JP2018528783A5 - - Google Patents
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- JP2018528783A5 JP2018528783A5 JP2018515456A JP2018515456A JP2018528783A5 JP 2018528783 A5 JP2018528783 A5 JP 2018528783A5 JP 2018515456 A JP2018515456 A JP 2018515456A JP 2018515456 A JP2018515456 A JP 2018515456A JP 2018528783 A5 JP2018528783 A5 JP 2018528783A5
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| CN111819283A (zh) | 2018-01-12 | 2020-10-23 | 百时美施贵宝公司 | 靶向α-突触核蛋白的反义寡核苷酸及其用途 |
| US11447775B2 (en) | 2018-01-12 | 2022-09-20 | Bristol-Myers Squibb Company | Antisense oligonucleotides targeting alpha-synuclein and uses thereof |
| MX2020008581A (es) | 2018-02-21 | 2020-09-21 | Bristol Myers Squibb Co | Oligonucleotidos antisentido de la proteina cinasa del tipo ii delta dependiente del calcio/calmodulina (camk2d) y sus usos. |
| WO2019177061A1 (ja) | 2018-03-14 | 2019-09-19 | 国立大学法人東京医科歯科大学 | 核酸複合体 |
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| US9580708B2 (en) * | 2011-09-14 | 2017-02-28 | Rana Therapeutics, Inc. | Multimeric oligonucleotides compounds |
| CN104126010B (zh) | 2011-12-16 | 2021-04-06 | 国立大学法人东京医科齿科大学 | 嵌合的双链核酸 |
| AR092982A1 (es) | 2012-10-11 | 2015-05-13 | Isis Pharmaceuticals Inc | Modulacion de la expresion de receptores androgenicos |
| JP6440170B2 (ja) | 2013-03-01 | 2018-12-19 | 国立大学法人 東京医科歯科大学 | キメラ一本鎖アンチセンスポリヌクレオチドおよび二本鎖アンチセンス剤 |
| KR102138781B1 (ko) | 2013-05-01 | 2020-07-28 | 아이오니스 파마수티컬즈, 인코포레이티드 | 아포지질단백질 c-iii 발현을 조절하는 조성물 및 방법 |
| EP3004347B1 (en) | 2013-05-30 | 2018-09-26 | National University Corporation Tokyo Medical and Dental University | Double-stranded agents for delivering therapeutic oligonucleotides |
| AU2014282666A1 (en) | 2013-06-16 | 2016-01-07 | National University Corporation Tokyo Medical And Dental University | Double-stranded antisense nucleic acid with exon-skipping effect |
| TW201536329A (zh) | 2013-08-09 | 2015-10-01 | Isis Pharmaceuticals Inc | 用於調節失養性肌強直蛋白質激酶(dmpk)表現之化合物及方法 |
| WO2015183943A2 (en) * | 2014-05-27 | 2015-12-03 | Trustees Of Boston University | Inhibitors of fibroproliferative disorders and cancer |
| EP3686279B1 (en) * | 2014-08-17 | 2023-01-04 | The Broad Institute, Inc. | Genome editing using cas9 nickases |
| EP3353305A4 (en) | 2015-09-25 | 2019-09-18 | Ionis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
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2021
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