|
US918814A
(en)
|
1907-10-30 |
1909-04-20 |
Handy Mfg Company |
Funnel.
|
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
JPS6023084B2
(ja)
|
1979-07-11 |
1985-06-05 |
味の素株式会社 |
代用血液
|
|
US4485045A
(en)
|
1981-07-06 |
1984-11-27 |
Research Corporation |
Synthetic phosphatidyl cholines useful in forming liposomes
|
|
US4640835A
(en)
|
1981-10-30 |
1987-02-03 |
Nippon Chemiphar Company, Ltd. |
Plasminogen activator derivatives
|
|
US4544545A
(en)
|
1983-06-20 |
1985-10-01 |
Trustees University Of Massachusetts |
Liposomes containing modified cholesterol for organ targeting
|
|
US4496689A
(en)
|
1983-12-27 |
1985-01-29 |
Miles Laboratories, Inc. |
Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
|
|
US4666884A
(en)
|
1984-04-10 |
1987-05-19 |
New England Deaconess Hospital |
Method of inhibiting binding of von Willebrand factor to human platelets and inducing interaction of platelets with vessel walls
|
|
EP0206448B1
(en)
|
1985-06-19 |
1990-11-14 |
Ajinomoto Co., Inc. |
Hemoglobin combined with a poly(alkylene oxide)
|
|
US4791192A
(en)
|
1986-06-26 |
1988-12-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified protein with polyethyleneglycol
|
|
US5225538A
(en)
|
1989-02-23 |
1993-07-06 |
Genentech, Inc. |
Lymphocyte homing receptor/immunoglobulin fusion proteins
|
|
US5013556A
(en)
|
1989-10-20 |
1991-05-07 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
WO1991014438A1
(en)
|
1990-03-20 |
1991-10-03 |
The Trustees Of Columbia University In The City Of New York |
Chimeric antibodies with receptor binding ligands in place of their constant region
|
|
DK0752248T3
(da)
|
1992-11-13 |
2000-11-13 |
Idec Pharma Corp |
Terapeutisk anvendelse af kimæriske og radioaktivt mærkede antistoffer mod humant B-lymfocytbegrænset differentieringsantig
|
|
US5605793A
(en)
|
1994-02-17 |
1997-02-25 |
Affymax Technologies N.V. |
Methods for in vitro recombination
|
|
US5837458A
(en)
|
1994-02-17 |
1998-11-17 |
Maxygen, Inc. |
Methods and compositions for cellular and metabolic engineering
|
|
US5834252A
(en)
|
1995-04-18 |
1998-11-10 |
Glaxo Group Limited |
End-complementary polymerase reaction
|
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US6096871A
(en)
|
1995-04-14 |
2000-08-01 |
Genentech, Inc. |
Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
|
|
US5747035A
(en)
|
1995-04-14 |
1998-05-05 |
Genentech, Inc. |
Polypeptides with increased half-life for use in treating disorders involving the LFA-1 receptor
|
|
WO1997043316A1
(en)
|
1996-05-10 |
1997-11-20 |
Beth Israel Deaconess Medical Center, Inc. |
Physiologically active molecules with extended half-lives and methods of using same
|
|
US5961955A
(en)
*
|
1997-06-03 |
1999-10-05 |
Coulter Pharmaceutical, Inc. |
Radioprotectant for peptides labeled with radioisotope
|
|
HUP0100813A3
(en)
|
1998-02-25 |
2003-08-28 |
Lexigen Pharmaceuticals Corp L |
Enhancing the circulating half-life of antibody-based fusion proteins
|
|
EP1105427A2
(en)
|
1998-08-17 |
2001-06-13 |
Abgenix, Inc. |
Generation of modified molecules with increased serum half-lives
|
|
AU4445601A
(en)
|
2000-03-31 |
2001-10-08 |
Centre National De La Recherche Scientifique-Cnrs |
Peptides blocking vascular endothelial growth factor (vegf)-mediated angiogenesis, polynucleotides encoding said peptides and methods of use thereof
|
|
JP2003534813A
(ja)
|
2000-06-01 |
2003-11-25 |
アムジェン インコーポレーテッド |
シスチンノットポリペプチド：ｃｌｏａｋｅｄ−２分子およびその使用
|
|
US7083784B2
(en)
|
2000-12-12 |
2006-08-01 |
Medimmune, Inc. |
Molecules with extended half-lives, compositions and uses thereof
|
|
EP1404297B1
(en)
|
2001-06-12 |
2011-04-27 |
The Johns Hopkins University School Of Medicine |
Reservoir device for intraocular drug delivery
|
|
WO2003029275A2
(en)
|
2001-10-03 |
2003-04-10 |
Regeneron Pharmaceuticals, Inc. |
Anti-angiogenic peptides
|
|
GB0130738D0
(en)
*
|
2001-12-21 |
2002-02-06 |
Serono Internat S A |
Protein
|
|
US7696320B2
(en)
|
2004-08-24 |
2010-04-13 |
Domantis Limited |
Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
|
|
US20060182783A1
(en)
|
2004-04-30 |
2006-08-17 |
Allergan, Inc. |
Sustained release intraocular drug delivery systems
|
|
WO2005110374A1
(en)
|
2004-04-30 |
2005-11-24 |
Allergan, Inc. |
Intraocular drug delivery systems containing a therapeutic component, a cyclodextrin, and a polymeric component
|
|
DE102005002978B4
(de)
|
2005-01-21 |
2013-04-25 |
Merz Pharma Gmbh & Co. Kgaa |
Rekombinante Expression von Proteinen in einer disulfidverbrückten, zweikettigen Form
|
|
WO2006078161A1
(en)
|
2005-01-24 |
2006-07-27 |
Pepscan Systems B.V. |
Binding compounds, immunogenic compounds and peptidomimetics
|
|
US20060204548A1
(en)
|
2005-03-01 |
2006-09-14 |
Allergan, Inc. |
Microimplants for ocular administration
|
|
US20090305994A1
(en)
|
2005-06-29 |
2009-12-10 |
D Andrea Lucas Domenico |
Compounds Modulating Vegf Receptor and Uses Thereof
|
|
JP2009509535A
(ja)
*
|
2005-09-27 |
2009-03-12 |
アムニクス， インコーポレイテッド |
タンパク様薬剤およびその使用
|
|
CN101583370A
(zh)
*
|
2005-09-27 |
2009-11-18 |
阿穆尼克斯公司 |
蛋白质药物及其用途
|
|
TW200732347A
(en)
|
2005-10-06 |
2007-09-01 |
Trophogen Inc |
VEGF analogs and methods of use
|
|
US7918814B2
(en)
|
2006-05-02 |
2011-04-05 |
Georgia Tech Research Corporation |
Method for drug delivery to ocular tissue using microneedle
|
|
WO2008045252A2
(en)
|
2006-10-04 |
2008-04-17 |
The Board Of Trustees Of The Leland Stanford Junior University |
Engineered integrin binding peptides
|
|
US8039010B2
(en)
|
2006-11-03 |
2011-10-18 |
Allergan, Inc. |
Sustained release intraocular drug delivery systems comprising a water soluble therapeutic agent and a release modifier
|
|
EP2091482A2
(en)
|
2006-12-01 |
2009-08-26 |
Allergan, Inc. |
Method for determining optimum intraocular locations for drug delivery systems
|
|
JP6073043B2
(ja)
|
2007-08-21 |
2017-02-01 |
ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム |
医薬品適用のための熱−動力学的混合
|
|
EP2604279A1
(en)
|
2008-03-27 |
2013-06-19 |
ZymoGenetics, Inc. |
Compositions and methods for inhibiting PDGFRBETA and VEGF-A
|
|
US8557273B2
(en)
|
2008-04-18 |
2013-10-15 |
Medtronic, Inc. |
Medical devices and methods including polymers having biologically active agents therein
|
|
US8821870B2
(en)
|
2008-07-18 |
2014-09-02 |
Allergan, Inc. |
Method for treating atrophic age related macular degeneration
|
|
EP2349327A4
(en)
*
|
2008-10-23 |
2012-11-28 |
Massachusetts Inst Technology |
COMMITMENT DIRECTED FC RECEIVERS ACTIVATORS
|
|
BRPI0921469B1
(pt)
|
2008-11-03 |
2022-01-18 |
Molecular Partners Ag |
Proteínas de ligação que inibem a interação com o receptor de vegf-a, composição farmacêutica
|
|
AU2010208046B2
(en)
|
2009-01-29 |
2014-10-02 |
Forsight Vision4, Inc. |
Posterior segment drug delivery
|
|
US8778888B2
(en)
*
|
2009-11-06 |
2014-07-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
Cystine knot peptides binding to alpha IIb beta 3 integrins and methods of use
|
|
US20110207653A1
(en)
|
2009-12-21 |
2011-08-25 |
Adrian Raiche |
Microparticle Encapsulated Thiol-Containing Polypeptides Together with a Redox Reagent
|
|
WO2011079232A1
(en)
|
2009-12-23 |
2011-06-30 |
Psivida Us, Inc. |
Sustained release delivery devices
|
|
US8339139B2
(en)
*
|
2010-01-29 |
2012-12-25 |
Infineon Technologies Ag |
System and method for testing a circuit
|
|
US10844106B2
(en)
*
|
2010-11-08 |
2020-11-24 |
The Board Of Trustees Of The Leland Stanford Junior University |
Fusion proteins comprising an engineered knottin peptide and uses thereof
|
|
MX386293B
(es)
*
|
2011-02-18 |
2025-03-18 |
Libertas Bio Inc |
Compuestos de aminoindano y su uso en el tratamiento del dolor.
|
|
US9187553B2
(en)
*
|
2012-01-25 |
2015-11-17 |
Swey-Shen Chen |
Displaying native human IgE neutralizing FcepsilonRIa-contacting IgE B-cell epitopes by constraining super beta(b)-strands and cystine knots on thermostable protein scaffold
|
|
EP2890389A1
(en)
*
|
2012-08-28 |
2015-07-08 |
Novartis AG |
Use of a vegf antagonist in treating ocular vascular proliferative diseases
|
|
GB201218278D0
(en)
*
|
2012-10-11 |
2012-11-28 |
Cyclogenix Ltd |
Translocating peptide
|
|
US9587001B2
(en)
*
|
2012-10-19 |
2017-03-07 |
The Board Of Trustees Of The Leland Stanford Junior University |
Conjugated knottin mini-proteins containing non-natural amino acids
|
|
TWI799366B
(zh)
|
2015-09-15 |
2023-04-21 |
美商建南德克公司 |
胱胺酸結骨架平臺
|