JP2018533572A5 - - Google Patents
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- Publication number
- JP2018533572A5 JP2018533572A5 JP2018521074A JP2018521074A JP2018533572A5 JP 2018533572 A5 JP2018533572 A5 JP 2018533572A5 JP 2018521074 A JP2018521074 A JP 2018521074A JP 2018521074 A JP2018521074 A JP 2018521074A JP 2018533572 A5 JP2018533572 A5 JP 2018533572A5
- Authority
- JP
- Japan
- Prior art keywords
- deprotection
- coupling
- volume
- solution
- coupling solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000010511 deprotection reaction Methods 0.000 claims description 53
- 230000008878 coupling Effects 0.000 claims description 49
- 238000005859 coupling reaction Methods 0.000 claims description 49
- 238000010168 coupling process Methods 0.000 claims description 48
- 239000000203 mixture Substances 0.000 claims description 46
- 238000000034 method Methods 0.000 claims description 44
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 18
- 150000007530 organic bases Chemical class 0.000 claims description 17
- 239000007790 solid phase Substances 0.000 claims description 12
- 238000010647 peptide synthesis reaction Methods 0.000 claims description 11
- 150000001413 amino acids Chemical class 0.000 claims description 10
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 7
- UZOFELREXGAFOI-UHFFFAOYSA-N 4-methylpiperidine Chemical compound CC1CCNCC1 UZOFELREXGAFOI-UHFFFAOYSA-N 0.000 claims description 4
- 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 claims description 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 description 22
- 239000002253 acid Substances 0.000 description 11
- 230000008569 process Effects 0.000 description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 230000001627 detrimental effect Effects 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 230000008901 benefit Effects 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562245484P | 2015-10-23 | 2015-10-23 | |
| US62/245,484 | 2015-10-23 | ||
| US15/299,931 | 2016-10-21 | ||
| US15/299,931 US10125163B2 (en) | 2015-10-23 | 2016-10-21 | Solid phase peptide synthesis |
| PCT/US2016/058181 WO2017070512A1 (en) | 2015-10-23 | 2016-10-21 | Improvements in solid phase peptide synthesis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018533572A JP2018533572A (ja) | 2018-11-15 |
| JP2018533572A5 true JP2018533572A5 (https=) | 2020-07-16 |
| JP6763948B2 JP6763948B2 (ja) | 2020-09-30 |
Family
ID=58558077
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018521074A Active JP6763948B2 (ja) | 2015-10-23 | 2016-10-21 | 固相ペプチド合成における改良 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US10125163B2 (https=) |
| JP (1) | JP6763948B2 (https=) |
| CA (1) | CA3002871C (https=) |
| WO (1) | WO2017070512A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10239914B2 (en) | 2015-10-23 | 2019-03-26 | Cem Corporation | In-situ solvent recycling process for solid phase peptide synthesis at elevated temperatures |
| WO2017070512A1 (en) | 2015-10-23 | 2017-04-27 | Cem Corporation | Improvements in solid phase peptide synthesis |
| USRE49961E1 (en) | 2016-10-21 | 2024-05-07 | Cem Corporation | Solid phase peptide syntheses |
| EP3810627A4 (en) * | 2018-06-19 | 2022-03-09 | Shanghai Space Peptides Pharmaceutical Co., Ltd. | Synthetic method of bivalirundin |
| CN108912208A (zh) * | 2018-06-20 | 2018-11-30 | 南京肽业生物科技有限公司 | 一种温度可调的多肽固相合成装置 |
| CN110642936B (zh) * | 2018-06-26 | 2023-01-17 | 深圳翰宇药业股份有限公司 | 一种制备特立帕肽的方法 |
| JP7766028B2 (ja) | 2020-06-03 | 2025-11-07 | 中外製薬株式会社 | 高難度配列の効率的ペプチド縮合法 |
| CN116390723B (zh) | 2020-09-09 | 2024-12-31 | 社会利益网络公司 | 用于将生物素递送至线粒体的方法和组合物 |
| EP4370528A4 (en) | 2021-07-16 | 2025-11-19 | Polypeptide Laboratories Holding Ppl Ab | SYNTHESIS OF PEPTIDES IN SOLID-AQUEOUS PHASE |
| CA3232401A1 (en) * | 2021-09-17 | 2023-03-23 | Cem Corporation | Solid phase peptide synthesis (spps) processes and associated systems |
| WO2024058924A1 (en) * | 2022-09-16 | 2024-03-21 | Cem Corporation | Peptide synthesis processes |
| EP4406652A1 (en) | 2023-01-25 | 2024-07-31 | Lizenzia GmbH | Suction head |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4065781A (en) * | 1974-06-21 | 1977-12-27 | Westinghouse Electric Corporation | Insulated-gate thin film transistor with low leakage current |
| US5614608A (en) * | 1995-01-20 | 1997-03-25 | Selectide Corporation | Apparatus and method for multiple synthesis of organic compounds on polymer support |
| US6329139B1 (en) * | 1995-04-25 | 2001-12-11 | Discovery Partners International | Automated sorting system for matrices with memory |
| US6890491B1 (en) * | 1997-06-10 | 2005-05-10 | Pharmacopeia Drug Discovery, Inc. | Method and apparatus for universal fluid exchange |
| US6084226A (en) | 1998-04-21 | 2000-07-04 | Cem Corporation | Use of continuously variable power in microwave assisted chemistry |
| PT1280831E (pt) * | 2000-05-12 | 2006-12-29 | Lonza Ag | Processo para a preparação de cloreto de 2-clorotritilo ligado a um polimero |
| US20040238794A1 (en) * | 2003-05-30 | 2004-12-02 | Karandikar Prashant G. | Microwave processing of composite bodies made by an infiltration route |
| US7393920B2 (en) | 2003-06-23 | 2008-07-01 | Cem Corporation | Microwave-assisted peptide synthesis |
| US7902488B2 (en) * | 2003-06-23 | 2011-03-08 | Cem Corporation | Microwave-assisted peptide synthesis |
| US7803351B2 (en) * | 2004-08-20 | 2010-09-28 | Washington University | Blood brain barrier permeation peptides |
| US8314208B2 (en) * | 2006-02-10 | 2012-11-20 | Cem Corporation | Microwave enhanced N-fmoc deprotection in peptide synthesis |
| MX2009012134A (es) * | 2007-05-11 | 2009-11-25 | Echostar Technologies Llc | Aparato para controlar la ejecucion de un procesador en un ambiente seguro. |
| CN103140497A (zh) | 2010-08-16 | 2013-06-05 | Cem有限公司 | 水溶性固相肽合成 |
| US8906681B2 (en) * | 2011-08-02 | 2014-12-09 | The Scripps Research Institute | Reliable stabilization of N-linked polypeptide native states with enhanced aromatic sequons located in polypeptide tight turns |
| EP2703073A1 (en) * | 2012-08-31 | 2014-03-05 | Biotage AB | Apparatus and method for solid phase synthesis |
| US9169287B2 (en) * | 2013-03-15 | 2015-10-27 | Massachusetts Institute Of Technology | Solid phase peptide synthesis processes and associated systems |
| WO2015028599A1 (en) | 2013-08-30 | 2015-03-05 | Biotage Ab | Cleavage of synthetic peptides |
| WO2017070512A1 (en) | 2015-10-23 | 2017-04-27 | Cem Corporation | Improvements in solid phase peptide synthesis |
| US10239914B2 (en) * | 2015-10-23 | 2019-03-26 | Cem Corporation | In-situ solvent recycling process for solid phase peptide synthesis at elevated temperatures |
-
2016
- 2016-10-21 WO PCT/US2016/058181 patent/WO2017070512A1/en not_active Ceased
- 2016-10-21 US US15/299,931 patent/US10125163B2/en not_active Ceased
- 2016-10-21 JP JP2018521074A patent/JP6763948B2/ja active Active
- 2016-10-21 CA CA3002871A patent/CA3002871C/en active Active
-
2018
- 2018-09-27 US US16/143,917 patent/US20190194246A1/en not_active Abandoned
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