JP2018521640A5 - - Google Patents

Info

Publication number

JP2018521640A5

JP2018521640A5 JP2017563189A JP2017563189A JP2018521640A5 JP 2018521640 A5 JP2018521640 A5 JP 2018521640A5 JP 2017563189 A JP2017563189 A JP 2017563189A JP 2017563189 A JP2017563189 A JP 2017563189A JP 2018521640 A5 JP2018521640 A5 JP 2018521640A5

Authority

JP

Japan

Prior art keywords

peptide linker

amino acid

seq

acid sequence

residue

Prior art date

2016-06-03

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 108090000765 processed proteins & peptides Proteins 0.000 claims 119
• 125000003275 alpha amino acid group Chemical group 0.000 claims 55
• 235000018102 proteins Nutrition 0.000 claims 34
• 102000004169 proteins and genes Human genes 0.000 claims 34
• 108090000623 proteins and genes Proteins 0.000 claims 34
• 238000000034 method Methods 0.000 claims 26
• 102000037865 fusion proteins Human genes 0.000 claims 19
• 108020001507 fusion proteins Proteins 0.000 claims 19
• CKLJMWTZIZZHCS-REOHCLBHSA-N aspartic acid group Chemical group N[C@@H](CC(=O)O)C(=O)O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 15
• 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 13
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 13
• 229920001184 polypeptide Polymers 0.000 claims 10
• 102000004196 processed proteins & peptides Human genes 0.000 claims 10
• 230000015572 biosynthetic process Effects 0.000 claims 8
• 102000014914 Carrier Proteins Human genes 0.000 claims 6
• 102000003960 Ligases Human genes 0.000 claims 6
• 108090000364 Ligases Proteins 0.000 claims 6
• 108091008324 binding proteins Proteins 0.000 claims 6
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
• 102000039446 nucleic acids Human genes 0.000 claims 5
• 108020004707 nucleic acids Proteins 0.000 claims 5
• 150000007523 nucleic acids Chemical class 0.000 claims 5
• 229940024606 amino acid Drugs 0.000 claims 4
• 235000001014 amino acid Nutrition 0.000 claims 4
• CKLJMWTZIZZHCS-REOHCLBHSA-L aspartate group Chemical group N[C@@H](CC(=O)[O-])C(=O)[O-] CKLJMWTZIZZHCS-REOHCLBHSA-L 0.000 claims 4
• 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 4
• 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 4
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical group OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 3
• 150000001413 amino acids Chemical class 0.000 claims 3
• 239000000758 substrate Substances 0.000 claims 3
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 2
• 125000004432 carbon atom Chemical group C* 0.000 claims 2
• 235000013922 glutamic acid Nutrition 0.000 claims 2
• 239000004220 glutamic acid Substances 0.000 claims 2
• 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 claims 2
• 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
• 239000007787 solid Substances 0.000 claims 2
• 239000007790 solid phase Substances 0.000 claims 2
• 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
• DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Chemical group OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• 229960001230 asparagine Drugs 0.000 claims 1
• 235000009582 asparagine Nutrition 0.000 claims 1
• 125000004122 cyclic group Chemical group 0.000 claims 1
• 229930195712 glutamate Natural products 0.000 claims 1
• WHUUTDBJXJRKMK-VKHMYHEASA-L glutamate group Chemical group N[C@@H](CCC(=O)[O-])C(=O)[O-] WHUUTDBJXJRKMK-VKHMYHEASA-L 0.000 claims 1
• 230000002269 spontaneous effect Effects 0.000 claims 1