JPH06200A - Wound protective material - Google Patents

Abstract

PURPOSE:To improve shape holdability and absorptivity by using natural rubber as a buffer and alkyl cellulose, water-soluble high-polymer compd. and highly water-absorptive resin as a bleeding liquid absorbent and laminating a water- absorptive adhesive layer formed by compounding the mixture composed thereof and a pressure sensitive adhesive on the base of a foam. CONSTITUTION:The natural rubber to be used as the buffer includes gua rubber, etc., and the compounding amt. thereof is 5 to 50w/w%. The alkyl cellulose to be used as the bleeding liquid absorbent includes carboxymethyl-cellulose and the compounding amt. thereof is 3 to 50w/w%. The water-soluble high- polymer compd. to be used as the bleeding liquid absorbent includes agarose, etc., and the compounding amt. thereof is 5 to 50w/w%. The highly water- absorptive resin includes a starch system, etc. The pressure sensitive adhesive is prepd. by compounding 3 to 40w/w% rubber component, 5 to 50w/w% alicyclic satd. hydrocarbon resin and 3 to 40w/w% liquid rubber as its essential constituting components.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a wound protector suitable for treating wounds with open wounds such as skin ulcers such as bedsores and leg ulcers and burns.

[0002]

2. Description of the Related Art As a wound protection dressing material for the purpose of protecting skin wounds and promoting healing, dry dressing that keeps wounds dry and forms scabs and performs healing, and a prompt moist environment to form epidermal cells Wet dressing that promotes the migration of cells is known, and it is considered desirable to use a wet dressing that allows epidermal cells to move freely to promote tissue formation.

In drainage wounds such as decubitus tumors, blood,
Accumulation of exudates such as serum and purulent substances in the wound recess causes bacterial growth, which delays the treatment of the wound and poses a difficult treatment problem.

Therefore, there is a need for a protective material that can provide a protective coating to a wound while absorbing exudates from the wound.

A skin protective agent which is applied to a wound surface and is used as a wound treatment material is usually required to have the following functions.

1) When it is applied to the wound surface, it is flexible and adheres well to the wound surface, and also adheres well to the wound surface and its surroundings, and no other fixative is required.

2) It adheres firmly to the wound surface even during a long-term use period, does not become a culture medium of bacteria, and has a physiological pH of the skin.
It should have a buffering effect that approaches (4.5 to 5.5).

3) Follow body movements well and do not give physical irritation to the wound surface.

4) To be able to absorb the secretory fluid from the wound surface and to prevent the skin protective agent from falling off and flowing to the surroundings.

5) At the time of removal, it should be such that it does not adhere to the wound surface and can be easily peeled off so that the skin protectant does not remain on the wound surface and its surroundings.

Wound dressings based on karaya gum are currently used for the above-mentioned purposes. One of them is Karaya Disc (manufactured by Tokyo Hygiene Research Institute), which is superior in water absorption and buffering power, but has a drawback that it is not durable and has no adhesive force.

In order to make up for the drawbacks of this Karaya disc, a CMC-based wound dressing material has been prepared in which a hydrophilic polymer such as carboxymethyl cellulose (CMC), pectin or gelatin and a hydrophobic polymer such as polyisobutylene are blended (special feature: JP-A-63-6020, JP-A-57-1689
70).

[0013]

Although some improvements have been made by the combination of the above-mentioned compounding agents, none have been found to be satisfactory in terms of adhesion to tissues, absorbability of body fluids, buffering properties, shape retention and the like. It is not.

The present invention has excellent adhesiveness to the skin, has flexibility capable of sufficiently following the movement of the skin, absorbs exudate from the wound surface, does not disintegrate the preparation after absorption, and peels from the wound surface. It is intended to provide a wound protective material which has good properties and prevents infection of the wound surface due to invasion of bacteria from the outside.

[0015]

DISCLOSURE OF THE INVENTION The present invention is a wound protection material comprising a foam support and a water-absorptive adhesive layer laminated on the support, and a foam support having polyethylene, polyvinyl chloride, or polybutadiene. , A wound protective material which is one or more foam films consisting of a group such as polyurethane, and a wound protective material whose water-absorbing adhesive layer is a buffer, an exudate absorbent, a pressure-sensitive adhesive, and a buffer is guar rubber, A wound protection material, which is one kind or a combination of two or more kinds selected from the group consisting of natural rubbers such as locust bean rubber, gum arabic, and karaya gum, and whose compounding amount is 5 to 50 w / w%,
And a wound protector in which the exudate absorbent comprises alkyl cellulose and / or a water-soluble polymer and a super absorbent resin,
And the pressure-sensitive adhesive is a rubber-based component 3 to 40 w / w%, an alicyclic saturated hydrocarbon resin 5 to 50 w / w%, and a liquid rubber 3 to 4.
The present invention relates to a wound protection material containing 0 w / w% as a main component.

[0016]

[Function] As a result of intensive research conducted by the present inventors, a natural rubber was used as a buffer, an alkylcellulose, a water-soluble polymer compound and a superabsorbent resin were used as an exudate absorbent. It was found that a wound protection material formed by laminating a blended water-absorbing adhesive layer on a foam support exerts extremely high shape retention and absorption while exhibiting an appropriate cushioning effect and adhesiveness. Completed the invention.

The natural rubbers used as the buffer in the present invention include guar gum, locust bean gum, gum arabic, karaya gum and the like, and one kind or a combination of two or more kinds thereof may be used.

The amount thereof is 5 to 50 w / w%, preferably 10 to 30 w / w%. If the blending amount is 5% or less, the above-mentioned buffering effect is weakened, and if it is 50% or more, the formulation becomes very hard and other components cannot be mixed, which is not preferable.

The alkyl cellulose used as the exudate absorbent in the present invention includes carboxymethyl cellulose (CMC) and hydroxypropyl cellulose (HP
C), ethyl cellulose (EC), methyl cellulose (MC), methyl propyl cellulose (MPC) and the like can be mentioned, and one kind or a combination of two or more kinds thereof may be used.

The compounding amount thereof is 3 to 50 w / w%, preferably 5 to 20 w / w%. When the content is 3% or less, the exudate absorbency is weak, and when it is 50% or more, the adhesive strength of the preparation cannot be obtained, which is not preferable.

The water-soluble polymer compound used as the exudate absorbent in the present invention includes agarose, agar, albumin, alginate, carrageenan, casein, gelatin, pectin and the like, and one or more of them may be used. May be used in combination.

The compounding amount thereof is 5 to 50 w / w%, preferably 10 to 30 w / w%. If the blending amount is 5% or less, the exudate absorbency is not sufficient, and if it exceeds 50%, the other components cannot be mixed and the adhesiveness of the preparation is lost, which is not preferable.

The superabsorbent resin used as the exudate absorbent in the present invention includes starch-based, cellulose-based, polyvinyl alcohol-based, acrylic-based and the like, and one or more of them may be used in combination. .

In the starch type, starch-acrylonitrile graft (SGP: Henkel Japan Ltd., WAS:
Nippon starch chemistry), starch / acrylic acid graft (Sunwet: Sanyo Kasei), starch styrene sulfonic acid graft, starch vinyl sulfonic acid graft. Cellulosics include cellulose acrylonitrile grafts, cellulose styrene sulfonate grafts, and crosslinked methyl cellulose. In the case of polyvinyl alcohol type, cross-linked polyvinyl alcohol (Sumikagel S-
50: Sumitomo Chemical Co., Ltd.), saponified vinyl acetate. Acrylics include polyacrylic acid salt crosslinked products (Wonder Gel MX-2011: Kao Soap), polyacrylonitrile polymer saponification products (Aquakeep: Sumitomo Seika), polyethylene glycolate diacrylate crosslinked products and the like.

The blending amount thereof is 5 to 80 w / w%, preferably 10 to 50 w / w%. When the blending amount is 5% or less, the exudate absorbency is insufficient, and when it is 80% or more, the formulation is The adhesive strength is lost, which is not preferable.

The pressure-sensitive adhesive used in the present invention includes rubber components (silicone rubber, polyisoprene rubber, polyisobutylene rubber, styrene butadiene rubber, styrene-isoprene-styrene block copolymer rubber, styrene-butadiene-styrene). Block copolymer rubber) 3 ~
40 w / w%, alicyclic saturated hydrocarbon resin 5 to 50 w / w
%, Liquid rubber 3 to 40 w / w% as a main constituent component. Further, as the rubber component, vinyl type (polyvinyl alkyl ether, polyvinyl alcohol, polyvinyl acetate, etc.), acrylate copolymer and the like can be used.

Examples of the support for the foam used in the present invention include foam films of polyethylene, polyvinyl chloride, polybutadiene, polyurethane and the like.

Further, the water-absorbing pressure-sensitive adhesive layer in the present invention may be blended with an anti-tank substance such as neomycin or gentamicin.

When the functional test of the wound protective material of the present invention was conducted, a moderate cushioning effect and adhesiveness equivalent to those of conventional products were obtained, and further, the shape retention and water absorption, which are important functions as a wound protective material, were obtained. As is clear from the following test results, it was dramatically improved.

[0030]

[Test Example] The wound protective material of the present invention and a commercially available product (Duo Ac
(Tive: manufactured by Squibb) was used to perform a comparative test of shape retention and water absorption. Test method A sample (Example 1 and a commercial product) whose weight was measured in advance was floated in physiological saline with the plaster surface (water-absorptive adhesive layer) facing downward, and the sample weight was measured over time. The water absorption rate was defined as the percentage of the physiological saline water absorption amount with respect to the initial weight. The results are shown in Table 1.

[0031]

[Table 1] The commercial product disintegrated 10 hours after the test and could not be measured, but the product of the present invention maintained the shape retention of the preparation even after absorbing 6 times of water after 24 hours.

Examples of the present invention are shown below, but it goes without saying that the present invention is not limited to the following examples.

[0033]

【Example】

Example 1 Pressure-sensitive adhesive Styrene-isoprene-styrene block copolymer (SIS) 7w / w% Alicyclic saturated hydrocarbon (P-100) 14w / w% Liquid rubber (LIR-50) 22w / w% Antioxidant (BHT) 2w / w% Fine powder silica (Aerosil) 5w / w% Hydroxypropyl cellulose 9w / w% Karaya gum 15.5w / w% Pectin 10W / w% Gelatin 5w / w% Super absorbent resin (Sunwet IM- 1000MPS) 10w / w% titanium dioxide 0.5w / w% total 100w / w% (manufacturing method of Example 1) The kneading machine was warmed to 150 ° C, and SIS, antioxidant, alicyclic hydrocarbon After adding and melting, the temperature of the kneading machine is set to 120 ° C., liquid rubber and fine powder silica are added and kneaded well to form a pressure-sensitive adhesive. Cellulose, karaya gum, pectin, gelatin, superabsorbent resin, titanium dioxide are added and uniformly kneaded, and spread on a PET film siliconized on one side to give 500 to 1000 g / m2, to give a vinyl chloride foam film. Laminate to obtain the wound protection material of the present invention.

Example 2 Pressure-sensitive adhesive Vinyl acetate 25 w / w% Alicyclic saturated hydrocarbon resin 10 w / w% Liquid rubber (LIR-50) 10 w / w% Antioxidant (BHT) 0.5 w / w% Fine powder silica (aerosil) 3w / w% Locust bean rubber 5.5w / w% Methylcellulose 11w / w% Na alginate 25w / w% Super absorbent polymer (polyacrylonitrile polymer) 10w / w% Total 100w / w%

Example 3 Pressure-sensitive adhesive Styrene-butadiene-styrene rubber 7 w / w% Alicyclic saturated hydrocarbon resin 10 w / w% Liquid rubber (LIR-50) 10 w / w% Antioxidant (BHT) 0. 5w / w% Fine powder silica (Aerosil) 4.5w / w% Arabic gum 25w / w% Carrageenan 8w / w% Super absorbent polymer (polyvinyl alcohol) 35w / w% Total 100w / w%

Example 4 Pressure-sensitive adhesive Silicone rubber 5 w / w% Alicyclic saturated hydrocarbon resin 35 w / w% Liquid rubber (LIR-50) 10 w / w% Antioxidant (BHT) 2 w / w% Fine powder Silica (Aerosil) 3w / w% Locust bean gum 10w / w% Ethylcellulose 5w / w% Albumin 5w / w% Casein 5w / w% Super absorbent resin (starch-acrylic acid type) 20w / w% Total 100w / w%

Example 5 Pressure-sensitive adhesive Polyisoprene rubber 8 w / w% Alicyclic saturated hydrocarbon resin 15 w / w% Liquid rubber (LIR-50) 30 w / w% Antioxidant (BHT) 2 w / w% Fine Powdered silica (aerosil) 5 w / w% Gum arabic 10 w / w% Methyl propyl cellulose 8 w / w% Agarose 5 w / w% Agar 5 w / w% Super absorbent resin (starch-acrylonitrile type) 12 w / w% Total 100 w / w %

Example 6 Pressure-sensitive adhesive Styrene-butadiene rubber 10 w / w% Saturated alicyclic hydrocarbon resin 12 w / w% Liquid rubber (LIR-50) 25 w / w% Antioxidant (BHT) 1 w / w% Fine powder silica (aerosil) 3w / w% Karaya gum 9w / w% Hydroxypropyl cellulose 10w / w% Na alginate 5w / w% Gelatin 5w / w% Super absorbent resin (polyacrylonitrile-based) 20w / w% Total 100w / w %

Example 7 Pressure-sensitive adhesive Polyisobutylene rubber 40 w / w% Antioxidant 2 w / w% Fine powder silica (Aerosil) 3 w / w% Guar gum 5 w / w% Carboxymethyl cellulose 25 w / w% Pectin 10 w / w% Super absorbent resin (starch-acrylonitrile type) 15w / w% Total 100w / w%

[0040]

The wound protection material of the present invention has an appropriate buffering effect by a buffering agent selected from the group consisting of natural rubbers such as guar gum, locust bean gum, gum arabic and karaya gum. To demonstrate
Alkyl cellulose and / or water-soluble polymer while exhibiting appropriate adhesiveness and high shape retention by a pressure-sensitive adhesive mainly composed of a rubber-based component, an alicyclic saturated hydrocarbon resin and a liquid rubber. High water absorption can be obtained by the exudate absorbent comprising a compound and a super absorbent resin.

Claims (6)

[Claims] 1. A wound protection material comprising a foam support and a water-absorbing adhesive layer laminated on the support. 2. The wound protection material according to claim 1, wherein the foam support is one or more foam films selected from the group consisting of polyethylene, polyvinyl chloride, polybutadiene, polyurethane and the like. 3. The water-absorbent adhesive layer comprises a buffer, an exudate absorbent,
The wound protection material according to claim 1, which comprises a pressure-sensitive adhesive. 4. The buffering agent is one kind or a combination of two or more kinds selected from the group consisting of natural rubbers such as guar gum, locust bean gum, gum arabic and karaya gum, and the compounding amount thereof is 5 to 50 w / w%. The wound protection material according to claim 3. 5. The wound protection material according to claim 3, wherein the exudate absorbent comprises an alkyl cellulose and / or a water-soluble polymer compound and a super absorbent resin. 6. The pressure-sensitive adhesive is a rubber-based component 3 to 40 w /
The wound protection material according to claim 3, wherein w%, alicyclic saturated hydrocarbon resin 5 to 50 w / w%, and liquid rubber 3 to 40 w / w% are main constituent components.