JP2018524352A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018524352A5 JP2018524352A5 JP2017568376A JP2017568376A JP2018524352A5 JP 2018524352 A5 JP2018524352 A5 JP 2018524352A5 JP 2017568376 A JP2017568376 A JP 2017568376A JP 2017568376 A JP2017568376 A JP 2017568376A JP 2018524352 A5 JP2018524352 A5 JP 2018524352A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- pharmaceutically acceptable
- acceptable salt
- complex according
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C(NC(P(*)(O)=O)P(O)(O*)=O)=O Chemical compound *C(NC(P(*)(O)=O)P(O)(O*)=O)=O 0.000 description 5
- OUJRYYLEOPKIOL-ZANHISICSA-N OC(CN(CCN(CC(O)=O)Cc1cc(CCC(NC(P(O)(O)=O)P(O)(O)=O)=O)ccc1O)Cc(cc(CCC(NCCCCCC(NCCCC[C@@H](C(O)=O)NC(NC(C1)(C1C(O)=O)C(O)=O)=O)=O)=O)cc1)c1O)=O Chemical compound OC(CN(CCN(CC(O)=O)Cc1cc(CCC(NC(P(O)(O)=O)P(O)(O)=O)=O)ccc1O)Cc(cc(CCC(NCCCCCC(NCCCC[C@@H](C(O)=O)NC(NC(C1)(C1C(O)=O)C(O)=O)=O)=O)=O)cc1)c1O)=O OUJRYYLEOPKIOL-ZANHISICSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562189652P | 2015-07-07 | 2015-07-07 | |
| US62/189,652 | 2015-07-07 | ||
| US201662320296P | 2016-04-08 | 2016-04-08 | |
| US62/320,296 | 2016-04-08 | ||
| PCT/US2016/041040 WO2017007790A1 (en) | 2015-07-07 | 2016-07-06 | Hbed-bisphosphonates, radiometal conjugates thereof and their use as theranostic agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018524352A JP2018524352A (ja) | 2018-08-30 |
| JP2018524352A5 true JP2018524352A5 (enExample) | 2019-07-25 |
| JP6792875B2 JP6792875B2 (ja) | 2020-12-02 |
Family
ID=57685907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017568376A Active JP6792875B2 (ja) | 2015-07-07 | 2016-07-06 | Ｈｂｅｄ−ビスホスホネート、その放射性金属コンジュゲート、およびセラノスティック剤としてのそれらの使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10253052B2 (enExample) |
| EP (1) | EP3319643B1 (enExample) |
| JP (1) | JP6792875B2 (enExample) |
| KR (1) | KR102651945B1 (enExample) |
| CN (1) | CN107847618B (enExample) |
| AU (1) | AU2016289474C1 (enExample) |
| DK (1) | DK3319643T3 (enExample) |
| EA (1) | EA201890221A1 (enExample) |
| IL (1) | IL256726A (enExample) |
| MX (1) | MX377208B (enExample) |
| WO (1) | WO2017007790A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3319643T3 (da) | 2015-07-07 | 2020-06-15 | Five Eleven Pharma Inc | HBED-bisphosphonater og radiometalkonjugater deraf, anvendelige som theranostiske midler |
| WO2018160544A1 (en) * | 2017-03-02 | 2018-09-07 | Five Eleven Pharma Inc. | Radiopharmaceutical labeling device |
| WO2020028825A1 (en) * | 2018-08-03 | 2020-02-06 | Board Of Regents, The University Of Texas System | Method for extraction and purification of 68ga |
| CN109438517B (zh) * | 2018-12-27 | 2021-01-08 | 北京久杰净化工程技术有限公司 | 一种与羰基金属核心配位的双功能连接剂的配合物及其制备方法 |
| MX2021013055A (es) * | 2019-04-26 | 2021-12-10 | Five Eleven Pharma Inc | Inhibidores de antigenos de membrana especificos de prostata (psma) como agentes diagnosticos y terapeuticos con radionuclidos. |
| US20230001027A1 (en) * | 2019-10-01 | 2023-01-05 | City Of Hope | Metal chelating agents and methods of using the same |
| DE102021101216A1 (de) * | 2021-01-21 | 2022-07-21 | Johannes Gutenberg-Universität Mainz, Körperschaft des öffentlichen Rechts | Markierungsvorläufer und Radiotracer zur nuklearmedizinischen Diagnose und Therapie von Prostatakrebs induzierten Knochenmetastasen |
| DE102022105175A1 (de) * | 2022-03-04 | 2023-09-07 | Atoms for Cure GmbH | Markierungsvorläufer und Radiotracer mit drei oder mehr Targeting-Vektoren für die nuklearmedizinische Theranostik |
| CN119060094B (zh) * | 2024-08-26 | 2025-09-05 | 广州医科大学附属第一医院（广州呼吸中心） | 一种靶向成纤维细胞激活蛋白的抑制剂类放射性探针及其制备方法和应用 |
| CN119060093B (zh) * | 2024-08-26 | 2025-09-05 | 广州医科大学附属第一医院（广州呼吸中心） | 一种靶向成纤维细胞激活蛋白的抑制剂类放射性探针及其制备方法和应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005507001A (ja) * | 2001-10-22 | 2005-03-10 | ダウ グローバル テクノロジーズ インコーポレイティド | 初期癌の治療用放射線医薬薬剤 |
| WO2004089925A1 (en) * | 2003-04-03 | 2004-10-21 | Semafore Pharmaceuticals, Inc. | Pi-3 kinase inhibitor prodrugs |
| US7161000B2 (en) * | 2003-05-30 | 2007-01-09 | Sumitomo Chemical Company, Limited | Method for producing phenol condensate |
| US10925977B2 (en) * | 2006-10-05 | 2021-02-23 | Ceil>Point, LLC | Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications |
| WO2009002529A2 (en) * | 2007-06-26 | 2008-12-31 | The Johns Hopkins University | Labeled inhibitors of prostate specific membrane antigen (psma), biological evaluation, and use as imaging agents |
| EP2468760B1 (en) * | 2009-08-20 | 2014-10-01 | Fujifilm RI Pharma Co., Ltd. | Bisphosphonic acid derivative and compound thereof labeled with radioactive metal nuclide |
| US9212335B2 (en) * | 2011-04-13 | 2015-12-15 | Firmenich Sa | Equilibrated dynamic mixtures to control the release of perfuming aldehydes and ketones |
| ITMI20121156A1 (it) | 2012-06-29 | 2013-12-30 | Consiglio Nazionale Ricerche | Metodo di elaborazione di immagini di tomografia a coerenza ottica |
| EP2862857A1 (en) * | 2013-10-18 | 2015-04-22 | Deutsches Krebsforschungszentrum | Labeled inhibitors of prostate specific membrane antigen (PSMA), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer |
| DK3319643T3 (da) | 2015-07-07 | 2020-06-15 | Five Eleven Pharma Inc | HBED-bisphosphonater og radiometalkonjugater deraf, anvendelige som theranostiske midler |
-
2016
- 2016-07-06 DK DK16821892.3T patent/DK3319643T3/da active
- 2016-07-06 WO PCT/US2016/041040 patent/WO2017007790A1/en not_active Ceased
- 2016-07-06 JP JP2017568376A patent/JP6792875B2/ja active Active
- 2016-07-06 EA EA201890221A patent/EA201890221A1/ru unknown
- 2016-07-06 EP EP16821892.3A patent/EP3319643B1/en active Active
- 2016-07-06 MX MX2018000239A patent/MX377208B/es active IP Right Grant
- 2016-07-06 US US15/203,602 patent/US10253052B2/en active Active
- 2016-07-06 AU AU2016289474A patent/AU2016289474C1/en active Active
- 2016-07-06 KR KR1020187002872A patent/KR102651945B1/ko active Active
- 2016-07-06 CN CN201680046397.5A patent/CN107847618B/zh active Active
-
2018
- 2018-01-03 IL IL256726A patent/IL256726A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6977958B2 (ja) | Ｐｓｍａを標的としたイメージング及び放射線治療のための金属／放射性金属標識ｐｓｍａ阻害剤 | |
| Liu | Radiolabeled cyclic RGD peptide bioconjugates as radiotracers targeting multiple integrins | |
| EP3397968B1 (en) | Urea-based prostate specific membrane antigen (psma) inhibitors for imaging and therapy | |
| Edwards et al. | New and versatile ternary ligand system for technetium radiopharmaceuticals: water soluble phosphines and tricine as coligands in labeling a hydrazinonicotinamide-modified cyclic glycoprotein IIb/IIIa receptor antagonist with 99mTc | |
| Rathmann et al. | The radiopharmaceutical chemistry of technetium-99m | |
| JP6792875B2 (ja) | Ｈｂｅｄ−ビスホスホネート、その放射性金属コンジュゲート、およびセラノスティック剤としてのそれらの使用 | |
| Ferreira et al. | 68Ga small peptide imaging: comparison of NOTA and PCTA | |
| Isabel M. Prata | Gallium-68: a new trend in PET radiopharmacy | |
| CN109641924B (zh) | 作为检测前列腺特异性膜抗原的过表达的放射性药物的99mtc-edda/hynic-ipsma | |
| Maresca et al. | Novel polar single amino acid chelates for technetium-99m tricarbonyl-based radiopharmaceuticals with enhanced renal clearance: application to octreotide | |
| Chakraborty et al. | Evaluation of 111In-labeled cyclic RGD peptides: tetrameric not tetravalent | |
| Velikyan | Positron emitting [68Ga] Ga-based imaging agents: chemistry and diversity | |
| Zhao et al. | Synthesis and evaluation of 68Ga-and 177Lu-labeled (R)-vs (S)-DOTAGA prostate-specific membrane antigen-targeting derivatives | |
| Singh et al. | Multivalent bifunctional chelator scaffolds for gallium-68 based positron emission tomography imaging probe design: signal amplification via multivalency | |
| Maresca et al. | Comprehensive radiolabeling, stability, and tissue distribution studies of technetium-99m single amino acid chelates (SAAC) | |
| Shi et al. | 2-Mercaptoacetylglycylglycyl (MAG2) as a bifunctional chelator for 99mTc-labeling of cyclic RGD dimers: effect of technetium chelate on tumor uptake and pharmacokinetics | |
| Gomez et al. | Synthesis and Evaluation of Diastereoisomers of 1, 4, 7-Triazacyclononane-1, 4, 7-tris-(glutaric acid)(NOTGA) for Multimeric Radiopharmaceuticals of Gallium | |
| Liu et al. | Integrin alphavbeta3 directed radiopharmaceuticals for tumor imaging | |
| Badipa et al. | An overview of radiolabeled RGD peptides for theranostic applications | |
| Ferreira et al. | Pharmacokinetic modulation of radiolabeled chelates facilitated by phosphonate ester coordinating groups | |
| CN119751415B (zh) | 双靶向PSMA和FAP-α的前列腺癌诊断或治疗放射性药物 | |
| Johannsen | Institute of bioinorganic and Radiopharmaceutical Chemistry | |
| Maruk et al. | New radiopharmaceuticals based on technetium-99m with bifunctional chelating agents | |
| HK1248585A1 (en) | Hbed-bisphosphonates, radiometal conjugates thereof and their use as theranostic agents | |
| HK1255215B (en) | Urea-based prostate specific membrane antigen (psma) inhibitors for imaging and therapy |