JP2018532784A5 - - Google Patents
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- Publication number
- JP2018532784A5 JP2018532784A5 JP2018541543A JP2018541543A JP2018532784A5 JP 2018532784 A5 JP2018532784 A5 JP 2018532784A5 JP 2018541543 A JP2018541543 A JP 2018541543A JP 2018541543 A JP2018541543 A JP 2018541543A JP 2018532784 A5 JP2018532784 A5 JP 2018532784A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituent group
- alkyl
- optionally substituted
- substituent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000001424 substituent group Chemical group 0.000 claims 110
- 229910052760 oxygen Inorganic materials 0.000 claims 28
- 229910052717 sulfur Inorganic materials 0.000 claims 25
- 125000000217 alkyl group Chemical group 0.000 claims 21
- 125000000623 heterocyclic group Chemical group 0.000 claims 20
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 18
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 18
- 239000001301 oxygen Substances 0.000 claims 18
- 239000011593 sulfur Substances 0.000 claims 18
- 125000004432 carbon atom Chemical group C* 0.000 claims 17
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 15
- 150000001875 compounds Chemical class 0.000 claims 15
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 15
- 229910052757 nitrogen Inorganic materials 0.000 claims 15
- 239000003814 drug Substances 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 229940124597 therapeutic agent Drugs 0.000 claims 12
- 229910052799 carbon Inorganic materials 0.000 claims 10
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 10
- 125000004043 oxo group Chemical group O=* 0.000 claims 10
- 125000004093 cyano group Chemical group *C#N 0.000 claims 9
- 239000003112 inhibitor Substances 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 9
- 229910052794 bromium Inorganic materials 0.000 claims 8
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 8
- 229910052801 chlorine Inorganic materials 0.000 claims 8
- -1 cyano, cyclopropyl Chemical group 0.000 claims 8
- 229910052731 fluorine Inorganic materials 0.000 claims 8
- 229910052740 iodine Inorganic materials 0.000 claims 8
- 239000012453 solvate Substances 0.000 claims 8
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims 6
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 125000005842 heteroatom Chemical group 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 229920006395 saturated elastomer Polymers 0.000 claims 6
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 5
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 102000013742 Cyclin-Dependent Kinase 8 Human genes 0.000 claims 4
- 108010025415 Cyclin-Dependent Kinase 8 Proteins 0.000 claims 4
- 102100033145 Cyclin-dependent kinase 19 Human genes 0.000 claims 4
- 101710179322 Cyclin-dependent kinase 19 Proteins 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 125000004122 cyclic group Chemical group 0.000 claims 4
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000003396 thiol group Chemical class [H]S* 0.000 claims 4
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 3
- 125000004429 atom Chemical group 0.000 claims 3
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 3
- 210000003705 ribosome Anatomy 0.000 claims 3
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 2
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 2
- 125000006828 (C2-C7) alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000006773 (C2-C7) alkylcarbonyl group Chemical group 0.000 claims 2
- 102100033051 40S ribosomal protein S19 Human genes 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 208000033932 Blackfan-Diamond anemia Diseases 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 206010010356 Congenital anomaly Diseases 0.000 claims 2
- 206010053138 Congenital aplastic anaemia Diseases 0.000 claims 2
- 201000004449 Diamond-Blackfan anemia Diseases 0.000 claims 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 2
- 125000001931 aliphatic group Chemical group 0.000 claims 2
- 150000003973 alkyl amines Chemical class 0.000 claims 2
- 230000001195 anabolic effect Effects 0.000 claims 2
- 125000005129 aryl carbonyl group Chemical group 0.000 claims 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 claims 2
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 2
- 125000005143 heteroarylsulfonyl group Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000006413 ring segment Chemical group 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 125000004844 (C1-C6) alkoxyimino group Chemical group 0.000 claims 1
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 claims 1
- 206010053622 Asplenia Diseases 0.000 claims 1
- 208000020084 Bone disease Diseases 0.000 claims 1
- 201000007692 Bowen-Conradi syndrome Diseases 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 206010058314 Dysplasia Diseases 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 206010020649 Hyperkeratosis Diseases 0.000 claims 1
- 208000001126 Keratosis Diseases 0.000 claims 1
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 1
- 206010057178 Osteoarthropathies Diseases 0.000 claims 1
- 208000026928 Turner syndrome Diseases 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
- 208000007502 anemia Diseases 0.000 claims 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 1
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 claims 1
- 210000000845 cartilage Anatomy 0.000 claims 1
- 230000007882 cirrhosis Effects 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 229910003460 diamond Inorganic materials 0.000 claims 1
- 239000010432 diamond Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 1
- 125000006517 heterocyclyl carbonyl group Chemical group 0.000 claims 1
- 125000005844 heterocyclyloxy group Chemical group 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 150000003254 radicals Chemical class 0.000 claims 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- DBDCNCCRPKTRSD-UHFFFAOYSA-N thieno[3,2-b]pyridine Chemical group C1=CC=C2SC=CC2=N1 DBDCNCCRPKTRSD-UHFFFAOYSA-N 0.000 claims 1
- 229940125670 thienopyridine Drugs 0.000 claims 1
- 239000002175 thienopyridine Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1551419-3 | 2015-11-03 | ||
| SE1551419 | 2015-11-03 | ||
| PCT/EP2016/076550 WO2017076968A1 (en) | 2015-11-03 | 2016-11-03 | Compounds for treatment of hypoproliferative disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018532784A JP2018532784A (ja) | 2018-11-08 |
| JP2018532784A5 true JP2018532784A5 (https=) | 2019-12-12 |
| JP6977238B2 JP6977238B2 (ja) | 2021-12-08 |
Family
ID=57326350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018541543A Active JP6977238B2 (ja) | 2015-11-03 | 2016-11-03 | 低増殖性障害の治療のための化合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11471446B2 (https=) |
| EP (1) | EP3370720A1 (https=) |
| JP (1) | JP6977238B2 (https=) |
| KR (1) | KR20180073600A (https=) |
| CN (1) | CN108348509A (https=) |
| AU (1) | AU2016348659B2 (https=) |
| BR (1) | BR112018008931A8 (https=) |
| IL (1) | IL258593B (https=) |
| MX (1) | MX390651B (https=) |
| WO (1) | WO2017076968A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12281080B2 (en) | 2018-08-21 | 2025-04-22 | University Of South Carolina | Quinoline-based compounds and methods of inhibiting CDK8/19 |
| US11014906B2 (en) | 2018-08-21 | 2021-05-25 | University Of South Carolina | Quinoline-based compounds and methods of inhibiting CDK8/19 |
| CN113677341B (zh) * | 2019-02-01 | 2024-07-05 | 南卡罗莱纳大学 | 双环吡啶组合物及其用于癌症治疗的方法 |
| WO2020237014A1 (en) * | 2019-05-21 | 2020-11-26 | University Of South Carolina | 3-amino-4-(4-(4 (dimethylcarbamoyl) phenyl)-1,4-diazepan-1-yl) thieno [2,3-b] pyridine-2-carboxamide for use in cancer therapy and formulations comprising the same |
| GB202208226D0 (en) * | 2022-06-06 | 2022-07-20 | Royal Veterinary College | Method and treatment for osteoarthritis and diseases of chondrocyte hypertrophy |
| WO2023241627A1 (en) * | 2022-06-15 | 2023-12-21 | Insilico Medicine Ip Limited | Cdk8/19 dual inhibitors and methods of use thereof |
| WO2024193640A1 (zh) * | 2023-03-22 | 2024-09-26 | 上海齐鲁制药研究中心有限公司 | Cdk抑制剂 |
| CN121079397A (zh) * | 2023-04-18 | 2025-12-05 | 国立大学法人京都大学 | Ii型固有淋巴细胞的制造方法 |
| WO2026004819A1 (ja) * | 2024-06-24 | 2026-01-02 | 国立大学法人 長崎大学 | 骨形成促進用組成物 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60325051D1 (de) * | 2002-06-06 | 2009-01-15 | Boehringer Ingelheim Pharma | SUBSTITUIERTE 3-AMINO-THIENO(2,3-b)PYRIDINE-2-AMIDE UND HERSTELLUNGSVERFAHREN SOWIE DEREN VERWENDUNG |
| EP1764367A1 (en) | 2004-04-12 | 2007-03-21 | Sankyo Company, Limited | Thienopyridine derivatives |
| US8598344B2 (en) | 2009-11-30 | 2013-12-03 | Senex Biotechnology | CDKI pathway inhibitors and uses thereof |
| EA027531B1 (ru) * | 2011-09-13 | 2017-08-31 | Игорь Ронинсон | ЛЕЧЕНИЕ ЗАБОЛЕВАНИЙ И НАРУШЕНИЙ, ВЫЗВАННЫХ АКТИВНОСТЬЮ ТРАНСКРИПЦИОННОГО ФАКТОРА NF-κB |
| KR20150023223A (ko) | 2012-02-02 | 2015-03-05 | 세넥스 바이오테크놀러지 인코포레이티드 | Ｃｄｋ8/ｃｄｋ19 선택성 억제제 및 암에 대한 항-전이 및 화학예방 방법에서 이들의 용도 |
| WO2013138101A2 (en) * | 2012-03-16 | 2013-09-19 | Children's Medical Center Corporation | Calmodulin inhibitors for the treatment of ribosomal disorders and ribosomapathies |
| RU2015107550A (ru) | 2012-08-23 | 2016-10-10 | Ф. Хоффманн-Ля Рош Аг | Новые фенилпиридин/пиразинамиды для лечения рака |
| GB201220157D0 (en) | 2012-11-08 | 2012-12-26 | Selvita Sa | Substitute tricyclic benzimidazoles as kinase inhibitors |
| HK1213544A1 (zh) | 2012-12-10 | 2016-07-08 | 霍夫曼-拉罗奇有限公司 | 新型二环苯基-吡啶/吡嗪用於治疗癌症 |
| WO2014106606A1 (en) | 2013-01-05 | 2014-07-10 | F. Hoffmann-La Roche Ag | Nove phenyl/pyridine series substitued by hydroxyethylamino for the treatment of cancer |
| WO2014154723A1 (en) | 2013-03-29 | 2014-10-02 | F. Hoffmann-La Roche Ag | Novel pyrrole derivatives for the treatment of cancer |
| WO2014194245A2 (en) * | 2013-05-31 | 2014-12-04 | Nimbus Iris, Inc. | Cdk8 inhibitors and uses thereof |
| WO2015144290A1 (en) * | 2014-03-27 | 2015-10-01 | Merck Patent Gmbh | Pyridyl piperidines |
-
2016
- 2016-11-03 AU AU2016348659A patent/AU2016348659B2/en active Active
- 2016-11-03 JP JP2018541543A patent/JP6977238B2/ja active Active
- 2016-11-03 EP EP16797472.4A patent/EP3370720A1/en not_active Withdrawn
- 2016-11-03 MX MX2018005158A patent/MX390651B/es unknown
- 2016-11-03 BR BR112018008931A patent/BR112018008931A8/pt not_active Application Discontinuation
- 2016-11-03 US US15/772,633 patent/US11471446B2/en active Active
- 2016-11-03 WO PCT/EP2016/076550 patent/WO2017076968A1/en not_active Ceased
- 2016-11-03 KR KR1020187013367A patent/KR20180073600A/ko not_active Withdrawn
- 2016-11-03 CN CN201680063630.0A patent/CN108348509A/zh active Pending
-
2018
- 2018-04-10 IL IL258593A patent/IL258593B/en active IP Right Grant
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