JP2018527932A - ＣＤ８＋ＣＤ４５ＲＣｌｏｗ Ｔｒｅｇの新しい亜集団およびその使用 - Google Patents

ＣＤ８＋ＣＤ４５ＲＣｌｏｗ Ｔｒｅｇの新しい亜集団およびその使用 Download PDF

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JP2018527932A
JP2018527932A JP2018511706A JP2018511706A JP2018527932A JP 2018527932 A JP2018527932 A JP 2018527932A JP 2018511706 A JP2018511706 A JP 2018511706A JP 2018511706 A JP2018511706 A JP 2018511706A JP 2018527932 A JP2018527932 A JP 2018527932A
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human
cells
ifnγ
cd45rc low
treg
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JP2018527932A5 (https=
Inventor
ギヨンノー，キャロル
アネゴン，イグナシオ
ベジエ，セヴェリーヌ
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インセルム（インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル）
インセルム（インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル）
ユニバーシティ デ ナント
ユニバーシティ デ ナント
センター ホスピタリア ユニバーシタイア デ ナント
センター ホスピタリア ユニバーシタイア デ ナント
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Application filed by インセルム（インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル）, インセルム（インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル）, ユニバーシティ デ ナント, ユニバーシティ デ ナント, センター ホスピタリア ユニバーシタイア デ ナント, センター ホスピタリア ユニバーシタイア デ ナント filed Critical インセルム（インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル）
Publication of JP2018527932A publication Critical patent/JP2018527932A/ja
Publication of JP2018527932A5 publication Critical patent/JP2018527932A5/ja
Priority to JP2021133065A priority Critical patent/JP7254128B2/ja
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JP2018511706A 2015-09-07 2016-09-06 ＣＤ８＋ＣＤ４５ＲＣｌｏｗ Ｔｒｅｇの新しい亜集団およびその使用 Pending JP2018527932A (ja)

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JP2021133065A JP7254128B2 (ja) 2015-09-07 2021-08-18 ＣＤ８＋ＣＤ４５ＲＣｌｏｗ Ｔｒｅｇの新しい亜集団およびその使用

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EP15306366.4 2015-09-07
EP15306366 2015-09-07
PCT/EP2016/070991 WO2017042170A1 (en) 2015-09-07 2016-09-06 A new subpopulation of cd8+cd45rclow tregs and uses thereof

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JP2018527932A true JP2018527932A (ja) 2018-09-27
JP2018527932A5 JP2018527932A5 (https=) 2019-09-26

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JP2021133065A Active JP7254128B2 (ja) 2015-09-07 2021-08-18 ＣＤ８＋ＣＤ４５ＲＣｌｏｗ Ｔｒｅｇの新しい亜集団およびその使用

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US (1) US20180251731A1 (https=)
EP (1) EP3347452B1 (https=)
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KR (1) KR102768442B1 (https=)
CN (1) CN108291203A (https=)
AU (1) AU2016318762B2 (https=)
BR (1) BR112018004454A2 (https=)
CA (1) CA2997646C (https=)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022516408A (ja) * 2018-12-14 2022-02-28 インセルム（インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル） 単離されたＭＨＣ由来ヒトペプチドおよびＣＤ８＋ＣＤ４５ＲＣｌｏｗＴｒｅｇの抑制機能を刺激し、かつ活性化するためのその使用

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3042179A1 (en) * 2016-10-31 2018-05-03 Seattle Children's Hospital (dba Seattle Children's Research Institute) Method for treating autoimmune disease using cd4 t-cells with engineered stabilization of expression of endogenous foxp3 gene
EP4417210A1 (en) 2017-03-15 2024-08-21 Orca Biosystems, Inc. Compositions and methods for hematopoietic stem cell transplants
EP3652306A1 (en) 2017-07-13 2020-05-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for increasing expansion and immunosuppressive capacity of a population of cd8+cd45rclow/-tregs
WO2019141774A1 (en) * 2018-01-19 2019-07-25 Miltenyi Biotec Gmbh Regulatory t cell expressing a chimeric antigen receptor
EP3749334B1 (en) 2018-02-08 2024-12-11 The Board of Trustees of the Leland Stanford Junior University Allogenic hematopoietic stem cell transplantation
CN111936180B (zh) * 2018-03-14 2024-04-05 热动力医疗公司 浮力激活细胞分选(bacs)兼容的激活/转导系统和方法
AU2019378883A1 (en) 2018-11-14 2021-06-03 Flagship Pioneering Innovations V, Inc. Fusosome compositions for T cell delivery
MX2021013227A (es) * 2019-04-30 2022-01-06 Univ California Expansion ex-vivo sin microesferas de celulas t reguladoras humanas.
AU2020327949A1 (en) * 2019-08-14 2022-03-03 The Regents Of The University Of California CAR-T cells specific for modified proteins in extracellular spaces
WO2024028486A1 (en) * 2022-08-04 2024-02-08 Nantes Universite In vitro method for obtaining clinical-grade cd8+ cd45rclow/- regulatory t cells

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003530101A (ja) * 2000-04-11 2003-10-14 ユニバーシティ・オブ・サザン・カリフォルニア 抑制性Ｔ細胞を誘導するためにＴＧＦ−βを用いる移植拒絶反応を防止する方法
US20100135974A1 (en) * 2007-01-31 2010-06-03 Yeda Research And Development Co. Ltd. Redirected, genetically-engineered t regulatory cells and their use in suppression of autoimmune and inflammatory disease

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2702676T3 (es) * 2014-04-01 2019-03-04 Inst Nat Sante Rech Med Péptido de donante aislado derivado de MHC y usos del mismo
US10155025B2 (en) * 2014-07-17 2018-12-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for inhibiting or reducing transplant rejection by adminstration of interleukin-34

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003530101A (ja) * 2000-04-11 2003-10-14 ユニバーシティ・オブ・サザン・カリフォルニア 抑制性Ｔ細胞を誘導するためにＴＧＦ−βを用いる移植拒絶反応を防止する方法
US20100135974A1 (en) * 2007-01-31 2010-06-03 Yeda Research And Development Co. Ltd. Redirected, genetically-engineered t regulatory cells and their use in suppression of autoimmune and inflammatory disease

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GUILLONNEAU C. ET AL.: "CD40Ig treatment results in allograft acceptance mediated by CD8+CD45RClow T cells, IFN-γ, and indo", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 117, no. 4, JPN6020020438, April 2007 (2007-04-01), pages 1096 - 1106, ISSN: 0004487134 *
LI X. L. ET AL.: "Mechanism and localization of CD8 regulatory T cells in a heart transplant model of tolerance.' , ,", THE JOURNAL OF IMMUNOLOGY, vol. 185, no. 2, JPN6020020439, 15 July 2010 (2010-07-15), pages 823 - 833, ISSN: 0004286706 *
ORDONEZ L. ET AL.: "A higher risk of acute rejection of human kidney allografts can be predicted from the level of CD45R", PLOS ONE, vol. 8, no. 7, JPN6020020441, July 2013 (2013-07-01), pages 69791, ISSN: 0004286707 *
XYSTRAKIS E. ET AL.: "Functional and genetic analysis of two CD8 T cell subsets defined by the level of CD45RC expression", THE JOURNAL OF IMMUNOLOGY, vol. 173, no. 5, JPN6020020443, 2004, pages 3140 - 3147, ISSN: 0004286708 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022516408A (ja) * 2018-12-14 2022-02-28 インセルム（インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル） 単離されたＭＨＣ由来ヒトペプチドおよびＣＤ８＋ＣＤ４５ＲＣｌｏｗＴｒｅｇの抑制機能を刺激し、かつ活性化するためのその使用
JP7609775B2 (ja) 2018-12-14 2025-01-07 インセルム（インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル） 単離されたＭＨＣ由来ヒトペプチドおよびＣＤ８＋ＣＤ４５ＲＣｌｏｗＴｒｅｇの抑制機能を刺激し、かつ活性化するためのその使用

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RU2766691C2 (ru) 2022-03-15
JP7254128B2 (ja) 2023-04-07
CN108291203A (zh) 2018-07-17
BR112018004454A2 (pt) 2018-09-25
MX390494B (es) 2025-03-20
US20180251731A1 (en) 2018-09-06
IL257891A (en) 2018-05-31
KR102768442B1 (ko) 2025-02-17
RU2018107363A (ru) 2019-10-09
ZA201801265B (en) 2022-08-31
IL257891B (en) 2020-09-30
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