DK3362063T3 - Højdosisstatiner til aldersrelateret makuladegeneration - Google Patents

Højdosisstatiner til aldersrelateret makuladegeneration Download PDF

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Publication number
DK3362063T3
DK3362063T3 DK16856248.6T DK16856248T DK3362063T3 DK 3362063 T3 DK3362063 T3 DK 3362063T3 DK 16856248 T DK16856248 T DK 16856248T DK 3362063 T3 DK3362063 T3 DK 3362063T3
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DK
Denmark
Prior art keywords
age
macular degeneration
related macular
dose statins
statins
Prior art date
Application number
DK16856248.6T
Other languages
English (en)
Inventor
Demetrios Vavvas
Joan W Miller
Original Assignee
Massachusetts Eye & Ear Infirmary
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Eye & Ear Infirmary filed Critical Massachusetts Eye & Ear Infirmary
Application granted granted Critical
Publication of DK3362063T3 publication Critical patent/DK3362063T3/da

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • A61K31/366Lactones having six-membered rings, e.g. delta-lactones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK16856248.6T 2015-10-14 2016-10-14 Højdosisstatiner til aldersrelateret makuladegeneration DK3362063T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562241522P 2015-10-14 2015-10-14
PCT/US2016/056987 WO2017066529A1 (en) 2015-10-14 2016-10-14 High-dose statins for age-related macular degeneration

Publications (1)

Publication Number Publication Date
DK3362063T3 true DK3362063T3 (da) 2023-04-03

Family

ID=58517927

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16856248.6T DK3362063T3 (da) 2015-10-14 2016-10-14 Højdosisstatiner til aldersrelateret makuladegeneration

Country Status (13)

Country Link
US (2) US11331295B2 (da)
EP (1) EP3362063B1 (da)
JP (3) JP7037186B2 (da)
AU (1) AU2016338540B2 (da)
CA (1) CA3001661A1 (da)
DK (1) DK3362063T3 (da)
ES (1) ES2941347T3 (da)
FI (1) FI3362063T3 (da)
IL (1) IL258604B2 (da)
MX (1) MX2018004636A (da)
PH (1) PH12018500745A1 (da)
WO (1) WO2017066529A1 (da)
ZA (1) ZA201803097B (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11789024B2 (en) 2017-05-09 2023-10-17 Massachusetts Eye And Ear Infirmary Biomarkers for age-related macular degeneration
AU2018302022A1 (en) * 2017-07-17 2020-02-27 Macregen, Inc. Topical delivery of therapeutic agents comprising cell-penetrating peptides for use for the treatment of age-related macular degeneration and other eye diseases
JP2020537684A (ja) * 2017-10-17 2020-12-24 アペリオタス・テクノロジーズ・インコーポレイテッド 加齢性黄斑変性症(amd)におけるスタチン療法の機能的バイオマーカー

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030065020A1 (en) * 2001-07-13 2003-04-03 Catharine Gale Treatment of macular degeneration
EP1487489A4 (en) 2002-03-04 2008-10-01 Medimmune Inc METHODS FOR PREVENTING OR TREATING DISORDERS BY ADMINISTERING AN INTEGRIN AVB3 ANTAGONIST ASSOCIATED WITH HMG-COA REDUCTASE INHIBITOR OR BISPHOSPHONATE
WO2005083430A1 (en) 2004-02-25 2005-09-09 Massachusetts Eye & Ear Infirmary Biomarkers for age-related macular degeneration (amd)
US7919094B2 (en) * 2004-06-10 2011-04-05 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
JP2008527005A (ja) 2005-01-14 2008-07-24 ザ、リージェンツ、オブ、ザ、ユニバーシティ、オブ、カリフォルニア ドルーゼン形成を阻害するため、およびドルーゼン関連障害を診断または治療するための組成物および方法
EP2046293A2 (en) 2006-07-10 2009-04-15 Medigene AG Use of a cationic colloidal preparation for the diagnosis and treatment of ocular diseases
JP2008268506A (ja) * 2007-04-19 2008-11-06 Fuji Xerox Co Ltd 現像装置、像保持体ユニットおよび画像形成装置
WO2009023411A1 (en) 2007-08-09 2009-02-19 Bausch & Lomb Incorporated Compositions and methods for treating or controlling anterior- and posterior-segment ophthalmic diseases
US20120156202A1 (en) 2010-11-05 2012-06-21 Shantha Totada R Age related macular degeneration treatment
ES2947557T3 (es) 2013-09-06 2023-08-11 Vanda Pharmaceuticals Inc Tratamiento de afecciones mediadas por CYR61 y VEGF
WO2016009430A1 (en) 2014-07-14 2016-01-21 Yeda Research And Development Co. Ltd Reduction of aging-induced type i interferon signaling at the brain's choroid plexus or within the cns for treatment of disease or injury of the cns
WO2016018665A1 (en) 2014-07-31 2016-02-04 Uab Research Foundation Apoe mimetic peptides and higher potency to clear plasma cholesterol

Also Published As

Publication number Publication date
FI3362063T3 (fi) 2023-04-06
EP3362063B1 (en) 2023-01-11
AU2016338540B2 (en) 2022-04-28
IL258604A (en) 2018-06-28
ZA201803097B (en) 2022-12-21
US20210077457A1 (en) 2021-03-18
PH12018500745A1 (en) 2018-10-15
ES2941347T3 (es) 2023-05-22
MX2018004636A (es) 2019-06-20
US11331295B2 (en) 2022-05-17
US11744817B2 (en) 2023-09-05
EP3362063A1 (en) 2018-08-22
JP7037186B2 (ja) 2022-03-16
JP2024016045A (ja) 2024-02-06
EP3362063A4 (en) 2019-06-19
AU2016338540A1 (en) 2018-05-24
IL258604B1 (en) 2024-05-01
CA3001661A1 (en) 2017-04-20
JP2022003042A (ja) 2022-01-11
JP2018530586A (ja) 2018-10-18
US20190209522A1 (en) 2019-07-11
WO2017066529A1 (en) 2017-04-20
IL258604B2 (en) 2024-09-01

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