JP2019055223A - 光コヒーレンス断層撮影法及び圧力に基づくシステム及び方法 - Google Patents
光コヒーレンス断層撮影法及び圧力に基づくシステム及び方法 Download PDFInfo
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Abstract
Description
この出願は2011年5月27日に出願された米国仮特許出願第61/490,925号及び2011年8月31日に出願された米国仮特許出願第61/529,594号の利益及び優先権を主張し、それらの全文を参照としてここに援用する。
部分的に、本発明は、カテーテルのような、パージポートを有するデータ収集プローブの一部のパージ(除去)を行い、且つパージポート圧力測定を行うするのに適した、システム、方法、及び装置にも関する。この種の測定を図18に関して上で議論した。1つの実施態様では、パージポートと流体連絡する圧力測定装置を使用することによって、空腔内に配置されるパージポートを通じて、血管の空腔のある位置での圧力を測定し得る。図20乃至23に示すようなパージング及び圧力測定を行うために、様々の種類の流体供給又は流れ規制システム又は構成部品を使用し得る。図18に示すシステム又は構成部品と共に、或いは図18に示すシステム又は構成部品の代わりに、これらのシステム及び構成部品の一部を使用し得る。
プロセッサ(例えば、マイクロプロセッサ、マイクロコントローラ、デジタル信号プロセッサ、又は汎用コンピュータ)と共に使用するためのコンピュータプログラム論理、プログラム可能な論理装置(例えば、現場でプログラム可能な論理列(FPGA)又は他のPLD)と共に使用するためのプログラム可能な論理、別個の構成部品、集積回路(例えば、特定用途向け集積回路(ASIC))、又はそれらの任意の組合せを含む任意の他の手段を非限定的に含む多くの異なる形態において、本発明を具現し得る。本発明の典型的な実施態様において、OCTプローブ及びプロセッサに基づくシステムを使用して収集されるデータの処理の一部又は全部は、一組のコンピュータプログラム命令として実施され、コンピュータプログラム命令は、コンピュータ実行可能な形態に変換され、例えば、コンピュータ読取り可能な媒体内に記憶され、且つオペレーティングシステムの制御の下でマイクロプロセッサによって実行される。よって、問合わせ応答及び入力データは、OCTデータ、OCT画像、血管抵抗、FFR計算、圧力感知、輪郭検出、並びに上述の他の機能及び実施態様を生成するのに適した、プロセッサが理解可能な命令に変換される。
Claims (18)
- 血管内の1つ又はそれよりも多くの所定の場所で圧力を測定するよう構成される圧力組立体と、
光コヒーレンス断層撮影組立体を含む撮像プローブとを含み、
前記光コヒーレンス断層撮影組立体は、
光ファイバと、
第1の直径を有し、第1の管腔を定める、第1のトルクワイヤと、
第2の直径を有し、第2の管腔を定める、第2のトルクワイヤとを含み、
前記第1のトルクワイヤ及び前記第2のトルクワイヤは接合され、
前記第1のトルクワイヤの長さは、前記第2のトルクワイヤの長さよりも短く、
前記第2の直径は、前記第1の直径よりも大きく、
前記光ファイバは、前記第1の管腔及び前記第2の管腔を通じて進む、
データ収集システム。 - 前記光コヒーレンス断層撮影組立体は、前記光ファイバに隣接し且つ前記光ファイバと同軸であるビームディレクタを含み、該ビームディレクタは、第1の波長帯の光を反射するように構成され、
前記圧力組立体は、前記ビームディレクタ及び前記光ファイバと同軸であり且つ前記ビームディレクタに対して遠位に位置付けられる、光学圧力変換器を含み、前記光ファイバは、第1の波長帯及び第2の波長帯の光を伝えるように構成され、前記光学圧力変換器は、前記第2の波長帯の光を変調するように構成される、
請求項1に記載のデータ収集システム。 - 前記光コヒーレンス断層撮影組立体及び前記圧力組立体と通信するプロセッサを更に含み、該プロセッサは、プログラムを実行して、前記血管内の前記所定の場所のうちの1つ又はそれよりも多くの場所での幾何学的形状及び前記血管内の1つ又はそれよりも多くの所定の場所で測定される圧力に応答して前記血管についての補正された血流予備量比を計算する、ように構成される、請求項1に記載のデータ収集システム。
- 前記プロセッサは、前記プログラムを実行して、前記光コヒーレンス断層撮影組立体で測定される前記血管の前記幾何学的形状及び流体力学方程式を使用して初期的な血流予備流量比を補正する、ように構成される、請求項3に記載のデータ収集システム。
- 前記プロセッサは、前記プログラムを実行して、予期される圧力降下に対する測定される圧力降下の比として心筋損傷指数を出力する、ように構成される、請求項3に記載のデータ収集システム。
- 流体制限装置とパージ流体源とを含むパージ組立体を更に含み、前記流体制限装置は、前記撮像プローブの壁によって定められるパージポートと流体連通する、請求項1に記載のデータ収集システム。
- 前記流体制限装置は、調節可能であり、付勢素子と、孔を定める滑動可能な部材とを含み、前記孔は、前記パージ流体源からパージ流体を受け取るよう位置付けられ、前記付勢素子は、前記滑動可能な部材に付勢力を加えるように構成される、請求項6に記載のデータ収集システム。
- 空気充填キャビティが前記光学圧力変換器と前記ビームディレクタとの間に定められる、請求項2に記載のデータ収集システム。
- 前記撮像プローブの壁と、
該壁によって定められる管腔とを更に含み、
前記光コヒーレンス断層撮影組立体は、前記管腔内に配置される回転可能な光ファイバを含み、前記圧力組立体は、前記壁に配置されるポケット内に配置される圧力変換器を含む、請求項1に記載のデータ収集システム。 - 前記圧力変換器は、前記ポケット内に位置付けられるゲルによって前記管腔から分離される、請求項9に記載のデータ収集システム。
- パージ溶液を供給するように構成される流体源と、
該流体源と流体連通する逆止弁と、
該逆止弁と流体連通する流体流制御装置と、
前記撮像プローブの壁によって定められるパージポートに前記パージ溶液を輸送するように構成される流体給送通路とを含む、
請求項1に記載のデータ収集システム。 - 前記流体流制御装置は、制約部、調節可能な制約部、膨張可能なチューブ、及び膨張リミッタ内に配置される膨張可能なチューブで構成される群から選択される、請求項11に記載のデータ収集システム。
- 前記第1の直径の長さは、前記第2の直径の約10倍の長さである、請求項1に記載のデータ収集システム。
- 前記第1のトルクワイヤは、前記第2のトルクワイヤに当接し、前記第1及び第2のトルクワイヤは、前記第1及び前記第2のトルクワイヤの周りに熱収縮されるチューブ内に配置され且つそのようなチューブによって一体に保持される、請求項1に記載のデータ収集システム。
- 前記プローブは、
管腔を定める壁を有するカテーテルと、
パージポートとを含み、
流体源と、
前記管腔と連通する第1のポートと、前記流体源と連通する第2のポートと、前記圧力組立体と連通する第3のポートとを有する、三方向弁とを更に含み、
前記圧力組立体は、圧力変換器であり、第1の位置にあるとき、前記三方向弁は前記流体源を前記管腔と接続し、第2の位置にあるとき、前記三方向弁は、前記管腔と前記圧力変換器とを接続する、
請求項1に記載のデータ収集システム。 - 血管内の1つ又はそれよりも多くの場所で圧力を測定するように構成される圧力組立体と、
第1の直径を有し、第1の管腔を定める、第1のトルクワイヤと、
第2の直径を有し、第2の管腔を定める、第2のトルクワイヤとを含み、
前記第1のトルクワイヤ及び前記第2のトルクワイヤは接合され、
前記第1のトルクワイヤの長さは、前記第2のトルクワイヤの長さよりも短く、前記第2の直径は、前記第1の直径よりも大きい、
データ収集システム。 - 撮像組立体を更に含み、
該撮像組立体は、光ファイバを含み、該光ファイバは、前記第1の管腔及び前記第2の管腔を通じて進む、
請求項16に記載のデータ収集システム。 - 前記撮像組立体は、光コヒーレンス断層撮影組立体である、請求項17に記載のデータ収集システム。
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AU2017202107A1 (en) | 2017-04-20 |
AU2012262883B2 (en) | 2017-01-12 |
AU2017202107B2 (en) | 2019-08-29 |
CR20130639A (es) | 2014-02-21 |
JP6141264B2 (ja) | 2017-06-07 |
US20200352446A1 (en) | 2020-11-12 |
AU2012262883A1 (en) | 2013-12-19 |
CA2837577C (en) | 2018-05-29 |
WO2012166332A1 (en) | 2012-12-06 |
EP2713858A1 (en) | 2014-04-09 |
CA2837577A1 (en) | 2012-12-06 |
JP2014525761A (ja) | 2014-10-02 |
US20140094697A1 (en) | 2014-04-03 |
JP2017170159A (ja) | 2017-09-28 |
JP6799572B2 (ja) | 2020-12-16 |
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