JP2018528783A5 - - Google Patents
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- JP2018528783A5 JP2018528783A5 JP2018515456A JP2018515456A JP2018528783A5 JP 2018528783 A5 JP2018528783 A5 JP 2018528783A5 JP 2018515456 A JP2018515456 A JP 2018515456A JP 2018515456 A JP2018515456 A JP 2018515456A JP 2018528783 A5 JP2018528783 A5 JP 2018528783A5
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| US11725208B2 (en) * | 2017-12-14 | 2023-08-15 | Ionis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
| CN120310791A (zh) | 2018-01-12 | 2025-07-15 | 百时美施贵宝公司 | 靶向α-突触核蛋白的反义寡核苷酸及其用途 |
| SG11202006528XA (en) | 2018-01-12 | 2020-08-28 | Bristol Myers Squibb Co | Antisense oligonucleotides targeting alpha-synuclein and uses thereof |
| MX2020008581A (es) | 2018-02-21 | 2020-09-21 | Bristol Myers Squibb Co | Oligonucleotidos antisentido de la proteina cinasa del tipo ii delta dependiente del calcio/calmodulina (camk2d) y sus usos. |
| JP7394392B2 (ja) | 2018-03-14 | 2023-12-08 | 国立大学法人 東京医科歯科大学 | 核酸複合体 |
| KR20190110043A (ko) * | 2018-03-19 | 2019-09-27 | 주식회사 케이티 | 비디오 신호 처리 방법 및 장치 |
| EP3769769A4 (en) | 2018-03-19 | 2022-05-04 | National University Corporation Tokyo Medical and Dental University | NUCLEIC ACID WITH REDUCED TOXICITY |
| JP7262816B2 (ja) * | 2018-03-22 | 2023-04-24 | 国立大学法人 東京医科歯科大学 | ヘテロ核酸のｂｂｂ通過脂質リガンド |
| US20220064636A1 (en) * | 2018-10-05 | 2022-03-03 | Ionis Pharmaceuticals, Inc. | Modified oligomeric compounds and uses thereof |
| WO2020203880A1 (ja) * | 2019-03-29 | 2020-10-08 | 田辺三菱製薬株式会社 | Ｄｕｘ４の発現を調節するための化合物、方法及び医薬組成物 |
| CN113677374A (zh) * | 2019-04-08 | 2021-11-19 | 国立大学法人东京医科齿科大学 | 肌疾病治疗用药物组合物 |
| WO2021054370A1 (ja) | 2019-09-18 | 2021-03-25 | 国立大学法人東京医科歯科大学 | 核酸複合体 |
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| AU2021206234A1 (en) * | 2020-01-10 | 2022-09-01 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| JP2023540538A (ja) * | 2020-09-04 | 2023-09-25 | ザ ユニヴァーシティー オヴ シカゴ | 核酸誘導体化治療薬 |
| JP7607957B2 (ja) * | 2020-09-30 | 2025-01-06 | 納▲タイ▼得（青島）生物医薬有限公司 | アンギオポエチン様３（ＡＮＧＰＴＬ３）のｓｉＲＮＡ及びその用途 |
| EP4247949A1 (en) | 2020-11-23 | 2023-09-27 | Alpha Anomeric SAS | Nucleic acid duplexes |
| AR124713A1 (es) * | 2021-01-28 | 2023-04-26 | Dicerna Pharmaceuticals Inc | Composiciones y métodos para inhibir la expresión de genes en el sistema nervioso central |
| CN117015384A (zh) * | 2021-03-05 | 2023-11-07 | 戴瑟纳制药公司 | Rnai缀合物及其用途 |
| EP4301376A4 (en) * | 2021-03-05 | 2025-01-22 | Dicerna Pharmaceuticals, Inc. | RNAI CONJUGATES AND USES THEREOF |
| US11879125B2 (en) | 2022-03-16 | 2024-01-23 | Empirico Inc. | GalNAc compositions for improving siRNA bioavailability |
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| EP4522742A2 (en) | 2022-05-13 | 2025-03-19 | Alnylam Pharmaceuticals, Inc. | Single-stranded loop oligonucleotides |
| EP4709855A2 (en) | 2023-05-12 | 2026-03-18 | Alnylam Pharmaceuticals, Inc. | Single-stranded loop oligonucleotides |
| TW202508607A (zh) * | 2023-05-19 | 2025-03-01 | 大陸商北京炫景瑞醫藥科技有限公司 | 雙股寡核苷酸及其共軛物和用途 |
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| US20100048676A1 (en) * | 2008-08-04 | 2010-02-25 | University Of Rochester | Non-androgen dependent roles for androgen receptor in liver cancer |
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| ES2762610T3 (es) | 2009-02-12 | 2020-05-25 | Curna Inc | Tratamiento de enfermedades relacionadas con el factor neurotrófico derivado de cerebro (BDNF) por inhibición de transcrito antisentido natural para BDNF |
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| AU2012308320C1 (en) * | 2011-09-14 | 2018-08-23 | Translate Bio Ma, Inc. | Multimeric oligonucleotide compounds |
| JP6112569B2 (ja) | 2011-12-16 | 2017-04-12 | 国立大学法人 東京医科歯科大学 | キメラ２重鎖核酸 |
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| WO2014132671A1 (en) * | 2013-03-01 | 2014-09-04 | National University Corporation Tokyo Medical And Dental University | Chimeric single-stranded antisense polynucleotides and double-stranded antisense agent |
| DK2992098T3 (da) | 2013-05-01 | 2019-06-17 | Ionis Pharmaceuticals Inc | Sammensætninger og fremgangsmåder til modulering af hbv- og ttr-ekspression |
| EP3004347B1 (en) | 2013-05-30 | 2018-09-26 | National University Corporation Tokyo Medical and Dental University | Double-stranded agents for delivering therapeutic oligonucleotides |
| AU2014282666A1 (en) | 2013-06-16 | 2016-01-07 | National University Corporation Tokyo Medical And Dental University | Double-stranded antisense nucleic acid with exon-skipping effect |
| TW201536329A (zh) | 2013-08-09 | 2015-10-01 | Isis Pharmaceuticals Inc | 用於調節失養性肌強直蛋白質激酶(dmpk)表現之化合物及方法 |
| US12139542B2 (en) * | 2014-05-27 | 2024-11-12 | Trustees Of Boston University | Inhibitors of aortic carboxypeptidase-like protein (ACLP) |
| WO2016028682A1 (en) * | 2014-08-17 | 2016-02-25 | The Broad Institute Inc. | Genome editing using cas9 nickases |
| US20210052631A1 (en) | 2015-09-25 | 2021-02-25 | Ionis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
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2021
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