JP2018528181A5 - - Google Patents

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Publication number
JP2018528181A5
JP2018528181A5 JP2018505606A JP2018505606A JP2018528181A5 JP 2018528181 A5 JP2018528181 A5 JP 2018528181A5 JP 2018505606 A JP2018505606 A JP 2018505606A JP 2018505606 A JP2018505606 A JP 2018505606A JP 2018528181 A5 JP2018528181 A5 JP 2018528181A5
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JP
Japan
Prior art keywords
carboxamide
oxazol
benzo
piperidin
pyrazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2018505606A
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English (en)
Japanese (ja)
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JP6994454B2 (ja
JP2018528181A (ja
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Priority claimed from PCT/US2016/045176 external-priority patent/WO2017023941A1/en
Publication of JP2018528181A publication Critical patent/JP2018528181A/ja
Publication of JP2018528181A5 publication Critical patent/JP2018528181A5/ja
Priority to JP2021201355A priority Critical patent/JP7339997B2/ja
Application granted granted Critical
Publication of JP6994454B2 publication Critical patent/JP6994454B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2018505606A 2015-08-04 2016-08-02 ベンズアゾール化合物ならびに該化合物の作製方法および使用方法 Expired - Fee Related JP6994454B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021201355A JP7339997B2 (ja) 2015-08-04 2021-12-13 ベンズアゾール化合物ならびに該化合物の作製方法および使用方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562200778P 2015-08-04 2015-08-04
US62/200,778 2015-08-04
PCT/US2016/045176 WO2017023941A1 (en) 2015-08-04 2016-08-02 Benzazole compounds and methods for making and using the compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021201355A Division JP7339997B2 (ja) 2015-08-04 2021-12-13 ベンズアゾール化合物ならびに該化合物の作製方法および使用方法

Publications (3)

Publication Number Publication Date
JP2018528181A JP2018528181A (ja) 2018-09-27
JP2018528181A5 true JP2018528181A5 (enExample) 2021-08-19
JP6994454B2 JP6994454B2 (ja) 2022-01-14

Family

ID=56610048

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2018505606A Expired - Fee Related JP6994454B2 (ja) 2015-08-04 2016-08-02 ベンズアゾール化合物ならびに該化合物の作製方法および使用方法
JP2021201355A Active JP7339997B2 (ja) 2015-08-04 2021-12-13 ベンズアゾール化合物ならびに該化合物の作製方法および使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2021201355A Active JP7339997B2 (ja) 2015-08-04 2021-12-13 ベンズアゾール化合物ならびに該化合物の作製方法および使用方法

Country Status (8)

Country Link
US (4) US10065946B2 (enExample)
EP (2) EP3331879B1 (enExample)
JP (2) JP6994454B2 (enExample)
CA (1) CA2993661A1 (enExample)
DK (1) DK3331879T3 (enExample)
ES (1) ES2811136T3 (enExample)
HK (1) HK1256242A1 (enExample)
WO (1) WO2017023941A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112016015983A2 (pt) 2014-01-10 2017-08-08 Aurigene Discovery Tech Ltd Compostos de indazol como inibidores de irak4, seus usos, e composição farmacêutica
SMT202400142T1 (it) 2014-01-13 2024-05-14 Aurigene Oncology Ltd Enantiomeri (r) e (s) di n-(5-(3-idrossipirrolidin-1-il)-2-morfolinoossazolo[4,5-b]piridin-6-il)-2-(2-metilpiridin-4-il)ossazolo-carbossammide in qualità di inibitori di irak4 per il trattamento di un cancro
PT3286181T (pt) * 2015-04-22 2021-04-05 Rigel Pharmaceuticals Inc Compostos de pirazol e método para preparar e usar os compostos
ES2811136T3 (es) 2015-08-04 2021-03-10 Rigel Pharmaceuticals Inc Compuestos de benzazol y métodos para obtener y usar los compuestos
TWI733982B (zh) 2017-02-16 2021-07-21 美商基利科學股份有限公司 吡咯并[1,2-b]嗒衍生物
CN120267671A (zh) * 2017-03-31 2025-07-08 奥锐金肿瘤有限公司 用于治疗血液病的化合物和组合物
CN111032642B (zh) * 2017-06-29 2023-07-18 里格尔药品股份有限公司 激酶抑制剂及制造和使用方法
MX2020003666A (es) * 2017-10-31 2020-08-03 Curis Inc Compuestos y composiciones para el tratamiento de trastornos hematologicos.
WO2019111218A1 (en) 2017-12-08 2019-06-13 Cadila Healthcare Limited Novel heterocyclic compounds as irak4 inhibitors
TWI721483B (zh) 2018-07-13 2021-03-11 美商基利科學股份有限公司 吡咯并[1,2-b]嗒𠯤衍生物
CN112043696B (zh) * 2020-08-26 2023-02-24 深圳市第二人民医院(深圳市转化医学研究院) Ido-1抑制剂在制备治疗骨性关节炎药物中的应用
WO2022187303A1 (en) 2021-03-03 2022-09-09 Rigel Pharmaceuticals, Inc. A method for treating a disease or condition using a pyrazole compound or formulation thereof
US12178821B2 (en) 2021-04-08 2024-12-31 Curis, Inc. Combination therapies for the treatment of cancer
TWI890016B (zh) 2021-12-23 2025-07-11 大陸商杭州多域生物技術有限公司 一種五員并六員化合物、製備方法、藥物組成物和應用
US12384775B2 (en) 2022-03-23 2025-08-12 Rigel Pharmaceuticals, Inc. Pyrimid-2-yl-pyrazole compounds as IRAK inhibitors

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5087240A (en) 1983-08-18 1992-02-11 Drug Delivery Systems Inc. Transdermal drug patch with conductive fibers
US4921475A (en) 1983-08-18 1990-05-01 Drug Delivery Systems Inc. Transdermal drug patch with microtubes
US4738851A (en) 1985-09-27 1988-04-19 University Of Iowa Research Foundation, Inc. Controlled release ophthalmic gel formulation
US5163899A (en) 1987-03-20 1992-11-17 Drug Delivery Systems Inc. Transdermal drug delivery system
US5312325A (en) 1987-05-28 1994-05-17 Drug Delivery Systems Inc Pulsating transdermal drug delivery system
GB8804164D0 (en) 1988-02-23 1988-03-23 Tucker J M Bandage for administering physiologically active compound
US4882150A (en) 1988-06-03 1989-11-21 Kaufman Herbert E Drug delivery system
US5008110A (en) 1988-11-10 1991-04-16 The Procter & Gamble Company Storage-stable transdermal patch
US5088977A (en) 1988-12-21 1992-02-18 Drug Delivery Systems Inc. Electrical transdermal drug applicator with counteractor and method of drug delivery
US5521222A (en) 1989-09-28 1996-05-28 Alcon Laboratories, Inc. Topical ophthalmic pharmaceutical vehicles
ATE107176T1 (de) 1989-12-04 1994-07-15 Searle & Co System zur transdermalen albuterol applikation.
US5077033A (en) 1990-08-07 1991-12-31 Mediventures Inc. Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide
DK0495421T3 (da) 1991-01-15 1996-12-09 Alcon Lab Inc Anvendelse af carragenaner i topiske ophthalmiske sammensætninger
US5352456A (en) 1991-10-10 1994-10-04 Cygnus Therapeutic Systems Device for administering drug transdermally which provides an initial pulse of drug
CA2123809A1 (en) 1991-12-18 1993-06-24 Debra L. Wilfong Multilayered barrier structures
ATE132381T1 (de) 1992-01-29 1996-01-15 Voelkl Franz Ski Ballspielschläger, insbesondere tennisschläger
IL114193A (en) 1994-06-20 2000-02-29 Teva Pharma Ophthalmic pharmaceutical compositions based on sodium alginate
ES2094688B1 (es) 1994-08-08 1997-08-01 Cusi Lab Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion.
IT1283911B1 (it) 1996-02-05 1998-05-07 Farmigea Spa Soluzioni oftalmiche viscosizzate con polisaccaridi della gomma di tamarindo
US5800807A (en) 1997-01-29 1998-09-01 Bausch & Lomb Incorporated Ophthalmic compositions including glycerin and propylene glycol
US6261547B1 (en) 1998-04-07 2001-07-17 Alcon Manufacturing, Ltd. Gelling ophthalmic compositions containing xanthan gum
US6197934B1 (en) 1998-05-22 2001-03-06 Collagenesis, Inc. Compound delivery using rapidly dissolving collagen film
JP2012254939A (ja) 2009-10-07 2012-12-27 Astellas Pharma Inc オキサゾール化合物
WO2013042137A1 (en) 2011-09-19 2013-03-28 Aurigene Discovery Technologies Limited Bicyclic heterocycles as irak4 inhibitors
CN104582705A (zh) 2012-01-10 2015-04-29 林伯士艾瑞斯公司 白介素-1受体相关激酶(irak)抑制剂和其用途
WO2015048281A1 (en) * 2013-09-27 2015-04-02 Nimbus Iris, Inc. Irak inhibitors and uses thereof
TWI667233B (zh) 2013-12-19 2019-08-01 德商拜耳製藥公司 新穎吲唑羧醯胺，其製備方法、含彼等之醫藥製劑及其製造醫藥之用途
WO2015104668A2 (en) * 2014-01-09 2015-07-16 Camus Pharma Pvt. Ltd. Lyophilized formulations for parenteral use
BR112016015983A2 (pt) * 2014-01-10 2017-08-08 Aurigene Discovery Tech Ltd Compostos de indazol como inibidores de irak4, seus usos, e composição farmacêutica
SMT202400142T1 (it) * 2014-01-13 2024-05-14 Aurigene Oncology Ltd Enantiomeri (r) e (s) di n-(5-(3-idrossipirrolidin-1-il)-2-morfolinoossazolo[4,5-b]piridin-6-il)-2-(2-metilpiridin-4-il)ossazolo-carbossammide in qualità di inibitori di irak4 per il trattamento di un cancro
ES2811136T3 (es) * 2015-08-04 2021-03-10 Rigel Pharmaceuticals Inc Compuestos de benzazol y métodos para obtener y usar los compuestos

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