JP2019023181A5 - - Google Patents

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JP2019023181A5
JP2019023181A5 JP2018119595A JP2018119595A JP2019023181A5 JP 2019023181 A5 JP2019023181 A5 JP 2019023181A5 JP 2018119595 A JP2018119595 A JP 2018119595A JP 2018119595 A JP2018119595 A JP 2018119595A JP 2019023181 A5 JP2019023181 A5 JP 2019023181A5
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formula
compound
enantiomeric excess
salt
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JP2018119595A
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JP6917949B2 (ja
JP2019023181A (ja
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Priority claimed from EP17178755.9A external-priority patent/EP3421455B1/en
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JP2018119595A 2017-06-29 2018-06-25 トファシチニブの調製のための有用な中間体であるキラル３−アミノ−ピペリジンの調製のための改良された方法 Active JP6917949B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17178755.9 2017-06-29
EP17178755.9A EP3421455B1 (en) 2017-06-29 2017-06-29 Improved process for the preparation of chiral 3-amino-piperidins, useful intermediates for the preparation of tofacitinib

Publications (3)

Publication Number Publication Date
JP2019023181A JP2019023181A (ja) 2019-02-14
JP2019023181A5 true JP2019023181A5 (https=) 2021-05-20
JP6917949B2 JP6917949B2 (ja) 2021-08-11

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JP2018119595A Active JP6917949B2 (ja) 2017-06-29 2018-06-25 トファシチニブの調製のための有用な中間体であるキラル３−アミノ−ピペリジンの調製のための改良された方法

Country Status (4)

Country Link
US (1) US20190002407A1 (https=)
EP (1) EP3421455B1 (https=)
JP (1) JP6917949B2 (https=)
CN (1) CN109206361A (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109761884B (zh) * 2019-01-30 2020-03-31 湖北扬信医药科技有限公司 一种手性胺b的制备方法及其应用
WO2020204647A1 (en) * 2019-04-05 2020-10-08 Yuhan Corporation Processes for preparing (3r,4r)-1-benzyl-n,4-dimethylpiperidin-3-amine or a salt thereof and processes for preparing tofacitinib using the same
CN113125587B (zh) * 2019-12-30 2022-05-24 成都百裕制药股份有限公司 一种托法替尼中间体及其对映异构体的检测方法
CN113899831B (zh) * 2021-10-11 2023-08-15 湖北科益药业股份有限公司 一种枸橼酸托法替布起始物料的液相色谱检测方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6258979B1 (en) * 1999-11-22 2001-07-10 Henri Kagan Chiral ferrocene phosphines active in asymmetric catalysis
AU2003278529A1 (en) * 2002-11-21 2004-06-15 Pfizer Products Inc. 3-amino-piperidine derivatives and processes for their preparation
US7629470B2 (en) * 2004-07-08 2009-12-08 Merck & Co., Inc. Formation of tetra-substituted enamides and stereoselective reduction thereof
EP1913000B1 (en) 2005-07-29 2012-01-11 Pfizer Products Inc. Pyrrolo[2,3-d]pyrimidine derivatives; their intermediates and synthesis
PE20081849A1 (es) * 2007-01-04 2009-01-26 Prosidion Ltd Derivados de piperidin-4-il-propoxi-benzamida como agonistas de gpcr
AR070176A1 (es) * 2008-01-17 2010-03-17 Novartis Ag Procesos de sintesis de inhibidores de nep, compuestos intermediarios y uso de los mismos en la sintesis
AU2010239396B2 (en) * 2009-04-20 2016-06-23 Auspex Pharmaceuticals, Llc Piperidine inhibitors of Janus Kinase 3
MX2013002149A (es) * 2010-08-23 2013-04-03 Novartis Ag Nuevo proceso para la preparacion de intermediarios utiles para la elaboracion de inhibidores de nep.
EP2734041A4 (en) * 2011-07-18 2015-03-25 Adolor Corp METHOD FOR THE PRODUCTION OF PERIPHERAL OPIOID ANTAGONIST COMPOUNDS AND INTERMEDIATE PRODUCTS THEREOF
US9126906B2 (en) * 2012-02-21 2015-09-08 Celgene Corporation Asymmetric synthetic processes for the preparation of aminosulfone compounds
CA2900595A1 (en) * 2013-02-12 2014-08-21 Bayer Pharma Aktiengesellschaft Metal chelate compounds for binding to the platelet specific glycoprotein iib/iiia
US20160122354A1 (en) 2013-06-05 2016-05-05 Srinivasan Thirumalai Rajan PROCESS FOR THE PREPARATION OF (3R,4R)-4-METHYL-3-(METHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL-AMINO)-ß-OXO-1-PIPERIDINEPROPANENITRILE AND ITS SALTS
USRE50724E1 (en) * 2013-07-08 2026-01-06 Syngenta Crop Protection Ag 4-membered ring carboxamides used as nematicides
TW201617321A (zh) * 2014-09-18 2016-05-16 第一三共股份有限公司 光學活性吉草酸衍生物之製法
EP3078665A1 (en) * 2015-04-10 2016-10-12 OLON S.p.A. Efficient method for the preparation of tofacitinib citrate

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