JP2019104727A5 - - Google Patents
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- Publication number
- JP2019104727A5 JP2019104727A5 JP2018229557A JP2018229557A JP2019104727A5 JP 2019104727 A5 JP2019104727 A5 JP 2019104727A5 JP 2018229557 A JP2018229557 A JP 2018229557A JP 2018229557 A JP2018229557 A JP 2018229557A JP 2019104727 A5 JP2019104727 A5 JP 2019104727A5
- Authority
- JP
- Japan
- Prior art keywords
- salt
- aqueous liquid
- water
- soluble polymer
- content
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 20
- 239000011780 sodium chloride Substances 0.000 claims 20
- 239000007788 liquid Substances 0.000 claims 14
- 229920003169 water-soluble polymer Polymers 0.000 claims 12
- XYLJNLCSTIOKRM-UHFFFAOYSA-N Alphagan Chemical compound C1=CC2=NC=CN=C2C(Br)=C1NC1=NCCN1 XYLJNLCSTIOKRM-UHFFFAOYSA-N 0.000 claims 10
- 229960003679 brimonidine Drugs 0.000 claims 10
- 229960003333 chlorhexidine gluconate Drugs 0.000 claims 8
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 claims 8
- 230000002401 inhibitory effect Effects 0.000 claims 6
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 5
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 5
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 5
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 5
- 239000003112 inhibitor Substances 0.000 claims 5
- VUKAUDKDFVSVFT-UHFFFAOYSA-N 2-[6-[4,5-bis(2-hydroxypropoxy)-2-(2-hydroxypropoxymethyl)-6-methoxyoxan-3-yl]oxy-4,5-dimethoxy-2-(methoxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)-5-methoxyoxane-3,4-diol Chemical compound COC1C(OC)C(OC2C(C(O)C(OC)C(CO)O2)O)C(COC)OC1OC1C(COCC(C)O)OC(OC)C(OCC(C)O)C1OCC(C)O VUKAUDKDFVSVFT-UHFFFAOYSA-N 0.000 claims 3
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 3
- 239000007864 aqueous solution Substances 0.000 claims 3
- 229920002674 hyaluronan Polymers 0.000 claims 3
- 229960003160 hyaluronic acid Drugs 0.000 claims 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 3
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 3
- MAKUBRYLFHZREJ-JWBQXVCJSA-M sodium;(2S,3S,4R,5R,6R)-3-[(2S,3R,5S,6R)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylate Chemical compound [Na+].CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@H](O)[C@H]1O MAKUBRYLFHZREJ-JWBQXVCJSA-M 0.000 claims 3
- 229960003260 Chlorhexidine Drugs 0.000 claims 2
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Exidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 239000003889 eye drop Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017235962 | 2017-12-08 | ||
| JP2017235962 | 2017-12-08 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019096298A Division JP6701412B2 (ja) | 2017-12-08 | 2019-05-22 | 水溶性高分子を含む水性液剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019104727A JP2019104727A (ja) | 2019-06-27 |
| JP2019104727A5 true JP2019104727A5 (de) | 2019-08-08 |
| JP6603785B2 JP6603785B2 (ja) | 2019-11-06 |
Family
ID=66751450
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018229557A Active JP6603785B2 (ja) | 2017-12-08 | 2018-12-07 | 水溶性高分子を含む水性液剤 |
| JP2019096298A Active JP6701412B2 (ja) | 2017-12-08 | 2019-05-22 | 水溶性高分子を含む水性液剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019096298A Active JP6701412B2 (ja) | 2017-12-08 | 2019-05-22 | 水溶性高分子を含む水性液剤 |
Country Status (2)
| Country | Link |
|---|---|
| JP (2) | JP6603785B2 (de) |
| WO (1) | WO2019112030A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019235456A1 (ja) * | 2018-06-05 | 2019-12-12 | 千寿製薬株式会社 | 水性液剤 |
| JP2020033290A (ja) * | 2018-08-29 | 2020-03-05 | 興和株式会社 | 水性組成物 |
| CN113518646B (zh) * | 2019-02-27 | 2023-12-12 | 参天制药株式会社 | 含有地夸磷索或其盐，乙烯基系高分子及纤维素系高分子的眼科用组合物 |
| JP6797992B1 (ja) * | 2019-09-30 | 2020-12-09 | 千寿製薬株式会社 | 水性液剤 |
| JP6798001B1 (ja) * | 2019-12-27 | 2020-12-09 | 千寿製薬株式会社 | 医薬製品 |
| CN117571883B (zh) * | 2024-01-15 | 2024-03-19 | 四川智强医药科技开发有限公司 | 一种酒石酸溴莫尼定滴眼液的质量检测方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3499882B2 (ja) * | 1992-03-09 | 2004-02-23 | 日本製薬株式会社 | 粘性すり込み用消毒剤 |
| JPH07267840A (ja) * | 1994-03-30 | 1995-10-17 | Sunstar Inc | 口腔用組成物 |
| JPH10203960A (ja) * | 1997-01-24 | 1998-08-04 | Ofutekusu:Kk | 点眼液組成物 |
| JP2011042682A (ja) * | 1997-05-20 | 2011-03-03 | Senju Pharmaceut Co Ltd | 水性製剤の増粘剤 |
| US6242442B1 (en) * | 1998-12-17 | 2001-06-05 | Alcon Laboratories, Inc. | Brinzolamide and brimonidine for treating ocular conditions |
| US20050026924A1 (en) * | 2000-07-14 | 2005-02-03 | Allergan, Inc. | Compositions containing alpha-2-adrenergic agonist components |
| CA2475224C (en) * | 2002-02-07 | 2011-11-01 | The Trustees Of Columbia University In The City Of New York | Zinc salt compositions for the prevention of mucosal irritation from spermicides and microbicides |
| US9089562B2 (en) * | 2013-08-28 | 2015-07-28 | Presbyopia Therapies Llc | Compositions and methods for the treatment of presbyopia |
| JP6104433B2 (ja) * | 2015-06-05 | 2017-03-29 | 参天製薬株式会社 | 水性点眼液 |
| JP6716293B2 (ja) * | 2015-03-06 | 2020-07-01 | 参天製薬株式会社 | 眼科用組成物 |
| CA2977825A1 (en) * | 2015-03-19 | 2016-09-22 | Allergan, Inc. | Fixed dose combination of brimonidine and timolol |
| WO2016190306A1 (ja) * | 2015-05-28 | 2016-12-01 | ロート製薬株式会社 | 水性眼科組成物 |
| TW201733577A (zh) * | 2016-03-14 | 2017-10-01 | Santen Pharmaceutical Co Ltd | 含有多佐胺、噻嗎洛爾和界面活性劑之醫藥組成物 |
-
2018
- 2018-12-07 JP JP2018229557A patent/JP6603785B2/ja active Active
- 2018-12-07 WO PCT/JP2018/045044 patent/WO2019112030A1/ja active Application Filing
-
2019
- 2019-05-22 JP JP2019096298A patent/JP6701412B2/ja active Active
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