JP2019058671A5 - - Google Patents

Download PDF

Info

Publication number
JP2019058671A5
JP2019058671A5 JP2018194292A JP2018194292A JP2019058671A5 JP 2019058671 A5 JP2019058671 A5 JP 2019058671A5 JP 2018194292 A JP2018194292 A JP 2018194292A JP 2018194292 A JP2018194292 A JP 2018194292A JP 2019058671 A5 JP2019058671 A5 JP 2019058671A5
Authority
JP
Japan
Prior art keywords
electrode
electroporation
pulse
microcontroller
electrode array
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2018194292A
Other languages
English (en)
Japanese (ja)
Other versions
JP6626176B2 (ja
JP2019058671A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2019058671A publication Critical patent/JP2019058671A/ja
Publication of JP2019058671A5 publication Critical patent/JP2019058671A5/ja
Application granted granted Critical
Publication of JP6626176B2 publication Critical patent/JP6626176B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2018194292A 2011-06-28 2018-10-15 低侵襲表皮電気穿孔装置 Active JP6626176B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161502198P 2011-06-28 2011-06-28
US61/502,198 2011-06-28

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2017094200A Division JP6423042B2 (ja) 2011-06-28 2017-05-10 低侵襲表皮電気穿孔装置

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019214718A Division JP6799128B2 (ja) 2011-06-28 2019-11-27 低侵襲表皮電気穿孔装置

Publications (3)

Publication Number Publication Date
JP2019058671A JP2019058671A (ja) 2019-04-18
JP2019058671A5 true JP2019058671A5 (https=) 2019-05-30
JP6626176B2 JP6626176B2 (ja) 2019-12-25

Family

ID=48192559

Family Applications (7)

Application Number Title Priority Date Filing Date
JP2014518993A Withdrawn JP2014524796A (ja) 2011-06-28 2012-06-28 低侵襲表皮電気穿孔装置
JP2017094200A Active JP6423042B2 (ja) 2011-06-28 2017-05-10 低侵襲表皮電気穿孔装置
JP2018194292A Active JP6626176B2 (ja) 2011-06-28 2018-10-15 低侵襲表皮電気穿孔装置
JP2019214718A Active JP6799128B2 (ja) 2011-06-28 2019-11-27 低侵襲表皮電気穿孔装置
JP2020190104A Active JP6955076B2 (ja) 2011-06-28 2020-11-16 低侵襲表皮電気穿孔装置
JP2021161141A Active JP7519339B2 (ja) 2011-06-28 2021-09-30 低侵襲表皮電気穿孔装置
JP2024076760A Pending JP2024096416A (ja) 2011-06-28 2024-05-09 低侵襲表皮電気穿孔装置

Family Applications Before (2)

Application Number Title Priority Date Filing Date
JP2014518993A Withdrawn JP2014524796A (ja) 2011-06-28 2012-06-28 低侵襲表皮電気穿孔装置
JP2017094200A Active JP6423042B2 (ja) 2011-06-28 2017-05-10 低侵襲表皮電気穿孔装置

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2019214718A Active JP6799128B2 (ja) 2011-06-28 2019-11-27 低侵襲表皮電気穿孔装置
JP2020190104A Active JP6955076B2 (ja) 2011-06-28 2020-11-16 低侵襲表皮電気穿孔装置
JP2021161141A Active JP7519339B2 (ja) 2011-06-28 2021-09-30 低侵襲表皮電気穿孔装置
JP2024076760A Pending JP2024096416A (ja) 2011-06-28 2024-05-09 低侵襲表皮電気穿孔装置

Country Status (10)

Country Link
US (4) US9913978B2 (https=)
EP (4) EP3797824B1 (https=)
JP (7) JP2014524796A (https=)
KR (6) KR102081868B1 (https=)
CN (1) CN103687644B (https=)
AU (1) AU2012333211A1 (https=)
CA (1) CA2837214C (https=)
DK (2) DK2726145T3 (https=)
ES (1) ES2992120T3 (https=)
WO (1) WO2013066427A1 (https=)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012019168A2 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
RU2013120302A (ru) 2010-10-01 2014-11-20 Модерна Терапьютикс, Инк. Сконструированные нуклеиновые кислоты и способы их применения
EP2691101A2 (en) 2011-03-31 2014-02-05 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
KR102081868B1 (ko) * 2011-06-28 2020-02-26 이노비오 파마수티컬즈, 인크. 최소 침습 피부 전기천공 장치
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
RU2648950C2 (ru) 2011-10-03 2018-04-02 Модерна Терапьютикс, Инк. Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение
CN104114572A (zh) 2011-12-16 2014-10-22 现代治疗公司 经修饰的核苷、核苷酸和核酸组合物
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9254311B2 (en) 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
AU2013243948A1 (en) 2012-04-02 2014-10-30 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins associated with human disease
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US20140132274A1 (en) * 2012-11-13 2014-05-15 Awareness Technology Inc. Method and apparatus for providing information in an electrolyte measurment system
WO2014081507A1 (en) 2012-11-26 2014-05-30 Moderna Therapeutics, Inc. Terminally modified rna
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
US12559741B2 (en) 2013-06-08 2026-02-24 Suzhou Etta Biotech Co., Ltd. High density distributed three-dimensional electrode device
CN103275874B (zh) * 2013-06-08 2014-09-10 苏州文曲生物微系统有限公司 一种高密度分布式立体电极装置
US10023626B2 (en) 2013-09-30 2018-07-17 Modernatx, Inc. Polynucleotides encoding immune modulating polypeptides
JP2016538829A (ja) 2013-10-03 2016-12-15 モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. 低密度リポタンパク質受容体をコードするポリヌクレオチド
RU2699278C2 (ru) * 2014-05-02 2019-09-04 Конинклейке Филипс Н.В. Устройство для инактивации бактерий
KR102350517B1 (ko) * 2014-09-30 2022-01-14 주식회사 엘지생활건강 피부침투장치 및 피부침투방법
KR20160038566A (ko) * 2014-09-30 2016-04-07 엘지전자 주식회사 피부침투장치 및 피부침투방법
KR101507493B1 (ko) * 2014-10-22 2015-03-30 (주)와이브레인 전기 자극 장치
CN104403943B (zh) * 2014-12-02 2016-06-15 陈剑 一种电击管和具有电击管的细胞电转仪
ES2807439T3 (es) * 2015-03-31 2021-02-23 Oncosec Medical Inc Sistemas para electroporación mejorada basada en la detección de tejidos
RU2702091C2 (ru) * 2015-05-29 2019-10-04 Конинклейке Филипс Н.В. Устройство для обработки кожи с использованием нетепловой плазмы
JP6987642B2 (ja) * 2015-06-25 2022-01-05 ニューサウス・イノベーションズ・ピーティーワイ・リミテッド 治療学的物質の局所的送達を制御する電気穿孔法システム
KR101788301B1 (ko) * 2015-09-17 2017-10-20 주식회사 엘림텍 전기천공장치 및 그 제어방법
AU2016343077A1 (en) * 2015-10-19 2018-05-10 Bex Co.,Ltd. Bubble ejection chip, local ablation device, local ablation method, injection device, and injection method
PL3393575T3 (pl) * 2015-12-22 2024-06-17 Inovio Pharmaceuticals, Inc. Urządzenie do elektroporacji z pakietem baterii z przełącznikiem zasilania
EP3397144B1 (en) * 2015-12-28 2024-10-30 Inovio Pharmaceuticals, Inc. Intradermal jet injection electroporation device
IL300102B2 (en) 2015-12-30 2025-07-01 Inovio Pharmaceuticals Inc Electroporation device with detachable needle array with lock-out system
JP7250520B2 (ja) 2016-04-13 2023-04-03 ヤンセン ファーマシューティカルズ,インコーポレーテッド 組換えアルテリウイルスレプリコン系およびその使用
KR102718353B1 (ko) 2016-10-17 2024-10-15 얀센 파마슈티칼즈, 인코포레이티드 재조합 바이러스 레플리콘 시스템 및 그의 용도
JP7788787B2 (ja) 2016-12-05 2025-12-19 ヤンセン ファーマシューティカルズ,インコーポレーテッド 遺伝子発現増強のための組成物および方法
US20200147361A1 (en) * 2017-05-03 2020-05-14 Mayo Foundation For Medical Education And Research Skin treatment devices and methods
KR20180123312A (ko) * 2017-05-08 2018-11-16 (주)오스힐 미세전류 조절 수단을 구비한 스킨 부스터
IT201700102644A1 (it) * 2017-09-13 2019-03-13 Univ Degli Studi Padova Applicatore ed apparecchiatura per elettroporazione
EA202091513A1 (ru) 2017-12-19 2020-09-09 Янссен Сайенсиз Айрлэнд Анлимитед Компани Вакцины против вируса гепатита b (hbv) и их применение
US11389531B2 (en) * 2017-12-19 2022-07-19 Janssen Sciences Ireland Unlimited Company Methods and apparatus for the delivery of hepatitis B virus (HBV) vaccines
WO2019143949A2 (en) 2018-01-19 2019-07-25 Synthetic Genomics, Inc. Induce and enhance immune responses using recombinant replicon systems
KR20210074314A (ko) 2018-10-08 2021-06-21 얀센 파마슈티칼즈, 인코포레이티드 생체치료제의 투여를 위한 알파바이러스 기반 레플리콘
US12508423B2 (en) 2019-02-04 2025-12-30 Rutgers, The State University Of New Jersey Device for tissue electrotransfer using a microelectrode
US11071860B2 (en) 2019-02-06 2021-07-27 Oncosec Medical Incorporated Systems and methods for detecting fault conditions in electroporation therapy
KR102279603B1 (ko) * 2019-06-11 2021-07-20 (주)비올 바늘 조립체, 이를 포함하는 피부 자극기 및 그 제조 방법
WO2021173105A1 (ru) * 2020-02-28 2021-09-02 Ирына Мыхайливна УДОВИЧЕНКО Устройство для электростимуляции
US20210290941A1 (en) * 2020-03-20 2021-09-23 Inovio Pharmaceuticals Inc Vacuum-Assisted Electroporation Devices, And Related Systems And Methods
KR20220086094A (ko) 2020-12-16 2022-06-23 주식회사 은성글로벌 일렉트로포레이션 장치용 니들 주입 구성체
EP4363041A4 (en) * 2021-06-30 2025-05-14 Inovio Pharmaceuticals, Inc. Electrode arrays for electroporation and corresponding systems and methods
KR102832435B1 (ko) * 2022-04-11 2025-07-09 전우금 전극 교체형 전기 자극기
KR102812334B1 (ko) * 2022-09-30 2025-05-26 주식회사 밀알 니들의 종양 오염물을 제거할 수 있는 올가미 형태의 와이어를 갖는 전기천공장치
KR102812336B1 (ko) * 2022-09-30 2025-05-26 주식회사 밀알 니들의 종양 오염물을 밀폐할 수 있는 전기천공장치
KR102753355B1 (ko) * 2023-04-14 2025-01-13 (주)이지템 분할전극구조를 포함하는 에너지 기반 디바이스
US12485280B1 (en) 2024-07-15 2025-12-02 Tav-Tech Ltd Unitary enhanced jet spray dermal treatment handpiece

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648241A (en) 1989-09-15 1997-07-15 The General Hospital Corporation Conjugate vaccine against group B streptococcus
IL105503A (en) 1992-04-28 1999-05-09 Astra Ab Carbon peptide couplets capable of eliciting an immune response of T cells
US5702359A (en) * 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
US6413935B1 (en) 1993-09-14 2002-07-02 Epimmune Inc. Induction of immune response against desired determinants
US6277116B1 (en) * 1994-05-06 2001-08-21 Vidaderm Systems and methods for shrinking collagen in the dermis
US6207157B1 (en) 1996-04-23 2001-03-27 The United States Of America As Represented By The Department Of Health And Human Services Conjugate vaccine for nontypeable Haemophilus influenzae
CA2259437C (en) * 1996-07-03 2006-12-05 Altea Technologies, Inc. Multiple mechanical microporation of skin or mucosa
US6055453A (en) * 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
US6241701B1 (en) * 1997-08-01 2001-06-05 Genetronics, Inc. Apparatus for electroporation mediated delivery of drugs and genes
US7456012B2 (en) * 1997-11-06 2008-11-25 Cellectricon Ab Method and apparatus for spatially confined electroporation
EP1100579B1 (en) * 1998-07-13 2015-09-02 Inovio Pharmaceuticals, Inc. Skin and muscle-targeted gene therapy by pulsed electrical field
US7922709B2 (en) * 1998-07-13 2011-04-12 Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
US6713291B2 (en) * 1999-01-28 2004-03-30 Alan D. King Electrodes coated with treating agent and uses thereof
EP1163024B1 (en) * 1999-01-28 2003-12-17 Cyto Pulse Sciences, Inc. Delivery of macromolecules into cells
AU2938100A (en) * 1999-03-08 2000-09-28 Yoram Palti Transdermal drug delivery system and method
US6678558B1 (en) * 1999-03-25 2004-01-13 Genetronics, Inc. Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
WO2000067837A1 (en) * 1999-05-10 2000-11-16 Gentronics, Inc. Method of electroporation-enhanced delivery of active agents
US6493402B1 (en) 1999-05-27 2002-12-10 Zenith Electronics Corporation Mode control for trellis decoder
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6309633B1 (en) 1999-06-19 2001-10-30 Nobex Corporation Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
US6892099B2 (en) * 2001-02-08 2005-05-10 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation
US7496401B2 (en) * 2001-04-06 2009-02-24 Mattioli Engineering Ltd Method and apparatus for skin absorption enhancement and transdermal drug delivery
US7245963B2 (en) * 2002-03-07 2007-07-17 Advisys, Inc. Electrode assembly for constant-current electroporation and use
CA2531493A1 (en) * 2003-07-16 2005-02-03 University Of South Florida Device and method to facilitate directed delivery and electroporation
KR20060127394A (ko) 2003-10-31 2006-12-12 알자 코포레이션 경피 백신 전달 시스템 및 방법
US20060036210A1 (en) 2004-06-30 2006-02-16 Lei Zhang Modular electroporation device with disposable electrode and drug delivery components
US7850645B2 (en) * 2005-02-11 2010-12-14 Boston Scientific Scimed, Inc. Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power
US7657317B2 (en) 2005-04-26 2010-02-02 Boston Scientific Neuromodulation Corporation Evaluating stimulation therapies and patient satisfaction
US7713266B2 (en) * 2005-05-20 2010-05-11 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US20070066934A1 (en) 2005-09-19 2007-03-22 Transport Pharmaceuticals, Inc. Electrokinetic delivery system and methods therefor
US20070185432A1 (en) * 2005-09-19 2007-08-09 Transport Pharmaceuticals, Inc. Electrokinetic system and method for delivering methotrexate
CA3063263C (en) * 2006-02-11 2024-01-16 Genetronics, Inc. Device and method for single-needle in vivo electroporation
US20110023330A1 (en) 2006-09-15 2011-02-03 Shoo Sticks Pty Limited Substrate to releasably adhere to a region of apparel
US8133216B2 (en) * 2006-10-16 2012-03-13 Syneron Medical Ltd. Methods and devices for treating tissue
ES2993941T3 (en) * 2006-10-17 2025-01-14 Inovio Pharmaceuticals Inc Electroporation devices for electroporation of cells in mammals
CN101563132A (zh) * 2006-10-17 2009-10-21 Vgx药品公司 电穿孔装置及用其进行哺乳动物细胞电穿孔的方法
US20080132885A1 (en) * 2006-12-01 2008-06-05 Boris Rubinsky Methods for treating tissue sites using electroporation
WO2008157485A1 (en) * 2007-06-15 2008-12-24 Transport Pharmaceuticals, Inc. Current concentration system and method for electrokinetic delivery of medicaments
JP2011509743A (ja) * 2008-01-17 2011-03-31 ジェネトロニクス,インコーポレイティド 可変電流密度単一針電気穿孔システムおよび方法
US9066738B2 (en) * 2008-07-14 2015-06-30 Syneron Medical Ltd. Devices and methods for percutaneous energy delivery
EP3991783A1 (en) * 2009-04-16 2022-05-04 Inovio Pharmaceuticals, Inc. Contactless electropermeabilization electrode and method
US20100298761A1 (en) * 2009-05-20 2010-11-25 Sonion A/S Electroporation device with improved tip and electrode support
US9596920B2 (en) * 2009-08-04 2017-03-21 Pollogen Ltd. Cosmetic skin rejuvination
US8321012B2 (en) * 2009-12-22 2012-11-27 The Invention Science Fund I, Llc Device, method, and system for neural modulation as vaccine adjuvant in a vertebrate subject
EP2542299B1 (en) * 2010-03-01 2015-07-15 Inovio Pharmaceuticals, Inc. Multiple tissue layer electroporation applicator and device
KR101872408B1 (ko) * 2010-03-01 2018-06-28 이노비오 파마수티컬즈, 인크. 참을 수 있는 그리고 최소 침습적인 피부 전기천공 장치
US9289606B2 (en) * 2010-09-02 2016-03-22 St. Jude Medical, Atrial Fibrillation Division, Inc. System for electroporation therapy
KR102081868B1 (ko) 2011-06-28 2020-02-26 이노비오 파마수티컬즈, 인크. 최소 침습 피부 전기천공 장치

Similar Documents

Publication Publication Date Title
JP2019058671A5 (https=)
JP2020028759A5 (https=)
JP2021037322A5 (https=)
EP4494692A3 (en) Systems, devices, and methods for signal generation
ES2902988T3 (es) Electrodo y procedimiento de electropermeabilización sin contacto
JP2013521058A5 (https=)
JP2018514332A5 (https=)
JP2014054568A5 (https=)
JP2010506660A5 (https=)
EP4606419A3 (en) System for delivery of pulsed electric field ablative energy to endocardial tissue
JP2009525829A5 (https=)
JP2021522893A5 (https=)
JP2018518314A5 (https=)
CO2019005709A2 (es) Un dispositivo de tens para el monitoreo de actividades, análisis de marcha y evaluación del equilibrio
JP2002291910A5 (https=)
EP4480436A3 (en) Enhanced electroporation of cardiac tissue
JP2014530046A5 (https=)
GB2453294A (en) Method of powering implanted devices by direct transfer of electrical energy
CA2837214C (en) A minimally invasive dermal electroporation device
JP2013525017A5 (https=)
RU2014136343A (ru) Прибор электропортации, содержащий продолговатый аппликатор, кольцевые электроды и гнездо для шприца
JP2017506094A5 (https=)
NZ711655A (en) Implantable electroacupuncture device employing a high impedance coin-cell battery as a primary power source
JP2013240710A5 (https=)
US20190099599A1 (en) Rf fractional device with uniform effect around the conductive elements