CN107921114A - 包含克雷伯氏菌属蛋白的蛋白质和免疫组合物以及使用方法 - Google Patents

包含克雷伯氏菌属蛋白的蛋白质和免疫组合物以及使用方法 Download PDF

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Publication number
CN107921114A
CN107921114A CN201680047674.4A CN201680047674A CN107921114A CN 107921114 A CN107921114 A CN 107921114A CN 201680047674 A CN201680047674 A CN 201680047674A CN 107921114 A CN107921114 A CN 107921114A
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CN
China
Prior art keywords
seq
protein
composition
proteins
klebsiella
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201680047674.4A
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English (en)
Chinese (zh)
Inventor
D·T·布克哈特
D·艾默里
D·斯特劳布
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Epitopix LLC
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Epitopix LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epitopix LLC filed Critical Epitopix LLC
Publication of CN107921114A publication Critical patent/CN107921114A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0266—Klebsiella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/116—Polyvalent bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/26—Klebsiella (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201680047674.4A 2015-07-10 2016-07-08 包含克雷伯氏菌属蛋白的蛋白质和免疫组合物以及使用方法 Pending CN107921114A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562190947P 2015-07-10 2015-07-10
US62/190,947 2015-07-10
PCT/US2016/041614 WO2017011340A2 (en) 2015-07-10 2016-07-08 Proteins and immunizing compositions containing klebsiella proteins and methods of use

Publications (1)

Publication Number Publication Date
CN107921114A true CN107921114A (zh) 2018-04-17

Family

ID=56555778

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680047674.4A Pending CN107921114A (zh) 2015-07-10 2016-07-08 包含克雷伯氏菌属蛋白的蛋白质和免疫组合物以及使用方法

Country Status (7)

Country Link
US (3) US11000582B2 (enExample)
EP (1) EP3319628A2 (enExample)
JP (2) JP7222711B2 (enExample)
CN (1) CN107921114A (enExample)
CA (1) CA2991907A1 (enExample)
MX (1) MX2018000395A (enExample)
WO (1) WO2017011340A2 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115798574A (zh) * 2023-02-06 2023-03-14 中国医学科学院北京协和医院 一种预测克雷伯氏菌属对美罗培南敏感性的系统及方法
CN115975890A (zh) * 2023-02-02 2023-04-18 深圳元健生命科技有限公司 一种产气克雷伯氏菌及其应用
CN116438193A (zh) * 2020-09-04 2023-07-14 Intravacc有限责任公司 OmpA突变增强百日咳博德特氏菌中OMV产生
CN119679930A (zh) * 2025-02-24 2025-03-25 吉林大学第一医院 一种肺炎克雷伯菌表面膜蛋白的应用和疫苗
CN120330106A (zh) * 2025-06-05 2025-07-18 云南省农业科学院茶叶研究所 一种产酸克雷伯氏菌株及其应用

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1353689T3 (da) * 2001-01-03 2006-07-31 Epitopix Llc Immuniseringspræparater og anvendelse deraf
US11000582B2 (en) * 2015-07-10 2021-05-11 Epitopix, Llc Proteins and immunizing compositions containing klebsiella proteins and methods of use
US10166280B2 (en) 2016-06-08 2019-01-01 Epitopix, Llc Polypeptides and immunizing compositions containing Bacillus polypeptides and methods of use
MX2019009409A (es) 2017-02-10 2019-09-27 Epitopix Llc Proteinas y composiciones de inmunizacion que contienen proteinas de pasteurella y metodos de uso.
WO2020220014A1 (en) * 2019-04-26 2020-10-29 Cornell University Klebsiella vaccine and methods of use
CN111647057B (zh) * 2020-05-07 2022-09-13 西南医科大学附属中医医院 一种伤寒沙门菌疫苗重组蛋白及其编码基因和它们的应用
EP4422677A1 (en) * 2021-10-29 2024-09-04 Vaxxinova US, Inc. Methods and compositions for preventing infection

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2644346B1 (fr) 1989-03-20 1994-05-13 Rhone Merieux Vaccins contre les bacteries septicemiques, preparations d'antigenes de bacteries septicemiques, nouvelles bacteries et vecteurs pour la preparation de ces antigenes ou vaccins
ES2279511T3 (es) * 1994-02-09 2007-08-16 Epitopix Llc Inmunizacion activa utilizando una proteina receptor de sideroforo.
US5538733A (en) 1994-07-07 1996-07-23 Willmar Poultry Company, Inc. Method of priming an immune response in a one-day old animal
US6610836B1 (en) * 1999-01-29 2003-08-26 Genome Therapeutics Corporation Nucleic acid amino acid sequences relating to Klebsiella pneumoniae for diagnostics and therapeutics
US6682754B2 (en) 1999-11-24 2004-01-27 Willmar Poultry Company, Inc. Ovo delivery of an immunogen containing implant
DK1353689T3 (da) * 2001-01-03 2006-07-31 Epitopix Llc Immuniseringspræparater og anvendelse deraf
US8329192B2 (en) * 2003-09-19 2012-12-11 Epitopix Llc Campylobacter polypeptides and methods of use
NZ597997A (en) 2005-02-14 2013-10-25 Epitopix Llc Antibody compositions that bind polypeptides from staphylococcus aureus
CA2685805A1 (en) 2007-05-02 2008-11-13 Intercell Ag Klebsiella antigens
NZ614557A (en) 2009-03-23 2015-03-27 Epitopix Llc Polypeptides and immunizing compositions containing gram positive polypeptides and methods of use
EP2556085A2 (en) * 2010-04-05 2013-02-13 Bar-Ilan University Protease-activatable pore-forming polypeptides
US11000582B2 (en) * 2015-07-10 2021-05-11 Epitopix, Llc Proteins and immunizing compositions containing klebsiella proteins and methods of use

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116438193A (zh) * 2020-09-04 2023-07-14 Intravacc有限责任公司 OmpA突变增强百日咳博德特氏菌中OMV产生
CN115975890A (zh) * 2023-02-02 2023-04-18 深圳元健生命科技有限公司 一种产气克雷伯氏菌及其应用
CN115798574A (zh) * 2023-02-06 2023-03-14 中国医学科学院北京协和医院 一种预测克雷伯氏菌属对美罗培南敏感性的系统及方法
US12482537B2 (en) 2023-02-06 2025-11-25 Peking Union Medical College Hospital, Chinese Academy Of Medical Sciences System of predicting sensitivity of Klebsiella against MeropeneM and method
CN119679930A (zh) * 2025-02-24 2025-03-25 吉林大学第一医院 一种肺炎克雷伯菌表面膜蛋白的应用和疫苗
CN120330106A (zh) * 2025-06-05 2025-07-18 云南省农业科学院茶叶研究所 一种产酸克雷伯氏菌株及其应用
CN120330106B (zh) * 2025-06-05 2025-08-26 云南省农业科学院茶叶研究所 一种产酸克雷伯氏菌株及其应用

Also Published As

Publication number Publication date
EP3319628A2 (en) 2018-05-16
JP2018527405A (ja) 2018-09-20
MX2018000395A (es) 2018-05-23
US20190070281A1 (en) 2019-03-07
US20210330776A1 (en) 2021-10-28
WO2017011340A2 (en) 2017-01-19
US12691167B2 (en) 2026-07-28
WO2017011340A3 (en) 2017-04-13
CA2991907A1 (en) 2017-01-19
JP7222711B2 (ja) 2023-02-15
US20240216494A1 (en) 2024-07-04
US11872273B2 (en) 2024-01-16
US11000582B2 (en) 2021-05-11
JP2021063084A (ja) 2021-04-22

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Application publication date: 20180417