JP2018536707A5 - - Google Patents
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- JP2018536707A5 JP2018536707A5 JP2018543001A JP2018543001A JP2018536707A5 JP 2018536707 A5 JP2018536707 A5 JP 2018536707A5 JP 2018543001 A JP2018543001 A JP 2018543001A JP 2018543001 A JP2018543001 A JP 2018543001A JP 2018536707 A5 JP2018536707 A5 JP 2018536707A5
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- 239000000203 mixture Substances 0.000 claims description 131
- 238000000034 method Methods 0.000 claims description 43
- 239000011248 coating agent Substances 0.000 claims description 29
- 238000000576 coating method Methods 0.000 claims description 29
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 26
- 239000003826 tablet Substances 0.000 claims description 25
- 238000007906 compression Methods 0.000 claims description 23
- 230000006835 compression Effects 0.000 claims description 22
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 20
- 229960000894 sulindac Drugs 0.000 claims description 16
- MLKXDPUZXIRXEP-MFOYZWKCSA-N sulindac Chemical compound CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(S(C)=O)C=C1 MLKXDPUZXIRXEP-MFOYZWKCSA-N 0.000 claims description 16
- FJPAMFNRCFEGSD-UHFFFAOYSA-N eflornithine hydrochloride monohydrate Chemical compound O.Cl.NCCCC(N)(C(F)F)C(O)=O FJPAMFNRCFEGSD-UHFFFAOYSA-N 0.000 claims description 13
- 235000019359 magnesium stearate Nutrition 0.000 claims description 13
- 239000000314 lubricant Substances 0.000 claims description 10
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 claims description 8
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 8
- 229940000425 combination drug Drugs 0.000 claims description 8
- 206010028980 Neoplasm Diseases 0.000 claims description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 7
- 201000011510 cancer Diseases 0.000 claims description 7
- 229940075614 colloidal silicon dioxide Drugs 0.000 claims description 7
- 201000010099 disease Diseases 0.000 claims description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
- GUBGYTABKSRVRQ-UHFFFAOYSA-N 2-(hydroxymethyl)-6-[4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol Chemical compound OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O GUBGYTABKSRVRQ-UHFFFAOYSA-N 0.000 claims description 6
- 239000002202 Polyethylene glycol Substances 0.000 claims description 6
- 229920001577 copolymer Polymers 0.000 claims description 6
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 6
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 6
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 6
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 6
- 229920001223 polyethylene glycol Polymers 0.000 claims description 6
- 229920000193 polymethacrylate Polymers 0.000 claims description 6
- DKAGJZJALZXOOV-UHFFFAOYSA-N hydrate;hydrochloride Chemical compound O.Cl DKAGJZJALZXOOV-UHFFFAOYSA-N 0.000 claims description 5
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 4
- 229920000623 Cellulose acetate phthalate Polymers 0.000 claims description 4
- 206010009944 Colon cancer Diseases 0.000 claims description 4
- 229940081734 cellulose acetate phthalate Drugs 0.000 claims description 4
- 208000029742 colonic neoplasm Diseases 0.000 claims description 4
- IWVKTOUOPHGZRX-UHFFFAOYSA-M methyl 2-methylprop-2-enoate;2-methylprop-2-enoate Chemical compound CC(=C)C([O-])=O.COC(=O)C(C)=C IWVKTOUOPHGZRX-UHFFFAOYSA-M 0.000 claims description 4
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims description 4
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims description 4
- 239000004408 titanium dioxide Substances 0.000 claims description 4
- ARCGXLSVLAOJQL-UHFFFAOYSA-N trimellitic acid Chemical compound OC(=O)C1=CC=C(C(O)=O)C(C(O)=O)=C1 ARCGXLSVLAOJQL-UHFFFAOYSA-N 0.000 claims description 4
- 239000002702 enteric coating Substances 0.000 claims description 3
- 238000009505 enteric coating Methods 0.000 claims description 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims description 2
- 206010006187 Breast cancer Diseases 0.000 claims description 2
- 208000026310 Breast neoplasm Diseases 0.000 claims description 2
- 201000006107 Familial adenomatous polyposis Diseases 0.000 claims description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
- 206010029260 Neuroblastoma Diseases 0.000 claims description 2
- 206010033128 Ovarian cancer Diseases 0.000 claims description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 2
- 206010060862 Prostate cancer Diseases 0.000 claims description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 2
- 208000024313 Testicular Neoplasms Diseases 0.000 claims description 2
- 206010057644 Testis cancer Diseases 0.000 claims description 2
- ZUAAPNNKRHMPKG-UHFFFAOYSA-N acetic acid;butanedioic acid;methanol;propane-1,2-diol Chemical compound OC.CC(O)=O.CC(O)CO.OC(=O)CCC(O)=O ZUAAPNNKRHMPKG-UHFFFAOYSA-N 0.000 claims description 2
- CEGOLXSVJUTHNZ-UHFFFAOYSA-K aluminium tristearate Chemical compound [Al+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CEGOLXSVJUTHNZ-UHFFFAOYSA-K 0.000 claims description 2
- 229940063655 aluminum stearate Drugs 0.000 claims description 2
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 2
- 239000004327 boric acid Substances 0.000 claims description 2
- SXFILQHETIJGQZ-UHFFFAOYSA-N but-3-enoic acid;phthalic acid Chemical compound OC(=O)CC=C.OC(=O)C1=CC=CC=C1C(O)=O SXFILQHETIJGQZ-UHFFFAOYSA-N 0.000 claims description 2
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims description 2
- 235000013539 calcium stearate Nutrition 0.000 claims description 2
- 239000008116 calcium stearate Substances 0.000 claims description 2
- 229940078456 calcium stearate Drugs 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 229920002301 cellulose acetate Polymers 0.000 claims description 2
- 208000029664 classic familial adenomatous polyposis Diseases 0.000 claims description 2
- 239000006071 cream Substances 0.000 claims description 2
- GDCRSXZBSIRSFR-UHFFFAOYSA-N ethyl prop-2-enoate;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.CCOC(=O)C=C GDCRSXZBSIRSFR-UHFFFAOYSA-N 0.000 claims description 2
- 239000006260 foam Substances 0.000 claims description 2
- 206010017758 gastric cancer Diseases 0.000 claims description 2
- 229940075507 glyceryl monostearate Drugs 0.000 claims description 2
- 239000008187 granular material Substances 0.000 claims description 2
- 201000005787 hematologic cancer Diseases 0.000 claims description 2
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 201000007270 liver cancer Diseases 0.000 claims description 2
- 208000014018 liver neoplasm Diseases 0.000 claims description 2
- 201000005202 lung cancer Diseases 0.000 claims description 2
- 208000020816 lung neoplasm Diseases 0.000 claims description 2
- 229940057948 magnesium stearate Drugs 0.000 claims description 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000002207 metabolite Substances 0.000 claims description 2
- 239000008185 minitablet Substances 0.000 claims description 2
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims description 2
- 201000002528 pancreatic cancer Diseases 0.000 claims description 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 2
- 239000008188 pellet Substances 0.000 claims description 2
- 229920002689 polyvinyl acetate Polymers 0.000 claims description 2
- 239000011118 polyvinyl acetate Substances 0.000 claims description 2
- 201000000849 skin cancer Diseases 0.000 claims description 2
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 2
- 239000004299 sodium benzoate Substances 0.000 claims description 2
- 235000010234 sodium benzoate Nutrition 0.000 claims description 2
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 claims description 2
- 229940080350 sodium stearate Drugs 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 201000011549 stomach cancer Diseases 0.000 claims description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims description 2
- 201000003120 testicular cancer Diseases 0.000 claims description 2
- GLVYLTSKTCWWJR-UHFFFAOYSA-N 2-carbonoperoxoylbenzoic acid Chemical compound OOC(=O)C1=CC=CC=C1C(O)=O GLVYLTSKTCWWJR-UHFFFAOYSA-N 0.000 claims 1
- 238000013270 controlled release Methods 0.000 claims 1
- 210000003238 esophagus Anatomy 0.000 claims 1
- 229960002759 eflornithine Drugs 0.000 description 2
- VLCYCQAOQCDTCN-UHFFFAOYSA-N eflornithine Chemical compound NCCCC(N)(C(F)F)C(O)=O VLCYCQAOQCDTCN-UHFFFAOYSA-N 0.000 description 2
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 2
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 2
- 208000000461 Esophageal Neoplasms Diseases 0.000 description 1
- 206010020864 Hypertrichosis Diseases 0.000 description 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 201000004101 esophageal cancer Diseases 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021186911A JP7592001B2 (ja) | 2015-10-30 | 2021-11-17 | エフロルニチンとスリンダクの固定用量複合製剤 |
| JP2024079276A JP2024102339A (ja) | 2015-10-30 | 2024-05-15 | エフロルニチンとスリンダクの固定用量複合製剤 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562248810P | 2015-10-30 | 2015-10-30 | |
| US62/248,810 | 2015-10-30 | ||
| US201662358698P | 2016-07-06 | 2016-07-06 | |
| US62/358,698 | 2016-07-06 | ||
| EP16306429.8 | 2016-10-28 | ||
| EP16306429 | 2016-10-28 | ||
| EP16306430 | 2016-10-28 | ||
| EP16306430.6 | 2016-10-28 | ||
| PCT/US2016/059689 WO2017075576A1 (en) | 2015-10-30 | 2016-10-31 | Eflornithine and sulindac, fixed dose combination formulation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021186911A Division JP7592001B2 (ja) | 2015-10-30 | 2021-11-17 | エフロルニチンとスリンダクの固定用量複合製剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018536707A JP2018536707A (ja) | 2018-12-13 |
| JP2018536707A5 true JP2018536707A5 (enExample) | 2019-12-05 |
Family
ID=57256487
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018543001A Withdrawn JP2018536707A (ja) | 2015-10-30 | 2016-10-31 | エフロルニチンとスリンダクの固定用量複合製剤 |
| JP2021186911A Active JP7592001B2 (ja) | 2015-10-30 | 2021-11-17 | エフロルニチンとスリンダクの固定用量複合製剤 |
| JP2024079276A Pending JP2024102339A (ja) | 2015-10-30 | 2024-05-15 | エフロルニチンとスリンダクの固定用量複合製剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021186911A Active JP7592001B2 (ja) | 2015-10-30 | 2021-11-17 | エフロルニチンとスリンダクの固定用量複合製剤 |
| JP2024079276A Pending JP2024102339A (ja) | 2015-10-30 | 2024-05-15 | エフロルニチンとスリンダクの固定用量複合製剤 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US10973790B2 (enExample) |
| EP (1) | EP3368029A1 (enExample) |
| JP (3) | JP2018536707A (enExample) |
| KR (3) | KR20260033630A (enExample) |
| CN (1) | CN108366982A (enExample) |
| AU (1) | AU2016343851B2 (enExample) |
| BR (1) | BR112018008651A2 (enExample) |
| CA (1) | CA3003149C (enExample) |
| CL (1) | CL2018001157A1 (enExample) |
| CO (1) | CO2018005491A2 (enExample) |
| HK (1) | HK1258284A1 (enExample) |
| IL (1) | IL259009A (enExample) |
| MA (1) | MA43114A (enExample) |
| MX (1) | MX390899B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3003149C (en) | 2015-10-30 | 2023-10-31 | Cancer Prevention Pharmaceuticals, Inc. | Eflornithine and sulindac, fixed dose combination formulation |
| ES3058652T3 (en) | 2016-10-06 | 2026-03-12 | Orbus Therapeutics Inc | Formulations for administration of eflornithine |
| WO2020236562A1 (en) * | 2019-05-17 | 2020-11-26 | Cancer Prevention Pharmaceuticals, Inc. | Methods for treating familial adenomatous polyposis |
| US12605349B2 (en) | 2024-09-05 | 2026-04-21 | Orbus Therapeutics, Inc. | Methods of treating grade 3 astrocytoma |
| CN119909027B (zh) * | 2025-01-21 | 2025-11-18 | 福安药业集团宁波天衡制药有限公司 | 一种稳定的舒林酸片及其制备方法 |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4309442A (en) * | 1977-07-11 | 1982-01-05 | Merrell Toraude Et Compagnie | Method for controlling fertility in mammals |
| US4413141A (en) | 1977-07-11 | 1983-11-01 | Merrell Toraude Et Compagnie | 2-(Difluoromethyl)-2,5-diaminopentanoic acid |
| US4330559A (en) | 1977-07-11 | 1982-05-18 | Merrell-Toraude Et Cie | Method of treating benign prostatic hypertrophy |
| US4499072A (en) | 1982-11-29 | 1985-02-12 | Merrell Dow Pharmaceuticals Inc. | Process for treating diseases with ODC inhibitors |
| US4859452A (en) | 1986-01-17 | 1989-08-22 | Board Of Regents, The University Of Texas System | Methods for the reduction of difluoromethylornithine associated toxicity |
| US4925835A (en) | 1986-05-01 | 1990-05-15 | Sloan-Kettering Institute For Cancer Research | Aziridinyl putrescine containing compositions and their uses in treating prostate cancer |
| US5002879A (en) | 1986-05-06 | 1991-03-26 | Merrell Dow Pharmaceuticals | Treatment of tumors with autologous LAK cells, interleukin-2 and an ornithine decarboxylase inhibitor |
| FR2706255B1 (fr) | 1993-06-17 | 1995-10-27 | Univ Rennes | Composition à usage alimentaire et/ou pharmaceutique pauvre en polyamines et applications thérapeutiques. |
| US5843929A (en) | 1996-03-22 | 1998-12-01 | Mayo Foundation For Medical Education And Research | Chemoprevention of metachronous adenomatous colorectal polyps |
| JP2000507613A (ja) * | 1996-11-01 | 2000-06-20 | アイレックス・オンコロジー・インコーポレイテッド | Ｄｆｍｏ含有持続放出配合物 |
| US6486214B1 (en) | 1997-09-10 | 2002-11-26 | Rutgers, The State University Of New Jersey | Polyanhydride linkers for production of drug polymers and drug polymer compositions produced thereby |
| CA2325080A1 (en) | 1998-03-28 | 1999-10-07 | The Regents Of The University Of California | Dfmo and sulindac combination in cancer chemoprevention |
| US7700568B2 (en) | 1998-06-30 | 2010-04-20 | Sloan-Kettering Institute For Cancer Research | Uses of DNA-PK |
| US20050037090A1 (en) | 1998-12-23 | 2005-02-17 | Mckearn John P. | Combination therapy including a cyclooxygenase-2 inhibitor and an antineoplastic agent |
| CN1398189A (zh) | 1998-12-23 | 2003-02-19 | G.D.西尔公司 | 用于治疗肿瘤形成的放疗与cox－2抑制剂的联合治疗 |
| US6753422B2 (en) | 1999-03-01 | 2004-06-22 | O'brien Thomas G. | Odc allelic analysis method for assessing carcinogenic susceptibility |
| AU5140300A (en) | 1999-05-17 | 2000-12-05 | Ilex Oncology, Inc. | Dfmo and celecoxib in combination for cancer chemoprevention and therapy |
| US6602910B2 (en) | 2000-03-07 | 2003-08-05 | Ilex Oncology, Inc. | D-enantiomer of DFMO and methods of use therefor |
| WO2001068076A2 (en) | 2000-03-07 | 2001-09-20 | Ilex Oncology, Inc. | D-enantiomer of dfmo and methods of use thereof for treating cancer |
| WO2002015895A2 (en) | 2000-08-24 | 2002-02-28 | The Regents Of The University Of California | Alpha-difluoromethylornithine (dfmo) use in the human prostate |
| GB0125492D0 (en) * | 2001-10-24 | 2001-12-12 | Astrazeneca Ab | Formulation |
| AU2002343609B2 (en) | 2001-11-16 | 2008-12-11 | Als Therapy Development Foundation, Inc. | Treatment of neurodegenerative disorders through the modulation of the polyamine pathway |
| MXPA05005781A (es) * | 2002-11-29 | 2005-12-12 | Forest Laboratories | Combinacion de ibuprofeno y oxicodona para alivio de dolor agudo. |
| US20100009929A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof |
| CA2615496C (en) * | 2005-07-18 | 2014-11-18 | Horizon Therapeutics, Inc. | Medicaments containing famotidine and ibuprofen and administration of same |
| WO2007075673A1 (en) | 2005-12-20 | 2007-07-05 | University Of Hawaii | Treatment regimen for n-myc, c-myc, and l-myc amplified and overexpressed tumors |
| EP2438919A1 (en) * | 2006-07-18 | 2012-04-11 | Horizon Pharma USA, Inc. | Compositions comprising famotidine and ibuprofen as well as compositions comprising 25 mg to 28 mg famotidine |
| UA98799C2 (ru) | 2007-07-19 | 2012-06-25 | Такеда Фармасьютикал Компани Лимитед | Твердый препарат, включающий алоглиптин и гидрохлорид метформина |
| WO2009015981A2 (en) | 2007-08-01 | 2009-02-05 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Treatment of pediatric tumors |
| WO2009022670A1 (ja) * | 2007-08-10 | 2009-02-19 | Takeda Pharmaceutical Company Limited | 速崩壊性錠剤 |
| US8283331B2 (en) | 2007-10-09 | 2012-10-09 | Children's Medical Center Corporation | Methods to regulate miRNA processing by targeting Lin-28 |
| WO2009052518A2 (en) * | 2007-10-19 | 2009-04-23 | Aspen Benefits Group, Llc | Methods and compositions directed to reduction of facial hair hirsutism in females |
| EP2259844A4 (en) | 2008-03-05 | 2012-02-01 | Vicus Therapeutics Llc | COMPOSITIONS AND METHODS FOR MUCOSITIS AND ONCOLOGICAL THERAPIES |
| WO2010056919A2 (en) | 2008-11-12 | 2010-05-20 | Kyphia Pharmaceuticals, Inc. | Eflornithine prodrugs, conjugates and salts, and methods of use thereof |
| BRPI0922379B1 (pt) | 2008-12-08 | 2021-08-03 | The Procter & Gamble Company | Composição para cuidados pessoais na forma de um artigo que tem um revestimento hidrofóbico residente de superfície |
| HRP20140887T1 (hr) | 2009-05-14 | 2014-11-21 | Arizona Board Of Regents On Behalf Of University Of Arizona | Dijagnoza karcinoma i lijeäśenje, koje se temelji na odc1 genotipu |
| CN102802729A (zh) | 2009-05-20 | 2012-11-28 | 兰贝克赛实验室有限公司 | 异维a酸的液体剂型 |
| CN101898978A (zh) | 2009-05-31 | 2010-12-01 | 徐锋 | 依氟鸟氨酸前药和偶合物及其使用方法 |
| US20110256161A1 (en) | 2010-04-19 | 2011-10-20 | Aminex Therapeutics Inc. | Methods for enhancing immune response |
| WO2011135459A2 (en) | 2010-04-29 | 2011-11-03 | Medical Prognosis Institute A/S | Methods and devices for predicting treatment efficacy |
| EP2568978B1 (en) | 2010-05-14 | 2019-04-24 | Arizona Board of Regents on Behalf of University of Arizona | Cancer prevention and treatment based on dietary polyamine content |
| US8853423B2 (en) * | 2010-06-17 | 2014-10-07 | Seragon Pharmaceuticals, Inc. | Indane estrogen receptor modulators and uses thereof |
| ES2961381T3 (es) | 2010-06-19 | 2024-03-11 | Memorial Sloan Kettering Cancer Center | Anticuerpos anti-GD2 |
| PT2912193T (pt) | 2012-10-29 | 2018-11-29 | Arizona Board Of Regents On Behalf Of Univ Of Arizona | Marcadores preditivos para terapêuticas de cancro de inibidor de poliamina |
| GB2513299A (en) | 2013-03-12 | 2014-10-29 | Cellact Pharma Gmbh Biomedizinzentrum | Compounds for targeting cancer stem cells |
| RS63570B1 (sr) * | 2013-10-07 | 2022-10-31 | Bristol Myers Squibb Holdings Ireland | Formulacija atazanavira i kobicistata za lečenje hiv-a |
| KR20150079373A (ko) * | 2013-12-30 | 2015-07-08 | 한미약품 주식회사 | 에제티미브 및 로수바스타틴을 포함하는 경구용 복합제제 |
| JP2017519770A (ja) | 2014-06-18 | 2017-07-20 | アリゾナ ボード オブ リージェンツ オン ビハーフ オブ ザ ユニバーシティ オブ アリゾナ | Ｏｄｃ１遺伝子型に基づく癌腫の診断および処置 |
| WO2016130918A1 (en) | 2015-02-12 | 2016-08-18 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Methods for treating neuroblastoma |
| CA3003149C (en) * | 2015-10-30 | 2023-10-31 | Cancer Prevention Pharmaceuticals, Inc. | Eflornithine and sulindac, fixed dose combination formulation |
| WO2017075576A1 (en) | 2015-10-30 | 2017-05-04 | Cancer Prevention Pharmaceuticals, Inc. | Eflornithine and sulindac, fixed dose combination formulation |
-
2016
- 2016-10-31 CA CA3003149A patent/CA3003149C/en active Active
- 2016-10-31 US US15/771,484 patent/US10973790B2/en active Active
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- 2016-10-31 HK HK19100648.5A patent/HK1258284A1/zh unknown
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