JP2018525342A5 - - Google Patents
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- Publication number
- JP2018525342A5 JP2018525342A5 JP2017567632A JP2017567632A JP2018525342A5 JP 2018525342 A5 JP2018525342 A5 JP 2018525342A5 JP 2017567632 A JP2017567632 A JP 2017567632A JP 2017567632 A JP2017567632 A JP 2017567632A JP 2018525342 A5 JP2018525342 A5 JP 2018525342A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- alkylene
- cycloalkyl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 28
- 125000000217 alkyl group Chemical group 0.000 claims 21
- 229910052739 hydrogen Inorganic materials 0.000 claims 15
- 229910052799 carbon Inorganic materials 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 7
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 5
- 125000002947 alkylene group Chemical group 0.000 claims 5
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 4
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000006568 (C4-C7) heterocycloalkyl group Chemical group 0.000 claims 2
- 208000024412 Friedreich ataxia Diseases 0.000 claims 2
- 125000006580 bicyclic heterocycloalkyl group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 208000002320 spinal muscular atrophy Diseases 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 102000014461 Ataxins Human genes 0.000 claims 1
- 108010078286 Ataxins Proteins 0.000 claims 1
- 206010068597 Bulbospinal muscular atrophy congenital Diseases 0.000 claims 1
- 206010008025 Cerebellar ataxia Diseases 0.000 claims 1
- 208000001914 Fragile X syndrome Diseases 0.000 claims 1
- 201000011240 Frontotemporal dementia Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 208000027747 Kennedy disease Diseases 0.000 claims 1
- 206010068871 Myotonic dystrophy Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000025966 Neurological disease Diseases 0.000 claims 1
- 208000014060 Niemann-Pick disease Diseases 0.000 claims 1
- 208000009415 Spinocerebellar Ataxias Diseases 0.000 claims 1
- 208000006269 X-Linked Bulbo-Spinal Atrophy Diseases 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 201000004562 autosomal dominant cerebellar ataxia Diseases 0.000 claims 1
- 125000002393 azetidinyl group Chemical group 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 206010013663 drug dependence Diseases 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 206010027175 memory impairment Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 125000003566 oxetanyl group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 208000011117 substance-related disease Diseases 0.000 claims 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562188139P | 2015-07-02 | 2015-07-02 | |
| US62/188,139 | 2015-07-02 | ||
| PCT/US2016/040705 WO2017004522A1 (en) | 2015-07-02 | 2016-07-01 | Histone deacetylase inhibtors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018525342A JP2018525342A (ja) | 2018-09-06 |
| JP2018525342A5 true JP2018525342A5 (OSRAM) | 2019-08-08 |
Family
ID=56413909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017567632A Pending JP2018525342A (ja) | 2015-07-02 | 2016-07-01 | ヒストンデアセチラーゼ阻害剤 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10851058B2 (OSRAM) |
| EP (1) | EP3317253A1 (OSRAM) |
| JP (1) | JP2018525342A (OSRAM) |
| KR (1) | KR20180022840A (OSRAM) |
| CN (1) | CN107922342A (OSRAM) |
| AU (1) | AU2016288606A1 (OSRAM) |
| BR (1) | BR112017028139A2 (OSRAM) |
| CA (1) | CA2990660A1 (OSRAM) |
| HK (1) | HK1250367A1 (OSRAM) |
| IL (1) | IL256438B (OSRAM) |
| MX (1) | MX2017017127A (OSRAM) |
| RU (1) | RU2720678C2 (OSRAM) |
| SG (1) | SG10201913192VA (OSRAM) |
| WO (1) | WO2017004522A1 (OSRAM) |
| ZA (1) | ZA201800058B (OSRAM) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2911040T3 (es) * | 2017-07-10 | 2022-05-17 | Medibiofarma S L | Nuevos derivados de heteroaril amida como inhibidores selectivos de histona deacetilasa 1 y 2 (HDAC1/2) |
| CN108795867A (zh) * | 2018-06-05 | 2018-11-13 | 华东理工大学 | 用于构建结肠癌细胞腹膜转移体外三维模型的方法 |
| EP4074700A4 (en) | 2019-12-10 | 2024-02-07 | Shionogi & Co., Ltd | HISTONE DEACETYLASE INHIBITOR COMPRISING AROMATIC HETEROCYCLIC GROUP CONTAINING NITROGEN |
| GB202001023D0 (en) * | 2020-01-24 | 2020-03-11 | Univ Leicester | HDAC Degrader |
| CN112239422B (zh) * | 2020-10-16 | 2022-07-22 | 河北化工医药职业技术学院 | 一种布格替尼中间体、其盐、其制备方法以及布格替尼的制备方法 |
| WO2024245060A1 (zh) * | 2023-06-02 | 2024-12-05 | 苏州浦合医药科技有限公司 | HDAC1-CoREST高选择性抑制剂 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2465978C (en) * | 2001-09-14 | 2015-04-07 | Soon Hyung Woo | Inhibitors of histone deacetylase |
| TWI319387B (en) * | 2002-04-05 | 2010-01-11 | Astrazeneca Ab | Benzamide derivatives |
| WO2005092899A1 (en) * | 2004-03-26 | 2005-10-06 | Methylgene Inc. | Inhibitors of histone deacetylase |
| AR057579A1 (es) * | 2005-11-23 | 2007-12-05 | Merck & Co Inc | Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac) |
| JP5554988B2 (ja) | 2006-04-07 | 2014-07-23 | メチルジーン インコーポレイテッド | ヒストンデアセチラーゼの阻害剤 |
| US8030344B2 (en) * | 2007-03-13 | 2011-10-04 | Methylgene Inc. | Inhibitors of histone deacetylase |
| JP2010531875A (ja) * | 2007-06-26 | 2010-09-30 | ギリード・サイエンシズ・インコーポレーテッド | イミダゾピリジニルチアゾリルヒストンデアセチラーゼ阻害剤 |
| JP5469604B2 (ja) * | 2007-09-19 | 2014-04-16 | ４エスツェー アクチェンゲゼルシャフト | 新規テトラヒドロ融合ピリジン |
| JP2011500783A (ja) * | 2007-10-22 | 2011-01-06 | オーキッド リサーチ ラボラトリーズ リミテッド | ヒストンデアセチラーゼ阻害剤 |
| CN102477001B (zh) | 2010-11-29 | 2015-07-15 | 江苏先声药物研究有限公司 | 一种苯甲酰胺类组蛋白去乙酰化酶抑制剂 |
| US8404738B2 (en) * | 2011-01-21 | 2013-03-26 | Hoffmann-La Roche Inc. | 4-amino-N-hydroxy-benzamides for the treatment of cancer |
| US8957066B2 (en) * | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| GB201111630D0 (en) * | 2011-07-07 | 2011-08-24 | Cancer Rec Tech Ltd | Novel compounds and their use |
-
2016
- 2016-07-01 CA CA2990660A patent/CA2990660A1/en not_active Abandoned
- 2016-07-01 AU AU2016288606A patent/AU2016288606A1/en not_active Abandoned
- 2016-07-01 RU RU2018103753A patent/RU2720678C2/ru active
- 2016-07-01 HK HK18109798.5A patent/HK1250367A1/zh unknown
- 2016-07-01 US US15/740,437 patent/US10851058B2/en active Active
- 2016-07-01 SG SG10201913192VA patent/SG10201913192VA/en unknown
- 2016-07-01 MX MX2017017127A patent/MX2017017127A/es unknown
- 2016-07-01 WO PCT/US2016/040705 patent/WO2017004522A1/en not_active Ceased
- 2016-07-01 BR BR112017028139-2A patent/BR112017028139A2/pt not_active Application Discontinuation
- 2016-07-01 EP EP16739365.1A patent/EP3317253A1/en not_active Withdrawn
- 2016-07-01 JP JP2017567632A patent/JP2018525342A/ja active Pending
- 2016-07-01 KR KR1020187002149A patent/KR20180022840A/ko not_active Withdrawn
- 2016-07-01 CN CN201680037989.0A patent/CN107922342A/zh active Pending
-
2017
- 2017-12-20 IL IL256438A patent/IL256438B/en active IP Right Grant
-
2018
- 2018-01-04 ZA ZA2018/00058A patent/ZA201800058B/en unknown
- 2018-07-27 US US16/047,179 patent/US10308608B2/en active Active
-
2020
- 2020-09-22 US US17/028,444 patent/US20210009519A1/en not_active Abandoned
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