JP2018534316A5 - - Google Patents

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Publication number
JP2018534316A5
JP2018534316A5 JP2018525743A JP2018525743A JP2018534316A5 JP 2018534316 A5 JP2018534316 A5 JP 2018534316A5 JP 2018525743 A JP2018525743 A JP 2018525743A JP 2018525743 A JP2018525743 A JP 2018525743A JP 2018534316 A5 JP2018534316 A5 JP 2018534316A5
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JP
Japan
Prior art keywords
compound according
alkyl
substituted
tumors
heterocycloalkyl
Prior art date
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Application number
JP2018525743A
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English (en)
Japanese (ja)
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JP2018534316A (ja
JP6946290B2 (ja
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Priority claimed from GBGB1520499.3A external-priority patent/GB201520499D0/en
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Publication of JP2018534316A publication Critical patent/JP2018534316A/ja
Publication of JP2018534316A5 publication Critical patent/JP2018534316A5/ja
Application granted granted Critical
Publication of JP6946290B2 publication Critical patent/JP6946290B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2018525743A 2015-11-20 2016-11-16 Ｍｎｋ阻害剤としてのピロロピリミジン化合物 Expired - Fee Related JP6946290B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1520499.3 2015-11-20
GBGB1520499.3A GB201520499D0 (en) 2015-11-20 2015-11-20 Compounds
PCT/GB2016/053579 WO2017085483A1 (en) 2015-11-20 2016-11-16 Pyrropyrimidine compounds as mnks inhibitors

Publications (3)

Publication Number Publication Date
JP2018534316A JP2018534316A (ja) 2018-11-22
JP2018534316A5 true JP2018534316A5 (https=) 2019-12-26
JP6946290B2 JP6946290B2 (ja) 2021-10-06

Family

ID=55133105

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018525743A Expired - Fee Related JP6946290B2 (ja) 2015-11-20 2016-11-16 Ｍｎｋ阻害剤としてのピロロピリミジン化合物

Country Status (9)

Country Link
US (1) US10604524B2 (https=)
EP (2) EP3792264B1 (https=)
JP (1) JP6946290B2 (https=)
CN (1) CN108368114B (https=)
AU (1) AU2016355103B2 (https=)
CA (1) CA3003554C (https=)
ES (2) ES2972862T3 (https=)
GB (1) GB201520499D0 (https=)
WO (1) WO2017085483A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI713455B (zh) 2014-06-25 2020-12-21 美商伊凡克特治療公司 ＭｎＫ抑制劑及其相關方法
BR112019016707A2 (pt) 2017-02-14 2020-04-07 Effector Therapeutics Inc inibidores de mnk substituídos por piperidina e métodos relacionados aos mesmos
CN109020957B (zh) * 2017-06-12 2023-01-13 南京天印健华医药科技有限公司 作为mnk抑制剂的杂环化合物
TWI857981B (zh) 2018-10-24 2024-10-11 美商伊凡克特治療公司 Ｍｎｋ抑制劑的結晶形式
CN110903286B (zh) * 2019-12-16 2021-09-24 沈阳药科大学 4,6-双取代吡啶[3,2-d]嘧啶类化合物及其制备和应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ207394A (en) 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
ATE247469T1 (de) * 1995-06-07 2003-09-15 Pfizer Heterocyclische kondensierte pyrimidin-derivate
US6413971B1 (en) * 1996-11-27 2002-07-02 Pfizer Inc Fused bicyclic pyrimidine derivatives
JP2004509059A (ja) 1999-06-03 2004-03-25 アボット・ラボラトリーズ 細胞接着抑制性抗炎症化合物
WO2005067546A2 (en) 2004-01-13 2005-07-28 Ambit Biosciences Corporation Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases
CA2572331A1 (en) 2004-07-02 2006-02-09 Exelixis, Inc. C-met modulators and method of use
TW200730527A (en) * 2005-12-02 2007-08-16 Takeda Pharmaceuticals Co Fused heterocyclic compound
CA2651898A1 (en) * 2006-04-07 2007-10-18 Develogen Aktiengesellschaft Thienopyrimidines having mnk1/mnk2 inhibiting activity for pharmaceutical compositions
EP1889847A1 (en) * 2006-07-10 2008-02-20 DeveloGen Aktiengesellschaft Pyrrolopyrimidines for pharmaceutical compositions
EP2219649A2 (en) * 2007-11-22 2010-08-25 Boehringer Ingelheim International Gmbh Use of mnk inhibitors for the treatment of alzheimer's disease
JP5626748B2 (ja) * 2008-07-02 2014-11-19 キッコーマン株式会社 ペプチド含有調味料
UY33246A (es) * 2010-02-26 2011-09-30 Boehringer Ingelheim Int Tienopirimidinas que contienen cicloalquilo para composiciones farmacéuticas
EP2539343B1 (en) 2010-02-26 2015-12-30 Evotec International GmbH Thienopyrimidines containing a substituted alkyl group for pharmaceutical compositions
JP2016506944A (ja) 2013-02-01 2016-03-07 バイエル・ファルマ・アクティエンゲゼルシャフト 置換ピラゾロピリミジニルアミノ−インダゾール
CA2903925A1 (en) 2013-03-06 2014-09-12 Bayer Pharma Aktiengesellschaft Substituted thiazolopyrimidines
CN104744446B (zh) * 2013-12-30 2019-06-25 广东东阳光药业有限公司 杂芳化合物及其在药物中的应用

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