WO2011155803A3 - 청각보호 작용을 하는 신규 화합물 - Google Patents

청각보호 작용을 하는 신규 화합물 Download PDF

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Publication number
WO2011155803A3
WO2011155803A3 PCT/KR2011/004297 KR2011004297W WO2011155803A3 WO 2011155803 A3 WO2011155803 A3 WO 2011155803A3 KR 2011004297 W KR2011004297 W KR 2011004297W WO 2011155803 A3 WO2011155803 A3 WO 2011155803A3
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WO
WIPO (PCT)
Prior art keywords
novel compound
hearing protection
compound
protection effects
present
Prior art date
Application number
PCT/KR2011/004297
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English (en)
French (fr)
Other versions
WO2011155803A2 (ko
Inventor
김철호
정영식
Original Assignee
아주대학교산학협력단
한국화학연구원
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아주대학교산학협력단, 한국화학연구원 filed Critical 아주대학교산학협력단
Priority to KR1020137000866A priority Critical patent/KR101388372B1/ko
Publication of WO2011155803A2 publication Critical patent/WO2011155803A2/ko
Publication of WO2011155803A3 publication Critical patent/WO2011155803A3/ko
Priority to US13/711,376 priority patent/US8772493B2/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • Veterinary Medicine (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)

Abstract

본 발명은 난청을 유발하는 다양한 이독성에 대해 청각유모세포의 세포사멸기전을 억제하고, 청각기관과 청력을 보호하는 본 명세서의 화학식 1로 표시되는 화합물, 이의 약학적으로 허용가능한 염, 및 이를 포함하는 조성물에 관한 것이다.
PCT/KR2011/004297 2010-06-11 2011-06-13 청각보호 작용을 하는 신규 화합물 WO2011155803A2 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR1020137000866A KR101388372B1 (ko) 2010-06-11 2011-06-13 청각보호 작용을 하는 신규 화합물
US13/711,376 US8772493B2 (en) 2010-06-11 2012-12-11 Compounds having auditory protective effect

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2010-0055536 2010-06-11
KR20100055536 2010-06-11

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/711,376 Continuation-In-Part US8772493B2 (en) 2010-06-11 2012-12-11 Compounds having auditory protective effect

Publications (2)

Publication Number Publication Date
WO2011155803A2 WO2011155803A2 (ko) 2011-12-15
WO2011155803A3 true WO2011155803A3 (ko) 2012-04-19

Family

ID=45098557

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/004297 WO2011155803A2 (ko) 2010-06-11 2011-06-13 청각보호 작용을 하는 신규 화합물

Country Status (3)

Country Link
US (1) US8772493B2 (ko)
KR (1) KR101388372B1 (ko)
WO (1) WO2011155803A2 (ko)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115927242A (zh) 2012-05-11 2023-04-07 珍白斯凯尔有限公司 具有抗炎活性的肽及其在制备抗炎组合物中的应用
US10967000B2 (en) 2012-07-11 2021-04-06 Gemvax & Kael Co., Ltd. Cell-penetrating peptide, conjugate comprising same and composition comprising same
KR101527803B1 (ko) * 2013-05-27 2015-06-11 한국화학연구원 신규한 헤테로사이클릭다이온 유도체 또는 이의 약학적으로 허용 가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 뇌신경세포 보호용 약학적 조성물
CN105535931A (zh) 2013-06-07 2016-05-04 凯尔杰姆维克斯有限公司 在癌症免疫疗法中有用的生物标记
TWI539960B (zh) 2013-06-21 2016-07-01 凱爾傑姆維克斯有限公司 激素分泌調節劑、包括其的組成物以及其用途
CN105848667B (zh) 2013-11-22 2020-05-19 珍白斯凯尔有限公司 具有血管生成抑制活性的肽和包含所述肽的组合物
KR102314231B1 (ko) 2013-12-17 2021-10-19 주식회사 젬백스앤카엘 전립선 암 치료용 조성물
CN106456697B (zh) 2014-04-11 2019-12-17 珍白斯凯尔有限公司 具有纤维化抑制活性的肽和含有其的组合物
US10662223B2 (en) 2014-04-30 2020-05-26 Gemvax & Kael Co., Ltd. Composition for organ, tissue, or cell transplantation, kit, and transplantation method
KR102413243B1 (ko) 2014-12-23 2022-06-27 주식회사 젬백스앤카엘 안질환 치료 펩티드 및 이를 포함하는 안질환 치료용 조성물
KR102636129B1 (ko) 2015-02-27 2024-02-14 주식회사 젬백스앤카엘 청력 손상 방어용 펩타이드 및 이를 포함하는 조성물
ES2886946T3 (es) 2015-07-02 2021-12-21 Gemvax & Kael Co Ltd Péptido con efecto antiviral y composición que lo contiene
WO2017176087A1 (ko) 2016-04-07 2017-10-12 주식회사 젬백스앤카엘 텔로머라제 활성 증가 및 텔로미어 연장 효능을 가지는 펩티드 및 이를 포함하는 조성물
CN115671101B (zh) * 2021-05-11 2024-01-26 哈尔滨商业大学 一种叠氮化合物的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100956576B1 (ko) * 2007-06-27 2010-05-07 아주대학교산학협력단 에피카테킨을 유효성분으로 하는 청각보호제 조성물

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100956576B1 (ko) * 2007-06-27 2010-05-07 아주대학교산학협력단 에피카테킨을 유효성분으로 하는 청각보호제 조성물

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KAFKA, S. ET AL.: "The first entry to pyrrolo[2, 3-c]quinoline-2, 4(3aH, 5H) -diones.", TETRAHEDRON, vol. 64, no. 19, 2008, pages 4387 - 4402 *
KLASEK, A. ET AL.: "Unprecedented reactivity of 3-amino-1H,3H-quinoline -2, 4-diones with urea: an efficient synthesis of 2, 6-dihydro-imidazo [1,5-c]quinazoline-3, 5-diones.", TETRAHEDRON, vol. 59, no. 8, 2003, pages 1283 - 1288 *
PRUCKOVA, Z. ET AL.: "Synthesis of 2-thioxoimidazolines via reaction of 1-unsubstituted 3-aminoquinoline-2, 4-diones with isothiocyanates.", TETRAHEDRON, vol. 65, no. 45, 2009, pages 9103 - 9115 *

Also Published As

Publication number Publication date
KR20130041896A (ko) 2013-04-25
WO2011155803A2 (ko) 2011-12-15
KR101388372B1 (ko) 2014-04-23
US8772493B2 (en) 2014-07-08
US20130217881A1 (en) 2013-08-22

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