JP2018527405A5 - - Google Patents
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- JP2018527405A5 JP2018527405A5 JP2018521193A JP2018521193A JP2018527405A5 JP 2018527405 A5 JP2018527405 A5 JP 2018527405A5 JP 2018521193 A JP2018521193 A JP 2018521193A JP 2018521193 A JP2018521193 A JP 2018521193A JP 2018527405 A5 JP2018527405 A5 JP 2018527405A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- seq
- protein
- subject
- spp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 115
- 108090000623 proteins and genes Proteins 0.000 claims description 59
- 102000004169 proteins and genes Human genes 0.000 claims description 59
- 238000000034 method Methods 0.000 claims description 42
- 208000015181 infectious disease Diseases 0.000 claims description 19
- 244000005700 microbiome Species 0.000 claims description 16
- 241000588748 Klebsiella Species 0.000 claims description 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 10
- 241000588923 Citrobacter Species 0.000 claims description 8
- 241000588914 Enterobacter Species 0.000 claims description 8
- 241000588747 Klebsiella pneumoniae Species 0.000 claims description 8
- 241000588769 Proteus <enterobacteria> Species 0.000 claims description 8
- 241000607720 Serratia Species 0.000 claims description 8
- 210000004027 cell Anatomy 0.000 claims description 8
- OEUUFNIKLCFNLN-LLVKDONJSA-N chembl432481 Chemical compound OC(=O)[C@@]1(C)CSC(C=2C(=CC(O)=CC=2)O)=N1 OEUUFNIKLCFNLN-LLVKDONJSA-N 0.000 claims description 8
- 239000008267 milk Substances 0.000 claims description 8
- 235000013336 milk Nutrition 0.000 claims description 8
- 210000004080 milk Anatomy 0.000 claims description 8
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 claims description 5
- 241001465754 Metazoa Species 0.000 claims description 5
- 239000003937 drug carrier Substances 0.000 claims description 5
- 238000001962 electrophoresis Methods 0.000 claims description 5
- 229920002401 polyacrylamide Polymers 0.000 claims description 5
- 229910052708 sodium Inorganic materials 0.000 claims description 5
- 239000011734 sodium Substances 0.000 claims description 5
- 241000124008 Mammalia Species 0.000 claims description 4
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims description 4
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims description 4
- 239000003153 chemical reaction reagent Substances 0.000 claims description 4
- 208000004396 mastitis Diseases 0.000 claims description 4
- 210000001082 somatic cell Anatomy 0.000 claims description 4
- 230000005757 colony formation Effects 0.000 claims description 3
- 241000589877 Campylobacter coli Species 0.000 claims description 2
- 241000588724 Escherichia coli Species 0.000 claims description 2
- 101800001554 RNA-directed RNA polymerase Proteins 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 235000013365 dairy product Nutrition 0.000 claims description 2
- 230000001502 supplementing effect Effects 0.000 claims description 2
- 208000024891 symptom Diseases 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562190947P | 2015-07-10 | 2015-07-10 | |
| US62/190,947 | 2015-07-10 | ||
| PCT/US2016/041614 WO2017011340A2 (en) | 2015-07-10 | 2016-07-08 | Proteins and immunizing compositions containing klebsiella proteins and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020206603A Division JP2021063084A (ja) | 2015-07-10 | 2020-12-14 | タンパク質及びｋｌｅｂｓｉｅｌｌａタンパク質を含有する免疫化組成物ならびにその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018527405A JP2018527405A (ja) | 2018-09-20 |
| JP2018527405A5 true JP2018527405A5 (enExample) | 2019-08-15 |
| JP7222711B2 JP7222711B2 (ja) | 2023-02-15 |
Family
ID=56555778
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018521193A Active JP7222711B2 (ja) | 2015-07-10 | 2016-07-08 | タンパク質及びｋｌｅｂｓｉｅｌｌａタンパク質を含有する免疫化組成物ならびにその使用方法 |
| JP2020206603A Withdrawn JP2021063084A (ja) | 2015-07-10 | 2020-12-14 | タンパク質及びｋｌｅｂｓｉｅｌｌａタンパク質を含有する免疫化組成物ならびにその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020206603A Withdrawn JP2021063084A (ja) | 2015-07-10 | 2020-12-14 | タンパク質及びｋｌｅｂｓｉｅｌｌａタンパク質を含有する免疫化組成物ならびにその使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US11000582B2 (enExample) |
| EP (1) | EP3319628A2 (enExample) |
| JP (2) | JP7222711B2 (enExample) |
| CN (1) | CN107921114A (enExample) |
| CA (1) | CA2991907A1 (enExample) |
| MX (1) | MX2018000395A (enExample) |
| WO (1) | WO2017011340A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002053180A2 (en) * | 2001-01-03 | 2002-07-11 | Willmar Poultry Company, Inc. | Immunizing compositions and methods of use |
| CA2991907A1 (en) * | 2015-07-10 | 2017-01-19 | Douglas T. Burkhardt | Proteins and immunizing compositions containing klebsiella proteins and methods of use |
| US10166280B2 (en) | 2016-06-08 | 2019-01-01 | Epitopix, Llc | Polypeptides and immunizing compositions containing Bacillus polypeptides and methods of use |
| ES2945137T3 (es) | 2017-02-10 | 2023-06-28 | Epitopix Llc | Proteínas y composiciones inmunitarias que contienen proteínas de Pasteurella y métodos de uso |
| CA3138237A1 (en) * | 2019-04-26 | 2020-10-29 | Cornell University | Klebsiella vaccine and methods of use |
| CN111647057B (zh) * | 2020-05-07 | 2022-09-13 | 西南医科大学附属中医医院 | 一种伤寒沙门菌疫苗重组蛋白及其编码基因和它们的应用 |
| EP4422677A1 (en) * | 2021-10-29 | 2024-09-04 | Vaxxinova US, Inc. | Methods and compositions for preventing infection |
| CN115975890A (zh) * | 2023-02-02 | 2023-04-18 | 深圳元健生命科技有限公司 | 一种产气克雷伯氏菌及其应用 |
| CN115798574B (zh) * | 2023-02-06 | 2023-06-02 | 中国医学科学院北京协和医院 | 一种预测克雷伯氏菌属对美罗培南敏感性的系统及方法 |
| CN119679930B (zh) * | 2025-02-24 | 2025-07-25 | 吉林大学第一医院 | 一种肺炎克雷伯菌表面膜蛋白的应用和疫苗 |
| CN120330106B (zh) * | 2025-06-05 | 2025-08-26 | 云南省农业科学院茶叶研究所 | 一种产酸克雷伯氏菌株及其应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2644346B1 (fr) * | 1989-03-20 | 1994-05-13 | Rhone Merieux | Vaccins contre les bacteries septicemiques, preparations d'antigenes de bacteries septicemiques, nouvelles bacteries et vecteurs pour la preparation de ces antigenes ou vaccins |
| CA2182976C (en) | 1994-02-09 | 2011-07-12 | Daryll A. Emery | Active immunization using a siderophore receptor protein |
| US5538733A (en) | 1994-07-07 | 1996-07-23 | Willmar Poultry Company, Inc. | Method of priming an immune response in a one-day old animal |
| US6610836B1 (en) | 1999-01-29 | 2003-08-26 | Genome Therapeutics Corporation | Nucleic acid amino acid sequences relating to Klebsiella pneumoniae for diagnostics and therapeutics |
| US6682754B2 (en) | 1999-11-24 | 2004-01-27 | Willmar Poultry Company, Inc. | Ovo delivery of an immunogen containing implant |
| WO2002053180A2 (en) | 2001-01-03 | 2002-07-11 | Willmar Poultry Company, Inc. | Immunizing compositions and methods of use |
| BRPI0414267A (pt) | 2003-09-19 | 2006-11-21 | Epitopix Llc | polipeptìdeos de campilobacter e métodos de uso |
| BRPI0607323B8 (pt) | 2005-02-14 | 2021-05-25 | Epitopix Llc | composições, usos de polipeptídeos e de anticorpos, bem como kits para a detecção de anticorpo que se liga especificamente a um polipeptídeo |
| EP2152731A2 (en) * | 2007-05-02 | 2010-02-17 | Intercell AG | Klebsiella antigens |
| BRPI1011856A2 (pt) * | 2009-03-23 | 2020-11-03 | Epitopix, Llc | polipeptídeos e composições de imunização contendo polipeptídeos gram-positivos e métodos de uso |
| US9073990B2 (en) * | 2010-04-05 | 2015-07-07 | Bar-Llan University | Protease-activatable pore-forming polypeptides |
| CA2991907A1 (en) * | 2015-07-10 | 2017-01-19 | Douglas T. Burkhardt | Proteins and immunizing compositions containing klebsiella proteins and methods of use |
-
2016
- 2016-07-08 CA CA2991907A patent/CA2991907A1/en active Pending
- 2016-07-08 CN CN201680047674.4A patent/CN107921114A/zh active Pending
- 2016-07-08 WO PCT/US2016/041614 patent/WO2017011340A2/en not_active Ceased
- 2016-07-08 US US15/741,574 patent/US11000582B2/en active Active
- 2016-07-08 EP EP16745287.9A patent/EP3319628A2/en active Pending
- 2016-07-08 JP JP2018521193A patent/JP7222711B2/ja active Active
- 2016-07-08 MX MX2018000395A patent/MX2018000395A/es unknown
-
2020
- 2020-12-14 JP JP2020206603A patent/JP2021063084A/ja not_active Withdrawn
-
2021
- 2021-04-09 US US17/226,761 patent/US11872273B2/en active Active
-
2023
- 2023-12-06 US US18/530,348 patent/US20240216494A1/en active Pending
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