JP2019163220A - 炎症性貧血処置のための組成物 - Google Patents
炎症性貧血処置のための組成物 Download PDFInfo
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- JP2019163220A JP2019163220A JP2018052084A JP2018052084A JP2019163220A JP 2019163220 A JP2019163220 A JP 2019163220A JP 2018052084 A JP2018052084 A JP 2018052084A JP 2018052084 A JP2018052084 A JP 2018052084A JP 2019163220 A JP2019163220 A JP 2019163220A
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Abstract
Description
[1] 乳タンパク質の加水分解物を含む、炎症性貧血の処置のための組成物。
[2] 乳タンパク質が、ホエイタンパク質、ホエイタンパク質単離物(WPI)、ホエイタンパク質濃縮物(WPC)、β-ラクトグロブリン、α-ラクトアルブミン、およびラクトフェリンからなる群より選択されるいずれかである、1に記載の組成物。
[3] 飲料の形態である、1または2に記載の組成物。
[4] 乳タンパク質の加水分解物を、一回量または一日量当たり、1〜25g含有する、食品組成物。
[5] 炎症性疾患、感染性腸炎、感冒による下痢・嘔吐・発熱を伴う脱水状態、および過度の発汗による脱水状態からなる群より選択されるいずれかの疾患もしくは状態にある者、またはその発症リスクのある者に摂取させるための、4に記載の食品組成物。
[6] 炎症性貧血の処置のための、4または5に記載の食品組成物。
[7] 炎症性貧血の処置のための組成物を製造するための、乳タンパク質の加水分解物の使用。
[8] 乳タンパク質が、ホエイタンパク質、ホエイタンパク質単離物(WPI)、ホエイタンパク質濃縮物(WPC)、β-ラクトグロブリン、α-ラクトアルブミン、およびラクトフェリンからなる群より選択されるいずれかである、7に記載の使用。
[9] 乳タンパク質の加水分解物を含む、炎症性貧血の処置のための組成物の製造方法。
[10] 乳タンパク質が、ホエイタンパク質、ホエイタンパク質単離物(WPI)、ホエイタンパク質濃縮物(WPC)、β-ラクトグロブリン、α-ラクトアルブミン、およびラクトフェリンからなる群より選択されるいずれかである、9に記載の組成物の製造方法。
[11] 炎症性貧血の処置のために用いられる、乳タンパク質の加水分解物。
[12] 乳タンパク質が、ホエイタンパク質、ホエイタンパク質単離物(WPI)、ホエイタンパク質濃縮物(WPC)、β-ラクトグロブリン、α-ラクトアルブミン、およびラクトフェリンからなる群より選択されるいずれかである、11に記載の加水分解物。
[13] 乳タンパク質の加水分解物の、炎症性貧血の非治療的処置(例えば、発症リスクの低減)のための使用。
[14] 乳タンパク質が、ホエイタンパク質、ホエイタンパク質単離物(WPI)、ホエイタンパク質濃縮物(WPC)、β-ラクトグロブリン、α-ラクトアルブミン、およびラクトフェリンからなる群より選択されるいずれかである、13に記載の使用。
本発明は、炎症性貧血の処置のための組成物に関する。本発明の組成物は、乳タンパク質の加水分解物を有効成分とする。
乳タンパク質とは、乳由来のタンパク質をいう。本発明に用いる、乳タンパク質の加水分解物の原料である乳タンパク質の例は、ホエイタンパク質(ホエイタンパク質単離物(WPI)、およびホエイタンパク質濃縮物(WPC)を含む。)、β-ラクトグロブリン、α-ラクトアルブミン、ラクトフェリン、カゼイン、および乳タンパク質濃縮物(MPC)、総乳タンパク質(TMP)、ならびにこれらの混合物である。好ましい例は、ホエイタンパク質、β-ラクトグロブリン、α-ラクトアルブミン、およびラクトフェリンであり、より好ましい例は、ホエイタンパク質である。
・特許第3183945号公報に開示される、加熱変性したホエイタンパク質分離物(WPI)を、エンドペプチダーゼおよびエキソペプチダーゼで酵素分解後、この酵素分解物中の芳香族アミノ酸をイオン交換樹脂で吸着処理することにより、Fischer比が10 以上、分岐鎖アミノ酸が15%以上、芳香族アミノ酸が2%未満のホエイタンパク酵素分解物(分子量200〜3,000のペプチド混合物)。
カゼインとホエイタンパク質を別々に酵素分解してから、疎水性部分を吸着・除去した後に、両者を所定割合で混合する方法(日本特許第2,986,764号);
ホエイタンパク質をバチルス属由来のプロテアーゼと放線菌由来のプロテアーゼにより酵素分解した後に、酵素と不溶性の酵素分解物を除去する方法(日本特許第3,222,638号);
β-ラクトグロブリンを酵素で分解して、分岐鎖アミノ酸/芳香族アミノ酸のモル比が10重量%以上、芳香族アミノ酸が2.0重量%未満、平均分子量が数百〜数千のペプチドの混合物を得る方法(日本特許第3,183,945号);
ホエイタンパク質中のβ-ラクトグロブリンを選択的に酵素分解する方法(日本特許第2,794,305号);または
ホエイタンパク質をバシラス・リシェニフォルムス(B. licheniformis)由来のプロテアーゼおよび/または枯草菌(B. subtilis)由来のプロテアーゼにより、非-pH-スタット法を用いて、15〜30%の酵素分解度(DE)まで酵素分解し、カットオフ値10,000を超える限外濾過膜の透過液を得る方法(日本特許第3167723号)、
などを挙げることができるがこれらに限定されない。本発明の乳タンパク質加水分解物には、これらの特許文献以外の方法や技術で調製されたものも包含される。
カラムとしてタンパク質分離に適した充填剤、例えば表面にジオール官能基を含むリガンドを導入してタンパク質との相互作用を防止したシリカを使用する。
展開溶媒としては、有機溶媒(アセトニトリル、プロパノール)/水にトリフルオロ酢酸またはリン酸を添加して酸性条件としたものを使用する。
分子量マーカーとしては分子量300〜30,000程度の分子量が既知のもの、例えば、cytochrome c (分子量12400)、副腎皮質刺激ホルモン (ACTH) (分子量2933)、oxytocin (分子量1007), およびglutathione (分子量307)を使用することができる。
乳タンパク質の加水分解物を含む本発明の組成物は、炎症性貧血の処置のために用いることができる。炎症性貧血(anemia of inflammation)は、感染症、悪性腫瘍、関節リウマチなどの炎症を有する疾患においてしばしば認められる。炎症性貧血は、炎症により産生されたインターロイキン-6(IL-6)が肝臓におけるヘプシジン産生を亢進し、ヘプシジンが腸管からの鉄吸収および網内系からの鉄放出を抑制することによって、生体内での鉄利用性を障害することによって生じる(日本鉄バイオサイエンス学会, 鉄剤の適正使用による貧血治療指針. 2009: 響文社)。
(食品組成物等)
本発明の組成物は、食品組成物、または経口摂取される医薬組成物とすることができる。食品は、特に記載した場合を除き、一般食品、保健機能食品(特定保健用食品、栄養機能食品、および機能性表示食品を含む。)、機能性食品、健康食品、サプリメント、栄養組成物を含み、また治療食(治療の目的を果たすもの。医師が食事箋を出し、それに従い栄養士等が作成した献立に基づいて調理されたもの。)、食事療法食、成分調整食、介護食を含む。食品は、特に記載した場合を除き、固形物のみならず、液状のもの、例えば飲料、ドリンク剤、およびスープを含む。食品組成物としての好ましい形態の例は、清涼飲料、酸性清涼飲料、栄養強化飲料、特定保健食品飲料、乳酸菌飲料等の飲料類(ドリンク類)、菓子、サプリメント、ゼリー剤、ドリンク剤、チューブ入り剤、カプセル剤(軟カプセル剤、硬カプセル剤)、錠剤(タブレット)、丸剤、粉末剤、顆粒剤、細粒剤である。
本発明の組成物における、乳タンパク質の加水分解物の含有量(複数種類の乳タンパク質の加水分解物を用いる場合は、すべての乳タンパク質の加水分解物の総量に基づく。)は、目的の効果が発揮される量であればよい。
本発明の組成物の製造において、乳タンパク質の加水分解物の配合の段階は、適宜選択することができる。乳タンパク質の加水分解物の特性を著しく損なわない限り配合の段階は特に制限されない。例えば、製造の初期の段階に、原材料に混合して配合することができる。
乳タンパク質の加水分解物としては、WPIを微生物由来プロテアーゼにより処理して調製したもの(以下、ホエイペプチドという。)を使用した。サイズ排除クロマトグラフィーによって測定した重量平均分子量は717 Da、数平均分子量は595 Daであった。
1群、正常群
2群、テルペンチン投与群
3群、テルペンチン・ホエイペプチド投与群
貧血関連指標を図1に示す。テルペンチン投与群は正常群と比較し,血漿中鉄濃度,血液中ヘモグロビン濃度,赤血球数,ヘマトクリット値が有意に低下した(p<0.01)。ホエイペプチドを投与した群では、赤血球数は高値傾向(p<0.1)、それ以外の指標は有意な高値を示した(p<0.05)。
Claims (6)
- 乳タンパク質の加水分解物を含む、炎症性貧血の処置のための組成物。
- 乳タンパク質が、ホエイタンパク質、ホエイタンパク質単離物(WPI)、ホエイタンパク質濃縮物(WPC)、β-ラクトグロブリン、α-ラクトアルブミン、およびラクトフェリンからなる群より選択されるいずれかである、請求項1に記載の組成物。
- 飲料の形態である、請求項1または2に記載の組成物。
- 乳タンパク質の加水分解物を、一回量または一日量当たり、1〜25g含有する、食品組成物。
- 炎症性疾患、感染性腸炎、感冒による下痢・嘔吐・発熱を伴う脱水状態、および過度の発汗による脱水状態からなる群より選択されるいずれかの疾患もしくは状態にある者、またはその発症リスクのある者に摂取させるための、請求項4に記載の食品組成物。
- 炎症性貧血の処置のための、請求項4または5に記載の食品組成物。
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