CN114893585A - 微流阀和装置 - Google Patents

微流阀和装置 Download PDF

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Publication number
CN114893585A
CN114893585A CN202111648713.5A CN202111648713A CN114893585A CN 114893585 A CN114893585 A CN 114893585A CN 202111648713 A CN202111648713 A CN 202111648713A CN 114893585 A CN114893585 A CN 114893585A
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CN
China
Prior art keywords
fluid
channel
microfluidic
capture
agent
Prior art date
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Pending
Application number
CN202111648713.5A
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English (en)
Chinese (zh)
Inventor
阿伦·拉赫阿米
马修·戴维斯
路易斯·加西亚-甘塞多
安德烈亚斯·普罗基迪斯
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Senzo Health Co ltd
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Senzo Health Co ltd
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Filing date
Publication date
Application filed by Senzo Health Co ltd filed Critical Senzo Health Co ltd
Publication of CN114893585A publication Critical patent/CN114893585A/zh
Pending legal-status Critical Current

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    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0015—Diaphragm or membrane valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K7/00—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves
    • F16K7/12—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K7/00—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves
    • F16K7/12—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm
    • F16K7/123—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm the seat being formed on the bottom of the fluid line
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K7/00—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves
    • F16K7/12—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm
    • F16K7/126—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm the seat being formed on a rib perpendicular to the fluid line
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0042—Electric operating means therefor
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0042—Electric operating means therefor
    • F16K99/0046—Electric operating means therefor using magnets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micromachines (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Sampling And Sample Adjustment (AREA)
CN202111648713.5A 2015-04-30 2016-04-29 微流阀和装置 Pending CN114893585A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201562155470P 2015-04-30 2015-04-30
US62/155,470 2015-04-30
US201562156368P 2015-05-04 2015-05-04
US62/156,368 2015-05-04
PCT/EP2016/059660 WO2016174230A1 (en) 2015-04-30 2016-04-29 Microfluidic valves and devices
CN201680039266.4A CN108136388A (zh) 2015-04-30 2016-04-29 微流阀和装置

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201680039266.4A Division CN108136388A (zh) 2015-04-30 2016-04-29 微流阀和装置

Publications (1)

Publication Number Publication Date
CN114893585A true CN114893585A (zh) 2022-08-12

Family

ID=55948812

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202111648713.5A Pending CN114893585A (zh) 2015-04-30 2016-04-29 微流阀和装置
CN201680039266.4A Pending CN108136388A (zh) 2015-04-30 2016-04-29 微流阀和装置

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201680039266.4A Pending CN108136388A (zh) 2015-04-30 2016-04-29 微流阀和装置

Country Status (7)

Country Link
US (2) US20180093269A1 (enExample)
EP (1) EP3288681A1 (enExample)
JP (3) JP2018522206A (enExample)
CN (2) CN114893585A (enExample)
HK (1) HK1250681A1 (enExample)
SG (1) SG11201708866YA (enExample)
WO (1) WO2016174230A1 (enExample)

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CN112055813B (zh) * 2018-04-25 2023-03-10 Bbb有限公司 血液分析装置
CN109012769B (zh) * 2018-07-11 2020-01-21 西安交通大学 一种基于表面声波的微流控液滴生成装置及方法
WO2020033307A1 (en) * 2018-08-06 2020-02-13 Signal Biosystems Llc Microfluidic devices and uses thereof
CN110857743B (zh) * 2018-08-22 2020-10-16 厦门大学 用于微流控芯片的液流导向阀及微流控芯片
CN118080035A (zh) * 2018-12-13 2024-05-28 迪亚莱博（张家港）生物科技有限公司 床旁诊断微流控芯片的制备方法
CN109622083A (zh) * 2019-01-24 2019-04-16 京东方科技集团股份有限公司 一种微流控系统及其制备方法
EP4472240A3 (en) * 2019-02-07 2025-01-22 Oticon A/s A hearing device comprising an adjustable vent
CN109967144B (zh) * 2019-03-25 2021-02-19 宁波美康盛德生物科技有限公司 用于检测微流控芯片的干式化学分析仪及微流控芯片
EP3763439A1 (en) 2019-07-12 2021-01-13 Curiosity Diagnostics sp. z o.o Microfluidic chip and valve, production process and uses
CN110568202B (zh) * 2019-09-12 2022-05-24 重庆科技学院 一种自动分样定容免疫荧光定量快速检测微流控芯片
CN110597328B (zh) * 2019-09-18 2021-04-23 重庆大学 一种基于液晶温控微阀的流量协同控制系统
CN110605147B (zh) * 2019-09-18 2021-04-06 重庆大学 一种基于液晶的温控微阀及其单、多级控制系统
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CN113275044B (zh) * 2020-02-20 2022-07-12 北京京东方健康科技有限公司 检测芯片及其使用方法、检测装置
CN113275046B (zh) * 2020-02-20 2023-08-08 北京京东方健康科技有限公司 检测芯片及其使用方法、检测装置
JP7477378B2 (ja) * 2020-06-19 2024-05-01 シスメックス株式会社 粒子ソーター、粒子分取方法およびマイクロ流路カートリッジ
CN113967486A (zh) * 2020-07-22 2022-01-25 京东方科技集团股份有限公司 离心式微流控芯片
CN112067533B (zh) * 2020-09-26 2024-01-19 宁波大学 单细胞质谱分析系统及方法
CN114545988A (zh) * 2020-11-19 2022-05-27 潘晨 一种并行流体背压控制器
CN114768894B (zh) * 2021-01-22 2023-08-11 中国科学院上海微系统与信息技术研究所 一种检测芯片及检测方法
JP7712853B2 (ja) * 2021-11-16 2025-07-24 アズビル株式会社 電空変換機構及び電空変換構造
CN116139948B (zh) * 2022-12-01 2025-06-20 中国科学院上海微系统与信息技术研究所 一种通过微阀结构控制的单液滴分离芯片
CN121038899A (zh) * 2023-03-20 2025-11-28 胡桃夹子治疗公司 具有弹性层和轮廓化表面的微流体装置
US20240335837A1 (en) * 2023-04-06 2024-10-10 Tdk U.S.A. Corporation Devices and methods for sample dissociation and manipulation in a microfluidic system
CN119804845A (zh) * 2025-01-16 2025-04-11 杭州艾儿默细胞生物科技有限公司 一种微流体样本检测装置及微流体样本检测系统

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US20080038714A1 (en) * 2005-11-02 2008-02-14 Affymetrix, Inc. Instrument to Pneumatically Control Lab Cards and Method Thereof
CN101706008A (zh) * 2009-11-10 2010-05-12 温州希伯伦流体设备有限公司 智能控制隔膜阀

Also Published As

Publication number Publication date
JP2021060118A (ja) 2021-04-15
JP7311156B2 (ja) 2023-07-19
JP2023130416A (ja) 2023-09-20
CN108136388A (zh) 2018-06-08
SG11201708866YA (en) 2017-11-29
EP3288681A1 (en) 2018-03-07
HK1250681A1 (zh) 2019-01-11
US20180093269A1 (en) 2018-04-05
WO2016174230A1 (en) 2016-11-03
JP2018522206A (ja) 2018-08-09
US20210291180A1 (en) 2021-09-23

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