GB201520499D0 - Compounds - Google Patents

Compounds

Info

Publication number
GB201520499D0
GB201520499D0 GBGB1520499.3A GB201520499A GB201520499D0 GB 201520499 D0 GB201520499 D0 GB 201520499D0 GB 201520499 A GB201520499 A GB 201520499A GB 201520499 D0 GB201520499 D0 GB 201520499D0
Authority
GB
United Kingdom
Prior art keywords
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB1520499.3A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LifeArc
Original Assignee
Medical Research Council Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical Research Council Technology filed Critical Medical Research Council Technology
Priority to GBGB1520499.3A priority Critical patent/GB201520499D0/en
Publication of GB201520499D0 publication Critical patent/GB201520499D0/en
Priority to PCT/GB2016/053579 priority patent/WO2017085483A1/en
Priority to CA3003554A priority patent/CA3003554C/en
Priority to ES20204385T priority patent/ES2972862T3/es
Priority to US15/776,574 priority patent/US10604524B2/en
Priority to EP16801015.5A priority patent/EP3377494B1/en
Priority to JP2018525743A priority patent/JP6946290B2/ja
Priority to ES16801015T priority patent/ES2872775T3/es
Priority to EP20204385.7A priority patent/EP3792264B1/en
Priority to AU2016355103A priority patent/AU2016355103B2/en
Priority to CN201680067666.6A priority patent/CN108368114B/zh
Priority to HK18112781.8A priority patent/HK1253576B/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
GBGB1520499.3A 2015-11-20 2015-11-20 Compounds Ceased GB201520499D0 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
GBGB1520499.3A GB201520499D0 (en) 2015-11-20 2015-11-20 Compounds
HK18112781.8A HK1253576B (en) 2015-11-20 2016-11-16 Pyrropyrimidine compounds as mnks inhibitors
US15/776,574 US10604524B2 (en) 2015-11-20 2016-11-16 Pyrropyrimidine compounds as MNKs inhibitors
CA3003554A CA3003554C (en) 2015-11-20 2016-11-16 Pyrropyrimidine compounds as mnks inhibitors
ES20204385T ES2972862T3 (es) 2015-11-20 2016-11-16 Compuestos de pirropirimidina como inhibidores de MNK
PCT/GB2016/053579 WO2017085483A1 (en) 2015-11-20 2016-11-16 Pyrropyrimidine compounds as mnks inhibitors
EP16801015.5A EP3377494B1 (en) 2015-11-20 2016-11-16 Pyrropyrimidine compounds as mnks inhibitors
JP2018525743A JP6946290B2 (ja) 2015-11-20 2016-11-16 Ｍｎｋ阻害剤としてのピロロピリミジン化合物
ES16801015T ES2872775T3 (es) 2015-11-20 2016-11-16 Compuestos de pirropirimidina como inhibidores de MNK
EP20204385.7A EP3792264B1 (en) 2015-11-20 2016-11-16 Pyrropyrimidine compounds as mnks inhibitors
AU2016355103A AU2016355103B2 (en) 2015-11-20 2016-11-16 Pyrropyrimidine compounds as MNKs inhibitors
CN201680067666.6A CN108368114B (zh) 2015-11-20 2016-11-16 作为mnk抑制剂的吡咯并嘧啶化合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1520499.3A GB201520499D0 (en) 2015-11-20 2015-11-20 Compounds

Publications (1)

Publication Number Publication Date
GB201520499D0 true GB201520499D0 (en) 2016-01-06

Family

ID=55133105

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB1520499.3A Ceased GB201520499D0 (en) 2015-11-20 2015-11-20 Compounds

Country Status (9)

Country Link
US (1) US10604524B2 (https=)
EP (2) EP3792264B1 (https=)
JP (1) JP6946290B2 (https=)
CN (1) CN108368114B (https=)
AU (1) AU2016355103B2 (https=)
CA (1) CA3003554C (https=)
ES (2) ES2972862T3 (https=)
GB (1) GB201520499D0 (https=)
WO (1) WO2017085483A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI713455B (zh) 2014-06-25 2020-12-21 美商伊凡克特治療公司 ＭｎＫ抑制劑及其相關方法
CA3053493A1 (en) 2017-02-14 2018-08-23 Effector Therapeutics, Inc. Piperidine-substituted mnk inhibitors and methods related thereto
CN109020957B (zh) * 2017-06-12 2023-01-13 南京天印健华医药科技有限公司 作为mnk抑制剂的杂环化合物
CN113286592A (zh) 2018-10-24 2021-08-20 效应治疗股份有限公司 Mnk抑制剂的结晶形式
CN110903286B (zh) * 2019-12-16 2021-09-24 沈阳药科大学 4,6-双取代吡啶[3,2-d]嘧啶类化合物及其制备和应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ207394A (en) 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
JP3290666B2 (ja) * 1995-06-07 2002-06-10 ファイザー・インコーポレーテッド 複素環式の縮合環ピリミジン誘導体
WO1998023613A1 (en) * 1996-11-27 1998-06-04 Pfizer Inc. Fused bicyclic pyrimidine derivatives
CA2390948A1 (en) 1999-06-03 2000-12-14 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
US20050239806A1 (en) 2004-01-13 2005-10-27 Ambit Biosciences Corporation Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases
US7977345B2 (en) 2004-07-02 2011-07-12 Exelixis, Inc. c-MET modulators and method of use
TW200730527A (en) * 2005-12-02 2007-08-16 Takeda Pharmaceuticals Co Fused heterocyclic compound
CA2651898A1 (en) * 2006-04-07 2007-10-18 Develogen Aktiengesellschaft Thienopyrimidines having mnk1/mnk2 inhibiting activity for pharmaceutical compositions
EP1889847A1 (en) * 2006-07-10 2008-02-20 DeveloGen Aktiengesellschaft Pyrrolopyrimidines for pharmaceutical compositions
WO2009065596A2 (en) * 2007-11-22 2009-05-28 Develogen Aktiengesellschaft Use of mnk inhibitors for the treatment of alzheimer's disease
JP5626748B2 (ja) * 2008-07-02 2014-11-19 キッコーマン株式会社 ペプチド含有調味料
JP5575274B2 (ja) * 2010-02-26 2014-08-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 医薬組成物のためのｍｎｋｌ／ｍｎｋ２阻害活性を有する４−［シクロアルキルオキシ（ヘテロ）アリールアミノ］チエノ「２，３−ｄ］ピリミジン
MX2012009851A (es) 2010-02-26 2012-09-12 Boehringer Ingelheim Int Tienopirimidinas que contienen un grupo alquilo sustituido para composiciones farmaceuticas.
CA2899662A1 (en) 2013-02-01 2014-08-07 Bayer Pharma Aktiengesellschaft Substituted pyrazolopyrimidinylamino-indazoles
WO2014135480A1 (en) 2013-03-06 2014-09-12 Bayer Pharma Aktiengesellschaft Substituted thiazolopyrimidines
CN104744446B (zh) * 2013-12-30 2019-06-25 广东东阳光药业有限公司 杂芳化合物及其在药物中的应用

Also Published As

Publication number Publication date
EP3377494A1 (en) 2018-09-26
CN108368114A (zh) 2018-08-03
AU2016355103B2 (en) 2021-07-08
ES2872775T3 (es) 2021-11-02
EP3792264A1 (en) 2021-03-17
CN108368114B (zh) 2023-10-24
WO2017085483A1 (en) 2017-05-26
EP3792264B1 (en) 2024-01-03
HK1253576A1 (en) 2019-06-21
JP6946290B2 (ja) 2021-10-06
JP2018534316A (ja) 2018-11-22
EP3377494B1 (en) 2021-03-03
ES2972862T3 (es) 2024-06-17
US20180346469A1 (en) 2018-12-06
AU2016355103A1 (en) 2018-05-31
CA3003554A1 (en) 2017-05-26
CA3003554C (en) 2023-08-29
US10604524B2 (en) 2020-03-31

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)