BR112018012325A2 - métodos para a preparação de 5,6-di-hidro-6-fenilbenzo[f]isoquinolin-2-amina substituída - Google Patents

métodos para a preparação de 5,6-di-hidro-6-fenilbenzo[f]isoquinolin-2-amina substituída

Info

Publication number
BR112018012325A2
BR112018012325A2 BR112018012325A BR112018012325A BR112018012325A2 BR 112018012325 A2 BR112018012325 A2 BR 112018012325A2 BR 112018012325 A BR112018012325 A BR 112018012325A BR 112018012325 A BR112018012325 A BR 112018012325A BR 112018012325 A2 BR112018012325 A2 BR 112018012325A2
Authority
BR
Brazil
Prior art keywords
methods
phenylbenzo
isoquinolin
dihydro
amine
Prior art date
Application number
BR112018012325A
Other languages
English (en)
Portuguese (pt)
Inventor
Bates Craig
P Reed David
Mao Jianmin
Original Assignee
Arqule Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arqule Inc filed Critical Arqule Inc
Publication of BR112018012325A2 publication Critical patent/BR112018012325A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BR112018012325A 2015-12-17 2016-12-16 métodos para a preparação de 5,6-di-hidro-6-fenilbenzo[f]isoquinolin-2-amina substituída BR112018012325A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562268758P 2015-12-17 2015-12-17
PCT/US2016/067161 WO2017106639A1 (en) 2015-12-17 2016-12-16 Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine

Publications (1)

Publication Number Publication Date
BR112018012325A2 true BR112018012325A2 (pt) 2018-12-04

Family

ID=59057623

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018012325A BR112018012325A2 (pt) 2015-12-17 2016-12-16 métodos para a preparação de 5,6-di-hidro-6-fenilbenzo[f]isoquinolin-2-amina substituída

Country Status (16)

Country Link
US (4) US9834519B2 (https=)
EP (2) EP4015508A1 (https=)
JP (2) JP6940504B2 (https=)
KR (1) KR20180085814A (https=)
CN (2) CN108602779A (https=)
AU (2) AU2016369520B2 (https=)
BR (1) BR112018012325A2 (https=)
CA (1) CA3006077A1 (https=)
EA (1) EA201891431A1 (https=)
HK (1) HK1255014A1 (https=)
IL (1) IL259557A (https=)
MX (2) MX2020012771A (https=)
NZ (1) NZ742785A (https=)
SG (1) SG11201804601TA (https=)
TW (1) TWI748972B (https=)
WO (1) WO2017106639A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201804601TA (en) * 2015-12-17 2018-07-30 Arqule Inc Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine
EA036295B1 (ru) 2015-12-17 2020-10-22 Аркьюл, Инк. Твердые формы замещенных 5,6-дигидро-6-фенилбензо[f]изохинолин-2-аминовых соединений
CN110669015A (zh) * 2018-07-03 2020-01-10 上海喀露蓝科技有限公司 一种fgfr抑制剂的制备方法
US10878412B2 (en) * 2019-05-13 2020-12-29 Truist Bank In-line verification of transactions
WO2022053708A1 (en) 2020-09-14 2022-03-17 Basilea Pharmaceutica International AG Pharmaceutical combinations for use in the treatment of gastric adenocarcinoma

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US6057329A (en) * 1996-12-23 2000-05-02 Celltech Therapeutics Limited Fused polycyclic 2-aminopyrimidine derivatives
GB9713087D0 (en) * 1997-06-20 1997-08-27 Celltech Therapeutics Ltd Chemical compounds
US7786132B2 (en) * 2004-12-17 2010-08-31 Amgen Inc. Aminopyrimidine compounds and methods of use
EP2079736B1 (en) 2006-12-29 2017-10-18 Rigel Pharmaceuticals, Inc. Substituted triazoles useful as axl inhibitors
GB2449293A (en) * 2007-05-17 2008-11-19 Evotec Compounds having Hsp90 inhibitory activity
TWI461410B (zh) * 2008-12-30 2014-11-21 Arqule Inc 經取代之５，６－二氫－６－苯基苯並〔f〕異喹啉－２－胺化合物類
CN103476770B (zh) 2010-11-25 2017-02-15 拉蒂欧制药有限责任公司 阿法替尼盐和多晶型物
US8815854B2 (en) 2011-06-24 2014-08-26 Arqule, Inc. Substituted imidazopyridinyl compounds
SG11201607772WA (en) * 2014-03-31 2016-10-28 Debiopharm Int Sa Fgfr fusions
SG11201804601TA (en) * 2015-12-17 2018-07-30 Arqule Inc Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine
EA036295B1 (ru) 2015-12-17 2020-10-22 Аркьюл, Инк. Твердые формы замещенных 5,6-дигидро-6-фенилбензо[f]изохинолин-2-аминовых соединений

Also Published As

Publication number Publication date
CN114874149A (zh) 2022-08-09
US20200102276A1 (en) 2020-04-02
NZ742785A (en) 2023-06-30
KR20180085814A (ko) 2018-07-27
AU2021202610B2 (en) 2022-06-02
WO2017106639A1 (en) 2017-06-22
US10093632B2 (en) 2018-10-09
HK1255014A1 (zh) 2019-08-02
US20180065937A1 (en) 2018-03-08
CA3006077A1 (en) 2017-06-22
IL259557A (en) 2018-07-31
JP2018537495A (ja) 2018-12-20
US10766868B2 (en) 2020-09-08
US9834519B2 (en) 2017-12-05
AU2016369520B2 (en) 2021-02-18
MX385672B (es) 2025-03-18
TWI748972B (zh) 2021-12-11
AU2016369520A1 (en) 2018-06-07
SG11201804601TA (en) 2018-07-30
US20170174637A1 (en) 2017-06-22
AU2021202610A1 (en) 2021-05-27
MX2020012771A (es) 2022-10-04
MX2018007415A (es) 2018-11-09
JP2021191782A (ja) 2021-12-16
EP4015508A1 (en) 2022-06-22
US20190241527A1 (en) 2019-08-08
TW201733992A (zh) 2017-10-01
US11279679B2 (en) 2022-03-22
EP3390368A1 (en) 2018-10-24
EP3390368A4 (en) 2019-07-03
CN108602779A (zh) 2018-09-28
JP6940504B2 (ja) 2021-09-29
EA201891431A1 (ru) 2018-11-30

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]