JP2019023181A5 - - Google Patents

Download PDF

Info

Publication number
JP2019023181A5
JP2019023181A5 JP2018119595A JP2018119595A JP2019023181A5 JP 2019023181 A5 JP2019023181 A5 JP 2019023181A5 JP 2018119595 A JP2018119595 A JP 2018119595A JP 2018119595 A JP2018119595 A JP 2018119595A JP 2019023181 A5 JP2019023181 A5 JP 2019023181A5
Authority
JP
Japan
Prior art keywords
formula
compound
enantiomeric excess
salt
symbol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2018119595A
Other languages
English (en)
Japanese (ja)
Other versions
JP6917949B2 (ja
JP2019023181A (ja
Filing date
Publication date
Priority claimed from EP17178755.9A external-priority patent/EP3421455B1/en
Application filed filed Critical
Publication of JP2019023181A publication Critical patent/JP2019023181A/ja
Publication of JP2019023181A5 publication Critical patent/JP2019023181A5/ja
Application granted granted Critical
Publication of JP6917949B2 publication Critical patent/JP6917949B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2018119595A 2017-06-29 2018-06-25 トファシチニブの調製のための有用な中間体であるキラル３−アミノ−ピペリジンの調製のための改良された方法 Active JP6917949B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17178755.9A EP3421455B1 (en) 2017-06-29 2017-06-29 Improved process for the preparation of chiral 3-amino-piperidins, useful intermediates for the preparation of tofacitinib
EP17178755.9 2017-06-29

Publications (3)

Publication Number Publication Date
JP2019023181A JP2019023181A (ja) 2019-02-14
JP2019023181A5 true JP2019023181A5 (https=) 2021-05-20
JP6917949B2 JP6917949B2 (ja) 2021-08-11

Family

ID=59258098

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018119595A Active JP6917949B2 (ja) 2017-06-29 2018-06-25 トファシチニブの調製のための有用な中間体であるキラル３−アミノ−ピペリジンの調製のための改良された方法

Country Status (4)

Country Link
US (1) US20190002407A1 (https=)
EP (1) EP3421455B1 (https=)
JP (1) JP6917949B2 (https=)
CN (1) CN109206361A (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109761884B (zh) * 2019-01-30 2020-03-31 湖北扬信医药科技有限公司 一种手性胺b的制备方法及其应用
WO2020204647A1 (en) * 2019-04-05 2020-10-08 Yuhan Corporation Processes for preparing (3r,4r)-1-benzyl-n,4-dimethylpiperidin-3-amine or a salt thereof and processes for preparing tofacitinib using the same
CN113125587B (zh) * 2019-12-30 2022-05-24 成都百裕制药股份有限公司 一种托法替尼中间体及其对映异构体的检测方法
CN113899831B (zh) * 2021-10-11 2023-08-15 湖北科益药业股份有限公司 一种枸橼酸托法替布起始物料的液相色谱检测方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6258979B1 (en) * 1999-11-22 2001-07-10 Henri Kagan Chiral ferrocene phosphines active in asymmetric catalysis
KR100678800B1 (ko) * 2002-11-21 2007-02-05 화이자 프로덕츠 인코포레이티드 3-아미노-피페리딘 유도체 및 그의 제조 방법
US7629470B2 (en) * 2004-07-08 2009-12-08 Merck & Co., Inc. Formation of tetra-substituted enamides and stereoselective reduction thereof
BRPI0613876A2 (pt) * 2005-07-29 2011-02-15 Pfizer Prod Inc derivados de pirrolo [2,3-d] pirimidina; seus intermediários e sìntese
PE20081849A1 (es) * 2007-01-04 2009-01-26 Prosidion Ltd Derivados de piperidin-4-il-propoxi-benzamida como agonistas de gpcr
PE20091364A1 (es) * 2008-01-17 2009-10-13 Novartis Ag Proceso para la preparacion de inhibidores de nep
EP2421867B1 (en) * 2009-04-20 2015-09-02 Auspex Pharmaceuticals, Llc Piperidine inhibitors of janus kinase 3
MX2013002149A (es) * 2010-08-23 2013-04-03 Novartis Ag Nuevo proceso para la preparacion de intermediarios utiles para la elaboracion de inhibidores de nep.
CA2842183A1 (en) * 2011-07-18 2013-01-24 Adolor Corporation Processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto
US9126906B2 (en) * 2012-02-21 2015-09-08 Celgene Corporation Asymmetric synthetic processes for the preparation of aminosulfone compounds
CA2900595A1 (en) * 2013-02-12 2014-08-21 Bayer Pharma Aktiengesellschaft Metal chelate compounds for binding to the platelet specific glycoprotein iib/iiia
US20160122354A1 (en) 2013-06-05 2016-05-05 Srinivasan Thirumalai Rajan PROCESS FOR THE PREPARATION OF (3R,4R)-4-METHYL-3-(METHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL-AMINO)-ß-OXO-1-PIPERIDINEPROPANENITRILE AND ITS SALTS
PL3019476T3 (pl) * 2013-07-08 2018-05-30 Syngenta Participations Ag Związki karboksyamidowe o 4-członowym pierścieniu jako nematocydy
JPWO2016043254A1 (ja) * 2014-09-18 2017-07-27 第一三共株式会社 光学活性吉草酸誘導体の製法
EP3078665A1 (en) * 2015-04-10 2016-10-12 OLON S.p.A. Efficient method for the preparation of tofacitinib citrate

Similar Documents

Publication Publication Date Title
CN103764624B (zh) R‑联苯丙氨醇的合成
JP3320488B2 (ja) 均質触媒の配位子としてのフェロセニルジホスフィン
JP2019023181A5 (https=)
JP7164647B2 (ja) 金属錯体
JP5462932B2 (ja) ボロン酸エステル化合物の製造方法
EP2123661A1 (en) Chiral iridium aqua complex and method for producing optically active hydroxy compound by using the same
JP6917949B2 (ja) トファシチニブの調製のための有用な中間体であるキラル３−アミノ−ピペリジンの調製のための改良された方法
MXPA04006207A (es) Procedimiento para la preparacion de compuestos sin-1-(4 -hidroxi-fenil)-2 -(4-hidroxi-4- fenil-piperidin- 1-il)-1- propanol no racemicos.
JP2005516036A6 (ja) 非ラセミｓｙｎ−１−（４−ヒドロキシ−フェニル）−２−（４−ヒドロキシ−４−フェニル−ピペリジン−１−イル）−１−プロパノ−ル化合物の製造方法
JP2018039757A (ja) イミダゾール誘導体の製造方法
CN102076634A (zh) 手性胺的合成
JP2010512379A5 (https=)
KR20220140556A (ko) 비대칭 수소화를 사용하는 s-베플루부타미드의 합성 방법
JP6291179B2 (ja) 光学活性２級アルコールの製造方法
CN110684043B (zh) 一种c-n轴手性芳胺化合物及其制备方法
EP3609859B1 (en) Chiral metal complex compounds
JP4827531B2 (ja) エナンチオ選択的なエナミドのイミンへの求核付加反応方法とα−アミノ−γ−ケト酸エステルの合成方法
WO2021002407A1 (ja) フルオロアルキル基含有化合物とその製造方法
JPWO2021058458A5 (https=)
JP5001263B2 (ja) ジフェニルアラニン誘導体作製のための不斉水素化
JP4643566B2 (ja) Ｎ−アシルヒドラゾンのアリル化方法
JP2011519919A (ja) 不斉水素化のための触媒的プロセス
JP2011057619A (ja) 光学活性アミン化合物の製造方法、並びに、ジアステレオマー塩及びその製造方法
JP4658289B2 (ja) 光学活性な含フッ素アミノ酸誘導体の製造方法
WO2016119758A1 (zh) 一种手性的2-[1-环丙基乙基]-6-异丙基-苯酚的制备方法