JP2018537503A - 末梢神経障害を治療するための方法及び組成物 - Google Patents

末梢神経障害を治療するための方法及び組成物 Download PDF

Info

Publication number
JP2018537503A
JP2018537503A JP2018531499A JP2018531499A JP2018537503A JP 2018537503 A JP2018537503 A JP 2018537503A JP 2018531499 A JP2018531499 A JP 2018531499A JP 2018531499 A JP2018531499 A JP 2018531499A JP 2018537503 A JP2018537503 A JP 2018537503A
Authority
JP
Japan
Prior art keywords
percent
composition
weight
acid
amount
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2018531499A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018537503A5 (enExample
Inventor
フランガキス，クリスト，ジェイ．
ウィルキソン，ウィリアム
ブユクティムキン，セルヴェット
ブユクティムキン，ナディール
イェーガー，ジェームズ，エル．
Original Assignee
アケリオス セラピューティクス，インコーポレーテッド
アケリオス セラピューティクス，インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アケリオス セラピューティクス，インコーポレーテッド, アケリオス セラピューティクス，インコーポレーテッド filed Critical アケリオス セラピューティクス，インコーポレーテッド
Publication of JP2018537503A publication Critical patent/JP2018537503A/ja
Publication of JP2018537503A5 publication Critical patent/JP2018537503A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2018531499A 2015-12-16 2016-12-16 末梢神経障害を治療するための方法及び組成物 Pending JP2018537503A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562268007P 2015-12-16 2015-12-16
US62/268,007 2015-12-16
PCT/US2016/067276 WO2017106714A1 (en) 2015-12-16 2016-12-16 Methods and compositions for treating peripheral neuropathy

Publications (2)

Publication Number Publication Date
JP2018537503A true JP2018537503A (ja) 2018-12-20
JP2018537503A5 JP2018537503A5 (enExample) 2020-01-30

Family

ID=59057641

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018531499A Pending JP2018537503A (ja) 2015-12-16 2016-12-16 末梢神経障害を治療するための方法及び組成物

Country Status (4)

Country Link
US (1) US20180369174A1 (enExample)
JP (1) JP2018537503A (enExample)
CA (1) CA3045004A1 (enExample)
WO (1) WO2017106714A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017536421A (ja) 2014-12-01 2017-12-07 アケリオス セラピューティクス，インコーポレーテッド 片頭痛及び疼痛に関連する状態を処置するための方法及び組成物
US12005034B2 (en) 2017-04-25 2024-06-11 Algotherapeutix Topical pharmaceutical composition comprising at least amitriptyline, for the treatment of peripheral neuropathic pain
US20200230082A1 (en) * 2017-07-11 2020-07-23 University Of Miami Topical acetaminophen formulations for itch relief
CN112206222A (zh) * 2018-11-09 2021-01-12 北京德默高科医药技术有限公司 含有布洛芬结构类似物的多层经皮给药系统
KR20220066068A (ko) * 2019-08-21 2022-05-23 팀버 파마슈티칼스, 인코포레이티드 활성 제제의 국소 전달을 위한 용매 전달 시스템
FR3108841B1 (fr) 2020-04-06 2023-11-03 Algotherapeutix Composition pharmaceutique topique sous forme de gel aqueux comprenant au moins de l’amitriptyline
EP3907214A1 (en) * 2020-05-04 2021-11-10 Dompe' Farmaceutici S.P.A. Co-crystal of ketoprofen, lysine and gabapentin, pharmaceutical compositions and their medical use
MX2023013853A (es) 2021-05-24 2023-12-08 Medicon Pharmaceuticals Inc Tratamiento del dolor asociado a la neuropatia diabetica periferica.
JP2024520463A (ja) * 2021-05-24 2024-05-24 メディコン ファーマシューティカルズ，インコーポレイテッド 化学療法誘発性末梢神経障害に関連する疼痛の処置
CN117357502B (zh) * 2023-11-26 2024-09-03 重庆医科大学 甲磺酸去铁胺在制备预防或治疗神经病理性疼痛药物中的应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007504197A (ja) * 2003-09-04 2007-03-01 ビオグルト ビオガルデ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディートゲゼルシャフト ホスファチジルセリン塩基の生理学的活性組成物
JP2010502701A (ja) * 2006-09-06 2010-01-28 アイ エス ダブリュ グループ インコーポレイテッド 局所用組成物
JP2012505238A (ja) * 2008-10-08 2012-03-01 カイフィア ファーマシューティカルズ， インコーポレイテッド Ｇａｂａコンジュゲートおよびそれらの使用方法
JP2015531374A (ja) * 2012-09-27 2015-11-02 アケリオス セラピューティクス，インコーポレーテッド 局所ケトプロフェン組成物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU223343B1 (hu) * 1991-05-20 2004-06-28 Novartis Ag. Allil-amin-származékot tartalmazó gyógyászati készítmények és eljárás azok előállítására
US6083996A (en) * 1997-11-05 2000-07-04 Nexmed Holdings, Inc. Topical compositions for NSAI drug delivery
US20130209585A1 (en) * 2012-02-13 2013-08-15 Stanley Kim Topical NMDA Antagonist Formulations for the Treatment of Peripheral Neuropathy
MX2015008021A (es) * 2012-12-21 2016-03-04 Teikoku Pharma Usa Inc Composiciones y metodos para administracion transdermica de hormonas y otros agentes medicos.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007504197A (ja) * 2003-09-04 2007-03-01 ビオグルト ビオガルデ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディートゲゼルシャフト ホスファチジルセリン塩基の生理学的活性組成物
JP2010502701A (ja) * 2006-09-06 2010-01-28 アイ エス ダブリュ グループ インコーポレイテッド 局所用組成物
JP2012505238A (ja) * 2008-10-08 2012-03-01 カイフィア ファーマシューティカルズ， インコーポレイテッド Ｇａｂａコンジュゲートおよびそれらの使用方法
JP2015531374A (ja) * 2012-09-27 2015-11-02 アケリオス セラピューティクス，インコーポレーテッド 局所ケトプロフェン組成物

Also Published As

Publication number Publication date
WO2017106714A1 (en) 2017-06-22
US20180369174A1 (en) 2018-12-27
CA3045004A1 (en) 2017-06-22

Similar Documents

Publication Publication Date Title
JP2018537503A (ja) 末梢神経障害を治療するための方法及び組成物
AU2018256605B2 (en) Benzoquinone Derivative E3330 in Combination with Chemotherapeutic Agents for the Treatment of Cancer and Angiogenesis
EP3049056B1 (en) Antifungal topical composition and methods of treatment
JP6563954B2 (ja) 痛みの緩和のための局所組成物、製造および使用
JP6112867B2 (ja) サキシトキシン誘導体での触覚の喪失の処置
JP5897164B2 (ja) 外用組成物
TR201819658T4 (tr) Akne Lezyonlarını Tedavi Etmek İçin Adapalen Ve Benzoil Peroksit Kombinasyonu
KR102534078B1 (ko) 말초 신경병증 통증의 치료를 위한, 최소한 아미트립틸린을 포함하는 국소 제약학적 조성물
JP2019518795A (ja) 併用化学療法
JP2019006697A (ja) 活性酸素消去剤
JP2019006696A (ja) 活性酸素消去剤
CN103347507A (zh) 用于治疗痤疮的褪黑激素以及抗微生物剂或抗菌剂
WO2014176417A1 (en) Topical preparation for bypassing gi tract, delivery of therapeutics, and trans-epithelial drug delivery system
JP7299683B2 (ja) 皮膚外用組成物
AU2004281521A1 (en) Topical compositions comprising telmesteine for treating dermatological disorders
JP7001356B2 (ja) 皮膚色素沈着抑制剤
AU2004264332B2 (en) Method and composition for treating burned skin
JP2024507266A (ja) ヒドロゲル組成物、ならびに放射線によって引き起こされる皮膚損傷の予防および／または処置におけるその使用
WO2017062837A1 (en) Treatment of skin disorders by topical administration of vegf inhibitors
KR20230026449A (ko) (1s)-1-페닐-2-피리딘-2-일레탄아민의 국소 제형
US20080255238A1 (en) Composition containing a thiourea derivative for preventing or treating pruritic or irritant skin diseases
JP4974526B2 (ja) カンジダ症の予防又は治療用組成物
JP2020100576A (ja) 皮膚外用組成物
JP7299682B2 (ja) 皮膚外用組成物
JP7514598B2 (ja) 皮膚外用組成物

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20191216

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20191216

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20201020

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20210518