CN108743589B - 治疗疼痛的药物组合物 - Google Patents

治疗疼痛的药物组合物 Download PDF

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CN108743589B
CN108743589B CN201810482871.XA CN201810482871A CN108743589B CN 108743589 B CN108743589 B CN 108743589B CN 201810482871 A CN201810482871 A CN 201810482871A CN 108743589 B CN108743589 B CN 108743589B
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morphine
pain
mice
tolerance
opioid
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CN108743589A (zh
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卓敏
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Yongzhan Holdings Ltd
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Forever Cheer International Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • AHUMAN NECESSITIES
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    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201810482871.XA 2017-05-20 2018-05-18 治疗疼痛的药物组合物 Active CN108743589B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2017-100431 2017-05-20
JP2017100431A JP7332841B2 (ja) 2017-05-20 2017-05-20 疼痛を治療するための薬用組成物

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CN108743589A CN108743589A (zh) 2018-11-06
CN108743589B true CN108743589B (zh) 2021-05-14

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US (2) US20180333420A1 (enExample)
EP (1) EP3403674B1 (enExample)
JP (1) JP7332841B2 (enExample)
KR (1) KR102096557B1 (enExample)
CN (1) CN108743589B (enExample)
AU (1) AU2018203501B2 (enExample)
CA (1) CA3005375C (enExample)
DK (1) DK3403674T3 (enExample)
ES (1) ES2886855T3 (enExample)
IL (1) IL259442A (enExample)
TW (1) TWI729290B (enExample)
ZA (1) ZA201803320B (enExample)

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Publication number Priority date Publication date Assignee Title
CN114984020B (zh) * 2022-01-20 2024-08-30 永展控股有限公司 腺苷酸环化酶抑制剂在制备用于治疗癫痫及其相关疾病的药物中的用途
CN114931561B (zh) * 2022-05-25 2024-02-02 青岛永展医药科技有限公司 一种治疗慢性痛的胶囊组合物及其制备方法
CN115990167A (zh) * 2023-02-17 2023-04-21 永展控股有限公司 腺苷酸环化酶抑制剂nb001在制备治疗偏头痛和焦虑药物中的用途
CN115998745B (zh) * 2023-02-17 2024-05-14 永展控股有限公司 腺苷酸环化酶抑制剂nb001在制备治疗帕金森氏病疼痛和焦虑药物中的用途
CN118526502A (zh) * 2024-07-24 2024-08-23 浙江永展医药科技有限公司 腺苷酸环化酶抑制剂用于制备治疗围手术期疼痛药物的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007041863A1 (en) * 2005-10-14 2007-04-19 Min Zhuo Method for treating neuronal and non-neuronal pain
US20110098295A1 (en) * 2009-10-22 2011-04-28 Min Zhuo Methods of treating anxiety, itching and psychiatric disorders

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6902336B2 (ja) * 2016-08-01 2021-07-14 永展国際有限公司Forever Cheer International Limited 5−[2−[(6−アミノ)−9h−プリン−9−イル]エチルアミノ]−1−ペンタノール多結晶体

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007041863A1 (en) * 2005-10-14 2007-04-19 Min Zhuo Method for treating neuronal and non-neuronal pain
US20110098295A1 (en) * 2009-10-22 2011-04-28 Min Zhuo Methods of treating anxiety, itching and psychiatric disorders

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Co-administration of Nimodipine with Morphine in Rat, delayed the development of tolerance to analgesic effect of Morphine: The Tail Flick test study: New insight for treatment of chronic pain;Satya Narayan Shukla等;《International Journal of Biomedical Research》;20151231;第6卷(第10期);第786-793页 *
Identification of an Adenylyl Cyclase Inhibitor for Treating Neuropathic and Inflammatory Pain;Hansen Wang等;《Science Translational Medicine》;20110112;第3卷(第65期);第1-13页 *

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JP2019052094A (ja) 2019-04-04
KR20180127248A (ko) 2018-11-28
TWI729290B (zh) 2021-06-01
KR102096557B1 (ko) 2020-04-03
ES2886855T3 (es) 2021-12-21
TW201900173A (zh) 2019-01-01
AU2018203501B2 (en) 2019-11-21
EP3403674B1 (en) 2021-06-30
IL259442A (en) 2018-06-28
CN108743589A (zh) 2018-11-06
DK3403674T3 (da) 2021-08-30
JP7332841B2 (ja) 2023-08-24
US20200268766A1 (en) 2020-08-27
US20180333420A1 (en) 2018-11-22
EP3403674A1 (en) 2018-11-21
CA3005375C (en) 2020-12-08
AU2018203501A1 (en) 2018-12-06
ZA201803320B (en) 2019-04-24
CA3005375A1 (en) 2018-11-20
US11541060B2 (en) 2023-01-03

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