JP2018530586A5 - - Google Patents
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- Publication number
- JP2018530586A5 JP2018530586A5 JP2018519309A JP2018519309A JP2018530586A5 JP 2018530586 A5 JP2018530586 A5 JP 2018530586A5 JP 2018519309 A JP2018519309 A JP 2018519309A JP 2018519309 A JP2018519309 A JP 2018519309A JP 2018530586 A5 JP2018530586 A5 JP 2018530586A5
- Authority
- JP
- Japan
- Prior art keywords
- patient
- pharmaceutical composition
- per day
- statin
- amd
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 27
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 25
- 206010064930 age-related macular degeneration Diseases 0.000 claims 13
- 208000002780 macular degeneration Diseases 0.000 claims 13
- 206010003694 Atrophy Diseases 0.000 claims 9
- 230000037444 atrophy Effects 0.000 claims 9
- 230000002265 prevention Effects 0.000 claims 9
- 210000003583 retinal pigment epithelium Anatomy 0.000 claims 9
- 238000012544 monitoring process Methods 0.000 claims 5
- 108091008695 photoreceptors Proteins 0.000 claims 5
- 230000004304 visual acuity Effects 0.000 claims 5
- 230000004393 visual impairment Effects 0.000 claims 5
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 claims 4
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 claims 4
- 201000004569 Blindness Diseases 0.000 claims 4
- PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 claims 4
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 claims 4
- 229960005370 atorvastatin Drugs 0.000 claims 4
- 229960004844 lovastatin Drugs 0.000 claims 4
- PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 claims 4
- QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 claims 4
- 229960002855 simvastatin Drugs 0.000 claims 4
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 claims 4
- FJLGEFLZQAZZCD-MCBHFWOFSA-N (3R,5S)-fluvastatin Chemical compound C12=CC=CC=C2N(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)=C1C1=CC=C(F)C=C1 FJLGEFLZQAZZCD-MCBHFWOFSA-N 0.000 claims 3
- TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 claims 3
- 229960005110 cerivastatin Drugs 0.000 claims 3
- SEERZIQQUAZTOL-ANMDKAQQSA-N cerivastatin Chemical compound COCC1=C(C(C)C)N=C(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)=C1C1=CC=C(F)C=C1 SEERZIQQUAZTOL-ANMDKAQQSA-N 0.000 claims 3
- 229960003765 fluvastatin Drugs 0.000 claims 3
- 229960002797 pitavastatin Drugs 0.000 claims 3
- VGYFMXBACGZSIL-MCBHFWOFSA-N pitavastatin Chemical compound OC(=O)C[C@H](O)C[C@H](O)\C=C\C1=C(C2CC2)N=C2C=CC=CC2=C1C1=CC=C(F)C=C1 VGYFMXBACGZSIL-MCBHFWOFSA-N 0.000 claims 3
- 229960002965 pravastatin Drugs 0.000 claims 3
- TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 claims 3
- 229960000672 rosuvastatin Drugs 0.000 claims 3
- BPRHUIZQVSMCRT-VEUZHWNKSA-N rosuvastatin Chemical compound CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O BPRHUIZQVSMCRT-VEUZHWNKSA-N 0.000 claims 3
- 208000000208 Wet Macular Degeneration Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 208000011325 dry age related macular degeneration Diseases 0.000 claims 2
- 230000002708 enhancing effect Effects 0.000 claims 2
- 238000012423 maintenance Methods 0.000 claims 2
- 230000000242 pagocytic effect Effects 0.000 claims 2
- 239000000049 pigment Substances 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical compound O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 claims 1
- 229940121369 angiogenesis inhibitor Drugs 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 claims 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 1
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 208000018769 loss of vision Diseases 0.000 claims 1
- 231100000864 loss of vision Toxicity 0.000 claims 1
- 239000011707 mineral Substances 0.000 claims 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims 1
- 229940012843 omega-3 fatty acid Drugs 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 229940100615 topical ointment Drugs 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 150000003722 vitamin derivatives Chemical class 0.000 claims 1
Images
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021147620A JP7754480B2 (ja) | 2015-10-14 | 2021-09-10 | 加齢黄斑変性のための高用量スタチン |
| JP2023177353A JP2024016045A (ja) | 2015-10-14 | 2023-10-13 | 加齢黄斑変性のための高用量スタチン |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562241522P | 2015-10-14 | 2015-10-14 | |
| US62/241,522 | 2015-10-14 | ||
| PCT/US2016/056987 WO2017066529A1 (en) | 2015-10-14 | 2016-10-14 | High-dose statins for age-related macular degeneration |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021147620A Division JP7754480B2 (ja) | 2015-10-14 | 2021-09-10 | 加齢黄斑変性のための高用量スタチン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018530586A JP2018530586A (ja) | 2018-10-18 |
| JP2018530586A5 true JP2018530586A5 (enExample) | 2019-11-21 |
| JP7037186B2 JP7037186B2 (ja) | 2022-03-16 |
Family
ID=58517927
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018519309A Active JP7037186B2 (ja) | 2015-10-14 | 2016-10-14 | 加齢黄斑変性のための高用量スタチン |
| JP2021147620A Active JP7754480B2 (ja) | 2015-10-14 | 2021-09-10 | 加齢黄斑変性のための高用量スタチン |
| JP2023177353A Withdrawn JP2024016045A (ja) | 2015-10-14 | 2023-10-13 | 加齢黄斑変性のための高用量スタチン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021147620A Active JP7754480B2 (ja) | 2015-10-14 | 2021-09-10 | 加齢黄斑変性のための高用量スタチン |
| JP2023177353A Withdrawn JP2024016045A (ja) | 2015-10-14 | 2023-10-13 | 加齢黄斑変性のための高用量スタチン |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11331295B2 (enExample) |
| EP (1) | EP3362063B1 (enExample) |
| JP (3) | JP7037186B2 (enExample) |
| AU (1) | AU2016338540B2 (enExample) |
| CA (1) | CA3001661C (enExample) |
| DK (1) | DK3362063T3 (enExample) |
| ES (1) | ES2941347T3 (enExample) |
| FI (1) | FI3362063T3 (enExample) |
| IL (1) | IL258604B2 (enExample) |
| MX (1) | MX391944B (enExample) |
| PH (1) | PH12018500745B1 (enExample) |
| WO (1) | WO2017066529A1 (enExample) |
| ZA (1) | ZA201803097B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11789024B2 (en) | 2017-05-09 | 2023-10-17 | Massachusetts Eye And Ear Infirmary | Biomarkers for age-related macular degeneration |
| WO2019018350A1 (en) * | 2017-07-17 | 2019-01-24 | Keith Roizman | TOPICAL ADMINISTRATION OF THERAPEUTIC AGENTS COMPRISING CELL PENETRATION PEPTIDES, FOR USE IN THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION AND OTHER OCULAR DISEASES |
| US20200243170A1 (en) * | 2017-10-17 | 2020-07-30 | Apeliotus Technologies, Inc. | Functional biomarkers for statin therapy in age-related macular degeneration (amd) |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030065020A1 (en) * | 2001-07-13 | 2003-04-03 | Catharine Gale | Treatment of macular degeneration |
| CA2478317A1 (en) | 2002-03-04 | 2003-09-18 | Medimmune, Inc. | Methods of preventing or treating disorders by administering an integrin .alpha.v.beta.3 antagonist in combination with an hmg-coa reductase inhibitor or a bisphosphonate |
| WO2005083430A1 (en) | 2004-02-25 | 2005-09-09 | Massachusetts Eye & Ear Infirmary | Biomarkers for age-related macular degeneration (amd) |
| US7919094B2 (en) | 2004-06-10 | 2011-04-05 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| WO2006083533A2 (en) * | 2005-01-14 | 2006-08-10 | The Regents Of The University Of California | Compositions and methods for inhibiting drusen formation and for diagnosing or treating drusen-related disorders |
| WO2008006535A2 (en) | 2006-07-10 | 2008-01-17 | Medigene Ag | Use of a cationic colloidal preparation for the diagnosis and treatment of ocular diseases |
| JP2008268506A (ja) * | 2007-04-19 | 2008-11-06 | Fuji Xerox Co Ltd | 現像装置、像保持体ユニットおよび画像形成装置 |
| WO2009023411A1 (en) | 2007-08-09 | 2009-02-19 | Bausch & Lomb Incorporated | Compositions and methods for treating or controlling anterior- and posterior-segment ophthalmic diseases |
| US20120156202A1 (en) | 2010-11-05 | 2012-06-21 | Shantha Totada R | Age related macular degeneration treatment |
| ES2947557T3 (es) | 2013-09-06 | 2023-08-11 | Vanda Pharmaceuticals Inc | Tratamiento de afecciones mediadas por CYR61 y VEGF |
| WO2016009430A1 (en) | 2014-07-14 | 2016-01-21 | Yeda Research And Development Co. Ltd | Reduction of aging-induced type i interferon signaling at the brain's choroid plexus or within the cns for treatment of disease or injury of the cns |
| CA2954475C (en) | 2014-07-31 | 2023-05-16 | Uab Research Foundation | Apoe mimetic peptides and higher potency to clear plasma cholesterol |
-
2016
- 2016-10-14 JP JP2018519309A patent/JP7037186B2/ja active Active
- 2016-10-14 IL IL258604A patent/IL258604B2/en unknown
- 2016-10-14 US US15/768,367 patent/US11331295B2/en active Active
- 2016-10-14 FI FIEP16856248.6T patent/FI3362063T3/fi active
- 2016-10-14 AU AU2016338540A patent/AU2016338540B2/en active Active
- 2016-10-14 EP EP16856248.6A patent/EP3362063B1/en active Active
- 2016-10-14 ES ES16856248T patent/ES2941347T3/es active Active
- 2016-10-14 DK DK16856248.6T patent/DK3362063T3/da active
- 2016-10-14 PH PH1/2018/500745A patent/PH12018500745B1/en unknown
- 2016-10-14 WO PCT/US2016/056987 patent/WO2017066529A1/en not_active Ceased
- 2016-10-14 MX MX2018004636A patent/MX391944B/es unknown
- 2016-10-14 CA CA3001661A patent/CA3001661C/en active Active
-
2018
- 2018-05-11 ZA ZA2018/03097A patent/ZA201803097B/en unknown
-
2020
- 2020-12-01 US US17/108,065 patent/US11744817B2/en active Active
-
2021
- 2021-09-10 JP JP2021147620A patent/JP7754480B2/ja active Active
-
2023
- 2023-10-13 JP JP2023177353A patent/JP2024016045A/ja not_active Withdrawn
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