JP2018522206A - マイクロ流体バルブおよびマイクロ流体デバイス - Google Patents

マイクロ流体バルブおよびマイクロ流体デバイス Download PDF

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Publication number
JP2018522206A
JP2018522206A JP2017556233A JP2017556233A JP2018522206A JP 2018522206 A JP2018522206 A JP 2018522206A JP 2017556233 A JP2017556233 A JP 2017556233A JP 2017556233 A JP2017556233 A JP 2017556233A JP 2018522206 A JP2018522206 A JP 2018522206A
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Prior art keywords
fluid
channel
microfluidic
microfluidic chip
capture
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JP2017556233A
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English (en)
Japanese (ja)
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JP2018522206A5 (enExample
Inventor
ラチャミン，アーロン
デービーズ，マシュー
ガルシア‐ガンセド，ルイス
プログキディズ，アンドレアス
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オルフィディア リミテッド
オルフィディア リミテッド
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Publication of JP2018522206A publication Critical patent/JP2018522206A/ja
Publication of JP2018522206A5 publication Critical patent/JP2018522206A5/ja
Priority to JP2020180805A priority Critical patent/JP7311156B2/ja
Priority to JP2023107057A priority patent/JP2023130416A/ja
Pending legal-status Critical Current

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    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0015—Diaphragm or membrane valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K7/00—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves
    • F16K7/12—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K7/00—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves
    • F16K7/12—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm
    • F16K7/123—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm the seat being formed on the bottom of the fluid line
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K7/00—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves
    • F16K7/12—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm
    • F16K7/126—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm the seat being formed on a rib perpendicular to the fluid line
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0042—Electric operating means therefor
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0042—Electric operating means therefor
    • F16K99/0046—Electric operating means therefor using magnets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micromachines (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Sampling And Sample Adjustment (AREA)
JP2017556233A 2015-04-30 2016-04-29 マイクロ流体バルブおよびマイクロ流体デバイス Pending JP2018522206A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2020180805A JP7311156B2 (ja) 2015-04-30 2020-10-28 マイクロ流体バルブおよびマイクロ流体デバイス
JP2023107057A JP2023130416A (ja) 2015-04-30 2023-06-29 マイクロ流体バルブおよびマイクロ流体デバイス

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562155470P 2015-04-30 2015-04-30
US62/155,470 2015-04-30
US201562156368P 2015-05-04 2015-05-04
US62/156,368 2015-05-04
PCT/EP2016/059660 WO2016174230A1 (en) 2015-04-30 2016-04-29 Microfluidic valves and devices

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020180805A Division JP7311156B2 (ja) 2015-04-30 2020-10-28 マイクロ流体バルブおよびマイクロ流体デバイス

Publications (2)

Publication Number Publication Date
JP2018522206A true JP2018522206A (ja) 2018-08-09
JP2018522206A5 JP2018522206A5 (enExample) 2019-06-06

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Application Number Title Priority Date Filing Date
JP2017556233A Pending JP2018522206A (ja) 2015-04-30 2016-04-29 マイクロ流体バルブおよびマイクロ流体デバイス
JP2020180805A Active JP7311156B2 (ja) 2015-04-30 2020-10-28 マイクロ流体バルブおよびマイクロ流体デバイス
JP2023107057A Pending JP2023130416A (ja) 2015-04-30 2023-06-29 マイクロ流体バルブおよびマイクロ流体デバイス

Family Applications After (2)

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JP2020180805A Active JP7311156B2 (ja) 2015-04-30 2020-10-28 マイクロ流体バルブおよびマイクロ流体デバイス
JP2023107057A Pending JP2023130416A (ja) 2015-04-30 2023-06-29 マイクロ流体バルブおよびマイクロ流体デバイス

Country Status (7)

Country Link
US (2) US20180093269A1 (enExample)
EP (1) EP3288681A1 (enExample)
JP (3) JP2018522206A (enExample)
CN (2) CN114893585A (enExample)
HK (1) HK1250681A1 (enExample)
SG (1) SG11201708866YA (enExample)
WO (1) WO2016174230A1 (enExample)

Cited By (3)

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JP2022000611A (ja) * 2020-06-19 2022-01-04 シスメックス株式会社 粒子ソーター、粒子分取方法およびマイクロ流路カートリッジ
JP2023524069A (ja) * 2020-04-29 2023-06-08 アボット・ラボラトリーズ 試料分析のためのシステム及び方法
JP7785691B2 (ja) 2020-04-29 2025-12-15 アボット・ラボラトリーズ 試料分析のためのシステム及び方法

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CN109012769B (zh) * 2018-07-11 2020-01-21 西安交通大学 一种基于表面声波的微流控液滴生成装置及方法
WO2020033307A1 (en) * 2018-08-06 2020-02-13 Signal Biosystems Llc Microfluidic devices and uses thereof
CN110857743B (zh) * 2018-08-22 2020-10-16 厦门大学 用于微流控芯片的液流导向阀及微流控芯片
CN118080035A (zh) * 2018-12-13 2024-05-28 迪亚莱博（张家港）生物科技有限公司 床旁诊断微流控芯片的制备方法
CN109622083A (zh) * 2019-01-24 2019-04-16 京东方科技集团股份有限公司 一种微流控系统及其制备方法
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CN109967144B (zh) * 2019-03-25 2021-02-19 宁波美康盛德生物科技有限公司 用于检测微流控芯片的干式化学分析仪及微流控芯片
EP3763439A1 (en) 2019-07-12 2021-01-13 Curiosity Diagnostics sp. z o.o Microfluidic chip and valve, production process and uses
CN110568202B (zh) * 2019-09-12 2022-05-24 重庆科技学院 一种自动分样定容免疫荧光定量快速检测微流控芯片
CN110597328B (zh) * 2019-09-18 2021-04-23 重庆大学 一种基于液晶温控微阀的流量协同控制系统
CN110605147B (zh) * 2019-09-18 2021-04-06 重庆大学 一种基于液晶的温控微阀及其单、多级控制系统
EP3839467B1 (en) * 2019-12-19 2023-06-14 Paris Sciences et Lettres Microfluidic or millifluidic chip comprising a pressure sensing unit using colour-switching hydrogels
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CN113275044B (zh) * 2020-02-20 2022-07-12 北京京东方健康科技有限公司 检测芯片及其使用方法、检测装置
CN113275046B (zh) * 2020-02-20 2023-08-08 北京京东方健康科技有限公司 检测芯片及其使用方法、检测装置
CN113967486A (zh) * 2020-07-22 2022-01-25 京东方科技集团股份有限公司 离心式微流控芯片
CN112067533B (zh) * 2020-09-26 2024-01-19 宁波大学 单细胞质谱分析系统及方法
CN114545988A (zh) * 2020-11-19 2022-05-27 潘晨 一种并行流体背压控制器
CN114768894B (zh) * 2021-01-22 2023-08-11 中国科学院上海微系统与信息技术研究所 一种检测芯片及检测方法
JP7712853B2 (ja) * 2021-11-16 2025-07-24 アズビル株式会社 電空変換機構及び電空変換構造
CN116139948B (zh) * 2022-12-01 2025-06-20 中国科学院上海微系统与信息技术研究所 一种通过微阀结构控制的单液滴分离芯片
CN121038899A (zh) * 2023-03-20 2025-11-28 胡桃夹子治疗公司 具有弹性层和轮廓化表面的微流体装置
US20240335837A1 (en) * 2023-04-06 2024-10-10 Tdk U.S.A. Corporation Devices and methods for sample dissociation and manipulation in a microfluidic system
CN119804845A (zh) * 2025-01-16 2025-04-11 杭州艾儿默细胞生物科技有限公司 一种微流体样本检测装置及微流体样本检测系统

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JP2005186265A (ja) * 2000-11-28 2005-07-14 California Inst Of Technol 微細製作エラストマーバルブおよびポンプシステム
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023524069A (ja) * 2020-04-29 2023-06-08 アボット・ラボラトリーズ 試料分析のためのシステム及び方法
JP7785691B2 (ja) 2020-04-29 2025-12-15 アボット・ラボラトリーズ 試料分析のためのシステム及び方法
JP2022000611A (ja) * 2020-06-19 2022-01-04 シスメックス株式会社 粒子ソーター、粒子分取方法およびマイクロ流路カートリッジ
JP7477378B2 (ja) 2020-06-19 2024-05-01 シスメックス株式会社 粒子ソーター、粒子分取方法およびマイクロ流路カートリッジ

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JP2021060118A (ja) 2021-04-15
JP7311156B2 (ja) 2023-07-19
JP2023130416A (ja) 2023-09-20
CN108136388A (zh) 2018-06-08
SG11201708866YA (en) 2017-11-29
EP3288681A1 (en) 2018-03-07
HK1250681A1 (zh) 2019-01-11
US20180093269A1 (en) 2018-04-05
WO2016174230A1 (en) 2016-11-03
CN114893585A (zh) 2022-08-12
US20210291180A1 (en) 2021-09-23

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