JP2019052094A5 - - Google Patents
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- Publication number
- JP2019052094A5 JP2019052094A5 JP2017100431A JP2017100431A JP2019052094A5 JP 2019052094 A5 JP2019052094 A5 JP 2019052094A5 JP 2017100431 A JP2017100431 A JP 2017100431A JP 2017100431 A JP2017100431 A JP 2017100431A JP 2019052094 A5 JP2019052094 A5 JP 2019052094A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- medicinal composition
- purin
- ethyl
- paratolyloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 13
- CVPTTZZCRDVGSU-UHFFFAOYSA-N 5-[2-(6-aminopurin-9-yl)ethylamino]pentan-1-ol Chemical compound NC1=NC=NC2=C1N=CN2CCNCCCCCO CVPTTZZCRDVGSU-UHFFFAOYSA-N 0.000 claims 6
- MEOMXKNIFWDDGZ-UHFFFAOYSA-N 6-morpholin-4-yl-9h-purine Chemical compound C1COCCN1C1=NC=NC2=C1N=CN2 MEOMXKNIFWDDGZ-UHFFFAOYSA-N 0.000 claims 5
- KKSYXUAEBWBHOR-UHFFFAOYSA-N 6-amino-9-[2-(4-methylphenoxy)ethyl]-7h-purine-8-thione Chemical compound C1=CC(C)=CC=C1OCCN1C(=S)NC2=C(N)N=CN=C21 KKSYXUAEBWBHOR-UHFFFAOYSA-N 0.000 claims 4
- AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 claims 4
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 4
- 229940124636 opioid drug Drugs 0.000 claims 4
- 208000019901 Anxiety disease Diseases 0.000 claims 3
- 230000036506 anxiety Effects 0.000 claims 3
- 230000000202 analgesic effect Effects 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 230000002708 enhancing effect Effects 0.000 claims 2
- 229960005181 morphine Drugs 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 208000003251 Pruritus Diseases 0.000 claims 1
- FGNLEIGUMSBZQP-UHFFFAOYSA-N cadaverine dihydrochloride Chemical compound Cl.Cl.NCCCCCN FGNLEIGUMSBZQP-UHFFFAOYSA-N 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000007803 itching Effects 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 208000009935 visceral pain Diseases 0.000 claims 1
Priority Applications (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017100431A JP7332841B2 (ja) | 2017-05-20 | 2017-05-20 | 疼痛を治療するための薬用組成物 |
| TW107116441A TWI729290B (zh) | 2017-05-20 | 2018-05-15 | 治療疼痛的藥物組合物 |
| IL259442A IL259442A (en) | 2017-05-20 | 2018-05-16 | Medicinal preparations for the treatment of pain |
| ES18000462T ES2886855T3 (es) | 2017-05-20 | 2018-05-17 | Composiciones farmacéuticas para tratar el dolor |
| EP18000462.4A EP3403674B1 (en) | 2017-05-20 | 2018-05-17 | Pharmaceutical compositions for treating pain |
| AU2018203501A AU2018203501B2 (en) | 2017-05-20 | 2018-05-17 | Pharmaceutical compositions for treating pain |
| DK18000462.4T DK3403674T3 (da) | 2017-05-20 | 2018-05-17 | Farmaceutiske sammensætninger til behandling af smerte |
| KR1020180057362A KR102096557B1 (ko) | 2017-05-20 | 2018-05-18 | 통증 치료용 약학 조성물 |
| CA3005375A CA3005375C (en) | 2017-05-20 | 2018-05-18 | Pharmaceutical compositions for treating pain |
| CN201810482871.XA CN108743589B (zh) | 2017-05-20 | 2018-05-18 | 治疗疼痛的药物组合物 |
| ZA2018/03320A ZA201803320B (en) | 2017-05-20 | 2018-05-18 | Pharmaceutical compositions for treating pain |
| US15/984,410 US20180333420A1 (en) | 2017-05-20 | 2018-05-20 | Pharmaceutical compositions for treating pain |
| US16/871,628 US11541060B2 (en) | 2017-05-20 | 2020-05-11 | Pharmaceutical compositions for treating pain |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017100431A JP7332841B2 (ja) | 2017-05-20 | 2017-05-20 | 疼痛を治療するための薬用組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019052094A JP2019052094A (ja) | 2019-04-04 |
| JP2019052094A5 true JP2019052094A5 (enExample) | 2020-06-25 |
| JP7332841B2 JP7332841B2 (ja) | 2023-08-24 |
Family
ID=62200214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017100431A Active JP7332841B2 (ja) | 2017-05-20 | 2017-05-20 | 疼痛を治療するための薬用組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20180333420A1 (enExample) |
| EP (1) | EP3403674B1 (enExample) |
| JP (1) | JP7332841B2 (enExample) |
| KR (1) | KR102096557B1 (enExample) |
| CN (1) | CN108743589B (enExample) |
| AU (1) | AU2018203501B2 (enExample) |
| CA (1) | CA3005375C (enExample) |
| DK (1) | DK3403674T3 (enExample) |
| ES (1) | ES2886855T3 (enExample) |
| IL (1) | IL259442A (enExample) |
| TW (1) | TWI729290B (enExample) |
| ZA (1) | ZA201803320B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114984020B (zh) * | 2022-01-20 | 2024-08-30 | 永展控股有限公司 | 腺苷酸环化酶抑制剂在制备用于治疗癫痫及其相关疾病的药物中的用途 |
| CN114931561B (zh) * | 2022-05-25 | 2024-02-02 | 青岛永展医药科技有限公司 | 一种治疗慢性痛的胶囊组合物及其制备方法 |
| CN115990167A (zh) * | 2023-02-17 | 2023-04-21 | 永展控股有限公司 | 腺苷酸环化酶抑制剂nb001在制备治疗偏头痛和焦虑药物中的用途 |
| CN115998745B (zh) * | 2023-02-17 | 2024-05-14 | 永展控股有限公司 | 腺苷酸环化酶抑制剂nb001在制备治疗帕金森氏病疼痛和焦虑药物中的用途 |
| CN118526502A (zh) * | 2024-07-24 | 2024-08-23 | 浙江永展医药科技有限公司 | 腺苷酸环化酶抑制剂用于制备治疗围手术期疼痛药物的应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1947717B (zh) | 2005-10-14 | 2012-09-26 | 卓敏 | 选择性抑制腺苷酸环化酶1的化合物在制备用于治疗神经性疼痛和炎性疼痛的药物中的应用 |
| US20110098295A1 (en) | 2009-10-22 | 2011-04-28 | Min Zhuo | Methods of treating anxiety, itching and psychiatric disorders |
| JP6902336B2 (ja) * | 2016-08-01 | 2021-07-14 | 永展国際有限公司Ｆｏｒｅｖｅｒ Ｃｈｅｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｌｉｍｉｔｅｄ | ５−［２−［（６−アミノ）−９ｈ−プリン−９−イル］エチルアミノ］−１−ペンタノール多結晶体 |
-
2017
- 2017-05-20 JP JP2017100431A patent/JP7332841B2/ja active Active
-
2018
- 2018-05-15 TW TW107116441A patent/TWI729290B/zh active
- 2018-05-16 IL IL259442A patent/IL259442A/en unknown
- 2018-05-17 AU AU2018203501A patent/AU2018203501B2/en active Active
- 2018-05-17 EP EP18000462.4A patent/EP3403674B1/en active Active
- 2018-05-17 ES ES18000462T patent/ES2886855T3/es active Active
- 2018-05-17 DK DK18000462.4T patent/DK3403674T3/da active
- 2018-05-18 CA CA3005375A patent/CA3005375C/en active Active
- 2018-05-18 ZA ZA2018/03320A patent/ZA201803320B/en unknown
- 2018-05-18 KR KR1020180057362A patent/KR102096557B1/ko active Active
- 2018-05-18 CN CN201810482871.XA patent/CN108743589B/zh active Active
- 2018-05-20 US US15/984,410 patent/US20180333420A1/en not_active Abandoned
-
2020
- 2020-05-11 US US16/871,628 patent/US11541060B2/en active Active
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