JP2019085426A - 有効薬剤粒子を含む安定化されたスプレー可能なエマルション - Google Patents
有効薬剤粒子を含む安定化されたスプレー可能なエマルション Download PDFInfo
- Publication number
- JP2019085426A JP2019085426A JP2019045715A JP2019045715A JP2019085426A JP 2019085426 A JP2019085426 A JP 2019085426A JP 2019045715 A JP2019045715 A JP 2019045715A JP 2019045715 A JP2019045715 A JP 2019045715A JP 2019085426 A JP2019085426 A JP 2019085426A
- Authority
- JP
- Japan
- Prior art keywords
- emulsion
- sprayable
- propellant
- sprayable emulsion
- oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000839 emulsion Substances 0.000 title claims abstract description 206
- 239000002245 particle Substances 0.000 title claims abstract description 77
- 239000013543 active substance Substances 0.000 title claims abstract description 37
- 239000003380 propellant Substances 0.000 claims abstract description 73
- 239000003921 oil Substances 0.000 claims abstract description 53
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 40
- 239000003995 emulsifying agent Substances 0.000 claims description 62
- 239000007921 spray Substances 0.000 claims description 62
- 239000000203 mixture Substances 0.000 claims description 55
- 239000012071 phase Substances 0.000 claims description 53
- 239000003814 drug Substances 0.000 claims description 34
- 229940079593 drug Drugs 0.000 claims description 34
- -1 emulsifying system Substances 0.000 claims description 32
- 239000004034 viscosity adjusting agent Substances 0.000 claims description 26
- 230000001804 emulsifying effect Effects 0.000 claims description 25
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 22
- 239000000194 fatty acid Substances 0.000 claims description 22
- 229930195729 fatty acid Natural products 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 20
- 239000008346 aqueous phase Substances 0.000 claims description 19
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 18
- 230000005484 gravity Effects 0.000 claims description 18
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 18
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 17
- 229940008099 dimethicone Drugs 0.000 claims description 16
- 239000003755 preservative agent Substances 0.000 claims description 16
- 239000003795 chemical substances by application Substances 0.000 claims description 14
- 239000007762 w/o emulsion Substances 0.000 claims description 13
- 230000003750 conditioning effect Effects 0.000 claims description 11
- 239000003974 emollient agent Substances 0.000 claims description 11
- 229920002472 Starch Polymers 0.000 claims description 9
- 239000008107 starch Substances 0.000 claims description 9
- 235000019698 starch Nutrition 0.000 claims description 9
- 238000007710 freezing Methods 0.000 claims description 8
- 230000008014 freezing Effects 0.000 claims description 8
- 230000002335 preservative effect Effects 0.000 claims description 8
- 230000004888 barrier function Effects 0.000 claims description 6
- 229920002545 silicone oil Polymers 0.000 claims description 6
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 5
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 claims description 4
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 claims description 4
- 229920000642 polymer Polymers 0.000 claims description 4
- 150000005828 hydrofluoroalkanes Chemical class 0.000 claims description 3
- 239000003242 anti bacterial agent Substances 0.000 claims description 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 2
- 239000003429 antifungal agent Substances 0.000 claims description 2
- 229940121375 antifungal agent Drugs 0.000 claims description 2
- 239000003908 antipruritic agent Substances 0.000 claims description 2
- 150000001735 carboxylic acids Chemical class 0.000 claims 2
- 230000003444 anaesthetic effect Effects 0.000 claims 1
- 230000000202 analgesic effect Effects 0.000 claims 1
- 238000011282 treatment Methods 0.000 abstract description 4
- 238000009826 distribution Methods 0.000 abstract description 3
- 239000012875 nonionic emulsifier Substances 0.000 abstract description 3
- 238000004945 emulsification Methods 0.000 abstract 3
- 235000019198 oils Nutrition 0.000 description 46
- 210000003491 skin Anatomy 0.000 description 39
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 30
- 239000002585 base Substances 0.000 description 28
- 238000000576 coating method Methods 0.000 description 27
- 239000011248 coating agent Substances 0.000 description 25
- 238000002347 injection Methods 0.000 description 16
- 239000007924 injection Substances 0.000 description 16
- 239000004166 Lanolin Substances 0.000 description 15
- 235000019388 lanolin Nutrition 0.000 description 15
- 229940039717 lanolin Drugs 0.000 description 15
- 238000002156 mixing Methods 0.000 description 15
- 239000011787 zinc oxide Substances 0.000 description 15
- 229920001296 polysiloxane Polymers 0.000 description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- 150000004665 fatty acids Chemical class 0.000 description 12
- 239000004094 surface-active agent Substances 0.000 description 11
- CDOOAUSHHFGWSA-OWOJBTEDSA-N (e)-1,3,3,3-tetrafluoroprop-1-ene Chemical compound F\C=C\C(F)(F)F CDOOAUSHHFGWSA-OWOJBTEDSA-N 0.000 description 10
- 229920001223 polyethylene glycol Polymers 0.000 description 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
- 239000002202 Polyethylene glycol Substances 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 9
- 230000002209 hydrophobic effect Effects 0.000 description 9
- 238000003756 stirring Methods 0.000 description 9
- 239000000443 aerosol Substances 0.000 description 8
- 239000007764 o/w emulsion Substances 0.000 description 8
- 208000017520 skin disease Diseases 0.000 description 8
- 238000005507 spraying Methods 0.000 description 8
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- CDOOAUSHHFGWSA-UPHRSURJSA-N (z)-1,3,3,3-tetrafluoroprop-1-ene Chemical compound F\C=C/C(F)(F)F CDOOAUSHHFGWSA-UPHRSURJSA-N 0.000 description 6
- 125000000217 alkyl group Chemical group 0.000 description 6
- 125000004432 carbon atom Chemical group C* 0.000 description 6
- 239000006071 cream Substances 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 239000003595 mist Substances 0.000 description 6
- 229940084778 1,4-sorbitan Drugs 0.000 description 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 5
- 239000003205 fragrance Substances 0.000 description 5
- 239000002480 mineral oil Substances 0.000 description 5
- 239000000178 monomer Substances 0.000 description 5
- 229920000136 polysorbate Polymers 0.000 description 5
- 235000002639 sodium chloride Nutrition 0.000 description 5
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 4
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 4
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 229920001577 copolymer Polymers 0.000 description 4
- 239000006185 dispersion Substances 0.000 description 4
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 4
- 235000015112 vegetable and seed oil Nutrition 0.000 description 4
- CDOOAUSHHFGWSA-UHFFFAOYSA-N 1,3,3,3-tetrafluoropropene Chemical compound FC=CC(F)(F)F CDOOAUSHHFGWSA-UHFFFAOYSA-N 0.000 description 3
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 3
- IEKHISJGRIEHRE-UHFFFAOYSA-N 16-methylheptadecanoic acid;propan-2-ol;titanium Chemical compound [Ti].CC(C)O.CC(C)CCCCCCCCCCCCCCC(O)=O.CC(C)CCCCCCCCCCCCCCC(O)=O.CC(C)CCCCCCCCCCCCCCC(O)=O IEKHISJGRIEHRE-UHFFFAOYSA-N 0.000 description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 3
- 201000004624 Dermatitis Diseases 0.000 description 3
- 208000010201 Exanthema Diseases 0.000 description 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 3
- 206010021639 Incontinence Diseases 0.000 description 3
- 229920001214 Polysorbate 60 Polymers 0.000 description 3
- 208000004210 Pressure Ulcer Diseases 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 235000021355 Stearic acid Nutrition 0.000 description 3
- 208000025865 Ulcer Diseases 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- NWGKJDSIEKMTRX-BFWOXRRGSA-N [(2r)-2-[(3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)C1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-BFWOXRRGSA-N 0.000 description 3
- 238000013019 agitation Methods 0.000 description 3
- 229940099583 aluminum starch octenylsuccinate Drugs 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 229940085262 cetyl dimethicone Drugs 0.000 description 3
- 239000000460 chlorine Substances 0.000 description 3
- 150000005690 diesters Chemical class 0.000 description 3
- 201000005884 exanthem Diseases 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 229910052731 fluorine Inorganic materials 0.000 description 3
- 239000011737 fluorine Substances 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 3
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 3
- 229920000570 polyether Polymers 0.000 description 3
- 206010037844 rash Diseases 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000008117 stearic acid Substances 0.000 description 3
- 230000000699 topical effect Effects 0.000 description 3
- 150000005691 triesters Chemical class 0.000 description 3
- 231100000397 ulcer Toxicity 0.000 description 3
- 238000009827 uniform distribution Methods 0.000 description 3
- 239000008158 vegetable oil Substances 0.000 description 3
- 230000037303 wrinkles Effects 0.000 description 3
- YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-heptafluoropropane Chemical compound FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 description 2
- LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical group FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 description 2
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 2
- QHZLMUACJMDIAE-UHFFFAOYSA-N 1-monopalmitoylglycerol Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(O)CO QHZLMUACJMDIAE-UHFFFAOYSA-N 0.000 description 2
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 description 2
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- 206010012444 Dermatitis diaper Diseases 0.000 description 2
- 208000003105 Diaper Rash Diseases 0.000 description 2
- CMBYOWLFQAFZCP-UHFFFAOYSA-N Hexyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCCCCC CMBYOWLFQAFZCP-UHFFFAOYSA-N 0.000 description 2
- 239000005639 Lauric acid Substances 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 239000004721 Polyphenylene oxide Substances 0.000 description 2
- 235000019484 Rapeseed oil Nutrition 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical group CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- 206010052428 Wound Diseases 0.000 description 2
- SHOKWSLXDAIZPP-UHFFFAOYSA-N [4-(4-iodooxy-2-methyl-5-propan-2-ylphenyl)-5-methyl-2-propan-2-ylphenyl] hypoiodite Chemical compound C1=C(OI)C(C(C)C)=CC(C=2C(=CC(OI)=C(C(C)C)C=2)C)=C1C SHOKWSLXDAIZPP-UHFFFAOYSA-N 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 2
- 210000003423 ankle Anatomy 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 239000007859 condensation product Substances 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 229940086555 cyclomethicone Drugs 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000000994 depressogenic effect Effects 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 150000002170 ethers Chemical class 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 229940100463 hexyl laurate Drugs 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 210000003127 knee Anatomy 0.000 description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 2
- 235000019341 magnesium sulphate Nutrition 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- 239000011859 microparticle Substances 0.000 description 2
- 235000010446 mineral oil Nutrition 0.000 description 2
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 2
- 239000002736 nonionic surfactant Substances 0.000 description 2
- 239000010466 nut oil Substances 0.000 description 2
- MSRJTTSHWYDFIU-UHFFFAOYSA-N octyltriethoxysilane Chemical compound CCCCCCCC[Si](OCC)(OCC)OCC MSRJTTSHWYDFIU-UHFFFAOYSA-N 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 125000005010 perfluoroalkyl group Chemical group 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 2
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 2
- 229940113124 polysorbate 60 Drugs 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- 229940068968 polysorbate 80 Drugs 0.000 description 2
- 239000010491 poppyseed oil Substances 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- 239000003223 protective agent Substances 0.000 description 2
- 238000004062 sedimentation Methods 0.000 description 2
- 150000004756 silanes Chemical class 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 210000004872 soft tissue Anatomy 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000001593 sorbitan monooleate Substances 0.000 description 2
- 235000011069 sorbitan monooleate Nutrition 0.000 description 2
- 229940035049 sorbitan monooleate Drugs 0.000 description 2
- 229950004959 sorbitan oleate Drugs 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 229940032094 squalane Drugs 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 229940118404 thymol iodide Drugs 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- CUNWUEBNSZSNRX-RKGWDQTMSA-N (2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol;(z)-octadec-9-enoic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- DYLIWHYUXAJDOJ-OWOJBTEDSA-N (e)-4-(6-aminopurin-9-yl)but-2-en-1-ol Chemical compound NC1=NC=NC2=C1N=CN2C\C=C\CO DYLIWHYUXAJDOJ-OWOJBTEDSA-N 0.000 description 1
- KMZOJSINLAGOMV-UHFFFAOYSA-N (prop-2-enoylamino) propane-1-sulfonate Chemical compound CCCS(=O)(=O)ONC(=O)C=C KMZOJSINLAGOMV-UHFFFAOYSA-N 0.000 description 1
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
- QIZPVNNYFKFJAD-UHFFFAOYSA-N 1-chloro-2-prop-1-ynylbenzene Chemical compound CC#CC1=CC=CC=C1Cl QIZPVNNYFKFJAD-UHFFFAOYSA-N 0.000 description 1
- FDCJDKXCCYFOCV-UHFFFAOYSA-N 1-hexadecoxyhexadecane Chemical compound CCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCC FDCJDKXCCYFOCV-UHFFFAOYSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- FXRLMCRCYDHQFW-UHFFFAOYSA-N 2,3,3,3-tetrafluoropropene Chemical compound FC(=C)C(F)(F)F FXRLMCRCYDHQFW-UHFFFAOYSA-N 0.000 description 1
- XFOQWQKDSMIPHT-UHFFFAOYSA-N 2,3-dichloro-6-(trifluoromethyl)pyridine Chemical compound FC(F)(F)C1=CC=C(Cl)C(Cl)=N1 XFOQWQKDSMIPHT-UHFFFAOYSA-N 0.000 description 1
- XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 description 1
- GTJOHISYCKPIMT-UHFFFAOYSA-N 2-methylundecane Chemical compound CCCCCCCCCC(C)C GTJOHISYCKPIMT-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- RMTFNDVZYPHUEF-XZBKPIIZSA-N 3-O-methyl-D-glucose Chemical compound O=C[C@H](O)[C@@H](OC)[C@H](O)[C@H](O)CO RMTFNDVZYPHUEF-XZBKPIIZSA-N 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 235000019489 Almond oil Nutrition 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 244000144730 Amygdalus persica Species 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 229910052582 BN Inorganic materials 0.000 description 1
- 239000002028 Biomass Substances 0.000 description 1
- PZNSFCLAULLKQX-UHFFFAOYSA-N Boron nitride Chemical compound N#B PZNSFCLAULLKQX-UHFFFAOYSA-N 0.000 description 1
- 240000002791 Brassica napus Species 0.000 description 1
- 235000011293 Brassica napus Nutrition 0.000 description 1
- 235000000540 Brassica rapa subsp rapa Nutrition 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 239000005046 Chlorosilane Substances 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 1
- 235000009355 Dianthus caryophyllus Nutrition 0.000 description 1
- 240000006497 Dianthus caryophyllus Species 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 235000019487 Hazelnut oil Nutrition 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- SGVYKUFIHHTIFL-UHFFFAOYSA-N Isobutylhexyl Natural products CCCCCCCC(C)C SGVYKUFIHHTIFL-UHFFFAOYSA-N 0.000 description 1
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 240000003183 Manihot esculenta Species 0.000 description 1
- 235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000003447 Pistacia vera Nutrition 0.000 description 1
- 240000006711 Pistacia vera Species 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 235000009827 Prunus armeniaca Nutrition 0.000 description 1
- 244000018633 Prunus armeniaca Species 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 244000088415 Raphanus sativus Species 0.000 description 1
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 description 1
- 235000019774 Rice Bran oil Nutrition 0.000 description 1
- 235000019485 Safflower oil Nutrition 0.000 description 1
- 235000003434 Sesamum indicum Nutrition 0.000 description 1
- 244000040738 Sesamum orientale Species 0.000 description 1
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- IYFATESGLOUGBX-YVNJGZBMSA-N Sorbitan monopalmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O IYFATESGLOUGBX-YVNJGZBMSA-N 0.000 description 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
- 239000004147 Sorbitan trioleate Substances 0.000 description 1
- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 235000019486 Sunflower oil Nutrition 0.000 description 1
- 235000019498 Walnut oil Nutrition 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000001253 acrylic acids Chemical class 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 239000008168 almond oil Substances 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 229940035674 anesthetics Drugs 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 239000010477 apricot oil Substances 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 235000021302 avocado oil Nutrition 0.000 description 1
- 239000008163 avocado oil Substances 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 210000001217 buttock Anatomy 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- KOPOQZFJUQMUML-UHFFFAOYSA-N chlorosilane Chemical compound Cl[SiH3] KOPOQZFJUQMUML-UHFFFAOYSA-N 0.000 description 1
- 150000001841 cholesterols Chemical class 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000000498 cooling water Substances 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 229920006037 cross link polymer Polymers 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- DTPCFIHYWYONMD-UHFFFAOYSA-N decaethylene glycol Polymers OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO DTPCFIHYWYONMD-UHFFFAOYSA-N 0.000 description 1
- 230000000881 depressing effect Effects 0.000 description 1
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000001513 elbow Anatomy 0.000 description 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- XPBBUZJBQWWFFJ-UHFFFAOYSA-N fluorosilane Chemical compound [SiH3]F XPBBUZJBQWWFFJ-UHFFFAOYSA-N 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 239000003193 general anesthetic agent Substances 0.000 description 1
- 235000019717 geranium oil Nutrition 0.000 description 1
- 239000010648 geranium oil Substances 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 229940074046 glyceryl laurate Drugs 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 239000008169 grapeseed oil Substances 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical group 0.000 description 1
- 239000010468 hazelnut oil Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 210000000474 heel Anatomy 0.000 description 1
- 229940051250 hexylene glycol Drugs 0.000 description 1
- 210000001624 hip Anatomy 0.000 description 1
- 210000004394 hip joint Anatomy 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 238000007327 hydrogenolysis reaction Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229910052809 inorganic oxide Inorganic materials 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- OCVXZQOKBHXGRU-UHFFFAOYSA-N iodine(1+) Chemical compound [I+] OCVXZQOKBHXGRU-UHFFFAOYSA-N 0.000 description 1
- VKPSKYDESGTTFR-UHFFFAOYSA-N isododecane Natural products CC(C)(C)CC(C)CC(C)(C)C VKPSKYDESGTTFR-UHFFFAOYSA-N 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 229940091554 lauryl peg-9 polydimethylsiloxyethyl dimethicone Drugs 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 235000020778 linoleic acid Nutrition 0.000 description 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
- 235000021388 linseed oil Nutrition 0.000 description 1
- 239000000944 linseed oil Substances 0.000 description 1
- 150000004668 long chain fatty acids Chemical class 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 229960002337 magnesium chloride Drugs 0.000 description 1
- 235000011147 magnesium chloride Nutrition 0.000 description 1
- 229960003390 magnesium sulfate Drugs 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- 201000001119 neuropathy Diseases 0.000 description 1
- 230000007823 neuropathy Effects 0.000 description 1
- 235000019488 nut oil Nutrition 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 150000003961 organosilicon compounds Chemical class 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 208000033808 peripheral neuropathy Diseases 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000003209 petroleum derivative Substances 0.000 description 1
- 150000003014 phosphoric acid esters Chemical class 0.000 description 1
- 239000010665 pine oil Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- ARIWANIATODDMH-UHFFFAOYSA-N rac-1-monolauroylglycerol Chemical compound CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 description 1
- 239000002990 reinforced plastic Substances 0.000 description 1
- 239000005871 repellent Substances 0.000 description 1
- 230000002940 repellent Effects 0.000 description 1
- 239000008165 rice bran oil Substances 0.000 description 1
- 229940100486 rice starch Drugs 0.000 description 1
- WBHHMMIMDMUBKC-XLNAKTSKSA-N ricinelaidic acid Chemical compound CCCCCC[C@@H](O)C\C=C\CCCCCCCC(O)=O WBHHMMIMDMUBKC-XLNAKTSKSA-N 0.000 description 1
- WBHHMMIMDMUBKC-QJWNTBNXSA-M ricinoleate Chemical class CCCCCC[C@@H](O)C\C=C/CCCCCCCC([O-])=O WBHHMMIMDMUBKC-QJWNTBNXSA-M 0.000 description 1
- 229960003656 ricinoleic acid Drugs 0.000 description 1
- FEUQNCSVHBHROZ-UHFFFAOYSA-N ricinoleic acid Natural products CCCCCCC(O[Si](C)(C)C)CC=CCCCCCCCC(=O)OC FEUQNCSVHBHROZ-UHFFFAOYSA-N 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910000077 silane Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 229920005573 silicon-containing polymer Polymers 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229960002668 sodium chloride Drugs 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229940035044 sorbitan monolaurate Drugs 0.000 description 1
- 239000001570 sorbitan monopalmitate Substances 0.000 description 1
- 235000011071 sorbitan monopalmitate Nutrition 0.000 description 1
- 229940031953 sorbitan monopalmitate Drugs 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 229960005078 sorbitan sesquioleate Drugs 0.000 description 1
- 235000019337 sorbitan trioleate Nutrition 0.000 description 1
- 229960000391 sorbitan trioleate Drugs 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 229940035023 sucrose monostearate Drugs 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- LLZRNZOLAXHGLL-UHFFFAOYSA-J titanic acid Chemical compound O[Ti](O)(O)O LLZRNZOLAXHGLL-UHFFFAOYSA-J 0.000 description 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
- QQQSFSZALRVCSZ-UHFFFAOYSA-N triethoxysilane Chemical compound CCO[SiH](OCC)OCC QQQSFSZALRVCSZ-UHFFFAOYSA-N 0.000 description 1
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 1
- AXJAWMUPFHKOHY-UHFFFAOYSA-N trimethyl(octadecyl)silane Chemical compound CCCCCCCCCCCCCCCCCC[Si](C)(C)C AXJAWMUPFHKOHY-UHFFFAOYSA-N 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
- 239000008170 walnut oil Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000010497 wheat germ oil Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/124—Aerosols; Foams characterised by the propellant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Anesthesiology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
本願は、2014年2月14日出願の米国仮出願第61/939,829号の優先権を主張する。当該仮出願は、全文を引用することを以って本明細書の一部となす。
本発明のスプレー可能なエマルションは、発疹、潰瘍、切り傷または創傷などの皮膚疾患に罹患した皮膚の表面への有効薬剤粒子の噴射を助けるために必要なエネルギーを提供するために噴射剤を含む。換言すれば、噴射剤は、皮膚上に有効薬剤粒子をスプレーするために必要な推進力を提供することができる。したがって、噴射剤は、スプレー可能なエマルションの液体成分の表面張力に打ち勝つのに十分な分散エネルギーを有している。
で表される噴射剤を含む。
ここで、Rはそれぞれ独立して、水素またはハロゲン、例えば、フッ素(F)、臭素(Br)、ヨウ素(I)または塩素(Cl)、好適にはフッ素(F)であり、
R'は(CR2)nYであり、
YはCRF2であり、
nは0または1である。
本発明のスプレー可能なエマルションは、有効薬剤粒子をさらに含み、これは、ヒトなどの生物(例えば哺乳類)に接触すると生理学的結果をもたらす化合物単体または複数の化合物の混合物を意味し得る。有効薬剤粒子は、スプレー可能なエマルションの他の成分、例えば、防腐剤、コンディショニング剤、エモリエント剤、粘度調整剤、乳化剤などと区別可能であり得る。有効薬剤粒子は、生物学的プロセスを調節することができる任意の分子及びその結合部分またはフラグメントを含むことができる。いくつかの実施形態では、有効薬剤粒子は、疾患の診断、治療または予防に、あるいは、薬剤、医薬品、化粧品または薬用化粧品の成分として用いることができる。さらに、有効薬剤粒子は、生体における標的と相互作用するか、標的に影響を及ぼすか、または標的を別な方法で調節する化合物であってよい。標的は、数多くの様々な種類の天然に存在する構造体であってよく、対象の標的には細胞内及び細胞外の標的が含まれる。有効薬剤粒子は、例えば、モイスチャーバリア、抗真菌剤、抗菌剤、鎮痛剤、防腐剤、麻酔剤、抗炎症剤、止痒剤などを含むことができる。有効薬剤粒子は、約20〜1000nm、例えば約25〜500nm、例えば約30〜250nmの平均粒径を有するものであってよい。
スプレー可能なエマルションは、油相及び水相を含むこともできる。油相及び水相は、油中水型エマルションまたは水中油型エマルションを形成することができる。エマルションの油相において使用可能な適切な油には、鉱油、植物系油、シリコーン油、またはそれらの組合せが含まれる。鉱油は、本発明に従って用いることができる液体石油誘導体であり、市販の鉱油の例は、ウィトコ社(Witco Corporation)のCARNATION(登録商標)鉱油や、ペンレコ社(Penreco Corporation)のDRAKEOL(登録商標)鉱油を含むことができる。植物系油は非石油バイオマス系の油であり、使用可能な適切な植物系油には、植物又は果実油、例えば、アーモンド油、落花生油、小麦胚芽油、亜麻仁油、ホホバ油、アプリコットピット油、クルミ油、パームナッツ油、ピスタチオナッツ油、ゴマ種子油、ナタネ油、カデ油、トウモロコシ油、ピーチピット油、ケシ油、松根油、ヒマシ油、大豆油、アボカド油、サフラワー油、ヤシ油、ヘーゼルナッツ油、オリーブ油、ブドウ種子油、ヒマワリ油、アンズ油、ゼラニウム油、米ぬか油、及びそれらの混合物が含まれる。使用可能なシリコーン油には、ジシロキサン、シクロメチコン、ジメチコン及びその誘導体、並びにポリジメチルシロキサン流体が含まれる。シクロメチコンは、揮発性化合物であり、皮膚の表面に適用されると蒸発するので、結果として得られるコーティングは、触ってみるとより乾燥している。使用可能な他の同様の揮発性化合物には、イソドデカンが含まれる。
スプレー可能なエマルションは、乳化系を含むこともできる。乳化系は、1若しくは複数の乳化剤を含むことができ、それによって、スプレー可能なエマルションが各構成相へと分離することを妨げることで噴射剤及び有効薬剤粒子の安定的で実質的に均質かつ均一な分散液を作り出すのを助けることができる。乳化系は、1若しくは複数の非イオン性、アニオン性及び/または両性の乳化剤、例えば、異なる種を含む混合物や同種内での異なる界面有効薬剤の混合物などを含み得る。1つの特定の実施形態では、乳化系は、1若しくは複数の非イオン性乳化剤を含む。
さらに、本発明のスプレー可能なエマルションは、エマルションの様々な成分の分離を防止するのを助けることができる1若しくは複数の粘度調整剤を含むことができる。例えば、いくつかの実施形態では、エマルションの油相または水相に1若しくは複数の粘度調整剤を加えてエマルション中の別々の成分がより混ざり合うように粘度を調整することができる。さらに、エマルション全体の粘度を、エマルションを表面上にスプレーできないほど高くはないが、エマルションが低粘性すぎて表面を均一にコーティングしないほど低くないように調整することができる。したがって、エマルションは、約500〜10,000cP、例えば約1000〜8000cP、例えば約1500〜6000cP、例えば約2000〜4000cPの粘度を有することができる。
スプレー可能なエマルションは、皮膚の状態を整えるのを助けるために、1若しくは複数のコンディショニング剤をさらに含むことができる。例えば、スプレー可能なエマルションは、ヨウ化チモール、塩化ナトリウム、塩化マグネシウム、硫酸マグネシウム、ラノリン、ラノリン油、ラノリンワックス、ラノリンアルコール、ラノリン脂肪酸、イソプロピルラノレート、エトキシ化ラノリン、エトキシ化ラノリンアルコール、エトキシ化コレステロール、プロポキシル化ラノリンアルコール、アセチル化ラノリンアルコール、リノール酸ラノリンアルコール、リシノール酸ラノリンアルコール、ラノリンアルコールの酢酸、リシノール酸塩、エトキシル化アルコール−エステルの酢酸、ラノリンの水素化分解、エトキシル化水素化ラノリン、エトキシル化ソルビトールラノリン、またはそれらの組合せを含むことができる。ヨウ化チモール及び硫酸マグネシウムは、特に有用であろう。1若しくは複数のコンディショニング剤は、スプレー可能なエマルション中に、エマルションの総重量に対して約0.05〜10wt%、例えば約0.1〜7.5wt%、例えば約0.5〜5wt%の量を以って存在することができる。
スプレー可能なエマルションに含まれる他の任意成分は、スキンケア添加剤、例えば、エモリエント剤や、芳香剤及び防腐剤を含むことができる。例えば、スプレー可能なエマルションには、カプリル酸/カプリン酸トリグリセリドなどのエモリエント剤を含めることができる。他の適切なエモリエント剤は、ステアリルトリメチルシラン、乳酸セチル及び乳酸アルキル、例えばC12〜C15乳酸アルキルを含む。エモリエント剤を用いる場合には、スプレー可能なエマルションは、皮膚に適用された場合に、滑らかな触り心地がする。1若しくは複数のエモリエント剤は、スプレー可能なエマルション中に、エマルションの総重量に対して約0.1〜25wt%、例えば約0.5〜20wt%、例えば約1〜15wt%の量を以って存在することができる。
Claims (31)
- スプレー可能なエマルションであって、
ハイドロフルオロ系噴射剤、乳化系、油相、水相及び有効薬剤粒子を含み、
当該エマルションが、500〜10,000cPの粘度を有し、前記乳化系が、2〜12の範囲の親水性/親油性バランス(「HLB」)値を有し、かつ前記乳化系が、1または複数種の非イオン性親油性乳化剤及び1または複数種の非イオン性親水性乳化剤を含み、前記非イオン性親油性乳化剤対前記非イオン性親水性乳化剤の重量比が5〜30の範囲内にあることを特徴とするスプレー可能なエマルション。 - 前記非イオン性親油性乳化剤が、非架橋ジメチコンコポリオール、ソルビタン脂肪酸エステル、オクチルドデカノール、またはそれらの組合せを含むことを特徴とする請求項1に記載のスプレー可能なエマルション。
- 前記非イオン性親水性乳化剤が、ポリオキシエチレンで変性したソルビタン脂肪酸エステルを含むことを特徴とする請求項2に記載のスプレー可能なエマルション。
- 前記噴射剤が、当該エマルション全体にわたって均一に分布していることを特徴とする請求項1〜3のいずれか1項に記載のスプレー可能なエマルション。
- 前記有効薬剤粒子が、当該エマルション全体にわたって均一に分布していることを特徴とする請求項1〜4のいずれか1項に記載のスプレー可能なエマルション。
- 前記噴射剤が、当該エマルションの総重量に対して5〜95wt%の量を以って存在し、前記有効薬剤粒子が、0.5〜30wt%の量を以って存在することを特徴とする請求項1〜5のいずれか1項に記載のスプレー可能なエマルション。
- 当該エマルションが、油中水型エマルションであることを特徴とする請求項1〜6のいずれか1項に記載のスプレー可能なエマルション。
- 前記油相が、当該エマルションの総量の1〜35wt%を構成し、前記水相が、1〜50wt%を構成することを特徴とする請求項1〜7のいずれか1項に記載のスプレー可能なエマルション。
- 前記油相が、シリコーン油を含むことを特徴とする請求項1〜8のいずれか1項に記載のスプレー可能なエマルション。
- 前記水相が、水を含むことを特徴とする請求項1〜9のいずれか1項に記載のスプレー可能なエマルション。
- 当該エマルションの総重量に対して50wt%未満の量の水が存在することを特徴とする請求項10に記載のスプレー可能なエマルション。
- 当該エマルションが、粘度調整剤をさらに含むことを特徴とする請求項1〜11のいずれか1項に記載のスプレー可能なエマルション。
- 前記粘度調整剤が、カルボン酸ポリマー、デンプン、またはそれらの組合せを含むことを特徴とする請求項12に記載のスプレー可能なエマルション。
- 当該エマルションが、容器内に21℃で3日間貯蔵された場合に、該エマルションに含まれる有効薬剤粒子の3wt%未満が沈降することを特徴とする請求項1〜13のいずれか1項に記載のスプレー可能なエマルション。
- 前記噴射剤が第1の比重を有し、当該スプレー可能なエマルションが第2の比重を有し、前記第1の比重と前記第2の比重の比率が0.7〜1.6であることを特徴とする請求項1〜14のいずれか1項に記載のスプレー可能なエマルション。
- 前記噴射剤が、21℃において60psi未満の蒸気圧を有することを特徴とする請求項1〜15のいずれか1項に記載のスプレー可能なエマルション。
- 前記噴射剤が、ハイドロフルオロオレフィンまたはハイドロフルオロアルカンを含むことを特徴とする請求項1〜16のいずれか1項に記載のスプレー可能なエマルション。
- 前記有効薬剤粒子が、モイスチャーバリア、抗真菌剤、抗菌剤、鎮痛剤、防腐剤、麻酔剤、抗炎症剤、止痒剤、またはそれらの組合せを含むことを特徴とする請求項1〜17のいずれか1項に記載のスプレー可能なエマルション。
- 前記エマルションが、1若しくは複数のエモリエント剤、コンディショニング剤、凝固点降下剤、防腐剤、またはそれらの組合せをさらに含むことを特徴とする請求項1〜18のいずれか1項に記載のスプレー可能なエマルション。
- スプレー可能なエマルションを形成する方法であって、
有効薬剤粒子、乳化系、油相、及び水相を含むベースエマルション組成物を形成するステップであって、前記乳化系が、2〜12の範囲の親水性/親油性バランス(「HLB」)値を有し、前記乳化系が、1または複数種の非イオン性親油性乳化剤及び1または複数種の非イオン性親水性乳化剤を含み、前記非イオン性親油性乳化剤対前記非イオン性親水性乳化剤の重量比が、5〜30の範囲内にある、該ステップと、
前記ベースエマルション組成物をスプレー容器内に導入するステップと、
前記容器内にハイドロフルオロ系噴射剤を注入するステップとを含み、
前記スプレー可能なエマルションが、500〜10,000cPの粘度を有することを特徴とする方法。 - 前記非イオン性親油性乳化剤が、非架橋ジメチコンコポリオール、ソルビタン脂肪酸エステル、オクチルドデカノール、またはそれらの組合せを含むことを特徴とする請求項20に記載の方法。
- 前記非イオン性親水性乳化剤が、ポリオキシエチレンで変性したソルビタン脂肪酸エステルを含むことを特徴とする請求項21に記載の方法。
- 前記乳化系が前記油相に加えられることを特徴とする請求項20〜22のいずれか1項に記載の方法。
- 前記ベースエマルション系が、粘度調整剤をさらに含むことを特徴とする請求項20〜23のいずれか1項に記載の方法。
- 前記粘度調整剤が、カルボン酸ポリマー、デンプン、またはそれらの組合せを含むことを特徴とする請求項24に記載の方法。
- 前記粘度調整剤が前記水相に加えられることを特徴とする請求項24または25に記載の方法。
- 前記有効薬剤粒子が、前記スプレー可能なエマルション全体にわたって実質的に均一に分散されていることを特徴とする請求項20〜26のいずれか1項に記載の方法。
- 前記噴射剤が、前記スプレー可能なエマルション全体にわたって実質的に均一に分散されていることを特徴とする請求項20〜27のいずれか1項に記載の方法。
- 前記エマルションに1若しくは複数の防腐剤、エモリエント剤、スキンコンディショナー、凝固点降下剤、またはそれらの組合せを加えるステップをさらに含むことを特徴とする請求項20〜28のいずれか1項に記載の方法。
- 前記噴射剤が第1の比重を有し、前記スプレー可能なエマルションが第2の比重を有し、前記第1の比重と前記第2の比重の比率が0.7〜1.6であることを特徴とする請求項20〜29のいずれか1項に記載の方法。
- 前記スプレー可能なエマルションが、15〜40℃の室温において形成されることを特徴とする請求項20〜30のいずれか1項に記載の方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461939829P | 2014-02-14 | 2014-02-14 | |
US61/939,829 | 2014-02-14 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016551797A Division JP6499192B2 (ja) | 2014-02-14 | 2015-02-11 | 有効薬剤粒子を含む安定化されたスプレー可能なエマルション |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2019085426A true JP2019085426A (ja) | 2019-06-06 |
JP6826143B2 JP6826143B2 (ja) | 2021-02-03 |
Family
ID=53797101
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016551797A Active JP6499192B2 (ja) | 2014-02-14 | 2015-02-11 | 有効薬剤粒子を含む安定化されたスプレー可能なエマルション |
JP2019045715A Active JP6826143B2 (ja) | 2014-02-14 | 2019-03-13 | 有効薬剤粒子を含む安定化されたスプレー可能なエマルション |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016551797A Active JP6499192B2 (ja) | 2014-02-14 | 2015-02-11 | 有効薬剤粒子を含む安定化されたスプレー可能なエマルション |
Country Status (9)
Country | Link |
---|---|
US (2) | US9381156B2 (ja) |
EP (1) | EP3104843A4 (ja) |
JP (2) | JP6499192B2 (ja) |
KR (1) | KR102337618B1 (ja) |
CN (1) | CN105979932B (ja) |
AU (1) | AU2015217275B2 (ja) |
CA (1) | CA2936416C (ja) |
MX (1) | MX2016009388A (ja) |
WO (1) | WO2015123238A1 (ja) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11007151B2 (en) | 2014-02-14 | 2021-05-18 | Mission Pharmacal Company | Sprayable composition containing zinc oxide and a fluoro-olefin propellant |
MX2016009388A (es) * | 2014-02-14 | 2017-04-13 | Mission Pharma Co | Emulsion estabilizada que puede rociarse que contiene particulas de agentes activos. |
AU2015217276A1 (en) | 2014-02-14 | 2016-07-14 | Mission Pharmacal Company | Spray delivery device |
WO2017069447A1 (ko) * | 2015-10-23 | 2017-04-27 | (주)아모레퍼시픽 | 올레산 에스테르계 유화제를 포함하는 분사형 화장료 조성물 |
US20180042846A1 (en) * | 2016-07-28 | 2018-02-15 | Honeywell International Inc. | Propellants and emulsification compositions |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002524490A (ja) * | 1998-09-11 | 2002-08-06 | ソルテック リサーチ プロプライアタリィ リミティド | ムースの組成 |
JP2008540511A (ja) * | 2005-05-09 | 2008-11-20 | フォーミックス エルティーディー. | 糖類発泡性組成物 |
JP2008542353A (ja) * | 2005-06-01 | 2008-11-27 | スティーフェル リサーチ オーストラリア ピーティーワイ リミテッド | ビタミン製剤 |
JP2017508735A (ja) * | 2014-02-14 | 2017-03-30 | ミッション・ファーマカル・カンパニー | 有効薬剤粒子を含む安定化されたスプレー可能なエマルション |
Family Cites Families (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3770648A (en) | 1971-07-12 | 1973-11-06 | Bristol Myers Co | Anhydrous aerosol foam |
NZ183230A (en) | 1976-02-24 | 1978-11-13 | Johnson & Johnson | Deodorant aerosol composition in association with a container |
DE2624373C2 (de) | 1976-05-31 | 1983-02-03 | Arnold Dr. 8782 Karlstadt Seufert | Verfahren zur Herstellung von steril filtriertem Kryopräzipilat mit einer Anreicherung des Faktors VIII |
US4981677A (en) | 1987-09-23 | 1991-01-01 | L'oreal | Petrolatum-containing aerosol foam concentrate |
FR2668927B1 (fr) | 1990-11-09 | 1993-01-08 | Oreal | Composition cosmetique anhydre sous forme aerosol pour la formation d'une mousse. |
US5143288A (en) | 1991-02-14 | 1992-09-01 | S. C. Johnson & Son, Inc. | Compressed gas aerosol spray system with a dip tube vapor tap hole |
JPH0692382A (ja) | 1991-08-27 | 1994-04-05 | Pacific Ind Ltd | 清浄空気を推進剤として用いたエアゾールスプレー、及び、その製造方法 |
CA2210160A1 (en) * | 1995-01-18 | 1996-07-25 | Roger Jeffcoat | Cosmetics containing thermally-inhibited starches |
US5968494A (en) | 1998-02-24 | 1999-10-19 | National Starch And Chemical Investment Holding Corporation | Polyurethanes with carboxylate functionality for hair fixative applications |
US6047946A (en) | 1998-02-27 | 2000-04-11 | Precision Valve Corporation | Blocking structure for preventing actuation of a valve for pressurized containers |
US6345775B1 (en) | 1998-07-30 | 2002-02-12 | Wilsoart International, Inc. | Very high solid content aerosol delivery system |
JP4231577B2 (ja) * | 1998-10-26 | 2009-03-04 | 東洋エアゾール工業株式会社 | 人体用泡沫エアゾール組成物 |
US6165450A (en) | 1999-05-03 | 2000-12-26 | Em Industries, Inc. | Sprayable sunscreen compositions |
US6627178B1 (en) | 1999-07-30 | 2003-09-30 | Garret D. Cawthon | Methods, compositions and systems for the prevention and treatment of diaper rash |
US20060034937A1 (en) * | 1999-11-23 | 2006-02-16 | Mahesh Patel | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
EP1286652B1 (en) | 2000-05-08 | 2006-09-06 | Pfizer Products Inc. | Skin protectant spray compositions |
US6394321B1 (en) | 2001-12-20 | 2002-05-28 | Precision Valve Corporation | Aerosol powder valve |
EP1369113B1 (en) * | 2002-06-06 | 2006-11-22 | CHIESI FARMACEUTICI S.p.A. | Solubilisation of drugs in HFA propellant by means of emulsions |
US20080031907A1 (en) * | 2002-10-25 | 2008-02-07 | Foamix Ltd. | Cosmetic and pharmaceutical foam |
US20050058673A1 (en) * | 2003-09-09 | 2005-03-17 | 3M Innovative Properties Company | Antimicrobial compositions and methods |
WO2005115336A2 (en) | 2004-05-15 | 2005-12-08 | Collegium Pharmaceutical, Inc. | Sprayable formulations for the treatment of acute inflammatory skin conditions |
JP2008539255A (ja) | 2005-04-26 | 2008-11-13 | マイクロビア インコーポレーテッド | 高コレステロール血症のための4−ビアリーリル−1−フェニルアゼチジン−2−オングルクロニド誘導体 |
EP1896002A4 (en) * | 2005-06-27 | 2009-11-25 | Biovail Lab Int Srl | BUPROPIONAL SALT FORMULATIONS WITH MODIFIED RELEASE |
JP2008546506A (ja) | 2005-06-28 | 2008-12-25 | エス.シー. ジョンソン アンド サン、インコーポレイテッド | 空気中の臭気を除去する組成物およびその物理的仕様 |
US8465728B2 (en) | 2005-06-28 | 2013-06-18 | S.C. Johnson & Son, Inc. | Composition and aerosol spray dispenser for eliminating odors in air |
US20110150792A1 (en) | 2008-12-10 | 2011-06-23 | Yun Shao | Zinc oxide aqueous and non-aqueous dispersions |
US8863995B2 (en) | 2007-10-31 | 2014-10-21 | Plasticum Group B.V. | Spray cap |
EP2265124A4 (en) | 2008-04-15 | 2011-12-28 | Sarcode Bioscience Inc | AEROSOLISED LFA-1 ANTAGONISTS FOR THE USE IN THE LOCAL TREATMENT OF IMMUNE DISEASES |
US8087548B2 (en) | 2008-05-14 | 2012-01-03 | S.C. Johnson & Son, Inc. | Spray products with particles and improved valve for inverted dispensing without clogging |
NL2004437C2 (en) | 2010-03-19 | 2011-09-20 | Forte Iq B V | Spray-pumpable comprising composition suitable for topical skin application. |
EP2581431B1 (en) | 2010-06-11 | 2019-03-06 | Daizo Corporation | Aerosol composition |
US20120058973A1 (en) | 2010-09-02 | 2012-03-08 | Saroja Narasimhan | Compositions comprising a silicone water-in-oil emulsifier and a low nitrogen containing amino-functional silicone gum |
EP2614815B1 (en) * | 2010-09-10 | 2019-01-16 | Daizo Corporation | Foamable aerosol composition |
CA2854449A1 (en) | 2011-11-03 | 2013-05-10 | Precision Dermatology, Inc. | Stable dermatological aerosol foams utilizing reactive propellants |
NL2008443C2 (en) | 2012-03-09 | 2013-09-16 | Dreumex B V | Aerosol container comprising a dermatological compostion and a foaming agent. |
KR20140134712A (ko) | 2012-03-22 | 2014-11-24 | 프리시전 더마톨로지, 인크. | 시클로덱스트린 기재의 마이크로에멀젼 및 그의 피부과용 용도 |
US11007151B2 (en) * | 2014-02-14 | 2021-05-18 | Mission Pharmacal Company | Sprayable composition containing zinc oxide and a fluoro-olefin propellant |
AU2015217276A1 (en) | 2014-02-14 | 2016-07-14 | Mission Pharmacal Company | Spray delivery device |
-
2015
- 2015-02-11 MX MX2016009388A patent/MX2016009388A/es active IP Right Grant
- 2015-02-11 KR KR1020167021680A patent/KR102337618B1/ko active IP Right Grant
- 2015-02-11 JP JP2016551797A patent/JP6499192B2/ja active Active
- 2015-02-11 CA CA2936416A patent/CA2936416C/en active Active
- 2015-02-11 CN CN201580007957.1A patent/CN105979932B/zh active Active
- 2015-02-11 US US14/619,108 patent/US9381156B2/en active Active
- 2015-02-11 EP EP15749175.4A patent/EP3104843A4/en not_active Withdrawn
- 2015-02-11 WO PCT/US2015/015316 patent/WO2015123238A1/en active Application Filing
- 2015-02-11 AU AU2015217275A patent/AU2015217275B2/en active Active
-
2016
- 2016-06-06 US US15/173,849 patent/US9700510B2/en active Active
-
2019
- 2019-03-13 JP JP2019045715A patent/JP6826143B2/ja active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002524490A (ja) * | 1998-09-11 | 2002-08-06 | ソルテック リサーチ プロプライアタリィ リミティド | ムースの組成 |
JP2008540511A (ja) * | 2005-05-09 | 2008-11-20 | フォーミックス エルティーディー. | 糖類発泡性組成物 |
JP2008542353A (ja) * | 2005-06-01 | 2008-11-27 | スティーフェル リサーチ オーストラリア ピーティーワイ リミテッド | ビタミン製剤 |
JP2017508735A (ja) * | 2014-02-14 | 2017-03-30 | ミッション・ファーマカル・カンパニー | 有効薬剤粒子を含む安定化されたスプレー可能なエマルション |
Also Published As
Publication number | Publication date |
---|---|
WO2015123238A1 (en) | 2015-08-20 |
EP3104843A4 (en) | 2017-10-18 |
CA2936416A1 (en) | 2015-08-20 |
MX2016009388A (es) | 2017-04-13 |
JP2017508735A (ja) | 2017-03-30 |
US20160279061A1 (en) | 2016-09-29 |
JP6499192B2 (ja) | 2019-04-10 |
US9700510B2 (en) | 2017-07-11 |
AU2015217275B2 (en) | 2019-11-21 |
AU2015217275A1 (en) | 2016-07-14 |
US20150231072A1 (en) | 2015-08-20 |
KR102337618B1 (ko) | 2021-12-08 |
CN105979932A (zh) | 2016-09-28 |
CN105979932B (zh) | 2020-04-10 |
CA2936416C (en) | 2022-05-31 |
US9381156B2 (en) | 2016-07-05 |
EP3104843A1 (en) | 2016-12-21 |
JP6826143B2 (ja) | 2021-02-03 |
KR20160120284A (ko) | 2016-10-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6674896B2 (ja) | スプレー噴射装置 | |
JP6826143B2 (ja) | 有効薬剤粒子を含む安定化されたスプレー可能なエマルション | |
JP3911161B2 (ja) | 皮膚保護用噴霧組成物 | |
JP6626450B2 (ja) | 酸化亜鉛及びフルオロオレフィン噴射剤を含むスプレー可能な組成物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190314 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20190314 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20200303 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200525 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20200923 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20201124 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20210105 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20210114 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6826143 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |