IL259557A - Methods for the preparation of modified 6,5-dihydro-6-phenyl-benzo[f]isoquinoline-2-amine - Google Patents

Methods for the preparation of modified 6,5-dihydro-6-phenyl-benzo[f]isoquinoline-2-amine

Info

Publication number
IL259557A
IL259557A IL259557A IL25955718A IL259557A IL 259557 A IL259557 A IL 259557A IL 259557 A IL259557 A IL 259557A IL 25955718 A IL25955718 A IL 25955718A IL 259557 A IL259557 A IL 259557A
Authority
IL
Israel
Prior art keywords
phenylbenzo
isoquinolin
dihydro
amine
methods
Prior art date
Application number
IL259557A
Other languages
English (en)
Hebrew (he)
Original Assignee
Arqule Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arqule Inc filed Critical Arqule Inc
Publication of IL259557A publication Critical patent/IL259557A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL259557A 2015-12-17 2018-05-23 Methods for the preparation of modified 6,5-dihydro-6-phenyl-benzo[f]isoquinoline-2-amine IL259557A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562268758P 2015-12-17 2015-12-17
PCT/US2016/067161 WO2017106639A1 (en) 2015-12-17 2016-12-16 Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine

Publications (1)

Publication Number Publication Date
IL259557A true IL259557A (en) 2018-07-31

Family

ID=59057623

Family Applications (1)

Application Number Title Priority Date Filing Date
IL259557A IL259557A (en) 2015-12-17 2018-05-23 Methods for the preparation of modified 6,5-dihydro-6-phenyl-benzo[f]isoquinoline-2-amine

Country Status (16)

Country Link
US (4) US9834519B2 (https=)
EP (2) EP3390368A4 (https=)
JP (2) JP6940504B2 (https=)
KR (1) KR20180085814A (https=)
CN (2) CN114874149A (https=)
AU (2) AU2016369520B2 (https=)
BR (1) BR112018012325A2 (https=)
CA (1) CA3006077A1 (https=)
EA (1) EA201891431A1 (https=)
HK (1) HK1255014A1 (https=)
IL (1) IL259557A (https=)
MX (2) MX2020012771A (https=)
NZ (1) NZ742785A (https=)
SG (1) SG11201804601TA (https=)
TW (1) TWI748972B (https=)
WO (1) WO2017106639A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3006077A1 (en) 2015-12-17 2017-06-22 Arqule, Inc. Methods for preparing polymorphs of substituted 5,6-dihydrobenzo[h]quinazolin-2-amine
IL259556B2 (en) * 2015-12-17 2023-09-01 Arqule Inc Solid forms of substituted 6,5-dihydro-6-phenyl-benzo[f]isoquinoline-2-amine compounds
CN110669015A (zh) * 2018-07-03 2020-01-10 上海喀露蓝科技有限公司 一种fgfr抑制剂的制备方法
US10878412B2 (en) * 2019-05-13 2020-12-29 Truist Bank In-line verification of transactions
WO2022053708A1 (en) 2020-09-14 2022-03-17 Basilea Pharmaceutica International AG Pharmaceutical combinations for use in the treatment of gastric adenocarcinoma

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
EP0946523A1 (en) * 1996-12-23 1999-10-06 Celltech Therapeutics Limited Fused polycyclic 2-aminopyrimidine derivatives, their preparation and their use as protein tyrosine kinase inhibitors
GB9713087D0 (en) * 1997-06-20 1997-08-27 Celltech Therapeutics Ltd Chemical compounds
EP1831207B1 (en) 2004-12-17 2012-11-14 Amgen Inc. Aminopyrimidine compounds as plk inhibitors
JP2010514810A (ja) 2006-12-29 2010-05-06 ライジェル ファーマシューティカルズ， インコーポレイテッド Ａｘｌインヒビターとして有用な置換トリアゾール
GB2449293A (en) * 2007-05-17 2008-11-19 Evotec Compounds having Hsp90 inhibitory activity
TWI461410B (zh) * 2008-12-30 2014-11-21 Arqule Inc 經取代之５，６－二氫－６－苯基苯並〔f〕異喹啉－２－胺化合物類
US9012464B2 (en) 2010-11-25 2015-04-21 Ratiopharm Gmbh Salts and polymorphic forms of Afatinib
WO2012177852A1 (en) * 2011-06-24 2012-12-27 Arqule, Inc Substituted imidazopyridinyl compounds
CN106459993A (zh) * 2014-03-31 2017-02-22 德彪药业国际股份公司 Fgfr融合体
CA3006077A1 (en) * 2015-12-17 2017-06-22 Arqule, Inc. Methods for preparing polymorphs of substituted 5,6-dihydrobenzo[h]quinazolin-2-amine
IL259556B2 (en) 2015-12-17 2023-09-01 Arqule Inc Solid forms of substituted 6,5-dihydro-6-phenyl-benzo[f]isoquinoline-2-amine compounds

Also Published As

Publication number Publication date
US20180065937A1 (en) 2018-03-08
BR112018012325A2 (pt) 2018-12-04
WO2017106639A1 (en) 2017-06-22
JP6940504B2 (ja) 2021-09-29
SG11201804601TA (en) 2018-07-30
US20170174637A1 (en) 2017-06-22
US10093632B2 (en) 2018-10-09
NZ742785A (en) 2023-06-30
US20200102276A1 (en) 2020-04-02
HK1255014A1 (zh) 2019-08-02
US11279679B2 (en) 2022-03-22
EP3390368A4 (en) 2019-07-03
US9834519B2 (en) 2017-12-05
MX2020012771A (es) 2022-10-04
KR20180085814A (ko) 2018-07-27
US20190241527A1 (en) 2019-08-08
TWI748972B (zh) 2021-12-11
MX2018007415A (es) 2018-11-09
MX385672B (es) 2025-03-18
AU2021202610B2 (en) 2022-06-02
EP3390368A1 (en) 2018-10-24
JP2018537495A (ja) 2018-12-20
CA3006077A1 (en) 2017-06-22
EA201891431A1 (ru) 2018-11-30
US10766868B2 (en) 2020-09-08
AU2016369520B2 (en) 2021-02-18
AU2016369520A1 (en) 2018-06-07
CN108602779A (zh) 2018-09-28
TW201733992A (zh) 2017-10-01
JP2021191782A (ja) 2021-12-16
EP4015508A1 (en) 2022-06-22
AU2021202610A1 (en) 2021-05-27
CN114874149A (zh) 2022-08-09

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