JP2018522064A5 - - Google Patents
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- Publication number
- JP2018522064A5 JP2018522064A5 JP2018517685A JP2018517685A JP2018522064A5 JP 2018522064 A5 JP2018522064 A5 JP 2018522064A5 JP 2018517685 A JP2018517685 A JP 2018517685A JP 2018517685 A JP2018517685 A JP 2018517685A JP 2018522064 A5 JP2018522064 A5 JP 2018522064A5
- Authority
- JP
- Japan
- Prior art keywords
- hearing loss
- composition
- cell death
- cdk
- inner ear
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000016354 hearing loss disease Diseases 0.000 claims 6
- 206010011878 Deafness Diseases 0.000 claims 5
- 230000010370 hearing loss Effects 0.000 claims 5
- 231100000888 hearing loss Toxicity 0.000 claims 5
- 102000003903 Cyclin-dependent kinases Human genes 0.000 claims 4
- 108090000266 Cyclin-dependent kinases Proteins 0.000 claims 4
- 230000030833 cell death Effects 0.000 claims 3
- 210000003027 ear inner Anatomy 0.000 claims 3
- 230000032683 aging Effects 0.000 claims 2
- 230000003115 biocidal effect Effects 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 239000002875 cyclin dependent kinase inhibitor Substances 0.000 claims 1
- 229940043378 cyclin-dependent kinase inhibitor Drugs 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562181755P | 2015-06-18 | 2015-06-18 | |
| US62/181,755 | 2015-06-18 | ||
| PCT/US2016/038384 WO2016205806A1 (en) | 2015-06-18 | 2016-06-20 | Methods and compositions for the prevention and treatment of hearing loss |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020156803A Division JP7257367B2 (ja) | 2015-06-18 | 2020-09-18 | 聴覚損失の予防および治療のための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018522064A JP2018522064A (ja) | 2018-08-09 |
| JP2018522064A5 true JP2018522064A5 (OSRAM) | 2019-07-18 |
| JP6902025B2 JP6902025B2 (ja) | 2021-07-14 |
Family
ID=57546475
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018517685A Active JP6902025B2 (ja) | 2015-06-18 | 2016-06-20 | 聴覚損失の予防および治療のための方法および組成物 |
| JP2020156803A Active JP7257367B2 (ja) | 2015-06-18 | 2020-09-18 | 聴覚損失の予防および治療のための方法および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020156803A Active JP7257367B2 (ja) | 2015-06-18 | 2020-09-18 | 聴覚損失の予防および治療のための方法および組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US20180161340A1 (OSRAM) |
| EP (2) | EP3786164B1 (OSRAM) |
| JP (2) | JP6902025B2 (OSRAM) |
| CN (2) | CN108137595B (OSRAM) |
| WO (1) | WO2016205806A1 (OSRAM) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108137595B (zh) | 2015-06-18 | 2021-04-20 | 听治疗有限责任公司 | 预防和治疗听力损失的方法和组合物 |
| WO2018204226A1 (en) * | 2017-05-03 | 2018-11-08 | St. Jude Children's Research Hospital | Compositions and methods for prevention and treatment of hearing loss |
| CN108685754A (zh) * | 2018-07-30 | 2018-10-23 | 郑州兰茜生物工程有限公司 | 一种用于耳鸣及具有健耳舒耳功能的滴耳剂 |
| KR102177610B1 (ko) * | 2019-03-28 | 2020-11-11 | 단국대학교 천안캠퍼스 산학협력단 | 청각세포와의 공배양을 이용한 배아줄기세포의 내이 세포로의 분화 방법 |
| EP4073102A4 (en) | 2019-12-12 | 2024-05-08 | Ting Therapeutics LLC | Compositions and methods for the prevention and treatment of hearing loss |
| US20240350492A1 (en) * | 2020-07-10 | 2024-10-24 | Ting Therapeutics Llc | Methods for the Prevention and Treatment of Hearing Loss |
| CN115223704A (zh) * | 2022-03-03 | 2022-10-21 | 上海交通大学医学院附属第九人民医院 | 一种纯音听力图的自动识别与判断方法、装置及设备 |
| WO2024058527A1 (ko) * | 2022-09-13 | 2024-03-21 | 고려대학교 산학협력단 | 에스오메프라졸 또는 덱스란소프라졸을 유효성분으로 포함하는 난청 예방 또는 치료용 약학 조성물 |
| WO2024215467A1 (en) * | 2023-04-13 | 2024-10-17 | Ting Therapeutics Llc | Methods for the prevention and treatment of hearing loss |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3626187B2 (ja) | 1993-06-07 | 2005-03-02 | バイカル インコーポレイテッド | 遺伝子治療に適するプラスミド |
| US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
| AU723325B2 (en) | 1995-06-23 | 2000-08-24 | President And Fellows Of Harvard College | Transcriptional regulation of genes encoding vascular endothelial growth factor receptors |
| GB9718913D0 (en) * | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
| US7132406B2 (en) | 1998-02-23 | 2006-11-07 | Sound Pharmaceuticals Incorporated | Stimulation of cellular regeneration and differentiation in the inner ear |
| DK1471926T3 (da) | 1999-06-01 | 2011-02-28 | Baylor College Medicine | Sammensætninger og fremgangsmåder til terapeutisk anvendelse af en atonal-associeret sekvens |
| FR2804959B1 (fr) | 2000-02-15 | 2006-04-28 | Centre Nat Rech Scient | Utilisation de derives de paullones pour la fabrication de medicaments |
| AU2001251011A1 (en) * | 2000-03-27 | 2001-10-08 | The General Hospital Corporation | Treatments for immune-mediated ear disorders |
| AU2001252458A1 (en) | 2000-05-05 | 2001-11-20 | Martin Bachmann | Molecular antigen arrays and vaccines |
| US20020173507A1 (en) * | 2000-08-15 | 2002-11-21 | Vincent Santora | Urea compounds and methods of uses |
| GB0025414D0 (en) | 2000-10-16 | 2000-11-29 | Consejo Superior Investigacion | Nanoparticles |
| GB0205693D0 (en) * | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
| US7206639B2 (en) | 2002-03-15 | 2007-04-17 | Sarcos Investments Lc | Cochlear drug delivery system and method |
| US7867193B2 (en) | 2004-01-29 | 2011-01-11 | The Charles Stark Draper Laboratory, Inc. | Drug delivery apparatus |
| US7612196B2 (en) | 2002-11-14 | 2009-11-03 | Dharmacon, Inc. | siRNA targeting cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B) |
| WO2004055154A2 (en) * | 2002-12-17 | 2004-07-01 | Centre National De La Recherche Scientifique (Cnrs) | Use of purine derivatives for inducing differentiation of supernumerary hair cells and deiters' cells in the developing organ of corti for treating deafness |
| JP5022028B2 (ja) | 2003-03-26 | 2012-09-12 | サイトス・バイオテクノロジー・アクチェンゲゼルシャフト | メラン−aペプチドアナログ−ウイルス様粒子コンジュゲート |
| GB0317127D0 (en) * | 2003-07-22 | 2003-08-27 | Astex Technology Ltd | Pharmaceutical compounds |
| CA2532965C (en) * | 2003-07-22 | 2013-05-14 | Astex Therapeutics Limited | 3, 4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators |
| KR101281775B1 (ko) | 2003-12-19 | 2013-07-15 | 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 | 소프트 또는 임프린트 리소그래피를 이용하여 분리된마이크로- 및 나노- 구조를 제작하는 방법 |
| AU2005209331A1 (en) * | 2004-01-30 | 2005-08-11 | Peplin Biolipids Pty Ltd | Therapeutic and carrier molecules |
| EP1768692B8 (en) | 2004-07-01 | 2015-06-17 | Yale University | Targeted and high density drug loaded polymeric materials |
| US8404718B2 (en) * | 2005-01-21 | 2013-03-26 | Astex Therapeutics Limited | Combinations of pyrazole kinase inhibitors |
| WO2006117212A2 (en) | 2005-05-04 | 2006-11-09 | Develogen Aktiengesellschaft | Use of gsk-3 inhibitors for preventing and treating pancreatic autoimmune disorders |
| US9265933B2 (en) | 2005-09-08 | 2016-02-23 | Massachusetts Eye And Ear Infirmary | Cochlear implants containing biological cells and uses thereof |
| CN101374528A (zh) * | 2006-01-20 | 2009-02-25 | 夸克医药公司 | Rtp801的治疗用途 |
| US7754700B2 (en) * | 2006-04-24 | 2010-07-13 | Trager Seymour F | Composition and methods for alleviating symptoms of neurotoxicity |
| JP2009543771A (ja) * | 2006-07-14 | 2009-12-10 | アステックス・セラピューティクス・リミテッド | 医薬化合物 |
| JP2010509919A (ja) | 2006-11-15 | 2010-04-02 | マサチューセッツ・アイ・アンド・イア・インファーマリー | 内耳細胞の生成 |
| WO2008124165A2 (en) | 2007-04-09 | 2008-10-16 | Chimeros, Inc. | Self-assembling nanoparticle drug delivery system |
| DE102007032579B4 (de) | 2007-07-09 | 2017-05-04 | Tyco Electronics Services Gmbh | Endverschluss für die Telekommunikations- und Datentechnik |
| WO2009010298A2 (en) | 2007-07-18 | 2009-01-22 | Technische Universität Carolo-Wilhelmina Zu Braunschweig | Paullone derivatives and its use |
| BRPI0817664A2 (pt) | 2007-10-12 | 2015-03-24 | Massachusetts Inst Technology | Nanopartículas, método para preparar nanopartículas e método para tratar terapeuticamente ou profilaticamente um indivíduo |
| US9259399B2 (en) * | 2007-11-07 | 2016-02-16 | Cornell University | Targeting CDK4 and CDK6 in cancer therapy |
| AU2008326431A1 (en) * | 2007-11-19 | 2009-05-28 | Bionovo, Inc. | Scutellaria barbata extract and combinations for the treatment of cancer |
| US8004501B2 (en) | 2008-01-21 | 2011-08-23 | Sony Computer Entertainment America Llc | Hand-held device with touchscreen and digital tactile pixels |
| EP2732819B1 (en) | 2008-02-07 | 2019-10-16 | Massachusetts Eye & Ear Infirmary | Compounds that enhance Atoh-1 expression |
| US8496957B2 (en) * | 2008-07-21 | 2013-07-30 | Otonomy, Inc | Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders |
| WO2010047839A1 (en) | 2008-10-25 | 2010-04-29 | Aura Biosciences | Modified plant virus particles and uses therefor |
| CA2743436C (en) | 2008-11-24 | 2017-10-31 | Massachusetts Eye & Ear Infirmary | Pathways to generate hair cells |
| EP3299464B1 (en) | 2010-05-26 | 2019-10-02 | CuRNA, Inc. | Treatment of atonal homolog 1 (atoh1) related diseases by inhibition of natural antisense transcript to atoh1 |
| GB201107176D0 (en) * | 2011-04-28 | 2011-06-15 | Cxr Biosciences Ltd | Pyrrolnitrin derivatives |
| WO2013071415A1 (en) * | 2011-11-15 | 2013-05-23 | University Health Network | Targeting the rb pathway for the prevention of cancer |
| FR2993956B1 (fr) | 2012-07-27 | 2015-05-22 | Coutier Moulage Gen Ind | Ensemble de tuyau pour l’ecoulement d’un fluide et d’un courant et procede pour assembler un tel ensemble de tuyau |
| EP2925859B1 (en) * | 2012-11-29 | 2018-05-02 | Takara Bio Europe AB | Maturation of hepatocyte-like cells derived from human pluripotent stem cells |
| US9572815B2 (en) | 2013-03-15 | 2017-02-21 | St. Jude Children's Research Hospital | Methods and compositions of p27KIP1 transcriptional modulators |
| CN108137595B (zh) | 2015-06-18 | 2021-04-20 | 听治疗有限责任公司 | 预防和治疗听力损失的方法和组合物 |
-
2016
- 2016-06-20 CN CN201680046636.7A patent/CN108137595B/zh active Active
- 2016-06-20 CN CN202110302436.6A patent/CN112933094B/zh active Active
- 2016-06-20 EP EP20197304.7A patent/EP3786164B1/en active Active
- 2016-06-20 JP JP2018517685A patent/JP6902025B2/ja active Active
- 2016-06-20 WO PCT/US2016/038384 patent/WO2016205806A1/en not_active Ceased
- 2016-06-20 US US15/580,224 patent/US20180161340A1/en not_active Abandoned
- 2016-06-20 EP EP16812629.0A patent/EP3310783B1/en active Active
-
2019
- 2019-12-09 US US16/707,991 patent/US11446308B2/en active Active
-
2020
- 2020-09-18 JP JP2020156803A patent/JP7257367B2/ja active Active
-
2022
- 2022-07-12 US US17/862,656 patent/US12318391B2/en active Active
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