JP2018535277A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018535277A5 JP2018535277A5 JP2018547866A JP2018547866A JP2018535277A5 JP 2018535277 A5 JP2018535277 A5 JP 2018535277A5 JP 2018547866 A JP2018547866 A JP 2018547866A JP 2018547866 A JP2018547866 A JP 2018547866A JP 2018535277 A5 JP2018535277 A5 JP 2018535277A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical formulation
- patient
- formulation according
- pharmaceutical
- otitis media
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims description 29
- 239000004094 surface-active agent Substances 0.000 claims description 23
- 206010033078 Otitis media Diseases 0.000 claims description 13
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims description 10
- 206010015543 Eustachian tube dysfunction Diseases 0.000 claims description 10
- 210000000613 ear canal Anatomy 0.000 claims description 8
- 210000001989 nasopharynx Anatomy 0.000 claims description 8
- 230000003115 biocidal effect Effects 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 238000003780 insertion Methods 0.000 claims description 2
- 230000037431 insertion Effects 0.000 claims description 2
- 230000000306 recurrent effect Effects 0.000 claims description 2
- 208000024891 symptom Diseases 0.000 claims description 2
- 230000009885 systemic effect Effects 0.000 claims description 2
- 238000009423 ventilation Methods 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 29
- BBJQPKLGPMQWBU-UHFFFAOYSA-N Palmitinsaeurecholesterylester Natural products C12CCC3(C)C(C(C)CCCC(C)C)CCC3C2CC=C2C1(C)CCC(OC(=O)CCCCCCCCCCCCCCC)C2 BBJQPKLGPMQWBU-UHFFFAOYSA-N 0.000 claims 8
- BBJQPKLGPMQWBU-JADYGXMDSA-N cholesteryl palmitate Chemical compound C([C@@H]12)C[C@]3(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@H]3[C@@H]1CC=C1[C@]2(C)CC[C@H](OC(=O)CCCCCCCCCCCCCCC)C1 BBJQPKLGPMQWBU-JADYGXMDSA-N 0.000 claims 8
- 238000009472 formulation Methods 0.000 claims 6
- 239000000825 pharmaceutical preparation Substances 0.000 claims 4
- 230000001684 chronic effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 30
- 230000000069 prophylactic effect Effects 0.000 description 3
- 230000014509 gene expression Effects 0.000 description 2
- 208000024035 chronic otitis media Diseases 0.000 description 1
- 210000003454 tympanic membrane Anatomy 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562260732P | 2015-11-30 | 2015-11-30 | |
| US201562260734P | 2015-11-30 | 2015-11-30 | |
| US201562260742P | 2015-11-30 | 2015-11-30 | |
| US62/260,734 | 2015-11-30 | ||
| US62/260,732 | 2015-11-30 | ||
| US62/260,742 | 2015-11-30 | ||
| PCT/US2016/064190 WO2017095905A1 (en) | 2015-11-30 | 2016-11-30 | Compositions and methods for otologic prophylaxis and treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018535277A JP2018535277A (ja) | 2018-11-29 |
| JP2018535277A5 true JP2018535277A5 (enExample) | 2020-01-16 |
Family
ID=58778000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018547866A Pending JP2018535277A (ja) | 2015-11-30 | 2016-11-30 | 耳科学的予防および処置のための組成物および方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20170151173A1 (enExample) |
| EP (1) | EP3383369A4 (enExample) |
| JP (1) | JP2018535277A (enExample) |
| KR (1) | KR20180105129A (enExample) |
| AU (1) | AU2016365219A1 (enExample) |
| CA (1) | CA3006563A1 (enExample) |
| MX (1) | MX2018006575A (enExample) |
| WO (1) | WO2017095905A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020142420A1 (en) * | 2018-12-31 | 2020-07-09 | Novus Therapeutics, Inc. | Novel surfactant-lipid alloy drug substance, methods of making the same, and pharmaceutical compositions comprising the same |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997029738A1 (en) * | 1996-02-16 | 1997-08-21 | The Administrators Of The Tulane Educational Fund | Methods and compositions for treating eustachian tube dysfunction by inhalation |
| US5954682A (en) * | 1996-09-25 | 1999-09-21 | Advanced Medical Instruments | Therapeutic applicator apparatus and method |
| CO4910145A1 (es) * | 1996-10-01 | 2000-04-24 | Smithkline Beecham Corp | Uso |
| ATE271048T1 (de) * | 1997-11-24 | 2004-07-15 | Procter & Gamble | 5-(2-imidazolinylamino)-benzimidazol derivate, deren herstellung und deren verwendung als .alpha.-adrenoceptor agonisten mit verbesserter metabolischer stabilität |
| US6676930B2 (en) * | 1999-11-28 | 2004-01-13 | Scientific Development And Research, Inc. | Composition and method for treatment of otitis media |
| US6156294A (en) * | 1999-11-28 | 2000-12-05 | Scientific Development And Research, Inc. | Composition and method for treatment of otitis media |
| US20060207596A1 (en) * | 2005-03-18 | 2006-09-21 | Fairfield Clinical Trials, Llc | Device and method for delivery of combination nasal medication |
| US8568790B2 (en) * | 2006-05-31 | 2013-10-29 | Medihoney Pty Ltd. | Medicinal compositions containing honey |
| US8343464B2 (en) * | 2010-04-30 | 2013-01-01 | Burns Phillip E | Composition and method for treating eustachian tube dysfunction |
| SG11201406208QA (en) * | 2012-05-03 | 2014-11-27 | Janssen Sciences Ireland Uc | Polyinosinic-polycytidylic acid (poly (i:c)) formulations for the treatment of upper respiratory tract infections |
| EA201590124A1 (ru) * | 2012-06-29 | 2015-06-30 | Майкродоуз Терапьютикс, Инк. | Композиции и способы лечения или предупреждения пневмовирусной инфекции и связанных заболеваний |
-
2016
- 2016-11-30 KR KR1020187018607A patent/KR20180105129A/ko not_active Withdrawn
- 2016-11-30 JP JP2018547866A patent/JP2018535277A/ja active Pending
- 2016-11-30 WO PCT/US2016/064190 patent/WO2017095905A1/en not_active Ceased
- 2016-11-30 MX MX2018006575A patent/MX2018006575A/es unknown
- 2016-11-30 US US15/365,321 patent/US20170151173A1/en not_active Abandoned
- 2016-11-30 CA CA3006563A patent/CA3006563A1/en not_active Abandoned
- 2016-11-30 EP EP16871410.3A patent/EP3383369A4/en not_active Withdrawn
- 2016-11-30 AU AU2016365219A patent/AU2016365219A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2469726C2 (ru) | Композиции с контролируемым высвобождением на основе кортикостероидов для лечения ушных болезней | |
| US8318817B2 (en) | Controlled release antimicrobial compositions and methods for the treatment of otic disorders | |
| TWI460181B (zh) | 用於治療眼部、耳部或鼻部感染之組成物及方法 | |
| JP2019524657A5 (enExample) | ||
| PT2269602E (pt) | Composições de antibiótico para o tratamento do ouvido | |
| JP2002525319A (ja) | 眼、耳および鼻治療用の抗生物質組成物 | |
| Iino et al. | Effectiveness of instillation of triamcinolone acetonide into the middle ear for eosinophilic otitis media associated with bronchial asthma | |
| EP2299979A2 (en) | Controlled release antimicrobial compositions and methods for the treatment of otic disorders | |
| BRPI0508251A (pt) | métodos para o tratamento de tinido auditivo induzido por excitotoxicidade coclear | |
| Berjis et al. | Intratympanic dexamethasone injection vs methylprednisolone for the treatment of refractory sudden sensorineural hearing loss | |
| JP2020505432A5 (enExample) | ||
| Moreno et al. | Evaluating the efficacy of intratympanic dexamethasone in protecting against irreversible hearing loss in patients on cisplatin-based cancer treatment: a randomized controlled phase IIIB clinical trial | |
| AU2016217937A1 (en) | Method of preventing or treating hearing loss | |
| Chandrasekhar et al. | Otitis media: treatment with intranasal aerosolized surfactant | |
| Tang et al. | Intratympanic injection of dexamethasone after failure of intravenous prednisolone in simultaneous bilateral sudden sensorineural hearing loss | |
| US20080167281A1 (en) | Combination Otic Formulation | |
| Liu et al. | Modified titration intratympanic gentamicin injection for unilateral intractable Ménière’s disease | |
| CN118415969A (zh) | 一种用于治疗耳部疾病的药物组合物 | |
| KR20160040463A (ko) | 고막 절개관 배치 후 귀 감염의 치료 방법 | |
| Abdelhady | Value of ciprofloxacin/dexamethasone ear drops after tympanostomy tube insertion in children: Randomized Clinical Trial | |
| ES2958414T3 (es) | Composiciones tópicas de ciprofloxacina | |
| US20170151173A1 (en) | Compositions and methods for otologic prophylaxis and treatment | |
| Maksoud et al. | Intratympanic dexamethasone injection in Meniere’s disease | |
| Bradoo et al. | Invasive aspergillosis of the temporal bone | |
| YAPAR et al. | A recent overview of locally administered topical otic dosage forms |