JP2018537495A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018537495A5 JP2018537495A5 JP2018531343A JP2018531343A JP2018537495A5 JP 2018537495 A5 JP2018537495 A5 JP 2018537495A5 JP 2018531343 A JP2018531343 A JP 2018531343A JP 2018531343 A JP2018531343 A JP 2018531343A JP 2018537495 A5 JP2018537495 A5 JP 2018537495A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- slurry
- acetone
- mixture
- polymorph
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 **CCc1cc(NC(*)=N)ccc1 Chemical compound **CCc1cc(NC(*)=N)ccc1 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021142864A JP2021191782A (ja) | 2015-12-17 | 2021-09-02 | 置換５，６−ジヒドロ−６−フェニルベンゾ［ｆ］イソキノリン−２−アミンを調製するための方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562268758P | 2015-12-17 | 2015-12-17 | |
| US62/268,758 | 2015-12-17 | ||
| PCT/US2016/067161 WO2017106639A1 (en) | 2015-12-17 | 2016-12-16 | Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021142864A Division JP2021191782A (ja) | 2015-12-17 | 2021-09-02 | 置換５，６−ジヒドロ−６−フェニルベンゾ［ｆ］イソキノリン−２−アミンを調製するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018537495A JP2018537495A (ja) | 2018-12-20 |
| JP2018537495A5 true JP2018537495A5 (https=) | 2020-01-23 |
| JP6940504B2 JP6940504B2 (ja) | 2021-09-29 |
Family
ID=59057623
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018531343A Expired - Fee Related JP6940504B2 (ja) | 2015-12-17 | 2016-12-16 | 置換５，６−ジヒドロ−６−フェニルベンゾ［ｆ］イソキノリン−２−アミンを調製するための方法 |
| JP2021142864A Ceased JP2021191782A (ja) | 2015-12-17 | 2021-09-02 | 置換５，６−ジヒドロ−６−フェニルベンゾ［ｆ］イソキノリン−２−アミンを調製するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021142864A Ceased JP2021191782A (ja) | 2015-12-17 | 2021-09-02 | 置換５，６−ジヒドロ−６−フェニルベンゾ［ｆ］イソキノリン−２−アミンを調製するための方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US9834519B2 (https=) |
| EP (2) | EP4015508A1 (https=) |
| JP (2) | JP6940504B2 (https=) |
| KR (1) | KR20180085814A (https=) |
| CN (2) | CN108602779A (https=) |
| AU (2) | AU2016369520B2 (https=) |
| BR (1) | BR112018012325A2 (https=) |
| CA (1) | CA3006077A1 (https=) |
| EA (1) | EA201891431A1 (https=) |
| HK (1) | HK1255014A1 (https=) |
| IL (1) | IL259557A (https=) |
| MX (2) | MX2020012771A (https=) |
| NZ (1) | NZ742785A (https=) |
| SG (1) | SG11201804601TA (https=) |
| TW (1) | TWI748972B (https=) |
| WO (1) | WO2017106639A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201804601TA (en) * | 2015-12-17 | 2018-07-30 | Arqule Inc | Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine |
| EA036295B1 (ru) | 2015-12-17 | 2020-10-22 | Аркьюл, Инк. | Твердые формы замещенных 5,6-дигидро-6-фенилбензо[f]изохинолин-2-аминовых соединений |
| CN110669015A (zh) * | 2018-07-03 | 2020-01-10 | 上海喀露蓝科技有限公司 | 一种fgfr抑制剂的制备方法 |
| US10878412B2 (en) * | 2019-05-13 | 2020-12-29 | Truist Bank | In-line verification of transactions |
| WO2022053708A1 (en) | 2020-09-14 | 2022-03-17 | Basilea Pharmaceutica International AG | Pharmaceutical combinations for use in the treatment of gastric adenocarcinoma |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US6057329A (en) * | 1996-12-23 | 2000-05-02 | Celltech Therapeutics Limited | Fused polycyclic 2-aminopyrimidine derivatives |
| GB9713087D0 (en) * | 1997-06-20 | 1997-08-27 | Celltech Therapeutics Ltd | Chemical compounds |
| US7786132B2 (en) * | 2004-12-17 | 2010-08-31 | Amgen Inc. | Aminopyrimidine compounds and methods of use |
| EP2079736B1 (en) | 2006-12-29 | 2017-10-18 | Rigel Pharmaceuticals, Inc. | Substituted triazoles useful as axl inhibitors |
| GB2449293A (en) * | 2007-05-17 | 2008-11-19 | Evotec | Compounds having Hsp90 inhibitory activity |
| TWI461410B (zh) * | 2008-12-30 | 2014-11-21 | Arqule Inc | 經取代之５，６－二氫－６－苯基苯並〔f〕異喹啉－２－胺化合物類 |
| CN103476770B (zh) | 2010-11-25 | 2017-02-15 | 拉蒂欧制药有限责任公司 | 阿法替尼盐和多晶型物 |
| US8815854B2 (en) | 2011-06-24 | 2014-08-26 | Arqule, Inc. | Substituted imidazopyridinyl compounds |
| SG11201607772WA (en) * | 2014-03-31 | 2016-10-28 | Debiopharm Int Sa | Fgfr fusions |
| SG11201804601TA (en) * | 2015-12-17 | 2018-07-30 | Arqule Inc | Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine |
| EA036295B1 (ru) | 2015-12-17 | 2020-10-22 | Аркьюл, Инк. | Твердые формы замещенных 5,6-дигидро-6-фенилбензо[f]изохинолин-2-аминовых соединений |
-
2016
- 2016-12-16 SG SG11201804601TA patent/SG11201804601TA/en unknown
- 2016-12-16 EP EP21216064.2A patent/EP4015508A1/en active Pending
- 2016-12-16 WO PCT/US2016/067161 patent/WO2017106639A1/en not_active Ceased
- 2016-12-16 KR KR1020187020433A patent/KR20180085814A/ko not_active Ceased
- 2016-12-16 HK HK18114135.7A patent/HK1255014A1/zh unknown
- 2016-12-16 BR BR112018012325A patent/BR112018012325A2/pt not_active Application Discontinuation
- 2016-12-16 TW TW105141874A patent/TWI748972B/zh not_active IP Right Cessation
- 2016-12-16 CA CA3006077A patent/CA3006077A1/en active Pending
- 2016-12-16 CN CN201680081965.5A patent/CN108602779A/zh active Pending
- 2016-12-16 AU AU2016369520A patent/AU2016369520B2/en not_active Ceased
- 2016-12-16 MX MX2020012771A patent/MX2020012771A/es unknown
- 2016-12-16 US US15/381,418 patent/US9834519B2/en active Active
- 2016-12-16 EA EA201891431A patent/EA201891431A1/ru unknown
- 2016-12-16 MX MX2018007415A patent/MX385672B/es unknown
- 2016-12-16 NZ NZ742785A patent/NZ742785A/en not_active IP Right Cessation
- 2016-12-16 JP JP2018531343A patent/JP6940504B2/ja not_active Expired - Fee Related
- 2016-12-16 EP EP16876767.1A patent/EP3390368A4/en not_active Withdrawn
- 2016-12-16 CN CN202210565751.2A patent/CN114874149A/zh active Pending
-
2017
- 2017-11-01 US US15/800,648 patent/US10093632B2/en active Active
-
2018
- 2018-05-23 IL IL259557A patent/IL259557A/en unknown
-
2019
- 2019-04-22 US US16/390,205 patent/US10766868B2/en not_active Expired - Fee Related
- 2019-10-03 US US16/592,003 patent/US11279679B2/en active Active
-
2021
- 2021-04-28 AU AU2021202610A patent/AU2021202610B2/en not_active Ceased
- 2021-09-02 JP JP2021142864A patent/JP2021191782A/ja not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018537495A5 (https=) | ||
| JP6439050B2 (ja) | Ａｓｋ１阻害剤を調製するプロセス | |
| JP2022043078A5 (https=) | ||
| JP2006517546A5 (https=) | ||
| JP2012521377A5 (https=) | ||
| JP2019516692A5 (https=) | ||
| JP2014512451A5 (https=) | ||
| JP2018502909A5 (https=) | ||
| CN103804348A (zh) | 一种亲电三氟甲硫基试剂、合成方法及其应用 | |
| CN106632014B (zh) | 一种2-氨基-5-氯吡啶的制备方法 | |
| CN109694379A (zh) | 用于制备艾日布林的中间体及其制备方法 | |
| WO2018061032A1 (en) | Twelve-armed hexaphenylbenzene-based giant supramolecular sponge for molecular inclusion and process for preparation thereof | |
| CN106431979B (zh) | 一种2-硝基-4-三氟甲基苯腈的制备方法 | |
| CN107235970B (zh) | 一种氯噻啉的合成方法 | |
| CN105199017A (zh) | 一种Cs-CD-MOFs化合物及其制备方法 | |
| CN104016954B (zh) | 奈必洛尔中间体的制备及纯化方法 | |
| JP2018520134A5 (https=) | ||
| JP5452165B2 (ja) | キヌクリジン類の製造法 | |
| CN104447447A (zh) | 一个新的化合物及其制备方法和消除方法 | |
| JP2016525094A5 (https=) | ||
| JP5941338B2 (ja) | トリフルオロメチル化剤、その製造方法並びにそれを用いたトリフルオロメチル基含有化合物の製造方法 | |
| CN108690018B (zh) | 一种咪唑并[1,2-a]吡啶衍生物的制备方法 | |
| CN104788330B (zh) | 一种手性双l‑亮氨酸盐酸盐的制备及合成方法 | |
| CN103910668B (zh) | 一种3‑烷基吲哚的制备方法 | |
| Ligny et al. | One-step synthesis of conjugated enynenitriles from bromocyanoacetylene |