JP2018538241A5 - - Google Patents
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- Publication number
- JP2018538241A5 JP2018538241A5 JP2018519027A JP2018519027A JP2018538241A5 JP 2018538241 A5 JP2018538241 A5 JP 2018538241A5 JP 2018519027 A JP2018519027 A JP 2018519027A JP 2018519027 A JP2018519027 A JP 2018519027A JP 2018538241 A5 JP2018538241 A5 JP 2018538241A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- ck1δ
- compound
- alkyl
- breast cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010028980 Neoplasm Diseases 0.000 claims 10
- 201000011510 cancer Diseases 0.000 claims 10
- 206010006187 Breast cancer Diseases 0.000 claims 9
- 208000026310 Breast neoplasm Diseases 0.000 claims 9
- 101150047910 CSNK1D gene Proteins 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 9
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 102000015735 Beta-catenin Human genes 0.000 claims 5
- 108060000903 Beta-catenin Proteins 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 125000002733 (C1-C6) fluoroalkyl group Chemical group 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 206010005003 Bladder cancer Diseases 0.000 claims 3
- 206010009944 Colon cancer Diseases 0.000 claims 3
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 3
- 208000000172 Medulloblastoma Diseases 0.000 claims 3
- 206010038389 Renal cancer Diseases 0.000 claims 3
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 3
- 210000000988 bone and bone Anatomy 0.000 claims 3
- 210000004556 brain Anatomy 0.000 claims 3
- 208000029742 colonic neoplasm Diseases 0.000 claims 3
- 208000005017 glioblastoma Diseases 0.000 claims 3
- 201000010982 kidney cancer Diseases 0.000 claims 3
- 210000004072 lung Anatomy 0.000 claims 3
- 201000001441 melanoma Diseases 0.000 claims 3
- 238000011282 treatment Methods 0.000 claims 3
- 201000005112 urinary bladder cancer Diseases 0.000 claims 3
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 2
- 108010047048 Casein Kinase Idelta Proteins 0.000 claims 2
- 102100037402 Casein kinase I isoform delta Human genes 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 229940041181 antineoplastic drug Drugs 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 230000001419 dependent effect Effects 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 206010061289 metastatic neoplasm Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 206010027476 Metastases Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 238000011269 treatment regimen Methods 0.000 claims 1
- 230000003827 upregulation Effects 0.000 claims 1
- 210000003932 urinary bladder Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562240689P | 2015-10-13 | 2015-10-13 | |
| US62/240,689 | 2015-10-13 | ||
| PCT/US2016/055436 WO2017066055A1 (en) | 2015-10-13 | 2016-10-05 | THERAPEUTIC TARGETING OF CASEIN KINASE 1δ IN BREAST CANCER |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018538241A JP2018538241A (ja) | 2018-12-27 |
| JP2018538241A5 true JP2018538241A5 (enExample) | 2019-11-14 |
Family
ID=58517824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018519027A Pending JP2018538241A (ja) | 2015-10-13 | 2016-10-05 | 乳癌におけるカゼインキナーゼ１δの治療標的化 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10603322B2 (enExample) |
| EP (1) | EP3362452A4 (enExample) |
| JP (1) | JP2018538241A (enExample) |
| CN (1) | CN108431006A (enExample) |
| AU (1) | AU2016338639A1 (enExample) |
| CA (1) | CA3001903A1 (enExample) |
| HK (1) | HK1259409A1 (enExample) |
| WO (1) | WO2017066055A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20200078387A1 (en) * | 2016-12-16 | 2020-03-12 | The Johns Hopkins University | Chemical inhibitors against kinases to block telomere elongation in cancer |
| WO2019145386A1 (en) | 2018-01-26 | 2019-08-01 | Roche Innovation Center Copenhagen A/S | Oligonucleotides for modulating csnk1d expression |
| US11666578B2 (en) | 2018-05-08 | 2023-06-06 | The University Of Florida Research Foundation, Inc. | Small molecule inhibitors of CDK12/CDK13 |
| AU2019325593A1 (en) * | 2018-08-22 | 2021-03-18 | Merck Patent Gmbh | Treatment of triple negative breast cancer with targeted TGF-B inhibition |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9493464B2 (en) * | 2012-02-29 | 2016-11-15 | The Scripps Research Institute | Wee1 degradation inhibitors |
| ES2638179T3 (es) * | 2013-01-16 | 2017-10-19 | Signal Pharmaceuticals, Llc | Compuestos de pirrolopirimidina sustituidos, composiciones de los mismos, y métodos de tratamiento con los mismos |
-
2016
- 2016-10-05 EP EP16855974.8A patent/EP3362452A4/en not_active Withdrawn
- 2016-10-05 US US15/768,257 patent/US10603322B2/en not_active Expired - Fee Related
- 2016-10-05 AU AU2016338639A patent/AU2016338639A1/en not_active Abandoned
- 2016-10-05 CN CN201680071705.XA patent/CN108431006A/zh active Pending
- 2016-10-05 CA CA3001903A patent/CA3001903A1/en not_active Abandoned
- 2016-10-05 WO PCT/US2016/055436 patent/WO2017066055A1/en not_active Ceased
- 2016-10-05 HK HK19101778.5A patent/HK1259409A1/zh unknown
- 2016-10-05 JP JP2018519027A patent/JP2018538241A/ja active Pending
-
2019
- 2019-11-25 US US16/694,380 patent/US20200163972A1/en not_active Abandoned