JP2018534567A - 電気化学発光免疫測定システム及びそのフロースルーセルユニット - Google Patents
電気化学発光免疫測定システム及びそのフロースルーセルユニット Download PDFInfo
- Publication number
- JP2018534567A JP2018534567A JP2018521855A JP2018521855A JP2018534567A JP 2018534567 A JP2018534567 A JP 2018534567A JP 2018521855 A JP2018521855 A JP 2018521855A JP 2018521855 A JP2018521855 A JP 2018521855A JP 2018534567 A JP2018534567 A JP 2018534567A
- Authority
- JP
- Japan
- Prior art keywords
- flow
- electrode
- cell unit
- liquid
- hook
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000011984 electrochemiluminescence immunoassay Methods 0.000 title claims abstract description 22
- 239000007788 liquid Substances 0.000 claims abstract description 63
- 238000006243 chemical reaction Methods 0.000 claims abstract description 49
- 238000005259 measurement Methods 0.000 claims abstract description 23
- 230000009471 action Effects 0.000 claims description 23
- 238000001514 detection method Methods 0.000 claims description 17
- 239000011324 bead Substances 0.000 claims description 6
- 239000012780 transparent material Substances 0.000 claims description 2
- 238000004140 cleaning Methods 0.000 abstract description 17
- 230000000694 effects Effects 0.000 abstract description 7
- 230000006866 deterioration Effects 0.000 abstract description 5
- 238000003487 electrochemical reaction Methods 0.000 abstract description 3
- 239000000376 reactant Substances 0.000 abstract 2
- 206010063493 Premature ageing Diseases 0.000 abstract 1
- 208000032038 Premature aging Diseases 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
- 239000012327 Ruthenium complex Substances 0.000 description 9
- UVFCSOBLJHOWPF-UHFFFAOYSA-N [Ru+3].N1=CC=CC=C1 Chemical compound [Ru+3].N1=CC=CC=C1 UVFCSOBLJHOWPF-UHFFFAOYSA-N 0.000 description 8
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- 238000003018 immunoassay Methods 0.000 description 6
- 238000010586 diagram Methods 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 230000005281 excited state Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 230000003647 oxidation Effects 0.000 description 4
- 238000007254 oxidation reaction Methods 0.000 description 4
- 229910052697 platinum Inorganic materials 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 238000002372 labelling Methods 0.000 description 3
- IWSZDQRGNFLMJS-UHFFFAOYSA-N 2-(dibutylamino)ethanol Chemical compound CCCCN(CCO)CCCC IWSZDQRGNFLMJS-UHFFFAOYSA-N 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 230000003670 easy-to-clean Effects 0.000 description 2
- 230000005518 electrochemistry Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000003127 radioimmunoassay Methods 0.000 description 2
- 230000001603 reducing effect Effects 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 108020003215 DNA Probes Proteins 0.000 description 1
- 239000003298 DNA probe Substances 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 239000004696 Poly ether ether ketone Substances 0.000 description 1
- 108020004518 RNA Probes Proteins 0.000 description 1
- 239000003391 RNA probe Substances 0.000 description 1
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 229910021607 Silver chloride Inorganic materials 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- JUPQTSLXMOCDHR-UHFFFAOYSA-N benzene-1,4-diol;bis(4-fluorophenyl)methanone Chemical compound OC1=CC=C(O)C=C1.C1=CC(F)=CC=C1C(=O)C1=CC=C(F)C=C1 JUPQTSLXMOCDHR-UHFFFAOYSA-N 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 239000007772 electrode material Substances 0.000 description 1
- -1 etc. Chemical compound 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910002804 graphite Inorganic materials 0.000 description 1
- 239000010439 graphite Substances 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 239000000891 luminescent agent Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000005304 optical glass Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 229920002530 polyetherether ketone Polymers 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 description 1
- 239000013643 reference control Substances 0.000 description 1
- 229910052707 ruthenium Inorganic materials 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/05—Flow-through cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/403—Cells and electrode assemblies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54386—Analytical elements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/30—Electrochemically active labels
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Electrochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Description
前記フロースルーセルの側に設けられる参照電極をさらに含み、前記作用電極と、前記対電極と、前記参照電極との間の液体流路は互いに連通し、前記参照電極は液体流路と連通する第3の作用段を含み、且つ当該第3の作用段が液体流路と連通する接続面に多孔質構造が設けられている。
前記第2の作用段の少なくとも一方の端が前記下板を向く方向に屈折されて第2のフックを形成し、前記下板に前記第2のフックと合わせる第2のビアが開設され、前記第2のフックが前記第2のビアに係合する。
Claims (10)
- 測定待ちの液体が前記フロースルーセルユニット(1)内で電気化学発光反応が起こり、前記フロースルーセルユニット(1)は作用電極(12)と対電極(11)とを含む電気化学発光免疫測定システムのフロースルーセルユニットにおいて、
前記作用電極(12)と前記対電極(11)とは上下に設置されることを特徴とするフロースルーセルユニット。 - 前記対電極(11)は前記作用電極(12)の上方に設置される二つの針状電極を含み、前記作用電極(12)はシート状の電極であることを特徴とする請求項1に記載のフロースルーセルユニット。
- 前記対電極(11)と前記作用電極(12)とはフロースルーセル内に設置され、且つ前記フロースルーセルは、液体を流通させるための液体流路を有し、
前記フロースルーセルの側に設けられる参照電極(13)をさらに含み、前記作用電極(12)と、前記対電極(11)と、前記参照電極(13)との間の液体流路は互いに連通し、前記参照電極(13)は液体流路と連通する第3の作用段(132)を含み、且つ当該第3の作用段(132)が液体流路と連通する接続面に多孔質構造が設けられていることを特徴とする請求項1に記載のフロースルーセルユニット。 - 前記フロースルーセルは互いに合わせる上板(14)と下板(15)とから形成され、前記上板(14)が透明材料で製成され、前記対電極(11)が前記上板(14)に固定され、前記作用電極(12)が前記下板(15)に固定されることを特徴とする請求項3に記載のフロースルーセルユニット。
- 前記上板(14)と前記下板(15)との間にガスケット(16)が設けられ、当該ガスケット(16)に第1のビア(161)が開設されており、前記第1のビア(161)と、前記下板(15)及び前記上板(14)とが反応チャンバを形成し、前記反応チャンバ内に位置する前記下板(15)に液体入口と液体出口とが開設され、測定待ちの液体が前記反応チャンバ内で電気化学発光反応が起こることを特徴とする請求項4に記載のフロースルーセルユニット。
- 前記上板(14)と、前記ガスケット(16)と、前記下板(15)とに、いずれも、互い連通するねじ孔が開設されていることを特徴とする請求項5に記載のフロースルーセルユニット。
- 前記対電極(11)は第1の作用段(111)を含み、前記作用電極(12)は第2の作用段(122)を含み、前記第1の作用段(111)と前記第2の作用段(122)とが反応回路を形成することを特徴とする請求項5に記載のフロースルーセルユニット。
- 前記第1の作用段(111)の少なくとも一方の端が前記上板(14)を向く方向に屈折されて第1のフック(112)を形成し、前記上板(14)に前記第1のフック(112)と合わせる第1のフック溝が開設され、前記第1のフック(112)が前記第1のフック溝に係合し、
前記第2の作用段(122)の少なくとも一方の端が前記下板(15)を向く方向に屈折されて第2のフック(121)を形成し、前記下板(15)に前記第2のフック(121)と合わせる第2のビア(151)が開設され、前記第2のフック(121)が前記第2のビア(151)に係合することを特徴とする請求項7に記載のフロースルーセルユニット。 - フロースルーセルユニット(1)と、前記フロースルーセルユニット(1)を検出するための検出ユニット(3)とが含まれ、さらに、前記フロースルーセルユニット(1)の作動を制御するための制御ユニット(2)と、前記フロースルーセルユニット(1)と前記制御ユニット(2)とを固定するための固定板(4)とが含まれる電気化学発光免疫測定システムにおいて、
前記フロースルーセルユニット(1)は、請求項1−8のいずれか一項に記載のフロースルーセルユニット(1)である電気化学発光免疫測定システム。 - 前記制御ユニット(2)は回動アーム(21)とステッピングモータ(22)とを含み、前記回動アーム(21)の一方の端が前記ステッピングモータ(22)にヒンジ接続されて前記回動アーム(21)の回転を制御し、前記回動アーム(21)の他方の端が磁石(23)に接続されて測定待ちの液体中の磁気ビーズが前記作用電極(12)に吸着するように制御されることを特徴とする請求項9に記載の電気化学発光免疫測定システム。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510717595.7A CN105806828B (zh) | 2015-10-29 | 2015-10-29 | 一种电化学发光免疫分析系统及其流通池组件 |
CN201510717595.7 | 2015-10-29 | ||
PCT/CN2016/077481 WO2017071154A1 (zh) | 2015-10-29 | 2016-03-28 | 一种电化学发光免疫分析系统及其流通池组件 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2018534567A true JP2018534567A (ja) | 2018-11-22 |
JP6633748B2 JP6633748B2 (ja) | 2020-01-22 |
Family
ID=56465539
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018521855A Active JP6633748B2 (ja) | 2015-10-29 | 2016-03-28 | 電気化学発光免疫測定システム及びそのフロースルーセルユニット |
Country Status (8)
Country | Link |
---|---|
US (1) | US10976260B2 (ja) |
JP (1) | JP6633748B2 (ja) |
KR (1) | KR102127484B1 (ja) |
CN (1) | CN105806828B (ja) |
CH (1) | CH713287B1 (ja) |
DE (1) | DE112016004923T5 (ja) |
TR (1) | TR201806129T1 (ja) |
WO (1) | WO2017071154A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPWO2021205771A1 (ja) * | 2020-04-08 | 2021-10-14 |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL2019043B1 (en) * | 2017-04-25 | 2018-11-05 | Illumina Inc | Sensors having integrated protection circuitry |
CN107314396B (zh) * | 2017-07-26 | 2023-03-21 | 温州点旺电子科技有限公司 | 上下分体拼接的电弧点烟器绝缘支架及其应用方法 |
CN109342507B (zh) * | 2018-09-27 | 2021-10-29 | 中南林业科技大学 | 基于免疫传感的电子舌阻抗检测系统及其流动检测分析方法 |
CN109406594B (zh) * | 2018-11-16 | 2024-01-02 | 苏州赛谱仪器有限公司 | 能够进行流路切换的pH流通池装置 |
CN111198181A (zh) * | 2020-01-10 | 2020-05-26 | 苏州易莱生物技术有限公司 | 用于电化学发光检测的方法和装置 |
CN112763547B (zh) * | 2020-12-30 | 2022-10-25 | 安徽皖仪科技股份有限公司 | 一种基于二极电导池的电导率检测系统 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07209189A (ja) * | 1993-12-16 | 1995-08-11 | Boehringer Mannheim Gmbh | 試料液に電位を印加することにより、光学的に検出できるシグナルを発生する装置と方法 |
JPH11352092A (ja) * | 1998-06-10 | 1999-12-24 | Matsushita Electric Ind Co Ltd | 基質の定量法ならびにそれに用いる分析素子および測定器 |
JP2004208777A (ja) * | 2002-12-27 | 2004-07-29 | Nikkiso Co Ltd | 糖検出電極装置 |
JP2008051813A (ja) * | 2006-08-25 | 2008-03-06 | F Hoffmann-La Roche Ag | エレクトロルミネッセンス測定を行うためのセル |
JP2013152215A (ja) * | 2012-01-25 | 2013-08-08 | F. Hoffmann-La Roche Ag | 液体試料中の分析物を検出する発光法及び分析システム |
JP2014153178A (ja) * | 2013-02-08 | 2014-08-25 | F. Hoffmann-La Roche Ag | 自動分析装置 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5705402A (en) * | 1988-11-03 | 1998-01-06 | Igen International, Inc. | Method and apparatus for magnetic microparticulate based luminescence assay including plurality of magnets |
US5466416A (en) * | 1993-05-14 | 1995-11-14 | Ghaed; Ali | Apparatus and methods for carrying out electrochemiluminescence test measurements |
US5643721A (en) * | 1994-02-09 | 1997-07-01 | Abbott Laboratories | Bioreagent immobilization medium |
ATE227844T1 (de) * | 1997-02-06 | 2002-11-15 | Therasense Inc | Kleinvolumiger sensor zur in-vitro bestimmung |
US6200531B1 (en) * | 1998-05-11 | 2001-03-13 | Igen International, Inc. | Apparatus for carrying out electrochemiluminescence test measurements |
AU4228200A (en) * | 1999-04-09 | 2000-11-14 | Shot, Inc. | Multistage electromagnetic separator for purifying cells, chemicals and protein structures |
JP4597622B2 (ja) * | 2004-09-27 | 2010-12-15 | 根本特殊化学株式会社 | 電気化学式ガスセンサ |
US7695601B2 (en) * | 2006-05-09 | 2010-04-13 | The United States Of America As Represented By The Secretary Of The Army | Electrochemical test apparatus and method for its use |
CN102680456B (zh) | 2011-03-16 | 2015-07-08 | 北京联众泰克科技有限公司 | 一种电化学发光免疫测定方法 |
CN202631475U (zh) * | 2012-06-04 | 2012-12-26 | 广州军区广州总医院 | 一种电化学发光免疫检测池 |
CN203720142U (zh) * | 2014-03-07 | 2014-07-16 | 中国水产科学研究院 | 一种微型化电化学三电极体系检测池 |
CN204484303U (zh) * | 2015-03-20 | 2015-07-22 | 田静静 | 一种高频电刀笔 |
CN104950026B (zh) * | 2015-06-19 | 2017-07-28 | 苏州大学 | 基于磁珠的电化学发光生物分析流通池 |
CN205103164U (zh) * | 2015-10-29 | 2016-03-23 | 北京联众泰克科技有限公司 | 一种电化学发光免疫分析系统及其流通池组件 |
-
2015
- 2015-10-29 CN CN201510717595.7A patent/CN105806828B/zh active Active
-
2016
- 2016-03-28 CH CH00550/18A patent/CH713287B1/de unknown
- 2016-03-28 WO PCT/CN2016/077481 patent/WO2017071154A1/zh active Application Filing
- 2016-03-28 JP JP2018521855A patent/JP6633748B2/ja active Active
- 2016-03-28 TR TR2018/06129T patent/TR201806129T1/tr unknown
- 2016-03-28 KR KR1020187014696A patent/KR102127484B1/ko active IP Right Grant
- 2016-03-28 US US15/771,441 patent/US10976260B2/en active Active
- 2016-03-28 DE DE112016004923.4T patent/DE112016004923T5/de active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07209189A (ja) * | 1993-12-16 | 1995-08-11 | Boehringer Mannheim Gmbh | 試料液に電位を印加することにより、光学的に検出できるシグナルを発生する装置と方法 |
JPH11352092A (ja) * | 1998-06-10 | 1999-12-24 | Matsushita Electric Ind Co Ltd | 基質の定量法ならびにそれに用いる分析素子および測定器 |
JP2004208777A (ja) * | 2002-12-27 | 2004-07-29 | Nikkiso Co Ltd | 糖検出電極装置 |
JP2008051813A (ja) * | 2006-08-25 | 2008-03-06 | F Hoffmann-La Roche Ag | エレクトロルミネッセンス測定を行うためのセル |
JP2013152215A (ja) * | 2012-01-25 | 2013-08-08 | F. Hoffmann-La Roche Ag | 液体試料中の分析物を検出する発光法及び分析システム |
JP2014153178A (ja) * | 2013-02-08 | 2014-08-25 | F. Hoffmann-La Roche Ag | 自動分析装置 |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPWO2021205771A1 (ja) * | 2020-04-08 | 2021-10-14 | ||
WO2021205771A1 (ja) * | 2020-04-08 | 2021-10-14 | 株式会社日立ハイテク | 自動分析装置 |
JP7310013B2 (ja) | 2020-04-08 | 2023-07-18 | 株式会社日立ハイテク | 自動分析装置 |
Also Published As
Publication number | Publication date |
---|---|
CN105806828A (zh) | 2016-07-27 |
TR201806129T1 (tr) | 2018-08-27 |
KR102127484B1 (ko) | 2020-06-30 |
US20180335389A1 (en) | 2018-11-22 |
KR20180071356A (ko) | 2018-06-27 |
CN105806828B (zh) | 2019-05-14 |
JP6633748B2 (ja) | 2020-01-22 |
CH713287B1 (de) | 2019-12-30 |
US10976260B2 (en) | 2021-04-13 |
WO2017071154A1 (zh) | 2017-05-04 |
DE112016004923T5 (de) | 2018-07-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6633748B2 (ja) | 電気化学発光免疫測定システム及びそのフロースルーセルユニット | |
Fosdick et al. | Bipolar electrodes for rapid screening of electrocatalysts | |
Zhang et al. | New insight into a microfluidic-based bipolar system for an electrochemiluminescence sensing platform | |
Arora et al. | A wireless electrochemiluminescence detector applied to direct and indirect detection for electrophoresis on a microfabricated glass device | |
Knight et al. | Occurrence, mechanisms and analytical applications of electrogenerated chemiluminescence. A review | |
CN106018784A (zh) | 小型电化学发光免疫分析仪及其分析方法 | |
Xu et al. | Coupling of independent electrochemical reactions and fluorescence at closed bipolar interdigitated electrode arrays | |
CN106423313A (zh) | 一种基于双极电极阵列‑微流控芯片的可视化电化学发光传感器检测乳酸的方法 | |
CN101021529A (zh) | 多分析物同时检测的高通量检测系统及电化学免疫分析方法 | |
Rahn et al. | Alternating current voltammetry at a bipolar electrode with smartphone luminescence imaging for point‐of‐need sensing | |
EA031831B1 (ru) | Интегрированные электродные чипы для электрического возбуждения хелатов лантанидов и способы анализа с их использованием | |
Renault et al. | based bipolar electrochemistry | |
CN103575794A (zh) | 一种基于石墨烯/dna/银纳米复合材料对碘离子的检测方法 | |
Ding et al. | Confined Electrochemiluminescence Generation at Ultra-High-Density Gold Microwell Electrodes | |
CN205103164U (zh) | 一种电化学发光免疫分析系统及其流通池组件 | |
CN112710709A (zh) | 用于目标dna检测的硫化镉量子点玻碳电极及其制备方法、电化学发光传感器系统与应用 | |
JPH09189662A (ja) | 電気化学発光セル及び電気化学発光分析装置 | |
CN106483118A (zh) | 一种基于双极电极阵列的可视化胆碱传感器 | |
CN207147952U (zh) | 转盘式胶体金/荧光试纸芯片 | |
CN204314313U (zh) | 光电双寻址多通道生化分析仪 | |
JP3366842B2 (ja) | 電気化学発光測定用セル | |
CN1671864A (zh) | 指示电化学过程的光信号 | |
CN203881685U (zh) | 一种流动注射双恒电位激发电化学发光检测装置 | |
Xing et al. | Recent advances in bipolar electrochemiluminescence for analytical application | |
JP2006119128A (ja) | 増感色素の光励起により生じる光電流を用いた被検物質の特異的検出に用いられるセンサセルおよび測定装置 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20180427 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20190320 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20190409 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190708 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20191112 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20191212 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6633748 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |