JP2018532736A5 - - Google Patents
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- JP2018532736A5 JP2018532736A5 JP2018519039A JP2018519039A JP2018532736A5 JP 2018532736 A5 JP2018532736 A5 JP 2018532736A5 JP 2018519039 A JP2018519039 A JP 2018519039A JP 2018519039 A JP2018519039 A JP 2018519039A JP 2018532736 A5 JP2018532736 A5 JP 2018532736A5
- Authority
- JP
- Japan
- Prior art keywords
- neoepitope
- matched
- hla
- patient
- tumor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 21
- 206010028980 Neoplasm Diseases 0.000 claims 14
- 238000001914 filtration Methods 0.000 claims 10
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims 6
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims 6
- 230000035772 mutation Effects 0.000 claims 6
- 230000005778 DNA damage Effects 0.000 claims 4
- 231100000277 DNA damage Toxicity 0.000 claims 4
- 102000043129 MHC class I family Human genes 0.000 claims 4
- 108091054437 MHC class I family Proteins 0.000 claims 4
- 102000043131 MHC class II family Human genes 0.000 claims 4
- 108091054438 MHC class II family Proteins 0.000 claims 4
- 208000032818 Microsatellite Instability Diseases 0.000 claims 4
- 230000033607 mismatch repair Effects 0.000 claims 4
- 230000004797 therapeutic response Effects 0.000 claims 4
- 102000054765 polymorphisms of proteins Human genes 0.000 claims 3
- 108091092878 Microsatellite Proteins 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 230000000391 smoking effect Effects 0.000 claims 2
- 239000012275 CTLA-4 inhibitor Substances 0.000 claims 1
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 1
- 239000012270 PD-1 inhibitor Substances 0.000 claims 1
- 239000012668 PD-1-inhibitor Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000012790 confirmation Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 238000009169 immunotherapy Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 229940121655 pd-1 inhibitor Drugs 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562240494P | 2015-10-12 | 2015-10-12 | |
| US62/240,494 | 2015-10-12 | ||
| PCT/US2016/056692 WO2017066357A1 (en) | 2015-10-12 | 2016-10-12 | Systems, compositions, and methods for discovery of msi and neoepitopes that predict sensitivity to checkpoint inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018532736A JP2018532736A (ja) | 2018-11-08 |
| JP2018532736A5 true JP2018532736A5 (enExample) | 2019-01-17 |
Family
ID=57882841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018519039A Pending JP2018532736A (ja) | 2015-10-12 | 2016-10-12 | チェックポイント阻害物質への感受性を予測するｍｓｉおよびネオエピトープの探索のための系、組成物、および方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11626187B2 (enExample) |
| EP (1) | EP3362930A4 (enExample) |
| JP (1) | JP2018532736A (enExample) |
| KR (1) | KR20180087244A (enExample) |
| CN (1) | CN108701173A (enExample) |
| AU (1) | AU2016339035A1 (enExample) |
| CA (1) | CA3003251A1 (enExample) |
| HK (1) | HK1258091A1 (enExample) |
| IL (1) | IL258679A (enExample) |
| WO (1) | WO2017066357A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20190099475A1 (en) | 2015-04-08 | 2019-04-04 | Nantomics, Llc | Cancer neoepitopes |
| CN108701173A (zh) | 2015-10-12 | 2018-10-23 | 南托米克斯有限责任公司 | 用于发现预测对检查点抑制剂敏感的msi和新表位的系统、组合物和方法 |
| KR20180091119A (ko) | 2016-02-12 | 2018-08-14 | 난토믹스, 엘엘씨 | 암 면역요법을 위한 치료 표적으로 환자 특이적 네오에피토프의 높은 스루풋 식별 (high-throughput identification of patient-specific neoepitopes as therapeutic targets for cancer immunotherapies) |
| SG11201901432YA (en) | 2016-08-25 | 2019-03-28 | Nantomics Llc | Immunotherapy markers and uses therefor |
| JP7437939B2 (ja) * | 2017-03-03 | 2024-02-26 | トレオス バイオ リミテッド | 集団に基づいた免疫原性ペプチドの同定のプラットフォーム |
| US11104938B2 (en) | 2017-06-20 | 2021-08-31 | Bio-Rad Laboratories, Inc. | Digital amplification assays for genetic instability |
| EP3666887A4 (en) * | 2017-08-10 | 2021-09-01 | Good T Cells, Inc. | T-CELL ACTIVATION METHOD FOR CANCER TREATMENT |
| US11773449B2 (en) | 2017-09-01 | 2023-10-03 | The Hospital For Sick Children | Profiling and treatment of hypermutant cancer |
| US20200385815A1 (en) * | 2017-12-20 | 2020-12-10 | Nantomics, Llc | Using cfRNA for Diagnosing Minimal Residual Disease |
| WO2019206725A1 (en) * | 2018-04-25 | 2019-10-31 | Koninklijke Philips N.V. | Tumor functional mutation and epitope loads as improved predictive biomarkers for immunotherapy response |
| CA3106562A1 (en) | 2018-07-26 | 2020-01-30 | Frame Pharmaceuticals B.V. | Off-the-shelf cancer vaccines |
| US20210189505A1 (en) * | 2018-08-23 | 2021-06-24 | Nantcell, Inc. | Assessing microsatellite instability by liquid biopsy |
| MA53543A (fr) | 2018-09-04 | 2021-07-14 | Treos Bio Ltd | Vaccins peptidiques |
| WO2020091944A1 (en) * | 2018-10-31 | 2020-05-07 | Nantomics, Llc | Genomic and immune infiltration differences between msi and mss gi tumors |
| CN110556164B (zh) * | 2019-09-09 | 2023-02-07 | 深圳裕策生物科技有限公司 | 用于目标区域捕获测序检测msi的方法、装置和存储介质 |
| CN110910957B (zh) * | 2019-12-31 | 2023-06-27 | 求臻医学科技(浙江)有限公司 | 一种基于单肿瘤样本高通量测序微卫星不稳定性探测位点筛选方法 |
| CN111785324B (zh) * | 2020-07-02 | 2021-02-02 | 深圳市海普洛斯生物科技有限公司 | 一种微卫星不稳定分析方法及装置 |
| CN112183557A (zh) * | 2020-09-29 | 2021-01-05 | 山西医科大学 | 基于胃癌组织病理图像纹理特征的msi预测模型构建方法 |
| CN114974420A (zh) * | 2021-10-29 | 2022-08-30 | 无锡臻和生物科技有限公司 | 预测胃肠肿瘤免疫检查点抑制剂疗效的标志物及其应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003207459A1 (en) | 2002-01-03 | 2003-07-24 | The Scripps Research Institute | Cancer-associated epitope |
| CA2518569C (en) | 2003-03-10 | 2011-11-15 | Expression Pathology, Inc. | Liquid tissue preparation from histopathologically processed biological samples, tissues and cells |
| WO2005019432A2 (en) | 2003-08-20 | 2005-03-03 | Cleveland Clinic Foundation Innovations | A novel gene and protein associated with angiogenesis and endothelial apoptosis |
| US7767792B2 (en) | 2004-02-20 | 2010-08-03 | Ludwig Institute For Cancer Research Ltd. | Antibodies to EGF receptor epitope peptides |
| JP4852046B2 (ja) | 2004-10-12 | 2012-01-11 | クルセル ホランド ベー ヴェー | 癌の治療及び検出に用いる結合分子 |
| US7811993B2 (en) | 2005-06-29 | 2010-10-12 | The Wistar Institute Of Anatomy And Biology | Methods and compositions for treating melanoma |
| SG177954A1 (en) | 2007-01-05 | 2012-02-28 | Univ Zuerich | Method of providing disease-specific binding molecules and targets |
| DK3023788T3 (da) | 2010-05-14 | 2020-04-27 | Massachusetts Gen Hospital | Sammensætninger af tumorspecifikke neoantigener til anvendelse ved behandling af tumorer |
| US9646134B2 (en) | 2010-05-25 | 2017-05-09 | The Regents Of The University Of California | Bambam: parallel comparative analysis of high-throughput sequencing data |
| CN106951732B (zh) | 2010-05-25 | 2020-03-10 | 加利福尼亚大学董事会 | 基于计算机的基因组序列分析系统 |
| WO2013173223A1 (en) | 2012-05-15 | 2013-11-21 | Bristol-Myers Squibb Company | Cancer immunotherapy by disrupting pd-1/pd-l1 signaling |
| ES2737757T3 (es) | 2012-09-28 | 2020-01-15 | Univ Connecticut | Identificación de epítopos protectores contra tumores para el tratamiento de cánceres |
| KR102858313B1 (ko) | 2013-04-07 | 2025-09-10 | 더 브로드 인스티튜트, 인코퍼레이티드 | 개인맞춤화 신생물 백신을 위한 조성물 및 방법 |
| US20160258025A1 (en) | 2013-10-18 | 2016-09-08 | The Regents Of The University Of California | Predicting patient responsiveness to immune checkpoint inhibitors |
| KR20230076867A (ko) | 2013-12-20 | 2023-05-31 | 더 브로드 인스티튜트, 인코퍼레이티드 | 신생항원 백신과의 병용 요법 |
| RU2707530C2 (ru) * | 2014-01-02 | 2019-11-27 | Мемориал Слоан Кеттеринг Кэнсер Сентер | Детерминанты ответа раковой опухоли на иммунотерапию |
| US20190099475A1 (en) | 2015-04-08 | 2019-04-04 | Nantomics, Llc | Cancer neoepitopes |
| BR112017022845A2 (pt) | 2015-04-23 | 2018-07-17 | Nantomics, Llc | neoepítopos de câncer |
| RU2018106934A (ru) | 2015-08-25 | 2019-09-26 | Нантомикс, Ллс | Системы и способы высокоточного определения вариантов |
| CN108701173A (zh) | 2015-10-12 | 2018-10-23 | 南托米克斯有限责任公司 | 用于发现预测对检查点抑制剂敏感的msi和新表位的系统、组合物和方法 |
-
2016
- 2016-10-12 CN CN201680065549.6A patent/CN108701173A/zh not_active Withdrawn
- 2016-10-12 HK HK19100475.3A patent/HK1258091A1/zh unknown
- 2016-10-12 AU AU2016339035A patent/AU2016339035A1/en not_active Abandoned
- 2016-10-12 JP JP2018519039A patent/JP2018532736A/ja active Pending
- 2016-10-12 EP EP16856134.8A patent/EP3362930A4/en not_active Withdrawn
- 2016-10-12 US US15/292,021 patent/US11626187B2/en active Active
- 2016-10-12 CA CA3003251A patent/CA3003251A1/en active Pending
- 2016-10-12 WO PCT/US2016/056692 patent/WO2017066357A1/en not_active Ceased
- 2016-10-12 KR KR1020187013060A patent/KR20180087244A/ko not_active Withdrawn
-
2018
- 2018-04-12 IL IL258679A patent/IL258679A/en unknown
-
2023
- 2023-02-02 US US18/163,664 patent/US20230307090A1/en active Pending
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