JP2018525992A5 - - Google Patents
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- JP2018525992A5 JP2018525992A5 JP2018509533A JP2018509533A JP2018525992A5 JP 2018525992 A5 JP2018525992 A5 JP 2018525992A5 JP 2018509533 A JP2018509533 A JP 2018509533A JP 2018509533 A JP2018509533 A JP 2018509533A JP 2018525992 A5 JP2018525992 A5 JP 2018525992A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- protein
- module
- polypeptide
- protein domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108020001580 protein domains Proteins 0.000 claims 30
- 229920001184 polypeptide Polymers 0.000 claims 20
- 102000004196 processed proteins & peptides Human genes 0.000 claims 20
- 108090000765 processed proteins & peptides Proteins 0.000 claims 20
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 15
- 210000004027 cell Anatomy 0.000 claims 11
- 238000000034 method Methods 0.000 claims 11
- 108091033319 polynucleotide Proteins 0.000 claims 11
- 102000040430 polynucleotide Human genes 0.000 claims 11
- 239000002157 polynucleotide Substances 0.000 claims 11
- 108091026890 Coding region Proteins 0.000 claims 9
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 101710167800 Capsid assembly scaffolding protein Proteins 0.000 claims 4
- 101710163270 Nuclease Proteins 0.000 claims 4
- 108700019535 Phosphoprotein Phosphatases Proteins 0.000 claims 4
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 claims 4
- 101710130420 Probable capsid assembly scaffolding protein Proteins 0.000 claims 4
- 102000001253 Protein Kinase Human genes 0.000 claims 4
- 101710204410 Scaffold protein Proteins 0.000 claims 4
- 108091023040 Transcription factor Proteins 0.000 claims 4
- 102000040945 Transcription factor Human genes 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 150000002632 lipids Chemical class 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 108060006633 protein kinase Proteins 0.000 claims 4
- 230000009870 specific binding Effects 0.000 claims 4
- 102000018120 Recombinases Human genes 0.000 claims 3
- 108010091086 Recombinases Proteins 0.000 claims 3
- 230000027455 binding Effects 0.000 claims 3
- 230000000139 costimulatory effect Effects 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 238000012163 sequencing technique Methods 0.000 claims 3
- 108010013043 Acetylesterase Proteins 0.000 claims 2
- 101000879203 Caenorhabditis elegans Small ubiquitin-related modifier Proteins 0.000 claims 2
- 102000001477 Deubiquitinating Enzymes Human genes 0.000 claims 2
- 108010093668 Deubiquitinating Enzymes Proteins 0.000 claims 2
- 101000615488 Homo sapiens Methyl-CpG-binding domain protein 2 Proteins 0.000 claims 2
- 102100021299 Methyl-CpG-binding domain protein 2 Human genes 0.000 claims 2
- 102000005650 Notch Receptors Human genes 0.000 claims 2
- 108010070047 Notch Receptors Proteins 0.000 claims 2
- 102000045595 Phosphoprotein Phosphatases Human genes 0.000 claims 2
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 claims 2
- 108091000080 Phosphotransferase Proteins 0.000 claims 2
- 102000051619 SUMO-1 Human genes 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 230000001973 epigenetic effect Effects 0.000 claims 2
- 102000034356 gene-regulatory proteins Human genes 0.000 claims 2
- 108091006104 gene-regulatory proteins Proteins 0.000 claims 2
- 230000004068 intracellular signaling Effects 0.000 claims 2
- 102000020233 phosphotransferase Human genes 0.000 claims 2
- 102000027426 receptor tyrosine kinases Human genes 0.000 claims 2
- 108091008598 receptor tyrosine kinases Proteins 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 238000003786 synthesis reaction Methods 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 108090000854 Oxidoreductases Proteins 0.000 claims 1
- 102000004316 Oxidoreductases Human genes 0.000 claims 1
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 1
- 230000016396 cytokine production Effects 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 230000000149 penetrating effect Effects 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 108090000446 ribonuclease T(2) Proteins 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
- 230000009261 transgenic effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021076671A JP7397821B2 (ja) | 2015-09-01 | 2021-04-28 | モジュールポリペプチドライブラリならびにその作製方法及びその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562212999P | 2015-09-01 | 2015-09-01 | |
| US62/212,999 | 2015-09-01 | ||
| PCT/US2016/049745 WO2017040694A2 (en) | 2015-09-01 | 2016-08-31 | Modular polypeptide libraries and methods of making and using same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021076671A Division JP7397821B2 (ja) | 2015-09-01 | 2021-04-28 | モジュールポリペプチドライブラリならびにその作製方法及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018525992A JP2018525992A (ja) | 2018-09-13 |
| JP2018525992A5 true JP2018525992A5 (https=) | 2019-10-10 |
| JP6878408B2 JP6878408B2 (ja) | 2021-05-26 |
Family
ID=58188233
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018509533A Expired - Fee Related JP6878408B2 (ja) | 2015-09-01 | 2016-08-31 | モジュールポリペプチドライブラリならびにその作製方法及びその使用 |
| JP2021076671A Active JP7397821B2 (ja) | 2015-09-01 | 2021-04-28 | モジュールポリペプチドライブラリならびにその作製方法及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021076671A Active JP7397821B2 (ja) | 2015-09-01 | 2021-04-28 | モジュールポリペプチドライブラリならびにその作製方法及びその使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11560561B2 (https=) |
| EP (3) | EP4282979A3 (https=) |
| JP (2) | JP6878408B2 (https=) |
| KR (2) | KR102659574B1 (https=) |
| CN (2) | CN114657173A (https=) |
| AU (2) | AU2016315941B2 (https=) |
| CA (2) | CA2995389C (https=) |
| EA (1) | EA201890611A1 (https=) |
| ES (1) | ES2887593T3 (https=) |
| IL (2) | IL293963A (https=) |
| MX (2) | MX393983B (https=) |
| PT (1) | PT3344803T (https=) |
| SG (1) | SG10201913915WA (https=) |
| WO (1) | WO2017040694A2 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2018008345A (es) | 2016-01-11 | 2018-12-06 | Univ Leland Stanford Junior | Proteínas quiméricas y métodos de inmunoterapia. |
| IL260532B2 (en) | 2016-01-11 | 2023-12-01 | Univ Leland Stanford Junior | Chimeric proteins- containing systems and uses thereof in regulating gene expression |
| WO2019020733A1 (en) * | 2017-07-26 | 2019-01-31 | Cellectis | METHODS OF IMMUNE CELL SELECTION OF THE ANTIGEN-DEPENDENT CHIMERIC ANTIGENIC RECEPTOR (CAR) |
| WO2020036181A1 (ja) * | 2018-08-13 | 2020-02-20 | Ｓｐｉｂｅｒ株式会社 | 細胞を単離又は同定する方法及び細胞集団 |
| EP4253549A3 (en) * | 2018-09-19 | 2023-12-06 | The University of Hong Kong | Improved high-throughput combinatorial genetic modification system and optimized cas9 enzyme variants |
| GB201816522D0 (en) | 2018-10-10 | 2018-11-28 | Autolus Ltd | Methods and reagents for analysing nucleic acids from single cells |
| WO2020097254A1 (en) * | 2018-11-06 | 2020-05-14 | Gordian Biotechnology, Inc. | Compositions and methods for in vivo screening of therapeutics |
| CN109576292B (zh) | 2018-12-21 | 2022-11-29 | 深圳市爱思迪生物科技有限公司 | 一种抗体文库的构建方法及其应用 |
| US12241061B2 (en) | 2019-02-04 | 2025-03-04 | National University Corporation Ehime University | CAR library and scFv manufacturing method |
| WO2020209934A1 (en) * | 2019-04-11 | 2020-10-15 | Massachusetts Institute Of Technology | Novel chimeric antigen receptors and libraries |
| CN113728112A (zh) * | 2019-04-28 | 2021-11-30 | 加利福尼亚大学董事会 | 使用酶促消化来富集信息性dna片段的文库制备方法 |
| WO2021087205A1 (en) * | 2019-11-01 | 2021-05-06 | Senti Biosciences, Inc. | Chimeric receptor sensors |
| CN111304244A (zh) * | 2019-11-13 | 2020-06-19 | 沣潮医药科技（上海）有限公司 | 携带基因元件组合的载体组件、受体细胞文库、制备和筛选方法及用途 |
| US11739370B1 (en) | 2020-01-10 | 2023-08-29 | Gordian Biotechnology, Inc. | Methods and compositions for in vivo screening of therapeutics through spatial transcriptomics |
| CN114057890A (zh) * | 2020-07-31 | 2022-02-18 | 南京北恒生物科技有限公司 | 新型共刺激结构域及其用途 |
| US12163190B2 (en) | 2022-06-17 | 2024-12-10 | Insitro, Inc. | In situ sequencing of RNA transcripts with non-uniform 5 prime ends |
| JP2026009432A (ja) * | 2022-09-20 | 2026-01-21 | Ｓｐｉｂｅｒ株式会社 | Ｄｎａ配列のスクリーニング方法 |
| WO2025054202A1 (en) * | 2023-09-05 | 2025-03-13 | Sana Biotechnology, Inc. | Method of screening a sample comprising a transgene with a unique barcode |
| WO2025054284A1 (en) * | 2023-09-06 | 2025-03-13 | Baylor College Of Medicine | Refinement of car constructs via barcoded screening |
| CN120865430A (zh) * | 2024-04-30 | 2025-10-31 | 合源生物科技(天津)有限公司 | 一种增强型嵌合抗原受体及其应用 |
| CN119264271B (zh) * | 2024-10-08 | 2025-05-09 | 北京市神经外科研究所 | 一种nk细胞特异性的嵌合抗原受体及其应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR587222A (fr) | 1923-12-21 | 1925-04-14 | Rhodiaseta | Perfectionnements dans les procédés et appareils destinés à la fabrication des fis ou filaments artificiels |
| US20090233806A1 (en) * | 1999-07-06 | 2009-09-17 | Carr Francis J | Protein isolation and analysis |
| US20040121324A1 (en) * | 2001-01-18 | 2004-06-24 | Brenner Charles M. | Barcoded synthetic lethal screening to identify drug targets |
| CN100463962C (zh) * | 2001-12-07 | 2009-02-25 | 图尔金株式会社 | 嵌合蛋白质的表型筛选 |
| US7604805B2 (en) | 2003-07-03 | 2009-10-20 | Regents Of The University Of California | Protein logic gates |
| WO2005118788A2 (en) | 2004-05-27 | 2005-12-15 | The Trustees Of The University Of Pennsylvania | Novel artificial antigen presenting cells and uses therefor |
| US8153598B2 (en) * | 2005-10-19 | 2012-04-10 | Intrexon Corporation | PKD ligands and polynucleotides encoding PKD ligands |
| US8148085B2 (en) * | 2006-05-15 | 2012-04-03 | Sea Lane Biotechnologies, Llc | Donor specific antibody libraries |
| EP2069558B1 (en) * | 2006-10-02 | 2013-05-01 | Sea Lane Biotechnologies,llc. | Design and construction of diverse synthetic peptide and polypeptide libraries |
| US9051665B2 (en) * | 2008-11-20 | 2015-06-09 | Steven L. Zeichner | Method for screening biomolecules |
| EP2436766A1 (en) * | 2010-09-29 | 2012-04-04 | Deutsches Krebsforschungszentrum | Means and methods for improved protein interaction screening |
| WO2012061832A1 (en) * | 2010-11-05 | 2012-05-10 | Illumina, Inc. | Linking sequence reads using paired code tags |
| WO2012112804A1 (en) | 2011-02-18 | 2012-08-23 | Raindance Technoligies, Inc. | Compositions and methods for molecular labeling |
| EP2836611A4 (en) * | 2012-04-13 | 2015-12-30 | Sequenta Inc | DETECTION AND QUANTIFICATION OF SAMPLE CONTAMINATION IN AN IMMUNOLOGICAL DIRECTORY ANALYSIS |
| MX367730B (es) * | 2012-09-04 | 2019-09-04 | Cellectis | Receptor de antigeno quimerico multi-cadena y usos del mismo. |
| DK2956175T3 (da) * | 2013-02-15 | 2017-11-27 | Univ California | Kimærisk antigenreceptor og fremgangsmåder til anvendelse deraf |
| US20150011405A1 (en) * | 2013-07-03 | 2015-01-08 | Atreca, Inc. | Use of Nanoexpression to Interrogate Antigen Repertoires |
| KR102375998B1 (ko) * | 2014-02-14 | 2022-03-21 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 키메라 항원 수용체 및 제조방법 |
| WO2015163745A1 (ko) * | 2014-04-25 | 2015-10-29 | 재단법인 의약바이오컨버젼스연구단 | 바코드 이동 분석을 위한 이중 리포터 시스템을 보유한 효모 균주 |
| US20150315569A1 (en) * | 2014-05-02 | 2015-11-05 | The Board Of Trustees Of The Leland Stanford Junior University | Method for screening a nucleic acid-programmed small molecule library |
-
2016
- 2016-08-31 EP EP23199546.5A patent/EP4282979A3/en not_active Withdrawn
- 2016-08-31 MX MX2018002596A patent/MX393983B/es unknown
- 2016-08-31 PT PT168429298T patent/PT3344803T/pt unknown
- 2016-08-31 EP EP16842929.8A patent/EP3344803B1/en active Active
- 2016-08-31 EA EA201890611A patent/EA201890611A1/ru unknown
- 2016-08-31 SG SG10201913915WA patent/SG10201913915WA/en unknown
- 2016-08-31 WO PCT/US2016/049745 patent/WO2017040694A2/en not_active Ceased
- 2016-08-31 CA CA2995389A patent/CA2995389C/en active Active
- 2016-08-31 CN CN202210290324.8A patent/CN114657173A/zh active Pending
- 2016-08-31 AU AU2016315941A patent/AU2016315941B2/en not_active Ceased
- 2016-08-31 KR KR1020187008829A patent/KR102659574B1/ko active Active
- 2016-08-31 KR KR1020247012724A patent/KR20240056636A/ko active Pending
- 2016-08-31 CN CN201680057253.XA patent/CN108138362B/zh not_active Expired - Fee Related
- 2016-08-31 ES ES16842929T patent/ES2887593T3/es active Active
- 2016-08-31 CA CA3227545A patent/CA3227545A1/en active Pending
- 2016-08-31 JP JP2018509533A patent/JP6878408B2/ja not_active Expired - Fee Related
- 2016-08-31 EP EP21183296.9A patent/EP3954772B1/en active Active
- 2016-08-31 US US15/751,419 patent/US11560561B2/en active Active
- 2016-08-31 IL IL293963A patent/IL293963A/en unknown
- 2016-08-31 IL IL257453A patent/IL257453B/en unknown
-
2018
- 2018-03-01 MX MX2022007861A patent/MX2022007861A/es unknown
-
2021
- 2021-04-28 JP JP2021076671A patent/JP7397821B2/ja active Active
-
2022
- 2022-11-25 AU AU2022275510A patent/AU2022275510A1/en not_active Abandoned
- 2022-12-19 US US18/068,499 patent/US12460199B2/en active Active
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