JP2018534946A - キメラ転写後調節要素 - Google Patents

キメラ転写後調節要素 Download PDF

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Publication number
JP2018534946A
JP2018534946A JP2018542687A JP2018542687A JP2018534946A JP 2018534946 A JP2018534946 A JP 2018534946A JP 2018542687 A JP2018542687 A JP 2018542687A JP 2018542687 A JP2018542687 A JP 2018542687A JP 2018534946 A JP2018534946 A JP 2018534946A
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JP
Japan
Prior art keywords
seq
nucleic acid
acid sequence
sequence
fragment
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Pending
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JP2018542687A
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English (en)
Japanese (ja)
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JP2018534946A5 (enExample
Inventor
ゴエル、ニヒル
ゴエル、アミタ
Original Assignee
セルテオン コーポレイション
セルテオン コーポレイション
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Publication of JP2018534946A publication Critical patent/JP2018534946A/ja
Publication of JP2018534946A5 publication Critical patent/JP2018534946A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/106—Plasmid DNA for vertebrates
    • C12N2800/107—Plasmid DNA for vertebrates for mammalian
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/30—Vector systems having a special element relevant for transcription being an enhancer not forming part of the promoter region
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/48—Vector systems having a special element relevant for transcription regulating transport or export of RNA, e.g. RRE, PRE, WPRE, CTE
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/60—Vector systems having a special element relevant for transcription from viruses

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2018542687A 2015-10-27 2016-10-27 キメラ転写後調節要素 Pending JP2018534946A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562246841P 2015-10-27 2015-10-27
US62/246,841 2015-10-27
PCT/US2016/059151 WO2017075237A2 (en) 2015-10-27 2016-10-27 Chimeric post-transcriptional regulatory element

Publications (2)

Publication Number Publication Date
JP2018534946A true JP2018534946A (ja) 2018-11-29
JP2018534946A5 JP2018534946A5 (enExample) 2019-12-05

Family

ID=58561919

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018542687A Pending JP2018534946A (ja) 2015-10-27 2016-10-27 キメラ転写後調節要素

Country Status (6)

Country Link
US (2) US10190135B2 (enExample)
EP (1) EP3368672B1 (enExample)
JP (1) JP2018534946A (enExample)
CN (1) CN108291238A (enExample)
IL (1) IL259010A (enExample)
WO (1) WO2017075237A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11713468B2 (en) 2017-08-02 2023-08-01 Dna Twopointo Inc. DNA vectors and elements for sustained gene expression in eukaryotic cells
CN113383081B (zh) * 2018-12-07 2025-04-01 赛尔希恩公司 基质附着区和促进基因表达的用途
JP2022536692A (ja) 2019-06-11 2022-08-18 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド 調節不全の血漿カリクレインによって媒介される疾患の治療のための抗体のアデノ随伴ウイルスベクター送達
EP4048800A1 (en) 2019-10-23 2022-08-31 Shire Human Genetic Therapies, Inc. Adeno-associated virus vectors based gene therapy for hereditary angioedema
CN116829595A (zh) 2020-12-16 2023-09-29 武田药品工业株式会社 用于治疗由失调的血浆激肽释放酶介导的疾病的抗体的腺相关病毒载体递送

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6136597A (en) * 1997-09-18 2000-10-24 The Salk Institute For Biological Studies RNA export element

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005056057A1 (en) * 2003-12-04 2005-06-23 Childrens Hospital Los Angeles Research Institute Minimal lentiviral vector system
US9943611B2 (en) * 2012-11-01 2018-04-17 California Institute Of Technology Reversible gene expression
CA3246595A1 (en) * 2014-04-09 2025-07-08 Dna Twopointo Inc Enhanced polynucleotide constructs for eukaryotic gene expression
SI3689899T1 (sl) * 2014-04-25 2022-01-31 2Seventy Bio, Inc. MND promotor kimeričnih antigenskih receptorjev

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6136597A (en) * 1997-09-18 2000-10-24 The Salk Institute For Biological Studies RNA export element

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J VIROL, 1998 JUN, VOL. 72, NO. 6, PP. 5085-5092, JPN6020043190, ISSN: 0004384760 *

Also Published As

Publication number Publication date
CN108291238A (zh) 2018-07-17
US20170114363A1 (en) 2017-04-27
WO2017075237A2 (en) 2017-05-04
US10190135B2 (en) 2019-01-29
IL259010A (en) 2018-06-28
WO2017075237A3 (en) 2017-06-22
US20190309322A1 (en) 2019-10-10
EP3368672A2 (en) 2018-09-05
EP3368672A4 (en) 2019-03-27
EP3368672B1 (en) 2020-11-25

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