JP2018530386A - 植え込み可能弁及び方法 - Google Patents
植え込み可能弁及び方法 Download PDFInfo
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- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
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- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/9155—Adjacent bands being connected to each other
- A61F2002/91575—Adjacent bands being connected to each other connected peak to trough
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- A—HUMAN NECESSITIES
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- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
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Abstract
【選択図】図8
Description
本出願は、参照によりその全体が本明細書に組み込まれる2015年10月13日出願の米国特許仮出願番号第62/284,923号の優先権を主張するものである。
a)例えば、図5、図13又は図14に示すような植え込み可能弁を準備し、
b)植え込み可能装置を圧縮し、これを静脈内送達用カテーテルに挿入し、
c)静脈内にカテーテルを配置し、静脈内の所望の部位に植え込み可能弁を送達し、
d)フレーム10が静脈20よりも大きくなるように植え込み可能弁を自己拡張させ、所望の部位又は位置で植え込み可能弁を保持することで、静脈不全を治療するために使用することができる。
植え込み可能人工弁は、好ましくは、経皮的カテーテルにより身体血管内に送達される。植え込み可能人工弁は、好ましくは、経カテーテル経皮送達に適応しており、カテーテル送達用システムによる治療点への導入に適した圧縮送達状態から、身体血管内の治療点で保持されるために径方向に拡張した移植状態に変形することができる。径方向に拡張可能な支持フレームは、自己拡張性又はバルーン拡張型のフレームを含む。これら両タイプの支持フレームの構造的特徴は当該技術分野において知られているため、本明細書では詳述しない。人工静脈弁などの末梢血管系への移植を意図した本発明に係る植え込み可能弁は、自己拡張性支持フレームを効果的に含んでいる。
a)ディップコーティング用の弁のモールドをCADで設計した後、ABS樹脂で3D印刷し、弁構造用を意図した機械加工で丸みをつけた部分を本体に有し、熱硬化フレームが最終的に拡張した際の内径となる意図されるネガ形状として機械加工した。弁のモールドを溶媒に浸し、表面を調整して平らにした。次に、弁のモールドをシリコーンの薄層で被覆し、所定のポリマ材料がオーバーモールドできるよう平滑で非外傷的な表面とした。
b)端部8mm、直径10mmの膨張部及び意図する弁構造及びフレーム用に丸みをつけた部分を本体に有する最終的に拡張したバルブ及び熱硬化フレームの所定のネガ形状として、熱硬化用マンドレルを10mmのステンレス鋼ロッドから製造した。
a)一体化した弁構造と放射線不透過性マーカーを有するよう円周方向にパターン化してフレームを設計した。
b)意図する圧接時直径と拡張時直径との間の直径を有するニチノールチューブから基礎構造体をレーザーカットした。
c)カットした基礎構造体の内側の表面を砥石で研いだ。
d)カットした基礎構造体の外側をマイクロブラスト加工した。
e)基礎構造体を、フレームにしたとき内径が8mmで、意図する弁構造が取り付けられる10mmの膨張部を有するように拡張させ、熱硬化した。
f)その後、基礎構造体を電気研磨により表面仕上げした。
g)タンタル放射線不透過性マーカーを、基礎構造体パターンで指定される形状にスエージ加工した。
a)溶剤を用いたディップコーティング用にドラフトチャンバーを準備し、空気環境は温度及び湿度を制御した。
b)テトラヒドロフランに溶解したウレタンとポリカーボネートからなる熱可塑性ポリウレタン(TPU)ブレンドの5〜20%溶液を調製し、2000mLのガラス容器に入れてドラフトチャンバー内に維持した。
c)ニチノール製基礎構造体は、意図する弁方向の遠位端を部分的にディップコートし、意図する弁位置までの長さをTPUブレンドで包み込んだ。
d)部分的にディップコートされた基礎構造体を、ドラフトチャンバー内で機械的に回転させ、溶媒の蒸発中にTPU溶液を広げて平らにしてTPUを凝固させた。部分的な基礎構造体のディップコーティング工程を繰り返して、網状薄膜に基礎構造体を完全に包み込み(例えば、フレームを形成し)、最終的に硬化した壁厚2〜7ミルのTPUをフレーム及び弁のモールド上に得た。この工程は、湿度30%未満、20〜60℃、ディップ時間30分未満で連続的に実施した。
e)その後、部分的に被覆された基礎構造体を弁モールド上に組み付けた。具体的には、部分的にディップコートした端部を直径8mmの支持部分に配置し、熱硬化したフレームの直径10mmの膨張部n弁モールドを配置した。
f)弁モールドと基礎構造体との組立体に、TPU溶液中で弁の近位方向から既にディップした遠位端に至る部分までディップコートを施し、ドラフトチャンバー内で機械的に回転させ、溶媒の蒸発中にTPU溶液を広げて平らにしてTPUを凝固させた。この組立体のディップコーティング工程を繰り返して、網状薄膜に基礎構造体を完全に包み込み、最終的に硬化した壁厚2〜7ミルのTPUを得て、最終的なフレームと弁モールドとの特徴的構造を形成した。
g)最終コーティングされた組立体を、湿度20%未満、60℃で24時間硬化させた後、TPU成形した弁の特徴的構造を傷つけないように注意しながら弁モールドから取り出した。
h)二葉弁が意図する動作を行うように、成形された弁の特徴的構造を切って開口を形成した。余分な材料をフレームから取り除いた後、必要に応じて弁小葉を成形した。
i)最終的な支持されていない部分は、湿度20%未満、60℃、24〜48時間で完全に硬化させる。
11 基礎構造体
12 近位部
14 遠位部
16 中央部/球根形状部
15 弁流出口
20 静脈
21 血脈洞領域
22 小葉部
23 弁小葉
24 矢印
25 矢印
26 自己流動血流
27 上部領域
Claims (19)
- a)血液流入のための遠位部と、中央部と、血液流出のための近位部とを有する拡張可能な基礎構造体を備え、
b)前記中央部は、前記遠位部に隣接し、正面図において静脈よりも幅が広く、側面図において静脈の幅と概ね等しく、前記近位部に向かって次第に細くなる形に拡張された球根形状部を含み、
c)前記基礎構造体は、生体適合性のある血栓抵抗性ポリマに埋め込まれることでフレームを形成し、前記フレームは、前記遠位部、前記中央部及び前記近位部の全体にわたって平滑な内面を有し、前記基礎構造体を露出させることなくその内側部分とほぼ段差なく設けられ、
d)前記球根形状部の広幅部を横切る近位端と、前記球根形状部の遠位端で前記ポリマの内面と一体化した遠位部を有し、静脈血流に応じて開閉する弁流出口を形成する少なくとも2つのポリマ製のポリマ小葉部を備え、
e)前記小葉部は、生体適合性のある血栓抵抗性ポリマから形成され、前記球根形状部とともにバイオミメティックな血脈洞領域を構成し、
h)弁が開くと、前記血脈洞領域から血液が主にバイオミメティックに流出し、前記弁を通過する円滑で非外傷的な血流をもたらすことを特徴とする、静脈不全を治療するための植え込み可能弁。 - 前記フレームは、生体適合性のある血栓抵抗性ポリマに埋め込まれ、前記遠位部、前記中央部及び前記近位部の全体にわたって平滑な内面及び外面を形成し、前記フレームを露出させることなくその内側部分及び外側部分とほぼ段差なく設けられている、請求項1に記載の植え込み可能弁。
- 前記ポリマ小葉部及び前記内側部分のポリマ表面は、同じポリマである、請求項1に記載の植え込み可能弁。
- 前記小葉部の遠位部は、その隣接する前記遠位部の端部における前記内側部分のポリマ表面と一体化されており、前記ポリマ小葉部及び前記内側部分のポリマ表面は、同じポリマである、請求項2に記載の植え込み可能弁。
- 前記弁流出口は直線状である、請求項1に記載の植え込み可能弁。
- 前記弁流出口はS字状である、請求項1に記載の植え込み可能弁。
- 前記弁流出口が前記近位部に向かって螺旋状になっている、請求項1に記載の植え込み可能弁。
- 前記弁流出口が逆流口を含む、請求項1に記載の植え込み可能弁。
- 前記小葉部は1つ以上の逆流口を含む、請求項1に記載の植え込み可能弁。
- 前記球根形状部は、側面図において静脈よりも幅が狭い、請求項1に記載の植え込み可能弁。
- 前記弁流出口及び前記血脈洞領域が、前記球根形状部の下部約4分の1にある、請求項1に記載の植え込み可能弁。
- 前記フレームを埋め込んだポリマは、ウレタンポリマからなる、請求項1に記載の植え込み可能弁。
- 前記小葉部がウレタンポリマからなる、請求項1に記載の植え込み可能弁。
- 前記フレームは、自己拡張するニチノール、ステンレス又はコバルトクロムからなる、請求項1に記載の植え込み可能弁。
- 前記球根形状部は、非円形であり横方向に対称である、請求項1に記載の植え込み可能弁。
- 前記非円形の球根形状部は、楕円形、レーストラック形状、又は、複数の非円形が重なり合って形成される形状である、請求項15に記載の植え込み可能弁。
- 前記非円形の最も短い部分の寸法が、静脈の幅よりも小さい、請求項15に記載の植え込み可能弁。
- a)請求項1に記載の植え込み可能弁を準備し、
b)前記植え込み可能弁を圧縮して静脈内送達用カテーテルに挿入し、
c)静脈内に前記カテーテルを配置し、前記静脈内の所望の部位に植え込み可能弁を送達し、
d)植え込み可能弁を自己拡張させて静脈よりも大きくし、所望の部位又は位置で植え込み可能弁を保持することを含む、静脈不全の治療方法。 - a)血液流入のための遠位部と、中央部と、血液流出のための近位部を有する自己拡張性の基礎構造体を備え、
b)前記中央部は、前記遠位部に隣接し、正面図において静脈よりも幅広く、側面図において静脈の幅と概ね等しい又は狭く、非円形かつ横方向に対称であり、前記近位部に向かって次第に細くなる形に拡張された球根形状部を含み、
c)前記基礎構造体は、前記遠位部、前記中央部及び前記近位部の全体にわたって平滑な内面を有し、前記基礎構造体を露出させることなくその内側部分とほぼ段差なく設けられた生体適合性のある血栓抵抗性ポリマに埋め込まれることでフレームを形成し、
d)また、前記球根形状部の前記広幅部を横切る近位端と、前記球根形状部の遠位端で前記内側部分のポリマ表面と一体化した遠位部を有し、静脈血流に応じて開閉するS字状の弁流出口を形成する少なくとも2つのポリマ小葉部を備え、
e)前記小葉部は、生体適合性のある血栓抵抗性ポリマから形成され、前記球根形状部とともにバイオミメティックな血脈洞領域を構成し、前記弁流出口及び前記血脈洞領域は、前記球根形状部の下部約4分の1にあり、
h)弁を開くと、前記血脈洞領域から血液が主にバイオミメティックに流出し、前記弁を通過する円滑で非外傷的な血流をもたらすことを特徴とする、静脈不全を治療するための植え込み可能弁。
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Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8870950B2 (en) | 2009-12-08 | 2014-10-28 | Mitral Tech Ltd. | Rotation-based anchoring of an implant |
US20110224785A1 (en) | 2010-03-10 | 2011-09-15 | Hacohen Gil | Prosthetic mitral valve with tissue anchors |
US9763657B2 (en) | 2010-07-21 | 2017-09-19 | Mitraltech Ltd. | Techniques for percutaneous mitral valve replacement and sealing |
US11653910B2 (en) | 2010-07-21 | 2023-05-23 | Cardiovalve Ltd. | Helical anchor implantation |
WO2013019756A2 (en) * | 2011-07-29 | 2013-02-07 | Carnegie Mellon University | Artificial valved conduits for cardiac reconstructive procedures and methods for their production |
WO2013021374A2 (en) | 2011-08-05 | 2013-02-14 | Mitraltech Ltd. | Techniques for percutaneous mitral valve replacement and sealing |
EP3417813B1 (en) | 2011-08-05 | 2020-05-13 | Cardiovalve Ltd | Percutaneous mitral valve replacement |
US20140324164A1 (en) * | 2011-08-05 | 2014-10-30 | Mitraltech Ltd. | Techniques for percutaneous mitral valve replacement and sealing |
US8852272B2 (en) | 2011-08-05 | 2014-10-07 | Mitraltech Ltd. | Techniques for percutaneous mitral valve replacement and sealing |
ES2934670T3 (es) | 2013-01-24 | 2023-02-23 | Cardiovalve Ltd | Válvulas protésicas ancladas de forma ventricular |
EP4066786A1 (en) | 2014-07-30 | 2022-10-05 | Cardiovalve Ltd. | Articulatable prosthetic valve |
US9974651B2 (en) | 2015-02-05 | 2018-05-22 | Mitral Tech Ltd. | Prosthetic valve with axially-sliding frames |
CN110141399B (zh) | 2015-02-05 | 2021-07-27 | 卡迪尔维尔福股份有限公司 | 带有轴向滑动框架的人工瓣膜 |
US10201425B2 (en) * | 2015-03-02 | 2019-02-12 | Georgia Tech Research Corporation | Implantable open vein valve |
MA44837A (fr) | 2015-08-25 | 2018-07-04 | Innovein Inc | Prothèse de valvule veineuse |
US10492910B2 (en) * | 2015-10-13 | 2019-12-03 | Venarum Medical, Llc | Implantable valve and method |
US10531866B2 (en) | 2016-02-16 | 2020-01-14 | Cardiovalve Ltd. | Techniques for providing a replacement valve and transseptal communication |
US10098740B2 (en) * | 2016-07-15 | 2018-10-16 | Covidien Lp | Venous valve prostheses |
GB201613219D0 (en) | 2016-08-01 | 2016-09-14 | Mitraltech Ltd | Minimally-invasive delivery systems |
CN114587712A (zh) | 2016-08-10 | 2022-06-07 | 卡迪尔维尔福股份有限公司 | 具有同轴框架的人工瓣膜 |
DE202016105963U1 (de) * | 2016-10-24 | 2018-01-25 | Nvt Ag | Intraluminale Gefäßprothese zur Implantation in das Herz oder Herzgefäße eines Patienten |
US10575948B2 (en) | 2017-08-03 | 2020-03-03 | Cardiovalve Ltd. | Prosthetic heart valve |
US11246704B2 (en) | 2017-08-03 | 2022-02-15 | Cardiovalve Ltd. | Prosthetic heart valve |
US10537426B2 (en) | 2017-08-03 | 2020-01-21 | Cardiovalve Ltd. | Prosthetic heart valve |
US11793633B2 (en) | 2017-08-03 | 2023-10-24 | Cardiovalve Ltd. | Prosthetic heart valve |
US10888421B2 (en) | 2017-09-19 | 2021-01-12 | Cardiovalve Ltd. | Prosthetic heart valve with pouch |
GB201720803D0 (en) | 2017-12-13 | 2018-01-24 | Mitraltech Ltd | Prosthetic Valve and delivery tool therefor |
GB201800399D0 (en) | 2018-01-10 | 2018-02-21 | Mitraltech Ltd | Temperature-control during crimping of an implant |
EP3905990A4 (en) | 2019-01-03 | 2022-08-31 | Renovo Medsolutions, LLC | VENOUS VALVE PROSTHESIS |
WO2021113395A1 (en) * | 2019-12-02 | 2021-06-10 | Venarum Medical, Llc | Process for catheter loading an implantable venous valve and apparatus |
WO2021113405A1 (en) * | 2019-12-03 | 2021-06-10 | Venarum Medical, Llc | Implantable venous valve and process for making same |
WO2022048585A1 (zh) * | 2020-09-04 | 2022-03-10 | 杭州诺谊医疗科技有限公司 | 介入静脉瓣支架及静脉瓣假体 |
US11197755B1 (en) * | 2020-10-28 | 2021-12-14 | Occam Labs LLC | Systems, devices and methods for folded unibody heart valve stents |
WO2023168278A2 (en) * | 2022-03-01 | 2023-09-07 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Artificial polymeric valve system and methods of making and using thereof |
US20230363900A1 (en) | 2022-05-11 | 2023-11-16 | Envveno Medical Corporation | Transcatheter valve system and method for venous insufficiency |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006524119A (ja) * | 2003-04-24 | 2006-10-26 | クック インコーポレイティド | 流体力学特性を改善した人工弁プロテ−ゼ |
JP2007037763A (ja) * | 2005-08-03 | 2007-02-15 | National Cardiovascular Center | 人工弁を有するステント |
US20070067021A1 (en) * | 2005-09-21 | 2007-03-22 | Boston Scientific Scimed, Inc. | Venous valve, system, and method with sinus pocket |
US20080288055A1 (en) * | 2007-05-17 | 2008-11-20 | Cook Incorporated | Monocuspid Prosthetic Valve Having a Partial Sinus |
US20110118828A1 (en) * | 2009-11-16 | 2011-05-19 | Medtronic Vascular, Inc. | Implantable Valve Prosthesis for Treating Venous Valve Insufficiency |
US20130304196A1 (en) * | 2012-05-08 | 2013-11-14 | Medtronic Vascular, Inc. | Prosthetic venous valve having leaflets forming a scalloped commissure |
Family Cites Families (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2010105A (en) * | 1932-08-15 | 1935-08-06 | Burton Dixie Corp | Inner-tie mattress |
US5330437A (en) | 1993-11-12 | 1994-07-19 | Ethicon Endo-Surgery | Self sealing flexible elastomeric valve and trocar assembly for incorporating same |
WO1997040755A1 (en) * | 1996-04-29 | 1997-11-06 | W.L. Gore & Associates, Inc. | Device for restoring competence to venous valves |
NL1004827C2 (nl) | 1996-12-18 | 1998-06-19 | Surgical Innovations Vof | Inrichting voor het reguleren van de bloedsomloop. |
US7628803B2 (en) | 2001-02-05 | 2009-12-08 | Cook Incorporated | Implantable vascular device |
US8382822B2 (en) | 1999-06-02 | 2013-02-26 | Cook Medical Technologies Llc | Implantable vascular device |
US6241763B1 (en) | 1999-06-08 | 2001-06-05 | William J. Drasler | In situ venous valve device and method of formation |
US6299637B1 (en) | 1999-08-20 | 2001-10-09 | Samuel M. Shaolian | Transluminally implantable venous valve |
US20070043435A1 (en) * | 1999-11-17 | 2007-02-22 | Jacques Seguin | Non-cylindrical prosthetic valve system for transluminal delivery |
US6458153B1 (en) | 1999-12-31 | 2002-10-01 | Abps Venture One, Ltd. | Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof |
WO2001066043A1 (en) | 2000-03-03 | 2001-09-13 | Thorpe Patricia E | Bulbous valve and stent for treating vascular reflux |
US20040024447A1 (en) | 2000-04-27 | 2004-02-05 | Axel Haverich | Individual venous valve prosthesis |
US6527800B1 (en) | 2000-06-26 | 2003-03-04 | Rex Medical, L.P. | Vascular device and method for valve leaflet apposition |
US6494909B2 (en) | 2000-12-01 | 2002-12-17 | Prodesco, Inc. | Endovascular valve |
US6503272B2 (en) | 2001-03-21 | 2003-01-07 | Cordis Corporation | Stent-based venous valves |
AUPR389201A0 (en) | 2001-03-23 | 2001-04-12 | Lane, Rodney James | Improvements in design of external vendus valve stents for the correction fo incompetent vendods valves |
US6958076B2 (en) * | 2001-04-16 | 2005-10-25 | Biomedical Research Associates Inc. | Implantable venous valve |
WO2002087467A2 (en) | 2001-04-30 | 2002-11-07 | Thorpe Patricia E | Replacement venous valve |
IN2014DN10834A (ja) * | 2001-09-17 | 2015-09-04 | Psivida Inc | |
US6716241B2 (en) | 2002-03-05 | 2004-04-06 | John G. Wilder | Venous valve and graft combination |
US7125418B2 (en) * | 2002-04-16 | 2006-10-24 | The International Heart Institute Of Montana Foundation | Sigmoid valve and method for its percutaneous implantation |
EP1553897A1 (en) | 2002-10-24 | 2005-07-20 | Boston Scientific Limited | Venous valve apparatus and method |
US7717952B2 (en) * | 2003-04-24 | 2010-05-18 | Cook Incorporated | Artificial prostheses with preferred geometries |
WO2005011535A2 (en) | 2003-07-31 | 2005-02-10 | Cook Incorporated | Prosthetic valve for implantation in a body vessel |
US7347869B2 (en) | 2003-10-31 | 2008-03-25 | Cordis Corporation | Implantable valvular prosthesis |
US7070616B2 (en) | 2003-10-31 | 2006-07-04 | Cordis Corporation | Implantable valvular prosthesis |
US8128681B2 (en) | 2003-12-19 | 2012-03-06 | Boston Scientific Scimed, Inc. | Venous valve apparatus, system, and method |
US7854761B2 (en) | 2003-12-19 | 2010-12-21 | Boston Scientific Scimed, Inc. | Methods for venous valve replacement with a catheter |
US7717930B2 (en) | 2004-02-27 | 2010-05-18 | Cook Incorporated | Valvulotome with a cutting edge |
CA2496095A1 (en) | 2005-02-04 | 2006-08-04 | Sango S.A.S. Di Cattani Rita & C. | External support for restoring competence to venous valves by traction of their intercommissural walls |
US7780722B2 (en) | 2005-02-07 | 2010-08-24 | Boston Scientific Scimed, Inc. | Venous valve apparatus, system, and method |
US7670368B2 (en) | 2005-02-07 | 2010-03-02 | Boston Scientific Scimed, Inc. | Venous valve apparatus, system, and method |
US7867274B2 (en) | 2005-02-23 | 2011-01-11 | Boston Scientific Scimed, Inc. | Valve apparatus, system and method |
US8012198B2 (en) | 2005-06-10 | 2011-09-06 | Boston Scientific Scimed, Inc. | Venous valve, system, and method |
US20070038295A1 (en) | 2005-08-12 | 2007-02-15 | Cook Incorporated | Artificial valve prosthesis having a ring frame |
US20070050013A1 (en) | 2005-09-01 | 2007-03-01 | Jeffrey M. Gross | Venous valve prosthesis and method of fabrication |
US20070078510A1 (en) | 2005-09-26 | 2007-04-05 | Ryan Timothy R | Prosthetic cardiac and venous valves |
WO2007054015A1 (en) | 2005-11-09 | 2007-05-18 | Ning Wen | An artificial heart valve stent and weaving method thereof |
US20070112423A1 (en) | 2005-11-16 | 2007-05-17 | Chu Jack F | Devices and methods for treatment of venous valve insufficiency |
US7648527B2 (en) | 2006-03-01 | 2010-01-19 | Cook Incorporated | Methods of reducing retrograde flow |
US8303648B2 (en) | 2006-04-25 | 2012-11-06 | Cook Medical Technologies Llc | Artificial venous valve containing therapeutic agent |
US20080051879A1 (en) | 2006-08-23 | 2008-02-28 | Cook Incorporated | Methods of treating venous valve related conditions with a flow-modifying implantable medical device |
WO2008046092A2 (en) | 2006-10-13 | 2008-04-17 | Creighton University | Implantable valve prosthesis |
WO2008094894A1 (en) | 2007-01-29 | 2008-08-07 | Cook Incorporated | Artificial venous valve with discrete shaping members |
WO2008113193A1 (de) | 2007-03-22 | 2008-09-25 | Carag Ag | Stent mit gefässklappe |
US8728154B2 (en) | 2007-08-24 | 2014-05-20 | St. Jude Medical, Inc. | Prosthetic aortic heart valves |
US20090105810A1 (en) | 2007-10-17 | 2009-04-23 | Hancock Jaffe Laboratories | Biological valve for venous valve insufficiency |
US20090248142A1 (en) | 2008-03-25 | 2009-10-01 | Medtronic Vascular, Inc. | Methods, Devices and Systems for Treating Venous Insufficiency |
US20090254175A1 (en) | 2008-04-03 | 2009-10-08 | Quijano Rodolfo C | Valved stent for chronic venous insufficiency |
AU2009236062A1 (en) | 2008-04-18 | 2009-10-22 | Cook Medical Technologies Llc | Branched vessel prosthesis |
US9119714B2 (en) | 2008-10-29 | 2015-09-01 | The Regents Of The University Of Colorado, A Body Corporate | Shape memory polymer prosthetic medical device |
US8591573B2 (en) | 2008-12-08 | 2013-11-26 | Hector Daniel Barone | Prosthetic valve for intraluminal implantation |
ES2551694T3 (es) | 2008-12-23 | 2015-11-23 | Sorin Group Italia S.R.L. | Válvula protésica expansible dotada de apéndices de anclaje |
US20120053676A1 (en) | 2009-05-07 | 2012-03-01 | Ku David N | Implantable Prosthetic Vascular Valves |
US20110066226A1 (en) | 2009-09-15 | 2011-03-17 | Medtronic Vascular, Inc. | Implantable Venous Valve for Treatment of Erectile Dysfunction |
US9504572B2 (en) | 2010-02-17 | 2016-11-29 | Medtronic Vascular, Inc. | Apparatus and methods for creating a venous valve from autologous tissue |
US8292948B2 (en) | 2010-02-17 | 2012-10-23 | Medtronic Vascular, Inc. | Apparatus and methods for creating a venous valve from autologous tissue |
AU2011220402B2 (en) | 2010-02-26 | 2016-06-09 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and methods for endoluminal valve creation |
US8696737B2 (en) | 2010-08-11 | 2014-04-15 | Hlt, Inc. | Reinforced commissural support structure |
US9566149B2 (en) | 2010-11-16 | 2017-02-14 | W. L. Gore & Associates, Inc. | Devices and methods for in situ fenestration of a stent-graft at the site of a branch vessel |
JP6157007B2 (ja) | 2011-04-20 | 2017-07-05 | ザ・ボード・オブ・トラスティーズ・オブ・ザ・リーランド・スタンフォード・ジュニア・ユニバーシティThe Board Of Trustees Of The Leland Stanford Junior University | 腔内弁作製のためのシステムおよび方法 |
EP2522309A1 (de) * | 2011-05-10 | 2012-11-14 | Biotronik AG | Ventil für eine Herzklappenprothese |
US9301835B2 (en) | 2012-06-04 | 2016-04-05 | Edwards Lifesciences Corporation | Pre-assembled bioprosthetic valve and sealed conduit |
US9955990B2 (en) | 2013-01-10 | 2018-05-01 | Intervene, Inc. | Systems and methods for endoluminal valve creation |
US20140236283A1 (en) | 2013-02-15 | 2014-08-21 | Sangomed S.R.L. | Stent-based extra-venous support for venous valve repair |
US9101473B2 (en) | 2013-03-07 | 2015-08-11 | Medtronic Vascular, Inc. | Venous valve repair prosthesis for treatment of chronic venous insufficiency |
WO2015048565A2 (en) | 2013-09-27 | 2015-04-02 | Intervene, Inc. | Visualization devices, systems, and methods for informing intravascular procedures on blood vessel valves |
DE102015101418B4 (de) | 2014-02-04 | 2018-05-30 | Takatoshi FURUYA | Venenklappenschneidvorrichtung sowie Verfahren zu deren Herstellung |
US9668861B2 (en) | 2014-03-15 | 2017-06-06 | Rex Medical, L.P. | Vascular device for treating venous valve insufficiency |
EP3145451B1 (en) | 2014-05-21 | 2020-11-11 | Maleti, Oscar | Prosthetic valve for treating diseases causing reflux affecting the lower limbs |
US10492910B2 (en) * | 2015-10-13 | 2019-12-03 | Venarum Medical, Llc | Implantable valve and method |
-
2016
- 2016-06-30 US US15/306,121 patent/US10492910B2/en not_active Expired - Fee Related
- 2016-06-30 EP EP16855881.5A patent/EP3337425A4/en not_active Withdrawn
- 2016-06-30 MX MX2018004368A patent/MX2018004368A/es unknown
- 2016-06-30 CA CA2998576A patent/CA2998576A1/en not_active Abandoned
- 2016-06-30 WO PCT/US2016/040317 patent/WO2017065850A1/en active Application Filing
- 2016-06-30 CN CN202110005509.5A patent/CN112826638A/zh active Pending
- 2016-06-30 JP JP2018517394A patent/JP2018530386A/ja not_active Ceased
- 2016-06-30 KR KR1020187010129A patent/KR20180067537A/ko not_active Application Discontinuation
- 2016-06-30 CN CN201680059377.1A patent/CN108135689B/zh not_active Expired - Fee Related
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Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006524119A (ja) * | 2003-04-24 | 2006-10-26 | クック インコーポレイティド | 流体力学特性を改善した人工弁プロテ−ゼ |
JP2007037763A (ja) * | 2005-08-03 | 2007-02-15 | National Cardiovascular Center | 人工弁を有するステント |
US20070067021A1 (en) * | 2005-09-21 | 2007-03-22 | Boston Scientific Scimed, Inc. | Venous valve, system, and method with sinus pocket |
US20080288055A1 (en) * | 2007-05-17 | 2008-11-20 | Cook Incorporated | Monocuspid Prosthetic Valve Having a Partial Sinus |
US20110118828A1 (en) * | 2009-11-16 | 2011-05-19 | Medtronic Vascular, Inc. | Implantable Valve Prosthesis for Treating Venous Valve Insufficiency |
US20130304196A1 (en) * | 2012-05-08 | 2013-11-14 | Medtronic Vascular, Inc. | Prosthetic venous valve having leaflets forming a scalloped commissure |
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WO2017065850A1 (en) | 2017-04-20 |
IL258621B (en) | 2021-04-29 |
US20190099271A1 (en) | 2019-04-04 |
KR20180067537A (ko) | 2018-06-20 |
CN108135689A (zh) | 2018-06-08 |
IL281864A (en) | 2021-05-31 |
HK1256095A1 (zh) | 2019-09-13 |
CN108135689B (zh) | 2021-01-26 |
AU2016339794B2 (en) | 2021-07-08 |
CA2998576A1 (en) | 2017-04-20 |
EP3337425A1 (en) | 2018-06-27 |
IL258621A (en) | 2018-06-28 |
MX2018004368A (es) | 2019-05-27 |
EP3337425A4 (en) | 2018-11-07 |
US20170196692A1 (en) | 2017-07-13 |
CN112826638A (zh) | 2021-05-25 |
AU2016339794A1 (en) | 2018-04-19 |
US10492910B2 (en) | 2019-12-03 |
HK1252840A1 (zh) | 2019-06-06 |
US11083583B2 (en) | 2021-08-10 |
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