. The pressure-sensitive adhesive composition layer 2 is covered with the separator 5 during storage, and the pressure-sensitive adhesive surface is protected. A bag portion 6 serving as a container portion is fixed around the opening 4 on the backing material side of the face plate 1. This excretory part accommodation device is fixed around the excretion hole built in the human body by the pressure-sensitive adhesive composition layer 2 of the face plate 1, and excrement such as stool, urine, body fluid etc. excreted from the excretion hole is a bag part. 6 to accommodate.

The pressure-sensitive adhesive composition layer 2 of the face plate 1 is composed of the pressure-sensitive adhesive composition for skin application of the present invention.
The backing material 3 is made of an ethylene / vinyl acetate copolymer film, an ethyl methacrylate film, a polyethylene film, a polypropylene film, a polyvinyl alcohol film, a polyethylene nonwoven fabric, a polypropylene nonwoven fabric, and an ethylene / vinyl acetate copolymer. It can be comprised from a nonwoven fabric etc.

Hereinafter, the present invention will be described more specifically with reference to reference examples, examples and comparative examples. In addition, unless otherwise indicated, the part and% in each example are a basis of weight.
Each characteristic was evaluated by the following method.

[Peeling adhesive strength]
A test piece cut into a rectangle of 25 mm × 100 mm is used as a test piece, which is attached to the abdomen of the subject along the body axis direction. After elapse of a predetermined time, the subject is laid in a supine position in front of a tensile tester (Instron 5564) in a room at 23 ° C. and 65% RH, a chuck is attached to one side of the short side of the test piece, and its end is 180 °. Fold it back and attach one end of the wire to the chuck of the test piece. The wire is raised vertically through a pulley on a tensile tester, and the other end is sandwiched between chucks attached to the load cell of the tensile tester. Adjust the position and height of the subject so that the wire from the test piece to the pulley on the tensile tester is horizontal and parallel to the body axis. Using a tensile tester, peeling is performed at a tensile speed of 1,000 mm / min in the direction in which the test piece is folded, and the peel adhesive strength (unit: N / 25 mm) is measured.

[Retention rate after 72 hours]
(Peeling adhesive strength after 72 hours of sticking / peeling adhesive strength after 2 hours of sticking) × 100 (%).

Example 1
90 parts of polyisobutylene (molecular weight 50,000, manufactured by Nippon Petrochemical Co., Ltd., trade name “Himor 5H”) and tackifier (alicyclic saturated hydrocarbon resin, manufactured by Arakawa Chemical Industries, Ltd., trade name “Arcon P- 100 ") 100 parts of adhesive, 50 parts of Karaya gum, 40 parts of pectin, 40 parts of gelatin and 140 parts of water-absorbing material consisting of 10 parts of silica (product name" Nipseal VN-3 "manufactured by Nippon Silica Co., Ltd.) 0.1 part of type 2 ceramide (trade name “Sofcare Ceramide SL-E” manufactured by Kao Corporation) and sorbitan fatty acid ester of HLB4.7 as an emulsifier (trade name “Leodol SP-S10V”) 0. One part was uniformly mixed with a pressure kneader to obtain an adhesive composition 1. The pressure-sensitive adhesive composition 1 was rolled to form a sheet having a thickness of 1 mm, and a non-woven fabric made of polyethylene was bonded as a backing material on one side to prepare a test product. In addition, release paper was bonded to the surface opposite to where the backing material was bonded.
The test piece was measured for peel adhesion. The results are shown in Table 1 and FIG.

(Examples 2-6, Comparative Examples 1-3)
Except changing the mixing | blending of an adhesive composition as shown in Table 1, it carried out similarly to Example 1, and obtained the adhesive compositions 2-6 and C1-C3. Test pieces were prepared from these pressure-sensitive adhesive compositions. About this test piece, it peeled in the same manner as in Example 1, and the peel strength was measured. The results are shown in Tables 1 and 2 and FIGS.

From Tables 1 and 2 and FIGS. 1 and 2, the following can be understood.
When neither ceramide nor an emulsifier is blended (Comparative Example 1), the 2N peeling adhesive strength is maintained even after 72 hours, but the peeling adhesive strength after 2 hours of application is high, and 24 hours have elapsed. After that, it is 4.5 N, and when it peels in a short time, the adhesive force is too high. When emulsifier is not blended but only ceramide is blended (Comparative Example 2), the initial peel adhesive strength is high and finally falls below 4N after 12 hours, but after that, the peel strength decreases rapidly with time. After 72 hours, it will be less than 2N. Accordingly, the adhesive strength is too high for peeling in a short time, and on the other hand, the adhesive strength becomes too low if pasting is continued for a long time.

  When only emulsifier is blended and ceramide is not blended at all (Comparative Example 3), the initial peel adhesive strength is relatively low, but the peel adhesive strength after 72 hours is too low, and it is applied for a long time. You can't understand.

  On the other hand, when the pressure-sensitive adhesive composition satisfying the requirements of the present invention is used, the initial peel strength is 4 N or slightly less than that, and even after 72 hours, 2. It shows peeling adhesive strength exceeding 5N, and does not fall off from the site of application even if the application is continued for a long time. Further, it can be seen that there is little skin irritation at the time of peeling.

FIG. 1 is a diagram showing the change over time of the peel adhesive strength of the adhesive composition for skin application of the examples of the present invention. FIG. 2 is a diagram showing the change over time of the peel adhesive strength of the adhesive composition for skin application of a comparative example of the present invention. Fig.3 (a) is a front view of an example of the excrement accommodation apparatus of this invention. FIG.3 (b) is a vertical side view of an example of the excrement accommodation apparatus of this invention. FIG.3 (c) is an expanded sectional view of an example of the face plate for excrement accommodation braces of this invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Face plate 2 Adhesive composition layer 3 Backing material 4 Opening 5 Separator 6 Bag part

Claims (7)

Containing elastomer, water-absorbing compound, ceramide and emulsifier,
Adhesive for skin application wherein the content of the water-absorbing compound, ceramide and emulsifier is 30 to 140 parts by weight, 0.1 to 1.5 parts by weight and 0.1 to 3 parts by weight with respect to 100 parts by weight of the elastomer, respectively. Agent composition. Containing elastomer, water-absorbing compound, ceramide and emulsifier,
The content of the water-absorbing compound, ceramide and emulsifier is 30 to 140 parts by weight, 0.1 to 1.5 parts by weight and 0.1 to 3 parts by weight, respectively, with respect to 100 parts by weight of the elastomer.
A pressure-sensitive adhesive composition for skin application, wherein the total content of ceramide and emulsifier is 0.2 to 3 parts by weight per 100 parts by weight of the elastomer. The elastomer is natural rubber, styrene-isoprene-styrene block copolymer, styrene-butadiene copolymer, polyisobutylene, isobutylene-isoprene copolymer, polybutene, polyisoprene, ethylene-vinyl acetate copolymer, acrylate copolymer. One or more selected from a polymer, a vinyl acetate-acrylic acid ester copolymer, a silicone polymer, and a polyvinyl alkyl ether;
Water-absorbing compounds are corn starch, guar gum, locust bean gum, potato starch, kuzu starch, alginate, carrageenan, agar, pectin, karaya gum, gum arabic, xanthan gum, dextran, carboxymethylcellulose, hydroxyalkylmethylcellulose, methylcellulose, starch acetate, starch Phosphate, hydroxyethylated starch, hydroxypropyl starch, oxidized starch, dextrinized starch, polyacrylic acid, polyethylene oxide, polyvinyl alcohol, poly N-vinylpyrrolidone, kaolin, sulfur-containing aluminum silicate, quaternium-18 hectorite, silica 1 or more selected from talc, magnesium aluminate metasilicate,
Emulsifier is glycerin fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, aliphatic alkanolamide, polyoxyalkylene alkyl ether, alkyl glycoside, polyoxy Ethylene alkyl phenyl ether,
Higher fatty acid salt, α-sulfo fatty acid methyl ester salt, linear alkylbenzene sulfonate, alkyl sulfate ester salt, alkyl ether sulfate ester salt, alkyl phosphate ester salt, α-olefin sulfonate, alkane sulfonate,
Alkyltrimethylammonium salt, dialkyldimethylammonium salt, alkyldimethylbenzylammonium salt, N-methylbishydroxyethylamine fatty acid ester hydrochloride,
The pressure-sensitive adhesive composition for skin application according to claim 1 or 2, which is one or more selected from alkylamino fatty acid salts, alkylbetaines, and alkylamine oxides.   The pressure-sensitive adhesive composition for skin application according to any one of claims 1 to 3, wherein the ceramide is one or more types of ceramide selected from 2, 5, or 7.   The pressure-sensitive adhesive composition for skin application according to any one of claims 1 to 4, wherein the emulsifier is a nonionic emulsifier having 3 to 7 HLB.   The adhesive composition for skin application according to any one of claims 1 to 5, which has a peel strength value of 2 to 4 N / 25 mm in 2 to 72 hours after application.   The adhesive composition for skin application according to any one of claims 1 to 6, wherein the peel adhesive strength after 72 hours of sticking is 40% or more of the peel adhesive strength after 2 hours of sticking.

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