JP2018520750A5 - - Google Patents
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- JP2018520750A5 JP2018520750A5 JP2017564535A JP2017564535A JP2018520750A5 JP 2018520750 A5 JP2018520750 A5 JP 2018520750A5 JP 2017564535 A JP2017564535 A JP 2017564535A JP 2017564535 A JP2017564535 A JP 2017564535A JP 2018520750 A5 JP2018520750 A5 JP 2018520750A5
- Authority
- JP
- Japan
- Prior art keywords
- bone
- osteogenic precursor
- precursor cells
- cells
- opc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 18
- 230000002188 osteogenic effect Effects 0.000 claims 16
- 239000002243 precursor Substances 0.000 claims 16
- 210000000988 bone and bone Anatomy 0.000 claims 12
- 239000000203 mixture Substances 0.000 claims 12
- 239000000919 ceramic Substances 0.000 claims 8
- 210000000130 stem cell Anatomy 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- 108010035532 Collagen Proteins 0.000 claims 6
- 102000008186 Collagen Human genes 0.000 claims 6
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 6
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 6
- 229920001436 collagen Polymers 0.000 claims 6
- 210000002744 extracellular matrix Anatomy 0.000 claims 6
- 208000014674 injury Diseases 0.000 claims 6
- 239000006166 lysate Substances 0.000 claims 5
- 230000011164 ossification Effects 0.000 claims 5
- 102000016921 Integrin-Binding Sialoprotein Human genes 0.000 claims 4
- 108010028750 Integrin-Binding Sialoprotein Proteins 0.000 claims 4
- 201000009859 Osteochondrosis Diseases 0.000 claims 4
- 229920000954 Polyglycolide Polymers 0.000 claims 4
- 208000027418 Wounds and injury Diseases 0.000 claims 4
- 230000006378 damage Effects 0.000 claims 4
- 239000000017 hydrogel Substances 0.000 claims 4
- 229920001610 polycaprolactone Polymers 0.000 claims 4
- 239000004632 polycaprolactone Substances 0.000 claims 4
- 239000004633 polyglycolic acid Substances 0.000 claims 4
- 238000002360 preparation method Methods 0.000 claims 4
- 101100398412 Arabidopsis thaliana ASK1 gene Proteins 0.000 claims 3
- 102100040995 Collagen alpha-1(XXI) chain Human genes 0.000 claims 3
- -1 HAND2 Proteins 0.000 claims 3
- 101000748976 Homo sapiens Collagen alpha-1(XXI) chain Proteins 0.000 claims 3
- 101001013150 Homo sapiens Interstitial collagenase Proteins 0.000 claims 3
- 101000635895 Homo sapiens Myosin light chain 4 Proteins 0.000 claims 3
- 101000928535 Homo sapiens Protein delta homolog 1 Proteins 0.000 claims 3
- 101000825086 Homo sapiens Transcription factor SOX-11 Proteins 0.000 claims 3
- 101001053754 Homo sapiens Type II iodothyronine deiodinase Proteins 0.000 claims 3
- 101000976653 Homo sapiens Zinc finger protein ZIC 1 Proteins 0.000 claims 3
- 101000976643 Homo sapiens Zinc finger protein ZIC 2 Proteins 0.000 claims 3
- 102000000380 Matrix Metalloproteinase 1 Human genes 0.000 claims 3
- 102100030739 Myosin light chain 4 Human genes 0.000 claims 3
- 102100036467 Protein delta homolog 1 Human genes 0.000 claims 3
- 101150082840 SM30 gene Proteins 0.000 claims 3
- 101100401000 Saccharomyces cerevisiae MEL2 gene Proteins 0.000 claims 3
- 102100022415 Transcription factor SOX-11 Human genes 0.000 claims 3
- 102100024060 Type II iodothyronine deiodinase Human genes 0.000 claims 3
- 102100023497 Zinc finger protein ZIC 1 Human genes 0.000 claims 3
- 102100023492 Zinc finger protein ZIC 2 Human genes 0.000 claims 3
- 230000004069 differentiation Effects 0.000 claims 3
- 230000001737 promoting effect Effects 0.000 claims 3
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims 2
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims 2
- 102100025683 Alkaline phosphatase, tissue-nonspecific isozyme Human genes 0.000 claims 2
- 102000016942 Elastin Human genes 0.000 claims 2
- 108010014258 Elastin Proteins 0.000 claims 2
- 102000009123 Fibrin Human genes 0.000 claims 2
- 108010073385 Fibrin Proteins 0.000 claims 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims 2
- 108010010803 Gelatin Proteins 0.000 claims 2
- 101000574445 Homo sapiens Alkaline phosphatase, tissue-nonspecific isozyme Proteins 0.000 claims 2
- 101000591210 Homo sapiens Receptor-type tyrosine-protein phosphatase-like N Proteins 0.000 claims 2
- 108010044467 Isoenzymes Proteins 0.000 claims 2
- 206010060820 Joint injury Diseases 0.000 claims 2
- 208000023178 Musculoskeletal disease Diseases 0.000 claims 2
- 102000004264 Osteopontin Human genes 0.000 claims 2
- 102100040557 Osteopontin Human genes 0.000 claims 2
- 108010081689 Osteopontin Proteins 0.000 claims 2
- 102100034091 Receptor-type tyrosine-protein phosphatase-like N Human genes 0.000 claims 2
- 210000001691 amnion Anatomy 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 210000002805 bone matrix Anatomy 0.000 claims 2
- 239000001506 calcium phosphate Substances 0.000 claims 2
- 230000022159 cartilage development Effects 0.000 claims 2
- 239000000515 collagen sponge Substances 0.000 claims 2
- 239000002131 composite material Substances 0.000 claims 2
- 229920002549 elastin Polymers 0.000 claims 2
- 229950003499 fibrin Drugs 0.000 claims 2
- 239000008273 gelatin Substances 0.000 claims 2
- 229920000159 gelatin Polymers 0.000 claims 2
- 235000019322 gelatine Nutrition 0.000 claims 2
- 235000011852 gelatine desserts Nutrition 0.000 claims 2
- 210000004394 hip joint Anatomy 0.000 claims 2
- 210000005260 human cell Anatomy 0.000 claims 2
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 claims 2
- 229940099552 hyaluronan Drugs 0.000 claims 2
- 229920002674 hyaluronan Polymers 0.000 claims 2
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims 2
- 239000007943 implant Substances 0.000 claims 2
- 210000000629 knee joint Anatomy 0.000 claims 2
- 108010082117 matrigel Proteins 0.000 claims 2
- 208000017445 musculoskeletal system disease Diseases 0.000 claims 2
- 230000000399 orthopedic effect Effects 0.000 claims 2
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims 2
- 239000004626 polylactic acid Substances 0.000 claims 2
- 230000003014 reinforcing effect Effects 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 230000008733 trauma Effects 0.000 claims 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 2
- 229940078499 tricalcium phosphate Drugs 0.000 claims 2
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims 2
- 235000019731 tricalcium phosphate Nutrition 0.000 claims 2
- 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 claims 1
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims 1
- 239000003636 conditioned culture medium Substances 0.000 claims 1
- 210000002242 embryoid body Anatomy 0.000 claims 1
- 210000001808 exosome Anatomy 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000002934 lysing effect Effects 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562172808P | 2015-06-09 | 2015-06-09 | |
| US62/172,808 | 2015-06-09 | ||
| PCT/US2016/036778 WO2016201154A1 (en) | 2015-06-09 | 2016-06-09 | Osteogenic graft forming unit |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018520750A JP2018520750A (ja) | 2018-08-02 |
| JP2018520750A5 true JP2018520750A5 (enExample) | 2019-07-11 |
| JP6875297B2 JP6875297B2 (ja) | 2021-05-19 |
Family
ID=57504258
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017564535A Expired - Fee Related JP6875297B2 (ja) | 2015-06-09 | 2016-06-09 | 骨形成性移植片形成ユニット |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20180325958A1 (enExample) |
| EP (1) | EP3307287A4 (enExample) |
| JP (1) | JP6875297B2 (enExample) |
| AU (1) | AU2016274785A1 (enExample) |
| CA (1) | CA2988778A1 (enExample) |
| HK (1) | HK1254314A1 (enExample) |
| WO (1) | WO2016201154A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013010045A1 (en) | 2011-07-12 | 2013-01-17 | Biotime Inc. | Novel methods and formulations for orthopedic cell therapy |
| WO2018115871A1 (en) * | 2016-12-20 | 2018-06-28 | The University Of Birmingham | Composition and method for bone production |
| JP7204730B2 (ja) * | 2017-03-31 | 2023-01-16 | セラム バイオメディカル， インコーポレイテッド | 生体適合性馴化細胞培地組成物およびその使用 |
| CN108452378B (zh) * | 2018-02-08 | 2020-10-23 | 中山大学附属第一医院 | 一种3d生物打印成型方法 |
| CN108310463B (zh) * | 2018-02-08 | 2020-10-23 | 中山大学附属第一医院 | 一种3d打印生物墨水及其制备方法 |
| KR102232283B1 (ko) * | 2018-07-26 | 2021-03-25 | 에이비온 주식회사 | 연골세포 분화 마커 |
| CN109568665B (zh) * | 2018-12-28 | 2021-12-10 | 中国医科大学附属第一医院 | 负载脂肪干细胞外泌体的温敏型可注射水凝胶及其制备方法和应用 |
| CA3137836C (en) * | 2019-04-23 | 2024-04-09 | Cellatoz Therapeutics, Inc. | Method for regulation of selective differentiation of musculoskeletal stem cells |
| KR102236635B1 (ko) * | 2019-09-04 | 2021-04-13 | 경북대학교 산학협력단 | Meox2 억제제를 유효성분으로 포함하는 발치와 골 재생 촉진용 조성물 |
| KR102104933B1 (ko) * | 2019-10-31 | 2020-04-27 | 주식회사 라이프온 | 줄기세포 유래 엑소좀을 함유하는 치아 재강화 또는 치아골 이식재 조성물 및 그 제조방법 |
| CN110684710A (zh) * | 2019-11-23 | 2020-01-14 | 吉林省蔚来生物科技有限公司 | 一种骨膜生物支架与异体种子细胞复合的培养方法 |
| JP2021159499A (ja) * | 2020-04-01 | 2021-10-11 | 株式会社Dr.Cherry | 骨形成を促進することに用いられる新生骨の支持体 |
| KR102463245B1 (ko) * | 2020-06-19 | 2022-11-07 | 동국대학교 산학협력단 | Mettl7a 과발현 줄기세포를 포함하는 골재생용 조성물, 이를 제조하는 방법 및 이를 포함하는 세포치료제 |
| CN113249332A (zh) * | 2021-07-15 | 2021-08-13 | 北京大学第三医院（北京大学第三临床医学院） | 一种alpl基因缺失骨髓间充质干细胞的建立方法 |
| EP4230232A1 (en) | 2022-02-16 | 2023-08-23 | Hacettepe Üniversitesi | Binding of calcium phosphate bioceramic and exosomes via annexin v mediator molecule |
| CN115957378B (zh) * | 2023-02-08 | 2024-10-22 | 上海交通大学医学院附属瑞金医院 | 一种骨修复组合物及其制备方法和应用 |
| CN118028212B (zh) * | 2024-04-12 | 2024-06-18 | 广东医科大学附属医院 | 土元外泌体在制备抗骨质疏松药物中的应用、药物 |
| CN120209114A (zh) * | 2025-03-07 | 2025-06-27 | 首都医科大学 | 一种含有penk蛋白的组合物及其应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1722765A2 (en) * | 2004-01-28 | 2006-11-22 | The Regents of The University of Michigan | Osteoblast factor(s) that regulates human prostate cancer migration to and invasion of bone |
| CH700138B1 (it) * | 2008-12-19 | 2012-12-14 | Ind Biomediche Insubri S A | Matrice per impianto osseo e procedimento di preparazione della stessa. |
| WO2013010045A1 (en) * | 2011-07-12 | 2013-01-17 | Biotime Inc. | Novel methods and formulations for orthopedic cell therapy |
| CN104487569A (zh) * | 2012-05-10 | 2015-04-01 | 生物材料细胞公司 | 间充质干细胞的成骨分化 |
| US20140178988A1 (en) * | 2012-10-08 | 2014-06-26 | Biotime, Inc. | Differentiated Progeny of Clonal Progenitor Cell Lines |
| AU2014284440B2 (en) * | 2013-07-01 | 2018-07-19 | Amit Prakash Govil | Soft tissue implant |
| CA2923002C (en) * | 2013-09-02 | 2022-12-13 | Muffin Incorporated | Products comprising an extracellular matrix tissue material and osteogenic protein |
-
2016
- 2016-06-09 EP EP16808325.1A patent/EP3307287A4/en not_active Withdrawn
- 2016-06-09 CA CA2988778A patent/CA2988778A1/en not_active Abandoned
- 2016-06-09 HK HK18113282.0A patent/HK1254314A1/zh unknown
- 2016-06-09 JP JP2017564535A patent/JP6875297B2/ja not_active Expired - Fee Related
- 2016-06-09 WO PCT/US2016/036778 patent/WO2016201154A1/en not_active Ceased
- 2016-06-09 AU AU2016274785A patent/AU2016274785A1/en not_active Abandoned
-
2017
- 2017-12-07 US US15/834,242 patent/US20180325958A1/en not_active Abandoned
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