CL2018001157A1 - Formulación de combinación de dosis fija, eflornitina y sulindaco. - Google Patents
Formulación de combinación de dosis fija, eflornitina y sulindaco.Info
- Publication number
- CL2018001157A1 CL2018001157A1 CL2018001157A CL2018001157A CL2018001157A1 CL 2018001157 A1 CL2018001157 A1 CL 2018001157A1 CL 2018001157 A CL2018001157 A CL 2018001157A CL 2018001157 A CL2018001157 A CL 2018001157A CL 2018001157 A1 CL2018001157 A1 CL 2018001157A1
- Authority
- CL
- Chile
- Prior art keywords
- fixed dose
- eflornithine
- sulindac
- formulation
- dose combination
- Prior art date
Links
- 229940000425 combination drug Drugs 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- VLCYCQAOQCDTCN-UHFFFAOYSA-N eflornithine Chemical compound NCCCC(N)(C(F)F)C(O)=O VLCYCQAOQCDTCN-UHFFFAOYSA-N 0.000 title 1
- 229960002759 eflornithine Drugs 0.000 title 1
- 238000009472 formulation Methods 0.000 title 1
- MLKXDPUZXIRXEP-MFOYZWKCSA-N sulindac Chemical compound CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(S(C)=O)C=C1 MLKXDPUZXIRXEP-MFOYZWKCSA-N 0.000 title 1
- 229960000894 sulindac Drugs 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 abstract 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2813—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
COMPOSICION QUE COMPRENDE UNA COMBINACION DE DOSIS FIJA DE EFLORNITINA Y UN ANTIINFLAMATORIO NO ESTEROIDEO (NSAID) O UN METABOLITO DEL MISMO, UTIL PARA EL TRATAMIENTO DEL CANCER.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562248810P | 2015-10-30 | 2015-10-30 | |
US201662358698P | 2016-07-06 | 2016-07-06 | |
EP16306430 | 2016-10-28 | ||
EP16306429 | 2016-10-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2018001157A1 true CL2018001157A1 (es) | 2018-09-07 |
Family
ID=57256487
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2018001157A CL2018001157A1 (es) | 2015-10-30 | 2018-04-30 | Formulación de combinación de dosis fija, eflornitina y sulindaco. |
Country Status (14)
Country | Link |
---|---|
US (3) | US10973790B2 (es) |
EP (1) | EP3368029A1 (es) |
JP (2) | JP2018536707A (es) |
KR (1) | KR20180069068A (es) |
CN (1) | CN108366982A (es) |
AU (1) | AU2016343851B2 (es) |
BR (1) | BR112018008651A2 (es) |
CA (1) | CA3003149C (es) |
CL (1) | CL2018001157A1 (es) |
CO (1) | CO2018005491A2 (es) |
HK (1) | HK1258284A1 (es) |
IL (1) | IL259009A (es) |
MA (1) | MA43114A (es) |
MX (1) | MX2018005350A (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3003149C (en) | 2015-10-30 | 2023-10-31 | Cancer Prevention Pharmaceuticals, Inc. | Eflornithine and sulindac, fixed dose combination formulation |
NZ752894A (en) * | 2016-10-06 | 2023-05-26 | Orbus Therapeutics Inc | Formulations for administration of eflornithine |
WO2020236562A1 (en) * | 2019-05-17 | 2020-11-26 | Cancer Prevention Pharmaceuticals, Inc. | Methods for treating familial adenomatous polyposis |
Family Cites Families (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4330559A (en) | 1977-07-11 | 1982-05-18 | Merrell-Toraude Et Cie | Method of treating benign prostatic hypertrophy |
US4309442A (en) * | 1977-07-11 | 1982-01-05 | Merrell Toraude Et Compagnie | Method for controlling fertility in mammals |
US4413141A (en) | 1977-07-11 | 1983-11-01 | Merrell Toraude Et Compagnie | 2-(Difluoromethyl)-2,5-diaminopentanoic acid |
US4499072A (en) | 1982-11-29 | 1985-02-12 | Merrell Dow Pharmaceuticals Inc. | Process for treating diseases with ODC inhibitors |
US4859452A (en) | 1986-01-17 | 1989-08-22 | Board Of Regents, The University Of Texas System | Methods for the reduction of difluoromethylornithine associated toxicity |
US4925835A (en) | 1986-05-01 | 1990-05-15 | Sloan-Kettering Institute For Cancer Research | Aziridinyl putrescine containing compositions and their uses in treating prostate cancer |
US5002879A (en) | 1986-05-06 | 1991-03-26 | Merrell Dow Pharmaceuticals | Treatment of tumors with autologous LAK cells, interleukin-2 and an ornithine decarboxylase inhibitor |
FR2706255B1 (fr) | 1993-06-17 | 1995-10-27 | Univ Rennes | Composition à usage alimentaire et/ou pharmaceutique pauvre en polyamines et applications thérapeutiques. |
US5843929A (en) | 1996-03-22 | 1998-12-01 | Mayo Foundation For Medical Education And Research | Chemoprevention of metachronous adenomatous colorectal polyps |
WO1998019667A1 (en) * | 1996-11-01 | 1998-05-14 | Ilex Oncology, Inc. | Sustained release formulation containing dfmo |
US6486214B1 (en) | 1997-09-10 | 2002-11-26 | Rutgers, The State University Of New Jersey | Polyanhydride linkers for production of drug polymers and drug polymer compositions produced thereby |
US6258845B1 (en) | 1998-03-28 | 2001-07-10 | The Regents Of The University Of California | DFMO and sulindac combination in cancer chemoprevention |
US7700568B2 (en) | 1998-06-30 | 2010-04-20 | Sloan-Kettering Institute For Cancer Research | Uses of DNA-PK |
US20050037090A1 (en) | 1998-12-23 | 2005-02-17 | Mckearn John P. | Combination therapy including a cyclooxygenase-2 inhibitor and an antineoplastic agent |
CZ20012321A3 (cs) | 1998-12-23 | 2002-10-16 | G. D. Searle & Co. | Léčivo s obsahem inhibitoru cyklooxygenázy-2 a inhibitoru matricové metaloproteinázy pro kombinační terapii při léčení neoplasie |
US6753422B2 (en) | 1999-03-01 | 2004-06-22 | O'brien Thomas G. | Odc allelic analysis method for assessing carcinogenic susceptibility |
AU5140300A (en) | 1999-05-17 | 2000-12-05 | Ilex Oncology, Inc. | Dfmo and celecoxib in combination for cancer chemoprevention and therapy |
WO2001068076A2 (en) | 2000-03-07 | 2001-09-20 | Ilex Oncology, Inc. | D-enantiomer of dfmo and methods of use thereof for treating cancer |
US6602910B2 (en) | 2000-03-07 | 2003-08-05 | Ilex Oncology, Inc. | D-enantiomer of DFMO and methods of use therefor |
JP2004506683A (ja) | 2000-08-24 | 2004-03-04 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | α−ジフルオロメチルオルニチン(DFMO)は、ヒト前立腺におけるポリアミンレベルを抑制する |
GB0125492D0 (en) | 2001-10-24 | 2001-12-12 | Astrazeneca Ab | Formulation |
AU2002343609B2 (en) | 2001-11-16 | 2008-12-11 | Als Therapy Development Foundation, Inc. | Treatment of neurodegenerative disorders through the modulation of the polyamine pathway |
JP2006515861A (ja) * | 2002-11-29 | 2006-06-08 | フォレスト ラボラトリーズ インコーポレーテッド | イブプロフェンとオキシコドンを含有する単位剤形での急性痛の治療方法 |
US20100009929A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof |
JP2009501801A (ja) * | 2005-07-18 | 2009-01-22 | ホライゾン セラピューティクス, インコーポレイテッド | イブプロフェンとファモチジンとを含有する医薬およびその投与 |
WO2007075673A1 (en) | 2005-12-20 | 2007-07-05 | University Of Hawaii | Treatment regimen for n-myc, c-myc, and l-myc amplified and overexpressed tumors |
AU2007275360B2 (en) * | 2006-07-18 | 2013-05-16 | Horizon Medicines Llc | Methods and medicaments for administration of ibuprofen |
PE20140923A1 (es) | 2007-07-19 | 2014-08-11 | Takeda Pharmaceutical | Preparacion solida que comprende alogliptina y clorhidrato de metformina |
US8829021B2 (en) | 2007-08-01 | 2014-09-09 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Treatment of pediatric tumors |
WO2009022670A1 (ja) * | 2007-08-10 | 2009-02-19 | Takeda Pharmaceutical Company Limited | 速崩壊性錠剤 |
US8283331B2 (en) | 2007-10-09 | 2012-10-09 | Children's Medical Center Corporation | Methods to regulate miRNA processing by targeting Lin-28 |
CA2753844A1 (en) | 2008-03-05 | 2009-09-11 | Vicus Therapeutics, Llc | Compositions and methods for mucositis and oncology therapies |
US20100120727A1 (en) | 2008-11-12 | 2010-05-13 | Kyphia Pharmaceuticals, Inc. | Eflornithine Prodrugs, Conjugates and Salts, and Methods of Use Thereof |
US20100291165A1 (en) | 2008-12-08 | 2010-11-18 | Glenn Jr Robert Wayne | Personal care composition in the form of an article having a hydrophobic surface-resident coating |
EP2430452B1 (en) | 2009-05-14 | 2014-06-25 | Arizona Board of Regents on Behalf of University of Arizona | Carcinoma diagnosis and treatments, based on odc1 genotype |
CN102802729A (zh) | 2009-05-20 | 2012-11-28 | 兰贝克赛实验室有限公司 | 异维a酸的液体剂型 |
CN101898978A (zh) | 2009-05-31 | 2010-12-01 | 徐锋 | 依氟鸟氨酸前药和偶合物及其使用方法 |
US20110256161A1 (en) | 2010-04-19 | 2011-10-20 | Aminex Therapeutics Inc. | Methods for enhancing immune response |
AU2011246976B2 (en) | 2010-04-29 | 2016-01-28 | Allarity Therapeutics Europe ApS | Methods and devices for predicting treatment efficacy |
WO2011143579A2 (en) | 2010-05-14 | 2011-11-17 | Arizona Board Of Regents On Behalf Of University Of Arizona | Cancer prevention and treatment methods based on dietary polyamine content |
US8853423B2 (en) * | 2010-06-17 | 2014-10-07 | Seragon Pharmaceuticals, Inc. | Indane estrogen receptor modulators and uses thereof |
AU2011268110B2 (en) | 2010-06-19 | 2016-05-19 | Memorial Sloan-Kettering Cancer Center | Anti-GD2 antibodies |
LT2912193T (lt) | 2012-10-29 | 2018-12-27 | Arizona Board Of Regents On Behalf Of University Of Arizona | Prognozuojami žymenys, skirti vėžio terapijoms poliamino inhibitoriumi |
GB2513299A (en) | 2013-03-12 | 2014-10-29 | Cellact Pharma Gmbh Biomedizinzentrum | Compounds for targeting cancer stem cells |
PT3054926T (pt) * | 2013-10-07 | 2018-10-26 | Bristol Myers Squibb Holdings Ireland | Formulação de atazanavir e cobicistat para tratamento de hiv |
KR20150079373A (ko) * | 2013-12-30 | 2015-07-08 | 한미약품 주식회사 | 에제티미브 및 로수바스타틴을 포함하는 경구용 복합제제 |
CA2952771A1 (en) | 2014-06-18 | 2015-12-23 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Carcinoma diagnosis and treatment based on odc1 genotype |
JP2018507910A (ja) | 2015-02-12 | 2018-03-22 | ジ・アリゾナ・ボード・オブ・リージェンツ・オン・ビハーフ・オブ・ジ・ユニバーシティ・オブ・アリゾナ | 神経芽細胞腫を治療する方法 |
WO2017075576A1 (en) | 2015-10-30 | 2017-05-04 | Cancer Prevention Pharmaceuticals, Inc. | Eflornithine and sulindac, fixed dose combination formulation |
CA3003149C (en) | 2015-10-30 | 2023-10-31 | Cancer Prevention Pharmaceuticals, Inc. | Eflornithine and sulindac, fixed dose combination formulation |
-
2016
- 2016-10-31 CA CA3003149A patent/CA3003149C/en active Active
- 2016-10-31 AU AU2016343851A patent/AU2016343851B2/en active Active
- 2016-10-31 MX MX2018005350A patent/MX2018005350A/es unknown
- 2016-10-31 EP EP16794183.0A patent/EP3368029A1/en active Pending
- 2016-10-31 KR KR1020187015233A patent/KR20180069068A/ko not_active Application Discontinuation
- 2016-10-31 CN CN201680071715.3A patent/CN108366982A/zh active Pending
- 2016-10-31 US US15/771,484 patent/US10973790B2/en active Active
- 2016-10-31 MA MA043114A patent/MA43114A/fr unknown
- 2016-10-31 BR BR112018008651A patent/BR112018008651A2/pt not_active IP Right Cessation
- 2016-10-31 JP JP2018543001A patent/JP2018536707A/ja not_active Withdrawn
-
2018
- 2018-04-29 IL IL259009A patent/IL259009A/en unknown
- 2018-04-30 CL CL2018001157A patent/CL2018001157A1/es unknown
- 2018-05-25 CO CONC2018/0005491A patent/CO2018005491A2/es unknown
-
2019
- 2019-01-15 HK HK19100648.5A patent/HK1258284A1/zh unknown
-
2021
- 2021-03-05 US US17/193,588 patent/US11529326B2/en active Active
- 2021-11-17 JP JP2021186911A patent/JP2022028814A/ja active Pending
-
2022
- 2022-11-15 US US18/055,494 patent/US11925613B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
AU2016343851A1 (en) | 2018-05-10 |
US20200009098A1 (en) | 2020-01-09 |
JP2018536707A (ja) | 2018-12-13 |
AU2016343851B2 (en) | 2022-04-07 |
KR20180069068A (ko) | 2018-06-22 |
CO2018005491A2 (es) | 2018-06-12 |
MA43114A (fr) | 2018-09-05 |
US20230172887A1 (en) | 2023-06-08 |
JP2022028814A (ja) | 2022-02-16 |
HK1258284A1 (zh) | 2019-11-08 |
EP3368029A1 (en) | 2018-09-05 |
CA3003149A1 (en) | 2017-05-04 |
CN108366982A (zh) | 2018-08-03 |
IL259009A (en) | 2018-07-31 |
CA3003149C (en) | 2023-10-31 |
US11529326B2 (en) | 2022-12-20 |
US11925613B2 (en) | 2024-03-12 |
MX2018005350A (es) | 2018-08-14 |
US10973790B2 (en) | 2021-04-13 |
US20210267926A1 (en) | 2021-09-02 |
BR112018008651A2 (pt) | 2018-10-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO2017001994A2 (es) | Compuestos activos hacia bromodominios | |
CY1125205T1 (el) | Φαρμακευτικες συνθεσεις δραστικων απο θεραπευτικη αποψη ενωσεων | |
CL2018003754A1 (es) | Derivado de glucagon, conjugado del mismo, composición que comprende el mismo y uso terapéutico del mismo. | |
CL2016003422A1 (es) | Inhibidores de demetilasa-1 específico de lisina | |
CL2016001609A1 (es) | Composiciones farmacéuticas que comprenden azd9291. | |
CL2016003423A1 (es) | Inhibidores de demetilasa-1 específico de lisina | |
GT201700023A (es) | Derivados de heterociclico opcionalmente condensados de piridimina útiles para el tratamiento de enfermedades inflamatorias, metabolicas, oncológicas y autoinmunitarias | |
DK3513809T3 (da) | Medicinsk sammensætning, som omfatter tivozanib | |
CL2016002495A1 (es) | Derivados de piridina macrocíclicos . | |
CL2020003174S1 (es) | Dispositivo para administración de dosis. | |
CL2016000009A1 (es) | Tratamiento de rosacea papulopustular con ivermectina. | |
CL2015002180A1 (es) | Terapia de combinación para el tratamiento de neumonía nosocomial | |
CL2016001587A1 (es) | Derivado basado en 1,2-naftoquinona y método de preparación del mismo. | |
CL2017002214A1 (es) | Formulación de combinación de tesofensina y betabloqueante | |
BR112017000730B8 (pt) | Derivados de pirrolidinona como inibidores de metap-2, e medicamentos | |
CO2017012645A2 (es) | Agente antihipertensivo que comprende s-1-propenilcisteína o una sal del mismo como ingrediente activo | |
CY1122473T1 (el) | Βελτιστοποιημενο μεσαλαζiνουχο δισκιο υψηλης δοσης | |
UY37560A (es) | Combinación de un inhibidor de mcl-1 y un compuesto taxano, usos y composiciones farmacéuticas de ésta | |
UY37342A (es) | Combinación de un inhibidor de bcl-2 y un inhibidor de mcl1, usos y composiciones farmacéuticas de éstos | |
CL2018001157A1 (es) | Formulación de combinación de dosis fija, eflornitina y sulindaco. | |
CL2017000662A1 (es) | Inhibidores de la histona desmetilasa. | |
DK3394045T3 (da) | Co-krystal, fremstillingsfremgangsmåde deraf og medikament som indeholder co-krystal. | |
ECSP16086247A (es) | (s)-pirlindole y sus sales farmacéuticamente aceptables para uso en medicina | |
CY1123408T1 (el) | Φαρμακευτικες συνθεσεις και χρηση των αυτων | |
BR112017004745A2 (pt) | adição a um aplicador médico |