JP2018525345A5 - - Google Patents
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- JP2018525345A5 JP2018525345A5 JP2017568029A JP2017568029A JP2018525345A5 JP 2018525345 A5 JP2018525345 A5 JP 2018525345A5 JP 2017568029 A JP2017568029 A JP 2017568029A JP 2017568029 A JP2017568029 A JP 2017568029A JP 2018525345 A5 JP2018525345 A5 JP 2018525345A5
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- JP
- Japan
- Prior art keywords
- group
- alkyl
- compound
- halo
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims 17
- -1 2,3-dihydro-1H-indenyl group Chemical group 0.000 claims 12
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 8
- 125000005843 halogen group Chemical group 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 102000004547 Glucosylceramidase Human genes 0.000 claims 5
- 108010017544 Glucosylceramidase Proteins 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 2
- TVBNTFVSONEKOU-UHFFFAOYSA-N 2,3-dihydro-1,4-benzodioxine-3-carbaldehyde Chemical group C1=CC=C2OC(C=O)COC2=C1 TVBNTFVSONEKOU-UHFFFAOYSA-N 0.000 claims 2
- MJCYUVOCINOVJH-UHFFFAOYSA-N 3-methyl-2,3-dihydro-1,4-benzodioxine Chemical group C1=CC=C2OC(C)COC2=C1 MJCYUVOCINOVJH-UHFFFAOYSA-N 0.000 claims 2
- PFODEVGLOVUVHS-UHFFFAOYSA-N 4-(4-methylpiperazin-1-yl)benzaldehyde Chemical group C1CN(C)CCN1C1=CC=C(C=O)C=C1 PFODEVGLOVUVHS-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- IVRMZWNICZWHMI-UHFFFAOYSA-N azide group Chemical group [N-]=[N+]=[N-] IVRMZWNICZWHMI-UHFFFAOYSA-N 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 229960002685 biotin Drugs 0.000 claims 2
- 235000020958 biotin Nutrition 0.000 claims 2
- 239000011616 biotin Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 125000004193 piperazinyl group Chemical group 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- PVOAHINGSUIXLS-UHFFFAOYSA-N 1-Methylpiperazine Chemical group CN1CCNCC1 PVOAHINGSUIXLS-UHFFFAOYSA-N 0.000 claims 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 0 *C=C1O[C@@]1N* Chemical compound *C=C1O[C@@]1N* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562187461P | 2015-07-01 | 2015-07-01 | |
| US62/187,461 | 2015-07-01 | ||
| PCT/US2016/040467 WO2017004405A1 (en) | 2015-07-01 | 2016-06-30 | Substituted quinazoline compounds and uses thereof for modulating glucocerebrosidase activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018525345A JP2018525345A (ja) | 2018-09-06 |
| JP2018525345A5 true JP2018525345A5 (enExample) | 2019-08-08 |
Family
ID=57609612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017568029A Pending JP2018525345A (ja) | 2015-07-01 | 2016-06-30 | 置換キナゾリン化合物及びグルコセレブロシダーゼ活性の調節のためのその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US10167270B2 (enExample) |
| EP (1) | EP3317265A4 (enExample) |
| JP (1) | JP2018525345A (enExample) |
| CN (1) | CN108290855A (enExample) |
| WO (1) | WO2017004405A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3215511B1 (en) | 2014-11-06 | 2024-04-17 | Bial-R&D Investments, S.A. | Substituted pyrazolo(1,5-a)pyrimidines and their use in the treatment of medical disorders |
| WO2016073889A1 (en) | 2014-11-06 | 2016-05-12 | Lysosomal Therapeutics Inc. | Substituted imidazo[1,5-a]pyrimidines and their use in the treatment of medical disorders |
| US20180185368A1 (en) | 2014-11-06 | 2018-07-05 | Lysosomal Therapeutics Inc. | Substituted pyrrolo[1,2-a]pyrimidines and their use in the treatment of medical disorders |
| CN108290855A (zh) * | 2015-07-01 | 2018-07-17 | 西北大学 | 被取代的喹唑啉化合物及其调节葡糖脑苷脂酶活性的用途 |
| EP3380469B1 (en) * | 2015-11-25 | 2022-03-16 | Convergene Llc | Bicyclic bet bromodomain inhibitors and uses thereof |
| MX2021006804A (es) | 2015-12-17 | 2023-01-13 | Merck Patent Gmbh | Antagonistas policiclicos del receptor 7/8 tipo toll (tlr7/8) y uso de los mismos en el tratamiento de trastornos inmunitarios. |
| MX388912B (es) | 2016-04-06 | 2025-03-20 | Lysosomal Therapeutics Inc | Compuestos de pirrol[1,2-a]pirimidinil carboxamida y su uso en el tratamiento de trastornos médicos |
| KR20180133461A (ko) | 2016-04-06 | 2018-12-14 | 리소소말 테라퓨틱스 인크. | 피라졸로[1,5-a]피리미디닐 카르복스아미드 화합물 및 의학적 장애의 치료에서의 그의 용도 |
| WO2017176961A1 (en) | 2016-04-06 | 2017-10-12 | Lysosomal Therapeutics Inc. | Imidazo [1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
| WO2017192930A1 (en) | 2016-05-05 | 2017-11-09 | Lysosomal Therapeutics Inc. | SUBSTITUTED IMIDAZO[1,2-b]PYRIDAZINES, SUBSTITUTED IMIDAZO[1,5-b]PYRIDAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS |
| WO2017192931A1 (en) | 2016-05-05 | 2017-11-09 | Lysosomal Therapeutics Inc. | SUBSTITUTED IMDAZO[1,2-α]PYRIDINES, SUBSTITUTED IMIDAZO[1,2-α]PYRAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS |
| AU2017311047B2 (en) | 2016-08-08 | 2021-07-22 | Merck Patent Gmbh | TLR7/8 antagonists and uses thereof |
| MX2019012431A (es) | 2017-04-21 | 2020-08-03 | Ikena Oncology Inc | Inhibidores del receptor de hidrocarburos de arilo (ahr) de indol y usos de los mismos. |
| EP3661919A4 (en) * | 2017-08-02 | 2021-03-31 | Northwestern University | SUBSTITUTED FUSION PYRIMIDINE COMPOUNDS AND THEIR USES |
| SG11202100818RA (en) * | 2018-07-31 | 2021-02-25 | Merck Patent Gmbh | Tlr7/8 antagonists and uses thereof |
| US10882865B2 (en) | 2018-08-31 | 2021-01-05 | Northwestern University | Pyrrolopyrimidine compounds and uses thereof for modulating glucocerebrosidase activity |
| KR20210110566A (ko) * | 2018-10-16 | 2021-09-08 | 이케나 온콜로지, 인코포레이티드 | 인돌 ahr 저해제 및 이의 용도 |
| AU2020394424A1 (en) | 2019-11-26 | 2022-06-16 | Ikena Oncology, Inc. | Polymorphic carbazole derivatives and uses thereof |
| US20240166669A1 (en) * | 2021-03-05 | 2024-05-23 | Nikang Therapeutics, Inc. | Quinazoline amine derivatives as kras inhibitors |
| CA3218259A1 (en) * | 2021-04-30 | 2022-11-03 | Vanqua Bio, Inc. | Small molecule modulators of glucocerebrosidase activity and uses thereof |
| KR20240016286A (ko) * | 2021-04-30 | 2024-02-06 | 밴쿠아 바이오, 인크. | 글루코세레브로시다아제 활성의 저분자 조절제 및 이의 용도 |
| WO2023025109A1 (zh) * | 2021-08-23 | 2023-03-02 | 上海维申医药有限公司 | 一类Toll样受体抑制剂及其制备和应用 |
| US20250230172A1 (en) * | 2021-10-13 | 2025-07-17 | Vanqua Bio, Inc. | Small molecule modulators of glucocerebrosidase activity and uses thereof |
| CA3235270A1 (en) * | 2021-10-13 | 2023-04-20 | Vanqua Bio, Inc. | Small molecule modulators of glucocerebrosidase activity and uses thereof |
| TW202509030A (zh) * | 2023-05-08 | 2025-03-01 | 美商譚格醫療公司 | 化合物及使用方法 |
| WO2026020056A1 (en) * | 2024-07-18 | 2026-01-22 | Neumora Therapeutics, Inc. | Compounds and methods for treating neurological disorders |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1003299A (en) | 1910-08-06 | 1911-09-12 | Basf Ag | Process and apparatus for producing long stable electric arcs. |
| DE831249C (de) * | 1948-02-09 | 1952-02-11 | Ciba A G | Verfahren zur Herstellung heterocyclisch substituierter Diaminochinazoline |
| BE553585A (enExample) * | 1955-12-21 | |||
| GB1582407A (en) | 1977-06-07 | 1981-01-07 | Worcester Controls Uk Ltd | Annular seals |
| SV2002000205A (es) * | 1999-11-01 | 2002-06-07 | Lilly Co Eli | Compuestos farmaceuticos ref. x-01095 |
| US8338420B1 (en) * | 2002-12-04 | 2012-12-25 | Mitsubishi Tanabe Pharma Corporation | Treatment of Parkinson's disease and enhancement of dopamine signal using PDE 10 inhibitor |
| JP4895806B2 (ja) * | 2003-04-09 | 2012-03-14 | エクセリクシス， インク． | Ｔｉｅ−２モジュレータと使用方法 |
| CN101115736A (zh) * | 2005-03-14 | 2008-01-30 | 神经研究公司 | 钾通道调节剂和它们的医药用途 |
| WO2007071632A2 (en) * | 2005-12-20 | 2007-06-28 | Neurosearch A/S | 2-pyridin-2-yl-quinazoline derivatives as potassium channel modulating agents for the treatment of respiratory diseases |
| JP2009520700A (ja) * | 2005-12-21 | 2009-05-28 | ペインセプター ファーマ コーポレーション | 依存性イオンチャネルを調節するための組成物および方法 |
| WO2009049422A1 (en) * | 2007-10-18 | 2009-04-23 | The Hospital For Sick Children | Compositions and methods for enhancing enzyme activity in gaucher, gm1 -gangliosidosis/morquio b disease. and parkinson's disease |
| EP2262498A2 (en) | 2008-03-10 | 2010-12-22 | Vertex Pharmceuticals Incorporated | Pyrimidines and pyridines useful as inhibitors of protein kinases |
| WO2010120987A1 (en) * | 2009-04-17 | 2010-10-21 | Wyeth Llc | Ring fused, ureidoaryl- and carbamoylaryl-bridged morpholino-pyrimidine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses |
| EP2651405A2 (en) | 2010-12-14 | 2013-10-23 | Electrophoretics Limited | Casein kinase 1 (ck1 ) inhibitors |
| LT2685986T (lt) * | 2011-03-18 | 2020-03-10 | Genzyme Corporation | Gliukozilceramido sintazės slopiklis |
| KR20150065157A (ko) * | 2013-12-04 | 2015-06-12 | 에스에프씨 주식회사 | 유기발광 화합물 및 이를 포함하는 유기전계발광소자 |
| CN104693211A (zh) * | 2013-12-10 | 2015-06-10 | 南京明德新药研发股份有限公司 | 作为抗病毒剂的咪唑衍生物及其制药用途 |
| AU2014363032A1 (en) * | 2013-12-11 | 2016-06-09 | Pfizer Limited | Method for producing retinal pigment epithelial cells |
| JP6589241B2 (ja) * | 2013-12-18 | 2019-10-16 | 出光興産株式会社 | 化合物、有機エレクトロルミネッセンス素子用材料、インク組成物、有機エレクトロルミネッセンス素子、電子機器、及び化合物の製造方法 |
| WO2017004408A1 (en) | 2015-07-01 | 2017-01-05 | Northwestern University | Substituted 4-methyl-pyrrolo[1.2-a]pyrimidine-8-carboxamide compounds and uses thereof for modulating glucocerebrosidase activity |
| CN108290855A (zh) | 2015-07-01 | 2018-07-17 | 西北大学 | 被取代的喹唑啉化合物及其调节葡糖脑苷脂酶活性的用途 |
| US10882865B2 (en) | 2018-08-31 | 2021-01-05 | Northwestern University | Pyrrolopyrimidine compounds and uses thereof for modulating glucocerebrosidase activity |
-
2016
- 2016-06-30 CN CN201680049553.3A patent/CN108290855A/zh active Pending
- 2016-06-30 US US15/199,207 patent/US10167270B2/en active Active
- 2016-06-30 WO PCT/US2016/040467 patent/WO2017004405A1/en not_active Ceased
- 2016-06-30 EP EP16818810.0A patent/EP3317265A4/en not_active Withdrawn
- 2016-06-30 JP JP2017568029A patent/JP2018525345A/ja active Pending
-
2018
- 2018-10-30 US US16/175,220 patent/US10501435B2/en active Active
-
2019
- 2019-11-07 US US16/677,352 patent/US10934270B2/en active Active
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