JP2018533966A5 - - Google Patents
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- JP2018533966A5 JP2018533966A5 JP2018526570A JP2018526570A JP2018533966A5 JP 2018533966 A5 JP2018533966 A5 JP 2018533966A5 JP 2018526570 A JP2018526570 A JP 2018526570A JP 2018526570 A JP2018526570 A JP 2018526570A JP 2018533966 A5 JP2018533966 A5 JP 2018533966A5
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- Prior art keywords
- antibody
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- 210000004027 cell Anatomy 0.000 claims description 33
- 108700019146 Transgenes Proteins 0.000 claims description 26
- 238000000034 method Methods 0.000 claims description 20
- 206010028980 Neoplasm Diseases 0.000 claims description 14
- 201000011510 cancer Diseases 0.000 claims description 14
- 208000023275 Autoimmune disease Diseases 0.000 claims description 12
- 208000002193 Pain Diseases 0.000 claims description 12
- 201000008482 osteoarthritis Diseases 0.000 claims description 11
- 101710163270 Nuclease Proteins 0.000 claims description 10
- 201000001119 neuropathy Diseases 0.000 claims description 10
- 230000007823 neuropathy Effects 0.000 claims description 10
- 208000033808 peripheral neuropathy Diseases 0.000 claims description 10
- 108010088751 Albumins Proteins 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 102000009027 Albumins Human genes 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 239000003102 growth factor Substances 0.000 claims description 4
- 239000013603 viral vector Substances 0.000 claims description 4
- 239000013607 AAV vector Substances 0.000 claims description 2
- 102000009091 Amyloidogenic Proteins Human genes 0.000 claims description 2
- 108010048112 Amyloidogenic Proteins Proteins 0.000 claims description 2
- 102000000989 Complement System Proteins Human genes 0.000 claims description 2
- 108010069112 Complement System Proteins Proteins 0.000 claims description 2
- 108010070716 Intercellular Signaling Peptides and Proteins Proteins 0.000 claims description 2
- 102000005755 Intercellular Signaling Peptides and Proteins Human genes 0.000 claims description 2
- 102000003802 alpha-Synuclein Human genes 0.000 claims description 2
- 108090000185 alpha-Synuclein Proteins 0.000 claims description 2
- 239000000427 antigen Substances 0.000 claims description 2
- 108091007433 antigens Proteins 0.000 claims description 2
- 102000036639 antigens Human genes 0.000 claims description 2
- 210000004556 brain Anatomy 0.000 claims description 2
- 102000003675 cytokine receptors Human genes 0.000 claims description 2
- 108010057085 cytokine receptors Proteins 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 108020001507 fusion proteins Proteins 0.000 claims description 2
- 102000037865 fusion proteins Human genes 0.000 claims description 2
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims description 2
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims description 2
- 102000006495 integrins Human genes 0.000 claims description 2
- 108010044426 integrins Proteins 0.000 claims description 2
- 229940043355 kinase inhibitor Drugs 0.000 claims description 2
- 210000004185 liver Anatomy 0.000 claims description 2
- 210000005229 liver cell Anatomy 0.000 claims description 2
- 210000000663 muscle cell Anatomy 0.000 claims description 2
- 210000001665 muscle stem cell Anatomy 0.000 claims description 2
- 239000003757 phosphotransferase inhibitor Substances 0.000 claims description 2
- 108020003175 receptors Proteins 0.000 claims description 2
- 102000005962 receptors Human genes 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
- 210000000130 stem cell Anatomy 0.000 claims description 2
- 208000012902 Nervous system disease Diseases 0.000 claims 2
- 208000025966 Neurological disease Diseases 0.000 claims 2
- 206010003246 arthritis Diseases 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 238000010348 incorporation Methods 0.000 claims 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021122424A JP7493487B2 (ja) | 2015-11-23 | 2021-07-27 | 免疫を工学操作するための方法および組成物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562258864P | 2015-11-23 | 2015-11-23 | |
| US62/258,864 | 2015-11-23 | ||
| US201662405521P | 2016-10-07 | 2016-10-07 | |
| US62/405,521 | 2016-10-07 | ||
| PCT/US2016/063146 WO2017091512A1 (en) | 2015-11-23 | 2016-11-21 | Methods and compositions for engineering immunity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021122424A Division JP7493487B2 (ja) | 2015-11-23 | 2021-07-27 | 免疫を工学操作するための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018533966A JP2018533966A (ja) | 2018-11-22 |
| JP2018533966A5 true JP2018533966A5 (enExample) | 2019-10-24 |
| JP6976249B2 JP6976249B2 (ja) | 2021-12-08 |
Family
ID=58763566
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018526570A Active JP6976249B2 (ja) | 2015-11-23 | 2016-11-21 | 免疫を工学操作するための方法および組成物 |
| JP2021122424A Active JP7493487B2 (ja) | 2015-11-23 | 2021-07-27 | 免疫を工学操作するための方法および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021122424A Active JP7493487B2 (ja) | 2015-11-23 | 2021-07-27 | 免疫を工学操作するための方法および組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10639383B2 (enExample) |
| EP (1) | EP3380622A4 (enExample) |
| JP (2) | JP6976249B2 (enExample) |
| AU (1) | AU2016361350B2 (enExample) |
| CA (1) | CA3004349A1 (enExample) |
| WO (1) | WO2017091512A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017189964A2 (en) | 2016-04-29 | 2017-11-02 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| US11326182B2 (en) | 2016-04-29 | 2022-05-10 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| US11512287B2 (en) | 2017-06-16 | 2022-11-29 | Sangamo Therapeutics, Inc. | Targeted disruption of T cell and/or HLA receptors |
| JP7061750B2 (ja) * | 2017-12-01 | 2022-05-02 | 学校法人順天堂 | 抗ヒトｉｌ－２６抗体 |
| GB201720975D0 (en) | 2017-12-15 | 2018-01-31 | Ucb Biopharma Sprl | Anti-alpha synuclein antibodies |
| GB201720970D0 (en) | 2017-12-15 | 2018-01-31 | Ucb Biopharma Sprl | Antibodies |
| JP7520826B2 (ja) * | 2018-10-17 | 2024-07-23 | クリスパー・セラピューティクス・アクチェンゲゼルシャフト | 導入遺伝子を送達するための組成物および方法 |
| BR112021007301A2 (pt) * | 2018-10-18 | 2021-07-27 | Intellia Therapeutics, Inc. | composições e métodos para expressar fator ix |
| EP3867381A2 (en) * | 2018-10-18 | 2021-08-25 | Intellia Therapeutics, Inc. | Compositions and methods for transgene expression from an albumin locus |
| WO2020097561A1 (en) | 2018-11-08 | 2020-05-14 | Prothena Biosciences Limited | Antibodies recognizing tau |
| AU2020231366A1 (en) | 2019-03-03 | 2021-08-12 | Prothena Biosciences Limited | Antibodies recognizing tau |
| CN118064502A (zh) * | 2019-04-03 | 2024-05-24 | 瑞泽恩制药公司 | 用于将抗体编码序列插入到安全港基因座中的方法和组合物 |
| SG11202111256XA (en) | 2019-06-07 | 2021-11-29 | Regeneron Pharma | Non-human animals comprising a humanized albumin locus |
| CA3183994A1 (en) | 2020-06-24 | 2021-12-30 | Philip James Dolan Iii | Antibodies recognizing sortilin |
| WO2023081756A1 (en) | 2021-11-03 | 2023-05-11 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Precise genome editing using retrons |
| WO2023141602A2 (en) | 2022-01-21 | 2023-07-27 | Renagade Therapeutics Management Inc. | Engineered retrons and methods of use |
| WO2024044723A1 (en) | 2022-08-25 | 2024-02-29 | Renagade Therapeutics Management Inc. | Engineered retrons and methods of use |
| WO2025049959A2 (en) | 2023-09-01 | 2025-03-06 | Renagade Therapeutics Management Inc. | Gene editing systems, compositions, and methods for treatment of vexas syndrome |
| TW202530252A (zh) | 2023-09-15 | 2025-08-01 | 愛爾蘭商普羅希那生物科學有限公司 | 降低抗體免疫原性及改良抗體穩定性之組成物及方法 |
| WO2025174765A1 (en) | 2024-02-12 | 2025-08-21 | Renagade Therapeutics Management Inc. | Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents |
| WO2025188676A1 (en) * | 2024-03-04 | 2025-09-12 | The Board Of Trustees Of The Leland Stanford Junior University | Genetic engineering of cells for secretion of therapeutic antibodies |
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| US1013219A (en) | 1910-04-26 | 1912-01-02 | Rex Aerial Navigating And Construction Company | Aerial vehicle. |
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| US6242568B1 (en) | 1994-01-18 | 2001-06-05 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| EP0781331B1 (en) | 1994-08-20 | 2008-09-03 | Gendaq Limited | Improvements in or relating to binding proteins for recognition of dna |
| GB9824544D0 (en) | 1998-11-09 | 1999-01-06 | Medical Res Council | Screening system |
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-
2016
- 2016-11-21 AU AU2016361350A patent/AU2016361350B2/en active Active
- 2016-11-21 JP JP2018526570A patent/JP6976249B2/ja active Active
- 2016-11-21 EP EP16869135.0A patent/EP3380622A4/en active Pending
- 2016-11-21 CA CA3004349A patent/CA3004349A1/en active Pending
- 2016-11-21 WO PCT/US2016/063146 patent/WO2017091512A1/en not_active Ceased
- 2016-11-21 US US15/357,772 patent/US10639383B2/en active Active
-
2020
- 2020-03-30 US US16/834,481 patent/US11793888B2/en active Active
-
2021
- 2021-07-27 JP JP2021122424A patent/JP7493487B2/ja active Active
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